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Progesterone-receptor positive breast cancer

MedGen UID:
1843473
•Concept ID:
C4733094
•
Neoplastic Process
Synonym: progesterone-receptor positive breast cancer
 
Monarch Initiative: MONDO:0000615

Professional guidelines

PubMed

Systemic Therapy for Advanced Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer: ASCO Guideline Update.
Giordano SH, Franzoi MAB, Temin S, Anders CK, Chandarlapaty S, Crews JR, Kirshner JJ, Krop IE, Lin NU, Morikawa A, Patt DA, Perlmutter J, Ramakrishna N, Davidson NE
J Clin Oncol 2022 Aug 10;40(23):2612-2635. Epub 2022 May 31 doi: 10.1200/JCO.22.00519. PMID: 35640077
Neoadjuvant endocrine therapy in locally advanced estrogen or progesterone receptor-positive breast cancer: determining the optimal endocrine agent and treatment duration in postmenopausal women-a literature review and proposed guidelines.
Madigan LI, Dinh P, Graham JD
Breast Cancer Res 2020 Jul 20;22(1):77. doi: 10.1186/s13058-020-01314-6. PMID: 32690069Free PMC Article
Role of aromatase inhibitors in the treatment of breast cancer.
Choueiri TK, Alemany CA, Abou-Jawde RM, Budd GT
Clin Ther 2004 Aug;26(8):1199-214. doi: 10.1016/s0149-2918(04)80017-1. PMID: 15476902

Recent clinical studies

Etiology

Estrogen receptor-negative/progesterone receptor-positive breast cancer has distinct characteristics and pathologic complete response rate after neoadjuvant chemotherapy.
Dou H, Li F, Wang Y, Chen X, Yu P, Jia S, Ba Y, Luo D, Gao T, Li Z, Xiao M
Diagn Pathol 2024 Jan 4;19(1):5. doi: 10.1186/s13000-023-01433-6. PMID: 38178166Free PMC Article
Progestin-primed ovarian stimulation: for whom, when and how?
Ata B, Kalafat E
Reprod Biomed Online 2024 Feb;48(2):103639. Epub 2023 Oct 22 doi: 10.1016/j.rbmo.2023.103639. PMID: 38159467
Estrogen receptor-negative progesterone receptor-positive breast cancer - "Nobody's land" or just an artifact?
Kunc M, Biernat W, Senkus-Konefka E
Cancer Treat Rev 2018 Jun;67:78-87. Epub 2018 May 16 doi: 10.1016/j.ctrv.2018.05.005. PMID: 29772460
Characterization of estrogen receptor-negative/progesterone receptor-positive breast cancer.
Shen T, Brandwein-Gensler M, Hameed O, Siegal GP, Wei S
Hum Pathol 2015 Nov;46(11):1776-84. Epub 2015 Aug 4 doi: 10.1016/j.humpath.2015.07.019. PMID: 26363528
Outcomes of Estrogen Receptor Negative and Progesterone Receptor Positive Breast Cancer.
Chan M, Chang MC, González R, Lategan B, del Barco E, Vera-Badillo F, Quesada P, Goldstein R, Cruz I, Ocana A, Cruz JJ, Amir E
PLoS One 2015;10(7):e0132449. Epub 2015 Jul 10 doi: 10.1371/journal.pone.0132449. PMID: 26161666Free PMC Article

