From HPO
Epistaxis- MedGen UID:
- 4996
- •Concept ID:
- C0014591
- •
- Pathologic Function
Epistaxis, or nosebleed, refers to a hemorrhage localized in the nose.
Menorrhagia- MedGen UID:
- 44358
- •Concept ID:
- C0025323
- •
- Pathologic Function
Prolonged and excessive menses at regular intervals in excess of 80 mL or lasting longer than 7 days.
Prolonged bleeding time- MedGen UID:
- 56231
- •Concept ID:
- C0151529
- •
- Finding
Prolongation of the time taken for a standardized skin cut of fixed depth and length to stop bleeding.
Abnormal bleeding- MedGen UID:
- 264316
- •Concept ID:
- C1458140
- •
- Pathologic Function
An abnormal susceptibility to bleeding, often referred to as a bleeding diathesis. A bleeding diathesis may be related to vascular, platelet and coagulation defects.
Prolonged bleeding after dental extraction- MedGen UID:
- 369536
- •Concept ID:
- C1969572
- •
- Pathologic Function
Prolonged bleeding post dental extraction sufficient to require medical intervention.
Prolonged bleeding after surgery- MedGen UID:
- 867284
- •Concept ID:
- C4021646
- •
- Pathologic Function
Bleeding that persists longer than the normal time following a surgical procedure.
Decreased platelet glycoprotein IIb-IIIa- MedGen UID:
- 892761
- •Concept ID:
- C4021767
- •
- Finding
Decreased cell membrane concentration of glycoprotein IIb-IIIa.
Impaired ristocetin-induced platelet aggregation- MedGen UID:
- 868749
- •Concept ID:
- C4023154
- •
- Pathologic Function
Abnormal response to ristocetin as manifested by reduced or lacking aggregation of platelets upon addition of ristocetin.
Impaired collagen-induced platelet aggregation- MedGen UID:
- 870264
- •Concept ID:
- C4024703
- •
- Finding
Abnormal response to collagen or collagen-mimetics as manifested by reduced or lacking aggregation of platelets upon addition collagen or collagen-mimetics.
Impaired epinephrine-induced platelet aggregation- MedGen UID:
- 870285
- •Concept ID:
- C4024727
- •
- Finding
Abnormal response to epinephrine as manifested by reduced or lacking aggregation of platelets upon addition of epinephrine.
Impaired ADP-induced platelet aggregation- MedGen UID:
- 870824
- •Concept ID:
- C4025282
- •
- Finding
Abnormal platelet response to ADP as manifested by reduced or lacking aggregation of platelets upon addition of ADP.
Impaired clot retraction- MedGen UID:
- 1376447
- •Concept ID:
- C4476985
- •
- Finding
Platelets contain contractile proteins (actin and myosin) that induce clot retraction. As the platelets contract, they pull on the surrounding fibrin strands, squeezing serum form the mass, compacting the clot and drawing the ruptured edges of the blood vessel more closely together. Clot retraction is directly proportional to the platelet count and inversely proportional to the fibrinogen concentration.
Bruising susceptibility- MedGen UID:
- 140849
- •Concept ID:
- C0423798
- •
- Finding
An ecchymosis (bruise) refers to the skin discoloration caused by the escape of blood into the tissues from ruptured blood vessels. This term refers to an abnormally increased susceptibility to bruising. The corresponding phenotypic abnormality is generally elicited on medical history as a report of frequent ecchymoses or bruising without adequate trauma.
- Abnormality of blood and blood-forming tissues
- Abnormality of the integument