U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Metastatic human epidermal growth factor 2 positive carcinoma of breast

MedGen UID:
1636706
•Concept ID:
C4721209
•
Neoplastic Process
Synonyms: HER2 positive metastatic breast cancer; Metastasis from human epidermal growth factor 2 positive carcinoma of breast
SNOMED CT: Metastasis from human epidermal growth factor 2 positive carcinoma of breast (459391000124109); Metastatic human epidermal growth factor 2 positive carcinoma of breast (459391000124109); HER2 positive metastatic breast cancer (459391000124109)

Professional guidelines

PubMed

Optimizing treatment management of trastuzumab deruxtecan in clinical practice of breast cancer.
Rugo HS, Bianchini G, Cortes J, Henning JW, Untch M
ESMO Open 2022 Aug;7(4):100553. Epub 2022 Aug 11 doi: 10.1016/j.esmoop.2022.100553. PMID: 35964548Free PMC Article
Diagnosis and Treatment of ERBB2-Positive Metastatic Colorectal Cancer: A Review.
Strickler JH, Yoshino T, Graham RP, Siena S, Bekaii-Saab T
JAMA Oncol 2022 May 1;8(5):760-769. doi: 10.1001/jamaoncol.2021.8196. PMID: 35238866
Breast Cancer Treatment: A Review.
Waks AG, Winer EP
JAMA 2019 Jan 22;321(3):288-300. doi: 10.1001/jama.2018.19323. PMID: 30667505

Recent clinical studies

Etiology

Metastatic HER2-Positive Breast Cancer: Is There an Optimal Sequence of Therapy?
Dempsey N, Sandoval A, Mahtani R
Curr Treat Options Oncol 2023 Sep;24(9):1120-1137. Epub 2023 Jul 10 doi: 10.1007/s11864-023-01108-w. PMID: 37428332
Elacestrant: First Approval.
Hoy SM
Drugs 2023 Apr;83(6):555-561. doi: 10.1007/s40265-023-01861-0. PMID: 37060385Free PMC Article
Biomarkers of neoadjuvant/adjuvant chemotherapy for breast cancer.
Iwamoto T, Kajiwara Y, Zhu Y, Iha S
Chin Clin Oncol 2020 Jun;9(3):27. Epub 2020 Mar 13 doi: 10.21037/cco.2020.01.06. PMID: 32192349
Bioinformatics analysis of prognostic significance of COL10A1 in breast cancer.
Zhang M, Chen H, Wang M, Bai F, Wu K
Biosci Rep 2020 Feb 28;40(2) doi: 10.1042/BSR20193286. PMID: 32043519Free PMC Article
Breast Cancer Treatment: A Review.
Waks AG, Winer EP
JAMA 2019 Jan 22;321(3):288-300. doi: 10.1001/jama.2018.19323. PMID: 30667505

Diagnosis

ESR1 mutations in HR+/HER2-metastatic breast cancer: Enhancing the accuracy of ctDNA testing.
Venetis K, Pepe F, Pescia C, Cursano G, Criscitiello C, Frascarelli C, Mane E, Russo G, Taurelli Salimbeni B, Troncone G, Guerini Rocco E, Curigliano G, Fusco N, Malapelle U
Cancer Treat Rev 2023 Dec;121:102642. Epub 2023 Oct 13 doi: 10.1016/j.ctrv.2023.102642. PMID: 37864956
Metastatic HER2-Positive Breast Cancer: Is There an Optimal Sequence of Therapy?
Dempsey N, Sandoval A, Mahtani R
Curr Treat Options Oncol 2023 Sep;24(9):1120-1137. Epub 2023 Jul 10 doi: 10.1007/s11864-023-01108-w. PMID: 37428332
Evolution of overall survival and receipt of new therapies by subtype among 20 446 metastatic breast cancer patients in the 2008-2017 ESME cohort.
Grinda T, Antoine A, Jacot W, Blaye C, Cottu PH, Diéras V, Dalenc F, Gonçalves A, Debled M, Patsouris A, Mouret-Reynier MA, Mailliez A, Clatot F, Levy C, Ferrero JM, Desmoulins I, Uwer L, Petit T, Jouannaud C, Lacroix-Triki M, Deluche E, Robain M, Courtinard C, Bachelot T, Brain E, Pérol D, Delaloge S
ESMO Open 2021 Jun;6(3):100114. Epub 2021 Apr 23 doi: 10.1016/j.esmoop.2021.100114. PMID: 33895695Free PMC Article
Bioinformatics analysis of prognostic significance of COL10A1 in breast cancer.
Zhang M, Chen H, Wang M, Bai F, Wu K
Biosci Rep 2020 Feb 28;40(2) doi: 10.1042/BSR20193286. PMID: 32043519Free PMC Article
Breast Cancer Treatment: A Review.
Waks AG, Winer EP
JAMA 2019 Jan 22;321(3):288-300. doi: 10.1001/jama.2018.19323. PMID: 30667505

