U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cryptogenic late-onset epileptic spasms

MedGen UID:
1666207
•Concept ID:
C4755310
•
Disease or Syndrome
Synonyms: cryptogenic late-onset epileptic spasms; Late-onset infantile spasms; late-onset infantile spasms
SNOMED CT: Cryptogenic late-onset epileptic spasms (778063003); Late-onset infantile spasms (778063003)
 
Monarch Initiative: MONDO:0015585
Orphanet: ORPHA163708

Definition

A rare epilepsy syndrome characterised by late-onset (after 1 year old) epileptic spasms that occur in clusters, associated with tonic seizures, atypical absences and cognitive deterioration. Language difficulties and behaviour problems are frequently present. EEG is characterised by a temporal or temporofrontal slow wave or spike focus combined with synchronous spike-waves and no hypsarrhythmia or background activity. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCryptogenic late-onset epileptic spasms

Recent clinical studies

Etiology

Late-onset epileptic spasms: clinical evidence and outcome in 34 patients.
Ronzano N, Valvo G, Ferrari AR, Guerrini R, Sicca F
J Child Neurol 2015 Feb;30(2):153-9. Epub 2014 Jun 6 doi: 10.1177/0883073814532547. PMID: 24907139
Cryptogenic late-onset epileptic spasms: an overlooked syndrome of early childhood?
Eisermann MM, Ville D, Soufflet C, Plouin P, Chiron C, Dulac O, Kaminska A
Epilepsia 2006 Jun;47(6):1035-42. doi: 10.1111/j.1528-1167.2006.00518.x. PMID: 16822250

Diagnosis

Late-onset epileptic spasms: clinical evidence and outcome in 34 patients.
Ronzano N, Valvo G, Ferrari AR, Guerrini R, Sicca F
J Child Neurol 2015 Feb;30(2):153-9. Epub 2014 Jun 6 doi: 10.1177/0883073814532547. PMID: 24907139
Epileptic syndromes in infancy and childhood.
Nabbout R, Dulac O
Curr Opin Neurol 2008 Apr;21(2):161-6. doi: 10.1097/WCO.0b013e3282f7007e. PMID: 18317274
Cryptogenic late-onset epileptic spasms: an overlooked syndrome of early childhood?
Eisermann MM, Ville D, Soufflet C, Plouin P, Chiron C, Dulac O, Kaminska A
Epilepsia 2006 Jun;47(6):1035-42. doi: 10.1111/j.1528-1167.2006.00518.x. PMID: 16822250
Evidence of late-onset infantile spasms.
Bednarek N, Motte J, Soufflet C, Plouin P, Dulac O
Epilepsia 1998 Jan;39(1):55-60. doi: 10.1111/j.1528-1157.1998.tb01274.x. PMID: 9578013

Therapy

Evidence of late-onset infantile spasms.
Bednarek N, Motte J, Soufflet C, Plouin P, Dulac O
Epilepsia 1998 Jan;39(1):55-60. doi: 10.1111/j.1528-1157.1998.tb01274.x. PMID: 9578013

Prognosis

Late-onset epileptic spasms: clinical evidence and outcome in 34 patients.
Ronzano N, Valvo G, Ferrari AR, Guerrini R, Sicca F
J Child Neurol 2015 Feb;30(2):153-9. Epub 2014 Jun 6 doi: 10.1177/0883073814532547. PMID: 24907139
Cryptogenic late-onset epileptic spasms: an overlooked syndrome of early childhood?
Eisermann MM, Ville D, Soufflet C, Plouin P, Chiron C, Dulac O, Kaminska A
Epilepsia 2006 Jun;47(6):1035-42. doi: 10.1111/j.1528-1167.2006.00518.x. PMID: 16822250
Evidence of late-onset infantile spasms.
Bednarek N, Motte J, Soufflet C, Plouin P, Dulac O
Epilepsia 1998 Jan;39(1):55-60. doi: 10.1111/j.1528-1157.1998.tb01274.x. PMID: 9578013

Supplemental Content

Table of contents

    Clinical resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...