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Cataract 49(CTRCT49)

MedGen UID:
1794220
•Concept ID:
C5562010
•
Disease or Syndrome
Synonym: CARARACT 49, POSTERIOR
 
Gene (location): PANK4 (1p36.32)
 
Monarch Initiative: MONDO:0030465
OMIM®: 619593

Definition

Cataract-49 (CTRCT49) is characterized by congenital cataract located in the posterior region of the lens. Visual impairment has onset in early childhood (Sun et al., 2019). [from OMIM]

Clinical features

From HPO
Nystagmus
MedGen UID:
45166
•Concept ID:
C0028738
•
Disease or Syndrome
Rhythmic, involuntary oscillations of one or both eyes related to abnormality in fixation, conjugate gaze, or vestibular mechanisms.
See: Feature record | Search on this feature
Reduced visual acuity
MedGen UID:
65889
•Concept ID:
C0234632
•
Finding
Diminished clarity of vision.
See: Feature record | Search on this feature
Posterior cortical cataract
MedGen UID:
869227
•Concept ID:
C4023650
•
Finding
A cataract that affects the posterior part of the cortex of the lens.
See: Feature record | Search on this feature

Professional guidelines

PubMed

Comment on: Diagnosis and management of postrefractive surgery ectasia.
Wallerstein A, Gauvin M
J Cataract Refract Surg 2023 Apr 1;49(4):448. doi: 10.1097/j.jcrs.0000000000001162. PMID: 36745846
Endophthalmitis after Cataract Surgery: Changes in Management Based on Microbiologic Cultures.
Patel SN, Storey PP, Levin H, Pancholy M, Obeid A, Wibbelsman TD, Kuley B, Ho AC, Hsu J, Garg SJ, Vander JF, Dunn JP
Ophthalmol Retina 2021 Jan;5(1):16-22. Epub 2020 Jun 26 doi: 10.1016/j.oret.2020.06.028. PMID: 32599176
New observations and emerging ideas in diagnosis and management of non-infectious uveitis: A review.
Rosenbaum JT, Bodaghi B, Couto C, Zierhut M, Acharya N, Pavesio C, Tay-Kearney ML, Neri P, Douglas K, Pathai S, Song AP, Kron M, Foster CS
Semin Arthritis Rheum 2019 Dec;49(3):438-445. Epub 2019 Jun 10 doi: 10.1016/j.semarthrit.2019.06.004. PMID: 31301816

Recent clinical studies

Etiology

Long-term Outcomes from the HORIZON Randomized Trial for a Schlemm's Canal Microstent in Combination Cataract and Glaucoma Surgery.
Ahmed IIK, De Francesco T, Rhee D, McCabe C, Flowers B, Gazzard G, Samuelson TW, Singh K; HORIZON Investigators
Ophthalmology 2022 Jul;129(7):742-751. Epub 2022 Feb 23 doi: 10.1016/j.ophtha.2022.02.021. PMID: 35218867
Cataract and systemic disease: A review.
Ang MJ, Afshari NA
Clin Exp Ophthalmol 2021 Mar;49(2):118-127. Epub 2021 Jan 10 doi: 10.1111/ceo.13892. PMID: 33426783
Iridoschisis: Spectrum of Presentation.
Pegu J, Jain K, Dubey S
Middle East Afr J Ophthalmol 2020 Oct-Dec;27(4):224-227. Epub 2021 Jan 19 doi: 10.4103/meajo.MEAJO_120_19. PMID: 33814819Free PMC Article
The Complications of Myopia: A Review and Meta-Analysis.
Haarman AEG, Enthoven CA, Tideman JWL, Tedja MS, Verhoeven VJM, Klaver CCW
Invest Ophthalmol Vis Sci 2020 Apr 9;61(4):49. doi: 10.1167/iovs.61.4.49. PMID: 32347918Free PMC Article
Global causes of blindness and distance vision impairment 1990-2020: a systematic review and meta-analysis.
Flaxman SR, Bourne RRA, Resnikoff S, Ackland P, Braithwaite T, Cicinelli MV, Das A, Jonas JB, Keeffe J, Kempen JH, Leasher J, Limburg H, Naidoo K, Pesudovs K, Silvester A, Stevens GA, Tahhan N, Wong TY, Taylor HR; Vision Loss Expert Group of the Global Burden of Disease Study
Lancet Glob Health 2017 Dec;5(12):e1221-e1234. Epub 2017 Oct 11 doi: 10.1016/S2214-109X(17)30393-5. PMID: 29032195