Therapy

Metastatic HER2-Positive Breast Cancer: Is There an Optimal Sequence of Therapy?
Dempsey N, Sandoval A, Mahtani R
Curr Treat Options Oncol 2023 Sep;24(9):1120-1137. Epub 2023 Jul 10 doi: 10.1007/s11864-023-01108-w. PMID: 37428332
Systemic therapy for hormone receptor-positive/human epidermal growth factor receptor 2-negative early stage and metastatic breast cancer.
Huppert LA, Gumusay O, Idossa D, Rugo HS
CA Cancer J Clin 2023 Sep-Oct;73(5):480-515. Epub 2023 Mar 20 doi: 10.3322/caac.21777. PMID: 36939293
Overall Survival with Ribociclib plus Letrozole in Advanced Breast Cancer.
Hortobagyi GN, Stemmer SM, Burris HA, Yap YS, Sonke GS, Hart L, Campone M, Petrakova K, Winer EP, Janni W, Conte P, Cameron DA, André F, Arteaga CL, Zarate JP, Chakravartty A, Taran T, Le Gac F, Serra P, O'Shaughnessy J
N Engl J Med 2022 Mar 10;386(10):942-950. doi: 10.1056/NEJMoa2114663. PMID: 35263519
Novel HER2-targeted therapies for HER2-positive metastatic breast cancer.
Kunte S, Abraham J, Montero AJ
Cancer 2020 Oct 1;126(19):4278-4288. Epub 2020 Jul 28 doi: 10.1002/cncr.33102. PMID: 32721042
Breast Cancer Treatment: A Review.
Waks AG, Winer EP
JAMA 2019 Jan 22;321(3):288-300. doi: 10.1001/jama.2018.19323. PMID: 30667505

Prognosis

Metastatic HER2-Positive Breast Cancer: Is There an Optimal Sequence of Therapy?
Dempsey N, Sandoval A, Mahtani R
Curr Treat Options Oncol 2023 Sep;24(9):1120-1137. Epub 2023 Jul 10 doi: 10.1007/s11864-023-01108-w. PMID: 37428332
Biomarkers of neoadjuvant/adjuvant chemotherapy for breast cancer.
Iwamoto T, Kajiwara Y, Zhu Y, Iha S
Chin Clin Oncol 2020 Jun;9(3):27. Epub 2020 Mar 13 doi: 10.21037/cco.2020.01.06. PMID: 32192349
Breast Cancer Treatment: A Review.
Waks AG, Winer EP
JAMA 2019 Jan 22;321(3):288-300. doi: 10.1001/jama.2018.19323. PMID: 30667505
Updated results from MONALEESA-2, a phase III trial of first-line ribociclib plus letrozole versus placebo plus letrozole in hormone receptor-positive, HER2-negative advanced breast cancer.
Hortobagyi GN, Stemmer SM, Burris HA, Yap YS, Sonke GS, Paluch-Shimon S, Campone M, Petrakova K, Blackwell KL, Winer EP, Janni W, Verma S, Conte P, Arteaga CL, Cameron DA, Mondal S, Su F, Miller M, Elmeliegy M, Germa C, O'Shaughnessy J
Ann Oncol 2018 Jul 1;29(7):1541-1547. doi: 10.1093/annonc/mdy155. PMID: 29718092
Adjuvant paclitaxel and trastuzumab for node-negative, HER2-positive breast cancer.
Tolaney SM, Barry WT, Dang CT, Yardley DA, Moy B, Marcom PK, Albain KS, Rugo HS, Ellis M, Shapira I, Wolff AC, Carey LA, Overmoyer BA, Partridge AH, Guo H, Hudis CA, Krop IE, Burstein HJ, Winer EP
N Engl J Med 2015 Jan 8;372(2):134-41. doi: 10.1056/NEJMoa1406281. PMID: 25564897Free PMC Article

