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peginterferon alfa-2a, peginterferon alfa-2b, and ribavirin response - Efficacy

MedGen UID:
1002667
•Concept ID:
CN322718
•
Sign or Symptom

Professional guidelines

PubMed

Role of IL28B for chronic hepatitis C treatment toward personalized medicine.
Matsuura K, Watanabe T, Tanaka Y
J Gastroenterol Hepatol 2014 Feb;29(2):241-9. doi: 10.1111/jgh.12475. PMID: 24325405
Optimal treatment with boceprevir for chronic HCV infection.
Maasoumy B, Manns MP
Liver Int 2013 Feb;33 Suppl 1:14-22. doi: 10.1111/liv.12070. PMID: 23286841
Current treatment options and response rates in children with chronic hepatitis C.
Wirth S
World J Gastroenterol 2012 Jan 14;18(2):99-104. doi: 10.3748/wjg.v18.i2.99. PMID: 22253515Free PMC Article

Recent clinical studies

Etiology

Immunogenicity of branched polyethylene glycol modified interferon alpha.
Zhou W, Lu D, Liao X, Zhuang L, Sun L
Immunopharmacol Immunotoxicol 2018 Feb;40(1):35-42. Epub 2017 Nov 6 doi: 10.1080/08923973.2017.1392565. PMID: 29103340
Efficacy and safety of peginterferon plus ribavirin for patients aged ≥ 65 years with chronic hepatitis C: a systematic review and meta-analysis.
Yang Z, Zhuang L, Yang L, Liu C, Lu Y, Xu Q, Chen X, Chen L
Clin Res Hepatol Gastroenterol 2014 Sep;38(4):440-50. Epub 2013 Oct 28 doi: 10.1016/j.clinre.2013.08.013. PMID: 24176812
Peginterferon alfa and ribavirin for chronic hepatitis C in patients eligible for shortened treatment, re-treatment or in HCV/HIV co-infection: a systematic review and economic evaluation.
Hartwell D, Jones J, Baxter L, Shepherd J
Health Technol Assess 2011 Apr;15(17):i-xii, 1-210. doi: 10.3310/hta15170. PMID: 21473834Free PMC Article
A comparison of peginterferon α-2a and α-2b for treatment-naive patients with chronic hepatitis C virus: A meta-analysis of randomized trials.
Zhao S, Liu E, Chen P, Cheng D, Lu S, Yu Q, Wang Y, Wei K, Yang P
Clin Ther 2010 Aug;32(9):1565-77. doi: 10.1016/j.clinthera.2010.08.009. PMID: 20974315
Peginterferon alpha-2b: a new approach to improving response in hepatitis C patients.
Patel K, McHutchison J
Expert Opin Pharmacother 2001 Aug;2(8):1307-15. doi: 10.1517/14656566.2.8.1307. PMID: 11584999

Diagnosis

Optimal treatment with boceprevir for chronic HCV infection.
Maasoumy B, Manns MP
Liver Int 2013 Feb;33 Suppl 1:14-22. doi: 10.1111/liv.12070. PMID: 23286841
Hepatitis C: epidemiology, diagnosis, natural history and therapy.
Pol S, Vallet-Pichard A, Corouge M, Mallet VO
Contrib Nephrol 2012;176:1-9. Epub 2012 Jan 30 doi: 10.1159/000332374. PMID: 22310776
Peginterferon alpha and ribavirin combination therapy in patients with hepatitis C virus-related liver cirrhosis.
Kim KH, Jang BK, Chung WJ, Hwang JS, Kweon YO, Tak WY, Lee HJ, Lee CH, Suh JI
Korean J Hepatol 2011 Sep;17(3):220-5. doi: 10.3350/kjhep.2011.17.3.220. PMID: 22102389Free PMC Article
Improving anti-hepatitis C virus therapy.
Pol S, Mallet VO
Expert Opin Biol Ther 2006 Sep;6(9):923-33. doi: 10.1517/14712598.6.9.923. PMID: 16918259
Pegylated interferon alpha-2a and -2b in combination with ribavirin in the treatment of chronic hepatitis C: a systematic review and economic evaluation.
Shepherd J, Brodin H, Cave C, Waugh N, Price A, Gabbay J
Health Technol Assess 2004 Oct;8(39):iii-iv, 1-125. doi: 10.3310/hta8390. PMID: 15461877

Therapy

Antiviral therapy in chronic hepatitis E: a systematic review.
Peters van Ton AM, Gevers TJ, Drenth JP
J Viral Hepat 2015 Dec;22(12):965-73. Epub 2015 Mar 11 doi: 10.1111/jvh.12403. PMID: 25760481
Efficacy and safety of peginterferon plus ribavirin for patients aged ≥ 65 years with chronic hepatitis C: a systematic review and meta-analysis.
Yang Z, Zhuang L, Yang L, Liu C, Lu Y, Xu Q, Chen X, Chen L
Clin Res Hepatol Gastroenterol 2014 Sep;38(4):440-50. Epub 2013 Oct 28 doi: 10.1016/j.clinre.2013.08.013. PMID: 24176812
Pegylated interferon-α2a and ribavirin versus pegylated interferon-α2b and ribavirin in chronic hepatitis C : a meta-analysis.
Flori N, Funakoshi N, Duny Y, Valats JC, Bismuth M, Christophorou D, Daurès JP, Blanc P
Drugs 2013 Mar;73(3):263-77. doi: 10.1007/s40265-013-0027-1. PMID: 23436591
Pharmacokinetics and pharmacodynamics of peginterferon and ribavirin: implications for clinical efficacy in the treatment of chronic hepatitis C.
Noureddin M, Ghany MG
Gastroenterol Clin North Am 2010 Sep;39(3):649-58. doi: 10.1016/j.gtc.2010.08.008. PMID: 20951922Free PMC Article
Peginterferon alpha-2b: a new approach to improving response in hepatitis C patients.
Patel K, McHutchison J
Expert Opin Pharmacother 2001 Aug;2(8):1307-15. doi: 10.1517/14656566.2.8.1307. PMID: 11584999

