U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Metastatic Neuroblastoma

MedGen UID:
1660128
•Concept ID:
C4722306
•
Neoplastic Process

Definition

A neuroblastoma that has metastasized from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Neuroblastoma

Professional guidelines

PubMed

Targeting B7-H3-A Novel Strategy for the Design of Anticancer Agents for Extracranial Pediatric Solid Tumors Treatment.
Rasic P, Jeremic M, Jeremic R, Dusanovic Pjevic M, Rasic M, Djuricic SM, Milickovic M, Vukadin M, Mijovic T, Savic D
Molecules 2023 Apr 11;28(8) doi: 10.3390/molecules28083356. PMID: 37110590Free PMC Article
Mechanisms, Characteristics, and Treatment of Neuropathic Pain and Peripheral Neuropathy Associated with Dinutuximab in Neuroblastoma Patients.
Mastrangelo S, Rivetti S, Triarico S, Romano A, Attinà G, Maurizi P, Ruggiero A
Int J Mol Sci 2021 Nov 23;22(23) doi: 10.3390/ijms222312648. PMID: 34884452Free PMC Article
Incidence, Survival, and Treatment of Localized and Metastatic Neuroblastoma in Germany 1979-2015.
Berthold F, Spix C, Kaatsch P, Lampert F
Paediatr Drugs 2017 Dec;19(6):577-593. doi: 10.1007/s40272-017-0251-3. PMID: 28786082Free PMC Article

Recent clinical studies

Etiology

Phase II study of (131) I-metaiodobenzylguanidine with 5 days of topotecan for refractory or relapsed neuroblastoma: Results of the French study MIITOP.
Sevrin F, Kolesnikov-Gauthier H, Cougnenc O, Bogart E, Schleiermacher G, Courbon F, Gambart M, Giraudet AL, Corradini N, Badel JN, Rault E, Oudoux A, Deley MCL, Valteau-Couanet D, Defachelles AS
Pediatr Blood Cancer 2023 Nov;70(11):e30615. Epub 2023 Aug 13 doi: 10.1002/pbc.30615. PMID: 37574821
Anti-GD2 Directed Immunotherapy for High-Risk and Metastatic Neuroblastoma.
Chan GC, Chan CM
Biomolecules 2022 Feb 24;12(3) doi: 10.3390/biom12030358. PMID: 35327550Free PMC Article
GD2-targeted immunotherapy and radioimmunotherapy.
Dobrenkov K, Cheung NK
Semin Oncol 2014 Oct;41(5):589-612. Epub 2014 Jul 21 doi: 10.1053/j.seminoncol.2014.07.003. PMID: 25440605Free PMC Article
Autologous hematopoietic stem cell transplantation for pediatric solid tumors.
Hale GA
Expert Rev Anticancer Ther 2005 Oct;5(5):835-46. doi: 10.1586/14737140.5.5.835. PMID: 16221053
Aetiology of childhood proptosis.
Sindhu K, Downie J, Ghabrial R, Martin F
J Paediatr Child Health 1998 Aug;34(4):374-6. doi: 10.1046/j.1440-1754.1998.00243.x. PMID: 9727182

Diagnosis

Metastatic neuroblastoma mimicking an infantile hemangioma.
Chiloeches Fernández C, Feito Rodríguez M, Rodríguez Bandera A, Quintana Castanedo L, Ruiz Bravo E, de Lucas Laguna R
Pediatr Dermatol 2021 Jan;38(1):316-317. Epub 2020 Oct 25 doi: 10.1111/pde.14421. PMID: 33099811
Orbital metastatic neuroblastoma presenting as posttraumatic exophthalmos.
Frunză AM, Samoilă O
Rom J Ophthalmol 2020 Jan-Mar;64(1):75-77. PMID: 32292863Free PMC Article
Malignant osseous tumors of the pediatric spine.
Kim HJ, McLawhorn AS, Goldstein MJ, Boland PJ
J Am Acad Orthop Surg 2012 Oct;20(10):646-56. doi: 10.5435/JAAOS-20-10-646. PMID: 23027694
Aetiology of childhood proptosis.
Sindhu K, Downie J, Ghabrial R, Martin F
J Paediatr Child Health 1998 Aug;34(4):374-6. doi: 10.1046/j.1440-1754.1998.00243.x. PMID: 9727182
Chemotherapy of metastatic neuroblastoma.
Hartmann JR
J Pediatr Surg 1968 Feb;3(1):181-2. doi: 10.1016/0022-3468(68)91012-9. PMID: 5655572

