Classic Hodgkin lymphoma is a lymph node cancer of germinal center B-cell origin. Hodgkin lymphoma tumors consist of a minority of malignant cells, known as 'Reed-Sternberg' (RS) cells, mixed with reactive lymphocytes and other benign inflammatory cells. A defining feature of RS cells is the presence of 2 nuclei (summary by Salipante et al., 2009).

A disorder characterized by proliferation of lymphocytes at various stages of differentiation. Lymphoproliferative disorders can be neoplastic (clonal, as in lymphomas and leukemias) or reactive (polyclonal, as in infectious mononucleosis).

Warts, benign growths on the skin or mucous membranes that cause cosmetic problems as well as pain and discomfort. Warts most often occur on the hands, feet, and genital areas.

Failure of the foramen ovale to seal postnatally, leaving a potential conduit between the left and right cardiac atria.

A kind of atrial septum defect arising from an enlarged foramen ovale, inadequate growth of the septum secundum, or excessive absorption of the septum primum.

Persistent abnormal dilatation of the bronchi owing to localized and irreversible destruction and widening of the large airways.

A recurrent form of sinusitis.

An increased susceptibility to upper respiratory tract infections as manifested by a history of recurrent upper respiratory tract infections (running ears - otitis, sinusitis, pharyngitis, tonsillitis).

An increased susceptibility to pneumonia as manifested by a history of recurrent episodes of pneumonia.

An increased susceptibility to lower respiratory tract infections as manifested by a history of recurrent lower respiratory tract infections.

An autoimmune form of hemolytic anemia.

Recurrent or persistent superficial Candida infections of the skin, mucous membranes, and nails.

Failure of the immune system to protect the body adequately from infection, due to the absence or insufficiency of some component process or substance.

A reduced number of lymphocytes in the blood.

Molluscum contagiosum is a cutaneous viral infection that is commonly observed in both healthy and immunocompromised children. The infection is caused by a member of the Poxviridae family, the molluscum contagiosum virus. Molluscum contagiosum presents as single or multiple small white or flesh-colored papules that typically have a central umbilication. The central umbilication may be difficult to observe in young children and, instead, may bear an appearance similar to an acneiform eruption. The lesions vary in size (from 1 mm to 1 cm in diameter) and are painless, although a subset of patients report pruritus in the area of infection. On average, 11-20 papules appear on the body during the course of infection and generally remains a self-limiting disease. However, in immunosuppressed patients, molluscum contagiosum can be a severe infection with hundreds of lesions developing on the body. Extensive eruption is indicative of an advanced immunodeficiency state.

Systemic inflammatory response to infection.

An abnormally low number of neutrophils in the peripheral blood.

Increased susceptibility to viral infections, as manifested by recurrent episodes of viral infection.

Increased susceptibility to bacterial infections, as manifested by recurrent episodes of bacterial infection.

Increased susceptibility to fungal infections, as manifested by multiple episodes of fungal infection.

Infections of the skin that happen multiple times.

Persistent presence of Epstein-Barr virus in the blood.

The presence of molluscum contagiosum lesions across multiple areas of the body.

Periodic (episodic or recurrent) bouts of fever.

Recurrent episodes of ulceration of the oral mucosa, typically presenting as painful, sharply circumscribed fibrin-covered mucosal defects with a hyperemic border.