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Poly (ADP-Ribose) polymerase inhibitor response

MedGen UID:
1003353
•Concept ID:
CN322715
•
Sign or Symptom
Synonym: PARP Inhibitor response
Drug:
Poly (ADP-ribose) polymerase (PARP) inhibitior
MedGen UID:
364201
•Concept ID:
C1882413
•
Pharmacologic Substance
Any substance that inhibits Poly (ADP-Ribose) polymerase, an enzyme involved in detecting DNA single strand breaks and the initiation of DNA repair. Inhibition of Poly (ADP-Ribose) polymerase has direct cytotoxic effects by inhibiting DNA repair and causing cell death. [from NCI]
Poly (ADP-ribose) polymerase (PARP) inhibitior

Professional guidelines

PubMed

Strategies for the Management of Patients with Pancreatic Cancer with PARP Inhibitors.
Golan T, Raitses-Gurevich M, Beller T, Carroll J, Brody JR
Cancer Treat Res 2023;186:125-142. doi: 10.1007/978-3-031-30065-3_8. PMID: 37978134
Safety and management of niraparib monotherapy in ovarian cancer clinical trials.
Monk BJ, González-Martin A, Buckley L, Matulonis UA, Rimel BJ, Wu X, Moore KN, Mirza MR
Int J Gynecol Cancer 2023 Jun 5;33(6):971-981. doi: 10.1136/ijgc-2022-004079. PMID: 36792166Free PMC Article
Poly (ADP-ribose) polymerase inhibitors in the management of ovarian cancer.
Markman M
Womens Health (Lond) 2018 Jan-Dec;14:1745505717750694. doi: 10.1177/1745505717750694. PMID: 29313444Free PMC Article

Recent clinical studies

Therapy

Efficacy and Safety of Mirvetuximab Soravtansine in Patients With Platinum-Resistant Ovarian Cancer With High Folate Receptor Alpha Expression: Results From the SORAYA Study.
Matulonis UA, Lorusso D, Oaknin A, Pignata S, Dean A, Denys H, Colombo N, Van Gorp T, Konner JA, Marin MR, Harter P, Murphy CG, Wang J, Noble E, Esteves B, Method M, Coleman RL
J Clin Oncol 2023 May 1;41(13):2436-2445. Epub 2023 Jan 30 doi: 10.1200/JCO.22.01900. PMID: 36716407Free PMC Article
Overall Survival With Maintenance Olaparib at a 7-Year Follow-Up in Patients With Newly Diagnosed Advanced Ovarian Cancer and a BRCA Mutation: The SOLO1/GOG 3004 Trial.
DiSilvestro P, Banerjee S, Colombo N, Scambia G, Kim BG, Oaknin A, Friedlander M, Lisyanskaya A, Floquet A, Leary A, Sonke GS, Gourley C, Oza A, González-Martín A, Aghajanian C, Bradley W, Mathews C, Liu J, McNamara J, Lowe ES, Ah-See ML, Moore KN; SOLO1 Investigators
J Clin Oncol 2023 Jan 20;41(3):609-617. Epub 2022 Sep 9 doi: 10.1200/JCO.22.01549. PMID: 36082969Free PMC Article
Olaparib for Metastatic Castration-Resistant Prostate Cancer.
de Bono J, Mateo J, Fizazi K, Saad F, Shore N, Sandhu S, Chi KN, Sartor O, Agarwal N, Olmos D, Thiery-Vuillemin A, Twardowski P, Mehra N, Goessl C, Kang J, Burgents J, Wu W, Kohlmann A, Adelman CA, Hussain M
N Engl J Med 2020 May 28;382(22):2091-2102. Epub 2020 Apr 28 doi: 10.1056/NEJMoa1911440. PMID: 32343890
PARP and PARG inhibitors in cancer treatment.
Slade D
Genes Dev 2020 Mar 1;34(5-6):360-394. Epub 2020 Feb 6 doi: 10.1101/gad.334516.119. PMID: 32029455Free PMC Article
Olaparib for Metastatic Breast Cancer in Patients with a Germline BRCA Mutation.
Robson M, Im SA, Senkus E, Xu B, Domchek SM, Masuda N, Delaloge S, Li W, Tung N, Armstrong A, Wu W, Goessl C, Runswick S, Conte P
N Engl J Med 2017 Aug 10;377(6):523-533. Epub 2017 Jun 4 doi: 10.1056/NEJMoa1706450. PMID: 28578601