Prognosis

Peginterferon alfa-2a and peginterferon alfa-2b combined with ribavirin in patients with genotype 1 chronic hepatitis C: results of a prospective single-centre study.
Berak H, Laskus T, Kołakowska-Rządzka A, Wasilewski M, Stańczak JJ, Bardadin K, Walewska-Zielecka B, Horban A
Adv Med Sci 2014 Sep;59(2):261-5. Epub 2014 Jun 9 doi: 10.1016/j.advms.2014.01.005. PMID: 25117425
Treatment indication and response to standard of care with peginterferon and ribavirin in acute and chronic HCV infection.
Feld JJ
Best Pract Res Clin Gastroenterol 2012 Aug;26(4):429-44. doi: 10.1016/j.bpg.2012.09.013. PMID: 23199502
Phase III results of Boceprevir in treatment naïve patients with chronic hepatitis C genotype 1.
Manns MP, Markova AA, Calle Serrano B, Cornberg M
Liver Int 2012 Feb;32 Suppl 1:27-31. doi: 10.1111/j.1478-3231.2011.02725.x. PMID: 22212568
Peginterferon alpha and ribavirin combination therapy in patients with hepatitis C virus-related liver cirrhosis.
Kim KH, Jang BK, Chung WJ, Hwang JS, Kweon YO, Tak WY, Lee HJ, Lee CH, Suh JI
Korean J Hepatol 2011 Sep;17(3):220-5. doi: 10.3350/kjhep.2011.17.3.220. PMID: 22102389Free PMC Article
Peginterferon alfa and ribavirin for chronic hepatitis C in patients eligible for shortened treatment, re-treatment or in HCV/HIV co-infection: a systematic review and economic evaluation.
Hartwell D, Jones J, Baxter L, Shepherd J
Health Technol Assess 2011 Apr;15(17):i-xii, 1-210. doi: 10.3310/hta15170. PMID: 21473834Free PMC Article

Clinical prediction guides

Efficacy and safety of peginterferon plus ribavirin for patients aged ≥ 65 years with chronic hepatitis C: a systematic review and meta-analysis.
Yang Z, Zhuang L, Yang L, Liu C, Lu Y, Xu Q, Chen X, Chen L
Clin Res Hepatol Gastroenterol 2014 Sep;38(4):440-50. Epub 2013 Oct 28 doi: 10.1016/j.clinre.2013.08.013. PMID: 24176812
Phase III results of Boceprevir in treatment naïve patients with chronic hepatitis C genotype 1.
Manns MP, Markova AA, Calle Serrano B, Cornberg M
Liver Int 2012 Feb;32 Suppl 1:27-31. doi: 10.1111/j.1478-3231.2011.02725.x. PMID: 22212568
A review of the treatment of chronic hepatitis C virus infection in cirrhosis.
Vezali E, Aghemo A, Colombo M
Clin Ther 2010 Dec;32(13):2117-38. doi: 10.1016/S0149-2918(11)00022-1. PMID: 21316532
Pegylated interferons for the treatment of chronic hepatitis C: pharmacological and clinical differences between peginterferon-alpha-2a and peginterferon-alpha-2b.
Foster GR
Drugs 2010;70(2):147-65. doi: 10.2165/11531990-000000000-00000. PMID: 20108989
Improving anti-hepatitis C virus therapy.
Pol S, Mallet VO
Expert Opin Biol Ther 2006 Sep;6(9):923-33. doi: 10.1517/14712598.6.9.923. PMID: 16918259

Recent systematic reviews

Antiviral therapy in chronic hepatitis E: a systematic review.
Peters van Ton AM, Gevers TJ, Drenth JP
J Viral Hepat 2015 Dec;22(12):965-73. Epub 2015 Mar 11 doi: 10.1111/jvh.12403. PMID: 25760481
Efficacy and safety of peginterferon plus ribavirin for patients aged ≥ 65 years with chronic hepatitis C: a systematic review and meta-analysis.
Yang Z, Zhuang L, Yang L, Liu C, Lu Y, Xu Q, Chen X, Chen L
Clin Res Hepatol Gastroenterol 2014 Sep;38(4):440-50. Epub 2013 Oct 28 doi: 10.1016/j.clinre.2013.08.013. PMID: 24176812
Peginterferon alfa-2a is superior to peginterferon alfa-2b in the treatment of naïve patients with hepatitis C virus infection: meta-analysis of randomized controlled trials.
Singal AK, Jampana SC, Anand BS
Dig Dis Sci 2011 Aug;56(8):2221-6. Epub 2011 Jun 4 doi: 10.1007/s10620-011-1765-0. PMID: 21643737
Peginterferon alfa and ribavirin for chronic hepatitis C in patients eligible for shortened treatment, re-treatment or in HCV/HIV co-infection: a systematic review and economic evaluation.
Hartwell D, Jones J, Baxter L, Shepherd J
Health Technol Assess 2011 Apr;15(17):i-xii, 1-210. doi: 10.3310/hta15170. PMID: 21473834Free PMC Article
Treatment of chronic hepatitis C: a systematic review.
Chander G, Sulkowski MS, Jenckes MW, Torbenson MS, Herlong HF, Bass EB, Gebo KA
Hepatology 2002 Nov;36(5 Suppl 1):S135-44. doi: 10.1053/jhep.2002.37146. PMID: 12407587

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