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Type I complement component 8 deficiency(C8D1)

MedGen UID:
462431
Concept ID:
C3151081
Disease or Syndrome
Synonyms: C8 alpha-gamma deficiency; C8 deficiency type I; C81 deficiency; C8AG DEFICIENCY; COMPLEMENT C8 DEFICIENCY, TYPE I; Complement component 8 deficiency type 1
 
Gene (location): C8A (1p32.2)
 
Monarch Initiative: MONDO:0013422
OMIM®: 613790

Definition

Patients with deficiency of C8 suffer from recurrent neisserial infections, predominantly with meningococcus infection of rare serotypes. Most such patients are discovered among those having their first episode of meningitis at ages older than 10 years (Ross and Densen, 1984). Two kinds of inherited C8 deficiency have been reported in humans: type I (C8D1), in which only C8 alpha and C8 gamma (C8G; 120930) are deficient, and type II (C8D2; 613789), in which only C8 beta (C8B; 120960) is deficient (Marcus et al., 1982; Tedesco et al., 1983). The 2 types are clinically indistinguishable (Ross and Densen, 1984). [from OMIM]

Additional description

From MedlinePlus Genetics
There are two types of complement component 8 deficiency, types I and II, classified by their genetic cause. The two types have the same signs and symptoms.

The severity of complement component 8 deficiency varies widely. While some people with this condition experience one or more infections, others do not have any health problems related to the disorder.

Complement component 8 deficiency is a disorder that causes the immune system to malfunction, resulting in a form of immunodeficiency. Immunodeficiencies are conditions in which the immune system is not able to protect the body effectively from foreign invaders such as bacteria. People with complement component 8 deficiency have a significantly increased risk of recurrent bacterial infections, particularly by a bacterium called Neisseria meningitidis. Infection by this bacterium causes inflammation of the membranes surrounding the brain and spinal cord (meningitis). Although meningitis can be life-threatening, individuals with complement component 8 deficiency are less likely to die from the infection than people in the general population who contract it.  https://medlineplus.gov/genetics/condition/complement-component-8-deficiency

Clinical features

From HPO
Systemic lupus erythematosus
MedGen UID:
6146
Concept ID:
C0024141
Disease or Syndrome
Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by production of autoantibodies against nuclear, cytoplasmic, and cell surface molecules that transcend organ-specific boundaries. Tissue deposition of antibodies or immune complexes induces inflammation and subsequent injury of multiple organs and finally results in clinical manifestations of SLE, including glomerulonephritis, dermatitis, thrombosis, vasculitis, seizures, and arthritis. Evidence strongly suggests the involvement of genetic components in SLE susceptibility (summary by Oishi et al., 2008). Genetic Heterogeneity of Systemic Lupus Erythematosus An autosomal recessive form of systemic lupus erythematosus (SLEB16; 614420) is caused by mutation in the DNASE1L3 gene (602244) on chromosome 3p14.3. An X-linked dominant form of SLE (SLEB17; 301080) is caused by heterozygous mutation in the TLR7 gene (300365) on chromosome Xp22. See MAPPING and MOLECULAR GENETICS sections for a discussion of genetic heterogeneity of susceptibility to SLE.
Meningitis
MedGen UID:
6298
Concept ID:
C0025289
Disease or Syndrome
Inflammation of the meninges.
Decreased circulating complement C8 concentration
MedGen UID:
462432
Concept ID:
C3151082
Finding
Concentration of the complement component C8 in the blood circulation below the lower limit of normal.

Recent clinical studies

Etiology

Genel F, Erdem SB, Gülez N, Karaman S, Nacaroglu HT, Skattum L, Truedsson L
Iran J Immunol 2018 Dec;15(4):309-320. doi: 10.22034/IJI.2018.39400. PMID: 30593745
D'Amelio R, Agostoni A, Biselli R, Brai M, Caruso G, Cicardi M, Corvetta A, Fontana L, Misiano G, Perricone R
Scand J Immunol 1992 May;35(5):589-95. doi: 10.1111/j.1365-3083.1992.tb03258.x. PMID: 1579859
Rogde S, Høiby EA, Teisberg P, Olaisen B
Scand J Infect Dis 1990;22(6):673-9. doi: 10.3109/00365549009027120. PMID: 2284574
Ellison RT 3rd, Kohler PF, Curd JG, Judson FN, Reller LB
N Engl J Med 1983 Apr 21;308(16):913-6. doi: 10.1056/NEJM198304213081601. PMID: 6835295

Diagnosis

Genel F, Erdem SB, Gülez N, Karaman S, Nacaroglu HT, Skattum L, Truedsson L
Iran J Immunol 2018 Dec;15(4):309-320. doi: 10.22034/IJI.2018.39400. PMID: 30593745
Deppisch R, Schmitt V, Bommer J, Hänsch GM, Ritz E, Rauterberg EW
Kidney Int 1990 Feb;37(2):696-706. doi: 10.1038/ki.1990.36. PMID: 2407885
Darveau RP, Cunningham MD
J Infect Dis 1990 Oct;162(4):914-21. doi: 10.1093/infdis/162.4.914. PMID: 2119402
Rosenfeld SI, Jenkins DE Jr, Leddy JP
J Immunol 1985 Jan;134(1):506-11. PMID: 3964820

Therapy

Deppisch R, Schmitt V, Bommer J, Hänsch GM, Ritz E, Rauterberg EW
Kidney Int 1990 Feb;37(2):696-706. doi: 10.1038/ki.1990.36. PMID: 2407885

Prognosis

Genel F, Erdem SB, Gülez N, Karaman S, Nacaroglu HT, Skattum L, Truedsson L
Iran J Immunol 2018 Dec;15(4):309-320. doi: 10.22034/IJI.2018.39400. PMID: 30593745

Clinical prediction guides

Densen P, Ackermann L, Saucedo L, Figueroa JE, Si ZH, Stoltzfus CM
J Immunol 2020 Sep 15;205(6):1535-1539. Epub 2020 Aug 7 doi: 10.4049/jimmunol.2000272. PMID: 32769119Free PMC Article
Shen Y, Sullivan T, Lee CM, Meri S, Shiosaki K, Lin CW
Brain Res 1998 Jun 15;796(1-2):187-97. doi: 10.1016/s0006-8993(98)00346-1. PMID: 9689469
Darveau RP, Cunningham MD
J Infect Dis 1990 Oct;162(4):914-21. doi: 10.1093/infdis/162.4.914. PMID: 2119402
Young JD, Jiang S, Liu CC, Hasselkus-Light CS
J Immunol Methods 1990 Mar 27;128(1):133-42. doi: 10.1016/0022-1759(90)90472-8. PMID: 1691232
Holguin MH, Fredrick LR, Bernshaw NJ, Wilcox LA, Parker CJ
J Clin Invest 1989 Jul;84(1):7-17. doi: 10.1172/JCI114172. PMID: 2738160Free PMC Article

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