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Advanced Oral Cavity Squamous Cell Carcinoma

MedGen UID:
1650313
•Concept ID:
C4727683
•
Neoplastic Process
Synonym: Advanced Squamous Cell Carcinoma of the Oral Cavity

Definition

A squamous cell carcinoma of the oral cavity that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Oral Cavity Squamous Cell Carcinoma

Professional guidelines

PubMed

Primary Management of Operable Locally Advanced Oral Cavity Squamous Cell Carcinoma: Current Concepts and Strategies.
Asarkar AA, Chang BA, de Bree R, Kowalski LP, Guntinas-Lichius O, Bradley PJ, de Graaf P, Strojan P, Rao KN, Mäkitie AA, López F, Rinaldo A, Palme C, Genden EM, Sanabria A, Rodrigo JP, Ferlito A
Adv Ther 2024 Jun;41(6):2133-2150. Epub 2024 Apr 20 doi: 10.1007/s12325-024-02861-6. PMID: 38642199
Association of Neoadjuvant Pembrolizumab for Oral Cavity Squamous Cell Carcinoma With Adverse Events After Surgery in Treatment-Naive Patients.
Tang AL, O'Neil T, McDermott S, Tripathi S, Tikhtman R, Mark JR, Patil Y, Tabangin M, Altaye M, Wise-Draper TM, Zender CA
JAMA Otolaryngol Head Neck Surg 2022 Oct 1;148(10):935-939. doi: 10.1001/jamaoto.2022.2291. PMID: 36006622Free PMC Article
Treatment outcome of advance staged oral cavity cancer: concurrent chemoradiotherapy compared with primary surgery.
Tangthongkum M, Kirtsreesakul V, Supanimitjaroenporn P, Leelasawatsuk P
Eur Arch Otorhinolaryngol 2017 Jun;274(6):2567-2572. Epub 2017 Mar 20 doi: 10.1007/s00405-017-4540-9. PMID: 28321535

Recent clinical studies

Etiology

Prognostic Implications of Skin Invasion in Locally Advanced Oral Cavity Squamous Cell Carcinoma.
Diebolt JH, Yu KM, Wood S, Ziegler A, France A, Villwock MR, Alvi SA, Kakarala K, Shnayder Y, Gan GN, Lominska CE, Neupane P, Bur AM
Otolaryngol Head Neck Surg 2023 Jul;169(1):69-75. Epub 2023 Jan 28 doi: 10.1177/01945998221116746. PMID: 35917167Free PMC Article
Association of Neoadjuvant Pembrolizumab for Oral Cavity Squamous Cell Carcinoma With Adverse Events After Surgery in Treatment-Naive Patients.
Tang AL, O'Neil T, McDermott S, Tripathi S, Tikhtman R, Mark JR, Patil Y, Tabangin M, Altaye M, Wise-Draper TM, Zender CA
JAMA Otolaryngol Head Neck Surg 2022 Oct 1;148(10):935-939. doi: 10.1001/jamaoto.2022.2291. PMID: 36006622Free PMC Article
Neoadjuvant immunoradiotherapy in patients with locally advanced oral cavity squamous cell carcinoma: a retrospective study.
Shen P, Qiao B, Jin N, Wang S
Invest New Drugs 2022 Dec;40(6):1282-1289. Epub 2022 Aug 16 doi: 10.1007/s10637-022-01293-9. PMID: 35972629
Outcomes of primary radiotherapy with or without chemotherapy for advanced oral cavity squamous cell carcinoma: Systematic review.
Membreno PV, Luttrell JB, Mamidala MP, Schwartz DL, Hayes DN, Gleysteen JP, Gillespie MB
Head Neck 2021 Oct;43(10):3165-3176. Epub 2021 Jun 24 doi: 10.1002/hed.26779. PMID: 34165221
Prognostic Stratification of Patients With Advanced Oral Cavity Squamous Cell Carcinoma.
De Paz D, Kao HK, Huang Y, Chang KP
Curr Oncol Rep 2017 Aug 10;19(10):65. doi: 10.1007/s11912-017-0624-3. PMID: 28799122