Prognosis

Overall Survival With Maintenance Olaparib at a 7-Year Follow-Up in Patients With Newly Diagnosed Advanced Ovarian Cancer and a BRCA Mutation: The SOLO1/GOG 3004 Trial.
DiSilvestro P, Banerjee S, Colombo N, Scambia G, Kim BG, Oaknin A, Friedlander M, Lisyanskaya A, Floquet A, Leary A, Sonke GS, Gourley C, Oza A, González-Martín A, Aghajanian C, Bradley W, Mathews C, Liu J, McNamara J, Lowe ES, Ah-See ML, Moore KN; SOLO1 Investigators
J Clin Oncol 2023 Jan 20;41(3):609-617. Epub 2022 Sep 9 doi: 10.1200/JCO.22.01549. PMID: 36082969Free PMC Article
Preclinical Characterization of AZD5305, A Next-Generation, Highly Selective PARP1 Inhibitor and Trapper.
Illuzzi G, Staniszewska AD, Gill SJ, Pike A, McWilliams L, Critchlow SE, Cronin A, Fawell S, Hawthorne G, Jamal K, Johannes J, Leonard E, Macdonald R, Maglennon G, Nikkilä J, O'Connor MJ, Smith A, Southgate H, Wilson J, Yates J, Cosulich S, Leo E
Clin Cancer Res 2022 Nov 1;28(21):4724-4736. doi: 10.1158/1078-0432.CCR-22-0301. PMID: 35929986Free PMC Article
Triple‑negative breast cancer therapy: Current and future perspectives (Review).
Won KA, Spruck C
Int J Oncol 2020 Dec;57(6):1245-1261. Epub 2020 Oct 16 doi: 10.3892/ijo.2020.5135. PMID: 33174058Free PMC Article
PARP and PARG inhibitors in cancer treatment.
Slade D
Genes Dev 2020 Mar 1;34(5-6):360-394. Epub 2020 Feb 6 doi: 10.1101/gad.334516.119. PMID: 32029455Free PMC Article
PARP Inhibitors in Ovarian Cancer.
Mittica G, Ghisoni E, Giannone G, Genta S, Aglietta M, Sapino A, Valabrega G
Recent Pat Anticancer Drug Discov 2018;13(4):392-410. doi: 10.2174/1574892813666180305165256. PMID: 29512470

