U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Triple-negative breast carcinoma

MedGen UID:
1649548
•Concept ID:
C4722518
•
Neoplastic Process
Synonyms: Triple Negative Breast Carcinoma; Triple-Negative Breast Cancer; triple-negative breast cancer; Triple-Negative Breast Carcinoma; triple-negative breast carcinoma; triple-receptor negative breast cancer
 
Monarch Initiative: MONDO:0005494

Definition

An invasive breast carcinoma which is negative for expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). [from NCI]

Professional guidelines

PubMed

Suppression of Kynurenine 3-Monooxygenase as a Treatment for Triple-negative Breast Carcinoma.
Sordillo LA, Sordillo PP
Anticancer Res 2023 Dec;43(12):5275-5282. doi: 10.21873/anticanres.16731. PMID: 38030171
Triple-negative breast carcinomas of low malignant potential: review on diagnostic criteria and differential diagnoses.
Cima L, Kaya H, Marchiò C, Nishimura R, Wen HY, Fabbri VP, Foschini MP
Virchows Arch 2022 Jan;480(1):109-126. Epub 2021 Aug 30 doi: 10.1007/s00428-021-03174-7. PMID: 34458945Free PMC Article
Clinicopathological Features and Treatment Challenges in Triple Negative Breast Cancer Patients: A Retrospective Cohort Study.
Elwan A, Abdelrahman AE, Alnagar AA, Abdelhamid MI, Nawar N
Turk Patoloji Derg 2021;37(2):121-129. doi: 10.5146/tjpath.2020.01516. PMID: 33432555Free PMC Article

Recent clinical studies

Etiology

Tumor budding in breast carcinoma: A systematic review and meta-analysis.
Buch A, Khan U, Rathod H, Jain K, Dwivedi A, Rajesh A
J Cancer Res Ther 2023 Oct 1;19(7):1697-1713. Epub 2023 Apr 25 doi: 10.4103/jcrt.jcrt_188_22. PMID: 38376268
Clinicopathologic and Genomic Landscape of Breast Carcinoma Brain Metastases.
Huang RSP, Haberberger J, McGregor K, Mata DA, Decker B, Hiemenz MC, Lechpammer M, Danziger N, Schiavone K, Creeden J, Graf RP, Strowd R, Lesser GJ, Razis ED, Bartsch R, Giannoudis A, Bhogal T, Lin NU, Pusztai L, Ross JS, Palmieri C, Ramkissoon SH
Oncologist 2021 Oct;26(10):835-844. Epub 2021 Jun 23 doi: 10.1002/onco.13855. PMID: 34105210Free PMC Article
The signaling pathways and targets of traditional Chinese medicine and natural medicine in triple-negative breast cancer.
Yang Z, Zhang Q, Yu L, Zhu J, Cao Y, Gao X
J Ethnopharmacol 2021 Jan 10;264:113249. Epub 2020 Aug 15 doi: 10.1016/j.jep.2020.113249. PMID: 32810619
Triple-negative Breast Carcinoma: Morphologic and Molecular Subtypes.
Bose S
Adv Anat Pathol 2015 Sep;22(5):306-13. doi: 10.1097/PAP.0000000000000084. PMID: 26262513
Triple-negative breast carcinoma: current and emerging concepts.
Schmadeka R, Harmon BE, Singh M
Am J Clin Pathol 2014 Apr;141(4):462-77. doi: 10.1309/AJCPQN8GZ8SILKGN. PMID: 24619745

Diagnosis

TRPS1, GATA3, and SOX10 expression in triple-negative breast carcinoma.
Yoon EC, Wang G, Parkinson B, Huo L, Peng Y, Wang J, Salisbury T, Wu Y, Chen H, Albarracin CT, Resetkova E, Middleton LP, Krishnamurthy S, Gan Q, Sun H, Huang X, Shen T, Chen W, Parwani AV, Sahin AA, Li Z, Ding Q
Hum Pathol 2022 Jul;125:97-107. Epub 2022 Apr 9 doi: 10.1016/j.humpath.2022.04.006. PMID: 35413381
Programmed death ligand-1 (PD-L1) as a predictive marker for immunotherapy in solid tumours: a guide to immunohistochemistry implementation and interpretation.
Paver EC, Cooper WA, Colebatch AJ, Ferguson PM, Hill SK, Lum T, Shin JS, O'Toole S, Anderson L, Scolyer RA, Gupta R
Pathology 2021 Feb;53(2):141-156. Epub 2020 Dec 30 doi: 10.1016/j.pathol.2020.10.007. PMID: 33388161
Novel uses of immunohistochemistry in breast pathology: interpretation and pitfalls.
Cimino-Mathews A
Mod Pathol 2021 Jan;34(Suppl 1):62-77. Epub 2020 Oct 27 doi: 10.1038/s41379-020-00697-3. PMID: 33110239
Triple-negative Breast Carcinoma: Morphologic and Molecular Subtypes.
Bose S
Adv Anat Pathol 2015 Sep;22(5):306-13. doi: 10.1097/PAP.0000000000000084. PMID: 26262513
Triple-negative breast carcinoma: current and emerging concepts.
Schmadeka R, Harmon BE, Singh M
Am J Clin Pathol 2014 Apr;141(4):462-77. doi: 10.1309/AJCPQN8GZ8SILKGN. PMID: 24619745