Clinical prediction guides

ESR1 mutations in HR+/HER2-metastatic breast cancer: Enhancing the accuracy of ctDNA testing.
Venetis K, Pepe F, Pescia C, Cursano G, Criscitiello C, Frascarelli C, Mane E, Russo G, Taurelli Salimbeni B, Troncone G, Guerini Rocco E, Curigliano G, Fusco N, Malapelle U
Cancer Treat Rev 2023 Dec;121:102642. Epub 2023 Oct 13 doi: 10.1016/j.ctrv.2023.102642. PMID: 37864956
Correlative Biomarker Analysis of Intrinsic Subtypes and Efficacy Across the MONALEESA Phase III Studies.
Prat A, Chaudhury A, Solovieff N, Paré L, Martinez D, Chic N, Martínez-Sáez O, Brasó-Maristany F, Lteif A, Taran T, Babbar N, Su F
J Clin Oncol 2021 May 1;39(13):1458-1467. Epub 2021 Mar 26 doi: 10.1200/JCO.20.02977. PMID: 33769862Free PMC Article
Biomarkers of neoadjuvant/adjuvant chemotherapy for breast cancer.
Iwamoto T, Kajiwara Y, Zhu Y, Iha S
Chin Clin Oncol 2020 Jun;9(3):27. Epub 2020 Mar 13 doi: 10.21037/cco.2020.01.06. PMID: 32192349
Bioinformatics analysis of prognostic significance of COL10A1 in breast cancer.
Zhang M, Chen H, Wang M, Bai F, Wu K
Biosci Rep 2020 Feb 28;40(2) doi: 10.1042/BSR20193286. PMID: 32043519Free PMC Article
Breast Cancer Treatment: A Review.
Waks AG, Winer EP
JAMA 2019 Jan 22;321(3):288-300. doi: 10.1001/jama.2018.19323. PMID: 30667505

Recent systematic reviews

Incidence of interstitial lung disease and cardiotoxicity with trastuzumab deruxtecan in breast cancer patients: a systematic review and single-arm meta-analysis.
Soares LR, Vilbert M, Rosa VDL, Oliveira JL, Deus MM, Freitas-Junior R
ESMO Open 2023 Aug;8(4):101613. Epub 2023 Jul 23 doi: 10.1016/j.esmoop.2023.101613. PMID: 37481956Free PMC Article
Safety profile of cyclin-dependent kinase (CDK) 4/6 inhibitors with concurrent radiation therapy: A systematic review and meta-analysis.
Becherini C, Visani L, Caini S, Bhattacharya IS, Kirby AM, Nader Marta G, Morgan G, Salvestrini V, Coles CE, Cortes J, Curigliano G, de Azambuja E, Harbeck N, Isacke CM, Kaidar-Person O, Marangoni E, Offersen B, Rugo HS, Morandi A, Lambertini M, Poortmans P, Livi L, Meattini I
Cancer Treat Rev 2023 Sep;119:102586. Epub 2023 Jun 15 doi: 10.1016/j.ctrv.2023.102586. PMID: 37336117
Second-line Endocrine Therapy of Hormone Receptor-positive/HER2- negative Advanced Breast Cancer: A Systematic Review and Network Meta-analysis.
Wang T, Shen G, Li J, Huo X, Wang M, Liu Z, Zhao F, Ren D, Zhao J
Curr Cancer Drug Targets 2023;23(9):718-730. doi: 10.2174/1568009623666230407101128. PMID: 37026492
Endocrine Treatment and Targeted Therapy for Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer: ASCO Guideline Update.
Burstein HJ, Somerfield MR, Barton DL, Dorris A, Fallowfield LJ, Jain D, Johnston SRD, Korde LA, Litton JK, Macrae ER, Peterson LL, Vikas P, Yung RL, Rugo HS
J Clin Oncol 2021 Dec 10;39(35):3959-3977. Epub 2021 Jul 29 doi: 10.1200/JCO.21.01392. PMID: 34324367Free PMC Article
The incidence of brain metastases among patients with metastatic breast cancer: a systematic review and meta-analysis.
Kuksis M, Gao Y, Tran W, Hoey C, Kiss A, Komorowski AS, Dhaliwal AJ, Sahgal A, Das S, Chan KK, Jerzak KJ
Neuro Oncol 2021 Jun 1;23(6):894-904. doi: 10.1093/neuonc/noaa285. PMID: 33367836Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...