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Locally Advanced Cervical Carcinoma

MedGen UID:
1654850
•Concept ID:
C4744723
•
Neoplastic Process

Definition

A cervical carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Professional guidelines

PubMed

Mind the Gap Between Scientific Literature Recommendations and Effective Implementation. Is There Still a Role for Surgery in the Treatment of Locally Advanced Cervical Carcinoma?
Blidaru A, Bordea C, Burcoş T, Duduş L, Eniu D, Ioanid N, Kacso G, Minciuna C, Savu M, Scripcariu V, Tudor Ș, Vasilescu C, Voinea S
Chirurgia (Bucur) 2019 Jan-Feb;114(1):18-28. doi: 10.21614/chirurgia.114.1.18. PMID: 30830841
Why brachytherapy boost is the treatment of choice for most women with locally advanced cervical carcinoma?
Al Feghali KA, Elshaikh MA
Brachytherapy 2016 Mar-Apr;15(2):191-9. Epub 2016 Feb 1 doi: 10.1016/j.brachy.2015.12.003. PMID: 26810408
Modern management of locally advanced cervical carcinoma.
Dueñas-Gonzalez A, Cetina L, Mariscal I, de la Garza J
Cancer Treat Rev 2003 Oct;29(5):389-99. doi: 10.1016/s0305-7372(03)00068-9. PMID: 12972357

Recent clinical studies

Therapy

Impact of PET/CT Imaging with FDG in Locally Advanced Cervical Carcinoma-A Literature Review.
Molnar O, Straciuc OM, Mihuțiu S, Lazăr L
Curr Oncol 2024 Apr 29;31(5):2508-2526. doi: 10.3390/curroncol31050188. PMID: 38785469Free PMC Article
Optimal cisplatin cycles in locally advanced cervical carcinoma patients treated with concurrent chemoradiotherapy.
Zeng Z, Wang W, Liu X, Wang G, Ren K, Zhang F, Hu K
Clin Transl Oncol 2023 Oct;25(10):2892-2900. Epub 2023 Apr 7 doi: 10.1007/s12094-023-03151-3. PMID: 37027060
Neoadjuvant chemotherapy in locally advanced cervical cancer in pregnancy-Review of the literature.
Mandic A, Maricic S, Malenkovic G, Stojic I, Gutic B
J BUON 2020 Mar-Apr;25(2):597-604. PMID: 32521840
Multimodality therapy for locally advanced cervical carcinoma: state of the art and future directions.
Monk BJ, Tewari KS, Koh WJ
J Clin Oncol 2007 Jul 10;25(20):2952-65. doi: 10.1200/JCO.2007.10.8324. PMID: 17617527
Modern management of locally advanced cervical carcinoma.
Dueñas-Gonzalez A, Cetina L, Mariscal I, de la Garza J
Cancer Treat Rev 2003 Oct;29(5):389-99. doi: 10.1016/s0305-7372(03)00068-9. PMID: 12972357

Prognosis

Optimal cisplatin cycles in locally advanced cervical carcinoma patients treated with concurrent chemoradiotherapy.
Zeng Z, Wang W, Liu X, Wang G, Ren K, Zhang F, Hu K
Clin Transl Oncol 2023 Oct;25(10):2892-2900. Epub 2023 Apr 7 doi: 10.1007/s12094-023-03151-3. PMID: 37027060
Metabolic features of cancer cells impact immunosurveillance.
Joseph A, Juncheng P, Mondini M, Labaied N, Loi M, Adam J, Lafarge A, Astesana V, Obrist F, Klein C, Bloy N, Stoll G, Signolle N, Genestie C, Damotte D, Alifano M, Leary A, Pautier P, Morice P, Gouy S, Deutsch E, Chargari C, Dieu-Nosjean MC, Cremer I, Michels J, Kroemer G, Castedo M
J Immunother Cancer 2021 Jun;9(6) doi: 10.1136/jitc-2021-002362. PMID: 34162714Free PMC Article
Functional imaging to predict tumor response in locally advanced cervical cancer.
Barwick TD, Taylor A, Rockall A
Curr Oncol Rep 2013 Dec;15(6):549-58. doi: 10.1007/s11912-013-0344-2. PMID: 24114187
Multimodality therapy for locally advanced cervical carcinoma: state of the art and future directions.
Monk BJ, Tewari KS, Koh WJ
J Clin Oncol 2007 Jul 10;25(20):2952-65. doi: 10.1200/JCO.2007.10.8324. PMID: 17617527
Modern management of locally advanced cervical carcinoma.
Dueñas-Gonzalez A, Cetina L, Mariscal I, de la Garza J
Cancer Treat Rev 2003 Oct;29(5):389-99. doi: 10.1016/s0305-7372(03)00068-9. PMID: 12972357