Diagnosis

Predictors of early progression after curative resection followed by platinum-based adjuvant chemoradiotherapy in oral cavity squamous cell carcinoma.
Lu HJ, Tseng SW, Peng CY, Tseng HC, Hsin CH, Chen HL, Huang WS, Wu MF, Yang MH, Chang PM
Postgrad Med 2021 Apr;133(3):377-384. Epub 2020 Sep 11 doi: 10.1080/00325481.2020.1809869. PMID: 32791023
Postoperative infection predicts poor survival in locoregionally advanced oral cancer.
Mascarella MA, Azzi JL, da Silva SD, Mlynarek A, Forest VI, Hier M, Richardson K, Sadeghi N
Head Neck 2019 Oct;41(10):3624-3630. Epub 2019 Aug 5 doi: 10.1002/hed.25885. PMID: 31385387
Prognostic Stratification of Patients With Advanced Oral Cavity Squamous Cell Carcinoma.
De Paz D, Kao HK, Huang Y, Chang KP
Curr Oncol Rep 2017 Aug 10;19(10):65. doi: 10.1007/s11912-017-0624-3. PMID: 28799122
Human papillomavirus 16/18 E7 viral loads predict distant metastasis in oral cavity squamous cell carcinoma.
Huang CG, Lee LA, Tsao KC, Liao CT, Yang LY, Kang CJ, Chang KP, Huang SF, Chen IH, Yang SL, Lee LY, Hsueh C, Chen TC, Lin CY, Fan KH, Chang TC, Wang HM, Ng SH, Yen TC
J Clin Virol 2014 Oct;61(2):230-6. Epub 2014 Jul 22 doi: 10.1016/j.jcv.2014.07.007. PMID: 25097016
Survival outcomes of patients with advanced oral cavity squamous cell carcinoma treated with multimodal therapy: a multi-institutional analysis.
Zhang H, Dziegielewski PT, Biron VL, Szudek J, Al-Qahatani KH, O'Connell DA, Harris JR, Seikaly H
J Otolaryngol Head Neck Surg 2013 Apr 19;42(1):30. doi: 10.1186/1916-0216-42-30. PMID: 23672952Free PMC Article

Therapy

Efficacy and safety of induction chemotherapy in oral cavity cancer: An eight-year experience at a Portuguese reference center.
Barbosa-Martins J, Rolo A, Lima B, Pereira JC, Araújo C, Guimarães J, Dinis J, Vieira C
Tumori 2024 Oct;110(5):340-347. Epub 2024 Jun 2 doi: 10.1177/03008916241257099. PMID: 38825833
Association of Neoadjuvant Pembrolizumab for Oral Cavity Squamous Cell Carcinoma With Adverse Events After Surgery in Treatment-Naive Patients.
Tang AL, O'Neil T, McDermott S, Tripathi S, Tikhtman R, Mark JR, Patil Y, Tabangin M, Altaye M, Wise-Draper TM, Zender CA
JAMA Otolaryngol Head Neck Surg 2022 Oct 1;148(10):935-939. doi: 10.1001/jamaoto.2022.2291. PMID: 36006622Free PMC Article
Neoadjuvant immunoradiotherapy in patients with locally advanced oral cavity squamous cell carcinoma: a retrospective study.
Shen P, Qiao B, Jin N, Wang S
Invest New Drugs 2022 Dec;40(6):1282-1289. Epub 2022 Aug 16 doi: 10.1007/s10637-022-01293-9. PMID: 35972629
Role of induction chemotherapy for oral cavity squamous cell carcinoma.
Abdelmeguid AS, Silver NL, Boonsripitayanon M, Glisson BS, Ferrarotto R, Gunn GB, Phan J, Gillenwater AM, Hanna EY
Cancer 2021 Sep 1;127(17):3107-3112. Epub 2021 Apr 28 doi: 10.1002/cncr.33616. PMID: 33909292
Predictors of early progression after curative resection followed by platinum-based adjuvant chemoradiotherapy in oral cavity squamous cell carcinoma.
Lu HJ, Tseng SW, Peng CY, Tseng HC, Hsin CH, Chen HL, Huang WS, Wu MF, Yang MH, Chang PM
Postgrad Med 2021 Apr;133(3):377-384. Epub 2020 Sep 11 doi: 10.1080/00325481.2020.1809869. PMID: 32791023