Therapy

Evolving immunotherapeutic solutions for triple-negative breast carcinoma.
Wu S, Ge A, Deng X, Liu L, Wang Y
Cancer Treat Rev 2024 Nov;130:102817. Epub 2024 Aug 17 doi: 10.1016/j.ctrv.2024.102817. PMID: 39154410
Triple-negative Breast Carcinoma With Apocrine and Histiocytoid Features: A Clinicopathologic and Molecular Study of 18 Cases.
Wang Y, Hacking SM, Li Z, Graff SL, Yang D, Tan L, Liu F, Zhang T, Zhao Z, Luo S, Du P, Jia S, Cheng L
Am J Surg Pathol 2023 Sep 1;47(9):1011-1018. Epub 2023 Jun 13 doi: 10.1097/PAS.0000000000002073. PMID: 37310016
Narirutin downregulates lipoxygenase-5 expression and induces G0/G1 arrest in triple-negative breast carcinoma cells.
Singh S, Maurya AK, Meena A, Mishra N, Luqman S
Biochim Biophys Acta Gen Subj 2023 Jun;1867(6):130340. Epub 2023 Mar 2 doi: 10.1016/j.bbagen.2023.130340. PMID: 36868290
The signaling pathways and targets of traditional Chinese medicine and natural medicine in triple-negative breast cancer.
Yang Z, Zhang Q, Yu L, Zhu J, Cao Y, Gao X
J Ethnopharmacol 2021 Jan 10;264:113249. Epub 2020 Aug 15 doi: 10.1016/j.jep.2020.113249. PMID: 32810619
Anticancer activity of palladium-based complexes against triple-negative breast cancer.
Vojtek M, Marques MPM, Ferreira IMPLVO, Mota-Filipe H, Diniz C
Drug Discov Today 2019 Apr;24(4):1044-1058. Epub 2019 Mar 5 doi: 10.1016/j.drudis.2019.02.012. PMID: 30849441

Prognosis

Molecular Classification of Breast Cancer.
Roy M, Fowler AM, Ulaner GA, Mahajan A
PET Clin 2023 Oct;18(4):441-458. Epub 2023 May 31 doi: 10.1016/j.cpet.2023.04.002. PMID: 37268505
Programmed death ligand-1 (PD-L1) as a predictive marker for immunotherapy in solid tumours: a guide to immunohistochemistry implementation and interpretation.
Paver EC, Cooper WA, Colebatch AJ, Ferguson PM, Hill SK, Lum T, Shin JS, O'Toole S, Anderson L, Scolyer RA, Gupta R
Pathology 2021 Feb;53(2):141-156. Epub 2020 Dec 30 doi: 10.1016/j.pathol.2020.10.007. PMID: 33388161
The signaling pathways and targets of traditional Chinese medicine and natural medicine in triple-negative breast cancer.
Yang Z, Zhang Q, Yu L, Zhu J, Cao Y, Gao X
J Ethnopharmacol 2021 Jan 10;264:113249. Epub 2020 Aug 15 doi: 10.1016/j.jep.2020.113249. PMID: 32810619
Triple-negative Breast Carcinoma: Morphologic and Molecular Subtypes.
Bose S
Adv Anat Pathol 2015 Sep;22(5):306-13. doi: 10.1097/PAP.0000000000000084. PMID: 26262513
Triple-negative breast carcinoma: current and emerging concepts.
Schmadeka R, Harmon BE, Singh M
Am J Clin Pathol 2014 Apr;141(4):462-77. doi: 10.1309/AJCPQN8GZ8SILKGN. PMID: 24619745

Clinical prediction guides

Evolving immunotherapeutic solutions for triple-negative breast carcinoma.
Wu S, Ge A, Deng X, Liu L, Wang Y
Cancer Treat Rev 2024 Nov;130:102817. Epub 2024 Aug 17 doi: 10.1016/j.ctrv.2024.102817. PMID: 39154410
Molecular Classification of Breast Cancer.
Roy M, Fowler AM, Ulaner GA, Mahajan A
PET Clin 2023 Oct;18(4):441-458. Epub 2023 May 31 doi: 10.1016/j.cpet.2023.04.002. PMID: 37268505
Programmed death ligand-1 (PD-L1) as a predictive marker for immunotherapy in solid tumours: a guide to immunohistochemistry implementation and interpretation.
Paver EC, Cooper WA, Colebatch AJ, Ferguson PM, Hill SK, Lum T, Shin JS, O'Toole S, Anderson L, Scolyer RA, Gupta R
Pathology 2021 Feb;53(2):141-156. Epub 2020 Dec 30 doi: 10.1016/j.pathol.2020.10.007. PMID: 33388161
MicroRNAs in regulation of triple-negative breast cancer progression.
Piasecka D, Braun M, Kordek R, Sadej R, Romanska H
J Cancer Res Clin Oncol 2018 Aug;144(8):1401-1411. Epub 2018 Jun 19 doi: 10.1007/s00432-018-2689-2. PMID: 29923083Free PMC Article
Triple-negative Breast Carcinoma: Morphologic and Molecular Subtypes.
Bose S
Adv Anat Pathol 2015 Sep;22(5):306-13. doi: 10.1097/PAP.0000000000000084. PMID: 26262513

Recent systematic reviews

Tumor budding in breast carcinoma: A systematic review and meta-analysis.
Buch A, Khan U, Rathod H, Jain K, Dwivedi A, Rajesh A
J Cancer Res Ther 2023 Oct 1;19(7):1697-1713. Epub 2023 Apr 25 doi: 10.4103/jcrt.jcrt_188_22. PMID: 38376268

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...