Diagnosis

Five-Year Visual Field Outcomes of the HORIZON Trial.
Montesano G, Ometto G, Ahmed IIK, Ramulu PY, Chang DF, Crabb DP, Gazzard G
Am J Ophthalmol 2023 Jul;251:143-155. Epub 2023 Feb 21 doi: 10.1016/j.ajo.2023.02.008. PMID: 36813144
Diabetes-Related Microvascular Complications - A Practical Approach.
Mishriky BM, Cummings DM, Powell JR
Prim Care 2022 Jun;49(2):239-254. Epub 2022 Apr 22 doi: 10.1016/j.pop.2021.11.008. PMID: 35595480
Iridoschisis: Spectrum of Presentation.
Pegu J, Jain K, Dubey S
Middle East Afr J Ophthalmol 2020 Oct-Dec;27(4):224-227. Epub 2021 Jan 19 doi: 10.4103/meajo.MEAJO_120_19. PMID: 33814819Free PMC Article
The Complications of Myopia: A Review and Meta-Analysis.
Haarman AEG, Enthoven CA, Tideman JWL, Tedja MS, Verhoeven VJM, Klaver CCW
Invest Ophthalmol Vis Sci 2020 Apr 9;61(4):49. doi: 10.1167/iovs.61.4.49. PMID: 32347918Free PMC Article
Traumatic cataract.
Ajamian PC
Optom Clin 1993;3(2):49-56. PMID: 8268696

Therapy

Refractive outcomes after DMEK: meta-analysis.
Augustin VA, Son HS, Yildirim TM, Meis J, Łabuz G, Auffarth GU, Khoramnia R
J Cataract Refract Surg 2023 Sep 1;49(9):982-987. doi: 10.1097/j.jcrs.0000000000001212. PMID: 37144644
Five-Year Visual Field Outcomes of the HORIZON Trial.
Montesano G, Ometto G, Ahmed IIK, Ramulu PY, Chang DF, Crabb DP, Gazzard G
Am J Ophthalmol 2023 Jul;251:143-155. Epub 2023 Feb 21 doi: 10.1016/j.ajo.2023.02.008. PMID: 36813144
Long-term Outcomes from the HORIZON Randomized Trial for a Schlemm's Canal Microstent in Combination Cataract and Glaucoma Surgery.
Ahmed IIK, De Francesco T, Rhee D, McCabe C, Flowers B, Gazzard G, Samuelson TW, Singh K; HORIZON Investigators
Ophthalmology 2022 Jul;129(7):742-751. Epub 2022 Feb 23 doi: 10.1016/j.ophtha.2022.02.021. PMID: 35218867
Cataract surgery and dry eye disease: A review.
Naderi K, Gormley J, O'Brart D
Eur J Ophthalmol 2020 Sep;30(5):840-855. Epub 2020 Jun 9 doi: 10.1177/1120672120929958. PMID: 32515220Free PMC Article
The Complications of Myopia: A Review and Meta-Analysis.
Haarman AEG, Enthoven CA, Tideman JWL, Tedja MS, Verhoeven VJM, Klaver CCW
Invest Ophthalmol Vis Sci 2020 Apr 9;61(4):49. doi: 10.1167/iovs.61.4.49. PMID: 32347918Free PMC Article

Prognosis

An Outbreak of Fungal Endophthalmitis After Cataract Surgery in South Korea.
Kim SW, Kim JH, Choi M, Lee SJ, Shin JP, Kim JG, Kang SW, Park KH; Korean Retina Society members
JAMA Ophthalmol 2023 Mar 1;141(3):226-233. doi: 10.1001/jamaophthalmol.2022.5927. PMID: 36656597Free PMC Article
Major Ocular Abnormalities Among Hemodialysis Patients in Indonesia.
Widjaja SA, Ono K, Hiratsuka Y, Yustiarini I, Widodo W, Murakami A
Acta Med Indones 2022 Jan;54(1):52-61. PMID: 35398826
The Complications of Myopia: A Review and Meta-Analysis.
Haarman AEG, Enthoven CA, Tideman JWL, Tedja MS, Verhoeven VJM, Klaver CCW
Invest Ophthalmol Vis Sci 2020 Apr 9;61(4):49. doi: 10.1167/iovs.61.4.49. PMID: 32347918Free PMC Article
Myopia and age-related cataract: a systematic review and meta-analysis.
Pan CW, Cheng CY, Saw SM, Wang JJ, Wong TY
Am J Ophthalmol 2013 Nov;156(5):1021-1033.e1. Epub 2013 Aug 12 doi: 10.1016/j.ajo.2013.06.005. PMID: 23938120
Posterior capsule striae.
Vasavada AR, Trivedi RH
J Cataract Refract Surg 1999 Nov;25(11):1527-31. doi: 10.1016/s0886-3350(99)00197-2. PMID: 10569170