Clinical prediction guides

Overall Survival With Maintenance Olaparib at a 7-Year Follow-Up in Patients With Newly Diagnosed Advanced Ovarian Cancer and a BRCA Mutation: The SOLO1/GOG 3004 Trial.
DiSilvestro P, Banerjee S, Colombo N, Scambia G, Kim BG, Oaknin A, Friedlander M, Lisyanskaya A, Floquet A, Leary A, Sonke GS, Gourley C, Oza A, González-Martín A, Aghajanian C, Bradley W, Mathews C, Liu J, McNamara J, Lowe ES, Ah-See ML, Moore KN; SOLO1 Investigators
J Clin Oncol 2023 Jan 20;41(3):609-617. Epub 2022 Sep 9 doi: 10.1200/JCO.22.01549. PMID: 36082969Free PMC Article
Biomarker-Guided Development of DNA Repair Inhibitors.
Cleary JM, Aguirre AJ, Shapiro GI, D'Andrea AD
Mol Cell 2020 Jun 18;78(6):1070-1085. Epub 2020 May 26 doi: 10.1016/j.molcel.2020.04.035. PMID: 32459988Free PMC Article
Olaparib for Metastatic Castration-Resistant Prostate Cancer.
de Bono J, Mateo J, Fizazi K, Saad F, Shore N, Sandhu S, Chi KN, Sartor O, Agarwal N, Olmos D, Thiery-Vuillemin A, Twardowski P, Mehra N, Goessl C, Kang J, Burgents J, Wu W, Kohlmann A, Adelman CA, Hussain M
N Engl J Med 2020 May 28;382(22):2091-2102. Epub 2020 Apr 28 doi: 10.1056/NEJMoa1911440. PMID: 32343890
PARP and PARG inhibitors in cancer treatment.
Slade D
Genes Dev 2020 Mar 1;34(5-6):360-394. Epub 2020 Feb 6 doi: 10.1101/gad.334516.119. PMID: 32029455Free PMC Article
PARP Inhibitors in Ovarian Cancer.
Mittica G, Ghisoni E, Giannone G, Genta S, Aglietta M, Sapino A, Valabrega G
Recent Pat Anticancer Drug Discov 2018;13(4):392-410. doi: 10.2174/1574892813666180305165256. PMID: 29512470

Recent systematic reviews

Efficacy and safety of PARP inhibitors in metastatic castration-resistant prostate cancer: A systematic review and meta-analysis of clinical trials.
Iannantuono GM, Chandran E, Floudas CS, Choo-Wosoba H, Butera G, Roselli M, Gulley JL, Karzai F
Cancer Treat Rev 2023 Nov;120:102623. Epub 2023 Sep 9 doi: 10.1016/j.ctrv.2023.102623. PMID: 37716332Free PMC Article
Multiple Bayesian network meta-analyses to establish therapeutic algorithms for metastatic triple negative breast cancer.
Schettini F, Venturini S, Giuliano M, Lambertini M, Pinato DJ, Onesti CE, De Placido P, Harbeck N, Lüftner D, Denys H, Van Dam P, Arpino G, Zaman K, Mustacchi G, Gligorov J, Awada A, Campone M, Wildiers H, Gennari A, Tjan-Heijnen V, Bartsch R, Cortes J, Paris I, Martín M, De Placido S, Del Mastro L, Jerusalem G, Curigliano G, Prat A, Generali D
Cancer Treat Rev 2022 Dec;111:102468. Epub 2022 Sep 28 doi: 10.1016/j.ctrv.2022.102468. PMID: 36202026
Biomarkers for Systemic Therapy in Metastatic Breast Cancer: ASCO Guideline Update.
Henry NL, Somerfield MR, Dayao Z, Elias A, Kalinsky K, McShane LM, Moy B, Park BH, Shanahan KM, Sharma P, Shatsky R, Stringer-Reasor E, Telli M, Turner NC, DeMichele A
J Clin Oncol 2022 Sep 20;40(27):3205-3221. Epub 2022 Jun 27 doi: 10.1200/JCO.22.01063. PMID: 35759724
Poly(ADP-ribose) polymerase (PARP) inhibitors for the treatment of ovarian cancer.
Tattersall A, Ryan N, Wiggans AJ, Rogozińska E, Morrison J
Cochrane Database Syst Rev 2022 Feb 16;2(2):CD007929. doi: 10.1002/14651858.CD007929.pub4. PMID: 35170751Free PMC Article
PARP Inhibitors in the Management of Ovarian Cancer: ASCO Guideline.
Tew WP, Lacchetti C, Ellis A, Maxian K, Banerjee S, Bookman M, Jones MB, Lee JM, Lheureux S, Liu JF, Moore KN, Muller C, Rodriguez P, Walsh C, Westin SN, Kohn EC
J Clin Oncol 2020 Oct 20;38(30):3468-3493. Epub 2020 Aug 13 doi: 10.1200/JCO.20.01924. PMID: 32790492Free PMC Article

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