Diagnosis

Estrogen receptor-negative/progesterone receptor-positive breast cancer has distinct characteristics and pathologic complete response rate after neoadjuvant chemotherapy.
Dou H, Li F, Wang Y, Chen X, Yu P, Jia S, Ba Y, Luo D, Gao T, Li Z, Xiao M
Diagn Pathol 2024 Jan 4;19(1):5. doi: 10.1186/s13000-023-01433-6. PMID: 38178166Free PMC Article
Medicaid expansion is associated with treatment receipt, timeliness, and outcomes among young adults with breast cancer.
Ji X, Shi KS, Ruddy KJ, Zhao J, Mertens AC, Yabroff KR, Castellino SM, Han X
JNCI Cancer Spectr 2023 Aug 31;7(5) doi: 10.1093/jncics/pkad067. PMID: 37707583Free PMC Article
High expression of progesterone receptor may be an adverse prognostic factor in oestrogen receptor-negative/progesterone receptor-positive breast cancer: results of comprehensive re-evaluation of multi-institutional case series.
Kunc M, Pęksa R, Cserni G, Iżycka-Świeszewska E, Łacko A, Radecka B, Braun M, Pikiel J, Litwiniuk M, Pogoda K, Szwajkosz A, Biernat W, Senkus E
Pathology 2022 Apr;54(3):269-278. Epub 2022 Jan 21 doi: 10.1016/j.pathol.2021.10.003. PMID: 35074178
Outcomes of Estrogen Receptor Negative and Progesterone Receptor Positive Breast Cancer.
Chan M, Chang MC, González R, Lategan B, del Barco E, Vera-Badillo F, Quesada P, Goldstein R, Cruz I, Ocana A, Cruz JJ, Amir E
PLoS One 2015;10(7):e0132449. Epub 2015 Jul 10 doi: 10.1371/journal.pone.0132449. PMID: 26161666Free PMC Article
Estrogen receptor negative/progesterone receptor positive breast cancer is not a reproducible subtype.
Hefti MM, Hu R, Knoblauch NW, Collins LC, Haibe-Kains B, Tamimi RM, Beck AH
Breast Cancer Res 2013;15(4):R68. doi: 10.1186/bcr3462. PMID: 23971947Free PMC Article

Therapy

Progestin-primed ovarian stimulation: for whom, when and how?
Ata B, Kalafat E
Reprod Biomed Online 2024 Feb;48(2):103639. Epub 2023 Oct 22 doi: 10.1016/j.rbmo.2023.103639. PMID: 38159467
Systemic Therapy for Advanced Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer: ASCO Guideline Update.
Giordano SH, Franzoi MAB, Temin S, Anders CK, Chandarlapaty S, Crews JR, Kirshner JJ, Krop IE, Lin NU, Morikawa A, Patt DA, Perlmutter J, Ramakrishna N, Davidson NE
J Clin Oncol 2022 Aug 10;40(23):2612-2635. Epub 2022 May 31 doi: 10.1200/JCO.22.00519. PMID: 35640077
Neoadjuvant endocrine therapy in locally advanced estrogen or progesterone receptor-positive breast cancer: determining the optimal endocrine agent and treatment duration in postmenopausal women-a literature review and proposed guidelines.
Madigan LI, Dinh P, Graham JD
Breast Cancer Res 2020 Jul 20;22(1):77. doi: 10.1186/s13058-020-01314-6. PMID: 32690069Free PMC Article
Cognitive dysfunction in postmenopausal breast cancer patients on aromatase inhibitors.
Batalo M, Nagaiah G, Abraham J
Expert Rev Anticancer Ther 2011 Aug;11(8):1277-82. doi: 10.1586/era.11.112. PMID: 21916581
Managing patients on endocrine therapy: focus on quality-of-life issues.
Whelan TJ, Pritchard KI
Clin Cancer Res 2006 Feb 1;12(3 Pt 2):1056s-1060s. doi: 10.1158/1078-0432.CCR-05-2185. PMID: 16467124

Prognosis

Estrogen receptor-negative/progesterone receptor-positive breast cancer has distinct characteristics and pathologic complete response rate after neoadjuvant chemotherapy.
Dou H, Li F, Wang Y, Chen X, Yu P, Jia S, Ba Y, Luo D, Gao T, Li Z, Xiao M
Diagn Pathol 2024 Jan 4;19(1):5. doi: 10.1186/s13000-023-01433-6. PMID: 38178166Free PMC Article
Neoadjuvant endocrine therapy in locally advanced estrogen or progesterone receptor-positive breast cancer: determining the optimal endocrine agent and treatment duration in postmenopausal women-a literature review and proposed guidelines.
Madigan LI, Dinh P, Graham JD
Breast Cancer Res 2020 Jul 20;22(1):77. doi: 10.1186/s13058-020-01314-6. PMID: 32690069Free PMC Article
Estrogen receptor-negative progesterone receptor-positive breast cancer - "Nobody's land" or just an artifact?
Kunc M, Biernat W, Senkus-Konefka E
Cancer Treat Rev 2018 Jun;67:78-87. Epub 2018 May 16 doi: 10.1016/j.ctrv.2018.05.005. PMID: 29772460
Characterization of estrogen receptor-negative/progesterone receptor-positive breast cancer.
Shen T, Brandwein-Gensler M, Hameed O, Siegal GP, Wei S
Hum Pathol 2015 Nov;46(11):1776-84. Epub 2015 Aug 4 doi: 10.1016/j.humpath.2015.07.019. PMID: 26363528
Clinical significance of SPRR1A expression in progesterone receptor-positive breast cancer.
Chen G, Li G, Luo M, Wei X, Wang D, Zhang H, Zhao X, Chen B, Liu C
Tumour Biol 2015 Apr;36(4):2601-5. Epub 2014 Nov 26 doi: 10.1007/s13277-014-2879-8. PMID: 25424702