Prognosis

Cancer cell-specific PD-L1 expression is a predictor of poor outcome in patients with locally advanced oral cavity squamous cell carcinoma.
Wang M, Qin L, Thia K, Nguyen T, MacDonald S, Belobrov S, Kranz S, Goode D, Trapani JA, Wiesenfeld D, Neeson PJ
J Immunother Cancer 2024 Oct 2;12(10) doi: 10.1136/jitc-2024-009617. PMID: 39357980Free PMC Article
Prognostic Implications of Skin Invasion in Locally Advanced Oral Cavity Squamous Cell Carcinoma.
Diebolt JH, Yu KM, Wood S, Ziegler A, France A, Villwock MR, Alvi SA, Kakarala K, Shnayder Y, Gan GN, Lominska CE, Neupane P, Bur AM
Otolaryngol Head Neck Surg 2023 Jul;169(1):69-75. Epub 2023 Jan 28 doi: 10.1177/01945998221116746. PMID: 35917167Free PMC Article
TNM 8 staging is a better prognosticator than TNM 7 for patients with locally advanced oral cavity squamous cell carcinoma treated with surgery and post-operative radiotherapy.
Sambasivan K, Sassoon I, Thavaraj S, Kennedy R, Doss G, Michaelidou A, Odell E, Sandison A, Hall G, Morgan P, Collins LHC, Lyons A, Cascarini L, Fry A, Oakley R, Simo R, Jeannon JP, Petkar I, Reis Ferreira M, Kong A, Lei M, Guerrero Urbano T
Radiother Oncol 2021 Jul;160:54-60. Epub 2021 May 3 doi: 10.1016/j.radonc.2021.04.003. PMID: 33845044
Predictors of early progression after curative resection followed by platinum-based adjuvant chemoradiotherapy in oral cavity squamous cell carcinoma.
Lu HJ, Tseng SW, Peng CY, Tseng HC, Hsin CH, Chen HL, Huang WS, Wu MF, Yang MH, Chang PM
Postgrad Med 2021 Apr;133(3):377-384. Epub 2020 Sep 11 doi: 10.1080/00325481.2020.1809869. PMID: 32791023
Prognostic Stratification of Patients With Advanced Oral Cavity Squamous Cell Carcinoma.
De Paz D, Kao HK, Huang Y, Chang KP
Curr Oncol Rep 2017 Aug 10;19(10):65. doi: 10.1007/s11912-017-0624-3. PMID: 28799122

Clinical prediction guides

Cancer cell-specific PD-L1 expression is a predictor of poor outcome in patients with locally advanced oral cavity squamous cell carcinoma.
Wang M, Qin L, Thia K, Nguyen T, MacDonald S, Belobrov S, Kranz S, Goode D, Trapani JA, Wiesenfeld D, Neeson PJ
J Immunother Cancer 2024 Oct 2;12(10) doi: 10.1136/jitc-2024-009617. PMID: 39357980Free PMC Article
Prognostic Implications of Skin Invasion in Locally Advanced Oral Cavity Squamous Cell Carcinoma.
Diebolt JH, Yu KM, Wood S, Ziegler A, France A, Villwock MR, Alvi SA, Kakarala K, Shnayder Y, Gan GN, Lominska CE, Neupane P, Bur AM
Otolaryngol Head Neck Surg 2023 Jul;169(1):69-75. Epub 2023 Jan 28 doi: 10.1177/01945998221116746. PMID: 35917167Free PMC Article
Role of induction chemotherapy for oral cavity squamous cell carcinoma.
Abdelmeguid AS, Silver NL, Boonsripitayanon M, Glisson BS, Ferrarotto R, Gunn GB, Phan J, Gillenwater AM, Hanna EY
Cancer 2021 Sep 1;127(17):3107-3112. Epub 2021 Apr 28 doi: 10.1002/cncr.33616. PMID: 33909292
TNM 8 staging is a better prognosticator than TNM 7 for patients with locally advanced oral cavity squamous cell carcinoma treated with surgery and post-operative radiotherapy.
Sambasivan K, Sassoon I, Thavaraj S, Kennedy R, Doss G, Michaelidou A, Odell E, Sandison A, Hall G, Morgan P, Collins LHC, Lyons A, Cascarini L, Fry A, Oakley R, Simo R, Jeannon JP, Petkar I, Reis Ferreira M, Kong A, Lei M, Guerrero Urbano T
Radiother Oncol 2021 Jul;160:54-60. Epub 2021 May 3 doi: 10.1016/j.radonc.2021.04.003. PMID: 33845044
Predictors of early progression after curative resection followed by platinum-based adjuvant chemoradiotherapy in oral cavity squamous cell carcinoma.
Lu HJ, Tseng SW, Peng CY, Tseng HC, Hsin CH, Chen HL, Huang WS, Wu MF, Yang MH, Chang PM
Postgrad Med 2021 Apr;133(3):377-384. Epub 2020 Sep 11 doi: 10.1080/00325481.2020.1809869. PMID: 32791023

Recent systematic reviews

Outcomes of primary radiotherapy with or without chemotherapy for advanced oral cavity squamous cell carcinoma: Systematic review.
Membreno PV, Luttrell JB, Mamidala MP, Schwartz DL, Hayes DN, Gleysteen JP, Gillespie MB
Head Neck 2021 Oct;43(10):3165-3176. Epub 2021 Jun 24 doi: 10.1002/hed.26779. PMID: 34165221

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