Clinical prediction guides

Optimal cisplatin cycles in locally advanced cervical carcinoma patients treated with concurrent chemoradiotherapy.
Zeng Z, Wang W, Liu X, Wang G, Ren K, Zhang F, Hu K
Clin Transl Oncol 2023 Oct;25(10):2892-2900. Epub 2023 Apr 7 doi: 10.1007/s12094-023-03151-3. PMID: 37027060
Neoadjuvant Chemotherapy in Locally Advanced Cervical Carcinoma - a Role in Patients with Para-aortic Lymph Node Involvement? A 10-year Institutional Experience.
Green HM, Counsell N, Ward A, McCormack M
Clin Oncol (R Coll Radiol) 2022 Jul;34(7):e281-e290. Epub 2022 Jan 6 doi: 10.1016/j.clon.2021.12.005. PMID: 35000828
Metabolic features of cancer cells impact immunosurveillance.
Joseph A, Juncheng P, Mondini M, Labaied N, Loi M, Adam J, Lafarge A, Astesana V, Obrist F, Klein C, Bloy N, Stoll G, Signolle N, Genestie C, Damotte D, Alifano M, Leary A, Pautier P, Morice P, Gouy S, Deutsch E, Chargari C, Dieu-Nosjean MC, Cremer I, Michels J, Kroemer G, Castedo M
J Immunother Cancer 2021 Jun;9(6) doi: 10.1136/jitc-2021-002362. PMID: 34162714Free PMC Article
Laparoscopic paraaortic surgical staging in locally advanced cervical cancer: a single-center experience.
Vázquez-Vicente D, Fernández Del Bas B, García Villayzán J, Di Fiore HA, Luna Tirado J, Casado Echarren V, García-Foncillas J, Plaza Arranz J, Chiva L
Clin Transl Oncol 2018 Nov;20(11):1455-1459. Epub 2018 Apr 18 doi: 10.1007/s12094-018-1878-4. PMID: 29671223
Functional imaging to predict tumor response in locally advanced cervical cancer.
Barwick TD, Taylor A, Rockall A
Curr Oncol Rep 2013 Dec;15(6):549-58. doi: 10.1007/s11912-013-0344-2. PMID: 24114187

Recent systematic reviews

Efficacy and safety of endostar combined with chemoradiotherapy versus chemoradiotherapy alone in locally advanced cervical cancer: A PRISMA-compliant systematic review and meta-analysis.
Maimaitiming N, Ma X, Wei Y, Cao L, Gao Y, Zhang L
Medicine (Baltimore) 2022 Sep 9;101(36):e30170. doi: 10.1097/MD.0000000000030170. PMID: 36086700Free PMC Article
Combined use of hyperthermia and radiation therapy for treating locally advanced cervical carcinoma.
Lutgens L, van der Zee J, Pijls-Johannesma M, De Haas-Kock DF, Buijsen J, Mastrigt GA, Lammering G, De Ruysscher DK, Lambin P
Cochrane Database Syst Rev 2010 Jan 20;(1):CD006377. doi: 10.1002/14651858.CD006377.pub2. PMID: 20091593

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