Therapy

Phase II study of (131) I-metaiodobenzylguanidine with 5 days of topotecan for refractory or relapsed neuroblastoma: Results of the French study MIITOP.
Sevrin F, Kolesnikov-Gauthier H, Cougnenc O, Bogart E, Schleiermacher G, Courbon F, Gambart M, Giraudet AL, Corradini N, Badel JN, Rault E, Oudoux A, Deley MCL, Valteau-Couanet D, Defachelles AS
Pediatr Blood Cancer 2023 Nov;70(11):e30615. Epub 2023 Aug 13 doi: 10.1002/pbc.30615. PMID: 37574821
Anti-GD2 Directed Immunotherapy for High-Risk and Metastatic Neuroblastoma.
Chan GC, Chan CM
Biomolecules 2022 Feb 24;12(3) doi: 10.3390/biom12030358. PMID: 35327550Free PMC Article
Constitutive Signaling from an Engineered IL7 Receptor Promotes Durable Tumor Elimination by Tumor-Redirected T Cells.
Shum T, Omer B, Tashiro H, Kruse RL, Wagner DL, Parikh K, Yi Z, Sauer T, Liu D, Parihar R, Castillo P, Liu H, Brenner MK, Metelitsa LS, Gottschalk S, Rooney CM
Cancer Discov 2017 Nov;7(11):1238-1247. Epub 2017 Aug 22 doi: 10.1158/2159-8290.CD-17-0538. PMID: 28830878Free PMC Article
GD2-targeted immunotherapy and radioimmunotherapy.
Dobrenkov K, Cheung NK
Semin Oncol 2014 Oct;41(5):589-612. Epub 2014 Jul 21 doi: 10.1053/j.seminoncol.2014.07.003. PMID: 25440605Free PMC Article
Monoclonal antibody-based therapy of neuroblastoma.
Cheung NK, Kushner BH, Kramer K
Hematol Oncol Clin North Am 2001 Oct;15(5):853-66. doi: 10.1016/s0889-8588(05)70255-0. PMID: 11765377

Prognosis

Phase II study of (131) I-metaiodobenzylguanidine with 5 days of topotecan for refractory or relapsed neuroblastoma: Results of the French study MIITOP.
Sevrin F, Kolesnikov-Gauthier H, Cougnenc O, Bogart E, Schleiermacher G, Courbon F, Gambart M, Giraudet AL, Corradini N, Badel JN, Rault E, Oudoux A, Deley MCL, Valteau-Couanet D, Defachelles AS
Pediatr Blood Cancer 2023 Nov;70(11):e30615. Epub 2023 Aug 13 doi: 10.1002/pbc.30615. PMID: 37574821
Orbital metastatic neuroblastoma presenting as posttraumatic exophthalmos.
Frunză AM, Samoilă O
Rom J Ophthalmol 2020 Jan-Mar;64(1):75-77. PMID: 32292863Free PMC Article
Multifocal intraosseous ganglioneuroma.
Kang DG, Helgeson MD, Britt JD, Tracey RW, Bernstock JD
Am J Orthop (Belle Mead NJ) 2014 Oct;43(10):E232-6. PMID: 25303450
Metastatic neuroblastoma mimicking infantile hemangioma.
Hassanein AH, Fishman SJ, Mulliken JB, Alomari AI, Kurek KC, Padua HM, Greene AK
J Pediatr Surg 2010 Oct;45(10):2045-9. doi: 10.1016/j.jpedsurg.2010.06.003. PMID: 20920727
Chemotherapy of metastatic neuroblastoma.
Hartmann JR
J Pediatr Surg 1968 Feb;3(1):181-2. doi: 10.1016/0022-3468(68)91012-9. PMID: 5655572

Clinical prediction guides

Single-cell analyses of metastatic bone marrow in human neuroblastoma reveals microenvironmental remodeling and metastatic signature.
Mei S, Alchahin AM, Embaie BT, Gavriliuc IM, Verhoeven BM, Zhao T, Li X, Jeffries NE, Pepich A, Sarkar H, Olsen TK, Wickström M, Stenman J, Reina-Bedoya O, Kharchenko PV, Saylor PJ, Johnsen JI, Sykes DB, Kogner P, Baryawno N
JCI Insight 2024 Feb 15;9(6) doi: 10.1172/jci.insight.173337. PMID: 38358826Free PMC Article
Phase II study of (131) I-metaiodobenzylguanidine with 5 days of topotecan for refractory or relapsed neuroblastoma: Results of the French study MIITOP.
Sevrin F, Kolesnikov-Gauthier H, Cougnenc O, Bogart E, Schleiermacher G, Courbon F, Gambart M, Giraudet AL, Corradini N, Badel JN, Rault E, Oudoux A, Deley MCL, Valteau-Couanet D, Defachelles AS
Pediatr Blood Cancer 2023 Nov;70(11):e30615. Epub 2023 Aug 13 doi: 10.1002/pbc.30615. PMID: 37574821
Preclinical assessment of the efficacy and specificity of GD2-B7H3 SynNotch CAR-T in metastatic neuroblastoma.
Moghimi B, Muthugounder S, Jambon S, Tibbetts R, Hung L, Bassiri H, Hogarty MD, Barrett DM, Shimada H, Asgharzadeh S
Nat Commun 2021 Jan 21;12(1):511. doi: 10.1038/s41467-020-20785-x. PMID: 33479234Free PMC Article
Cabozantinib for relapsed neuroblastoma: Single institution case series.
Perisa MP, Storey M, Streby KA, Ranalli MA, Skeens M, Shah N
Pediatr Blood Cancer 2020 Jul;67(7):e28317. Epub 2020 Apr 28 doi: 10.1002/pbc.28317. PMID: 32343886
Metastatic neuroblastoma in bone marrow aspirate smears.
Head DR, Kennedy PS, Goyette RE
Am J Clin Pathol 1979 Dec;72(6):1008-11. doi: 10.1093/ajcp/72.6.1008. PMID: 92888

Recent systematic reviews

Incidence of subclinical and overt hypothyroidism in children treated with [131I]mIBG: a systematic review and meta-analysis.
Fiz F, Piticchio T, Bottoni G, Sorrentino S, Fragola M, Livellara V, Trimboli P, Piccardo A
Q J Nucl Med Mol Imaging 2024 Mar;68(1):40-47. Epub 2024 Feb 6 doi: 10.23736/S1824-4785.24.03552-0. PMID: 38319674

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...