Clinical prediction guides

Estrogen receptor-negative/progesterone receptor-positive breast cancer has distinct characteristics and pathologic complete response rate after neoadjuvant chemotherapy.
Dou H, Li F, Wang Y, Chen X, Yu P, Jia S, Ba Y, Luo D, Gao T, Li Z, Xiao M
Diagn Pathol 2024 Jan 4;19(1):5. doi: 10.1186/s13000-023-01433-6. PMID: 38178166Free PMC Article
Hyperglycemic conditions proliferate triple negative breast cancer cells: role of ornithine decarboxylase.
Capellen CC, Ortega-Rodas J, Morwitzer MJ, Tofilau HMN, Dunworth M, Casero RA Jr, Chandra S
Breast Cancer Res Treat 2021 Nov;190(2):255-264. Epub 2021 Sep 16 doi: 10.1007/s10549-021-06388-0. PMID: 34529197Free PMC Article
Neoadjuvant endocrine therapy in locally advanced estrogen or progesterone receptor-positive breast cancer: determining the optimal endocrine agent and treatment duration in postmenopausal women-a literature review and proposed guidelines.
Madigan LI, Dinh P, Graham JD
Breast Cancer Res 2020 Jul 20;22(1):77. doi: 10.1186/s13058-020-01314-6. PMID: 32690069Free PMC Article
Estrogen receptor-negative progesterone receptor-positive breast cancer - "Nobody's land" or just an artifact?
Kunc M, Biernat W, Senkus-Konefka E
Cancer Treat Rev 2018 Jun;67:78-87. Epub 2018 May 16 doi: 10.1016/j.ctrv.2018.05.005. PMID: 29772460
Estrogen receptor negative/progesterone receptor positive breast cancer is not a reproducible subtype.
Hefti MM, Hu R, Knoblauch NW, Collins LC, Haibe-Kains B, Tamimi RM, Beck AH
Breast Cancer Res 2013;15(4):R68. doi: 10.1186/bcr3462. PMID: 23971947Free PMC Article

Recent systematic reviews

Systemic Therapy for Advanced Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer: ASCO Guideline Update.
Giordano SH, Franzoi MAB, Temin S, Anders CK, Chandarlapaty S, Crews JR, Kirshner JJ, Krop IE, Lin NU, Morikawa A, Patt DA, Perlmutter J, Ramakrishna N, Davidson NE
J Clin Oncol 2022 Aug 10;40(23):2612-2635. Epub 2022 May 31 doi: 10.1200/JCO.22.00519. PMID: 35640077
Systemic Therapy for Patients With Advanced Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer: ASCO Clinical Practice Guideline Update.
Giordano SH, Temin S, Chandarlapaty S, Crews JR, Esteva FJ, Kirshner JJ, Krop IE, Levinson J, Lin NU, Modi S, Patt DA, Perlmutter J, Ramakrishna N, Winer EP, Davidson NE
J Clin Oncol 2018 Sep 10;36(26):2736-2740. Epub 2018 Jun 25 doi: 10.1200/JCO.2018.79.2697. PMID: 29939838
Systemic therapy for patients with advanced human epidermal growth factor receptor 2-positive breast cancer: American Society of Clinical Oncology clinical practice guideline.
Giordano SH, Temin S, Kirshner JJ, Chandarlapaty S, Crews JR, Davidson NE, Esteva FJ, Gonzalez-Angulo AM, Krop I, Levinson J, Lin NU, Modi S, Patt DA, Perez EA, Perlmutter J, Ramakrishna N, Winer EP; American Society of Clinical Oncology
J Clin Oncol 2014 Jul 1;32(19):2078-99. Epub 2014 May 5 doi: 10.1200/JCO.2013.54.0948. PMID: 24799465Free PMC Article

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