Clinical prediction guides

Effects of cataract surgery on blinking.
Talens-Estarelles C, Díez-Ajenjo MA, Pons ÁM, Peris-Martínez C, García-Lázaro S
J Cataract Refract Surg 2023 Feb 1;49(2):177-183. doi: 10.1097/j.jcrs.0000000000001081. PMID: 36255227
Current and effective advantages of femto phacoemulsification.
Agarwal A, Jacob S
Curr Opin Ophthalmol 2017 Jan;28(1):49-57. doi: 10.1097/ICU.0000000000000333. PMID: 27801688
Visual Rehabilitation in Pediatric Aphakia.
Repka MX
Dev Ophthalmol 2016;57:49-68. Epub 2016 Apr 1 doi: 10.1159/000442501. PMID: 27043392
Posterior capsule striae.
Vasavada AR, Trivedi RH
J Cataract Refract Surg 1999 Nov;25(11):1527-31. doi: 10.1016/s0886-3350(99)00197-2. PMID: 10569170
Traumatic cataract.
Ajamian PC
Optom Clin 1993;3(2):49-56. PMID: 8268696

Recent systematic reviews

Immediate sequential vs delayed sequential bilateral cataract surgery: systematic review and meta-analysis.
Aiello F, Gallo Afflitto G, Leviste K, Swaminathan SS, Yoo SH, Findl O, Maurino V, Nucci C
J Cataract Refract Surg 2023 Nov 1;49(11):1168-1179. doi: 10.1097/j.jcrs.0000000000001230. PMID: 37276258
Refractive outcomes after DMEK: meta-analysis.
Augustin VA, Son HS, Yildirim TM, Meis J, Łabuz G, Auffarth GU, Khoramnia R
J Cataract Refract Surg 2023 Sep 1;49(9):982-987. doi: 10.1097/j.jcrs.0000000000001212. PMID: 37144644
Artificial intelligence applications and cataract management: A systematic review.
Tognetto D, Giglio R, Vinciguerra AL, Milan S, Rejdak R, Rejdak M, Zaluska-Ogryzek K, Zweifel S, Toro MD
Surv Ophthalmol 2022 May-Jun;67(3):817-829. Epub 2021 Oct 1 doi: 10.1016/j.survophthal.2021.09.004. PMID: 34606818
The Complications of Myopia: A Review and Meta-Analysis.
Haarman AEG, Enthoven CA, Tideman JWL, Tedja MS, Verhoeven VJM, Klaver CCW
Invest Ophthalmol Vis Sci 2020 Apr 9;61(4):49. doi: 10.1167/iovs.61.4.49. PMID: 32347918Free PMC Article
Global causes of blindness and distance vision impairment 1990-2020: a systematic review and meta-analysis.
Flaxman SR, Bourne RRA, Resnikoff S, Ackland P, Braithwaite T, Cicinelli MV, Das A, Jonas JB, Keeffe J, Kempen JH, Leasher J, Limburg H, Naidoo K, Pesudovs K, Silvester A, Stevens GA, Tahhan N, Wong TY, Taylor HR; Vision Loss Expert Group of the Global Burden of Disease Study
Lancet Glob Health 2017 Dec;5(12):e1221-e1234. Epub 2017 Oct 11 doi: 10.1016/S2214-109X(17)30393-5. PMID: 29032195

Supplemental Content

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    Related information

    • ClinVar
      Related medical variations
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      Related information in NCBI Gene
    • OMIM
      Related records in OMIM
    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
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      Related information in PubMed Central Links
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