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Non-herpetic acute limbic encephalitis

MedGen UID:
1646654
Concept ID:
C4707262
Disease or Syndrome
Synonym: non-herpetic acute limbic encephalitis
SNOMED CT: Non-herpetic acute limbic encephalitis (764998005)
 
Monarch Initiative: MONDO:0015596

Definition

Non-herpetic acute limbic encephalitis is a rare neuroinflammatory/neuroautoimmune disease characterized by an acute (or subacute) onset of disturbance of consciousness (occasionally presenting as convulsions) and high fever, associated with cerebral lesions (on magnetic resonance imaging) that are restricted to the limbic system (particularly the hippocampi and amygdalae), in the absence of viral, bacterial, fungal, paraneoplastic and other disorders. [from MONDO]

Recent clinical studies

Etiology

Wada-Isoe K, Kusumi M, Kai T, Awaki E, Shimoda M, Yano H, Suzuki K, Nakayasu H, Oota K, Kowa H, Nakashima K
Eur J Neurol 2008 Oct;15(10):1075-9. Epub 2008 Aug 20 doi: 10.1111/j.1468-1331.2008.02249.x. PMID: 18717727
Asaoka K, Shoji H, Nishizaka S, Ayabe M, Abe T, Ohori N, Ichiyama T, Eizuru Y
Intern Med 2004 Jan;43(1):42-8. doi: 10.2169/internalmedicine.43.42. PMID: 14964578

Diagnosis

Takahashi Y, Mikami T, Suzuki H, Komatsu K, Yamamoto D, Shimohama S, Houkin K, Sugita S, Hasegawa T, Mikuni N
J Clin Neurosci 2018 Jul;53:250-253. Epub 2018 May 3 doi: 10.1016/j.jocn.2018.04.042. PMID: 29731274
Wada-Isoe K, Kusumi M, Kai T, Awaki E, Shimoda M, Yano H, Suzuki K, Nakayasu H, Oota K, Kowa H, Nakashima K
Eur J Neurol 2008 Oct;15(10):1075-9. Epub 2008 Aug 20 doi: 10.1111/j.1468-1331.2008.02249.x. PMID: 18717727
Asaoka K, Shoji H, Nishizaka S, Ayabe M, Abe T, Ohori N, Ichiyama T, Eizuru Y
Intern Med 2004 Jan;43(1):42-8. doi: 10.2169/internalmedicine.43.42. PMID: 14964578
Shoji H, Azuma K, Nishimura Y, Fujimoto H, Sugita Y, Eizuru Y
Intern Med 2002 Jun;41(6):420-8. doi: 10.2169/internalmedicine.41.420. PMID: 12135172

Prognosis

Ichiyama T, Shoji H, Takahashi Y, Matsushige T, Kajimoto M, Inuzuka T, Furukawa S
Cytokine 2008 Oct;44(1):149-53. Epub 2008 Aug 21 doi: 10.1016/j.cyto.2008.07.002. PMID: 18722137
Wada-Isoe K, Kusumi M, Kai T, Awaki E, Shimoda M, Yano H, Suzuki K, Nakayasu H, Oota K, Kowa H, Nakashima K
Eur J Neurol 2008 Oct;15(10):1075-9. Epub 2008 Aug 20 doi: 10.1111/j.1468-1331.2008.02249.x. PMID: 18717727
Maki T, Kokubo Y, Nishida S, Suzuki H, Kuzuhara S
Neuropathology 2008 Oct;28(5):521-5. Epub 2008 Feb 15 doi: 10.1111/j.1440-1789.2008.00872.x. PMID: 18282167
Mochizuki Y, Mizutani T, Isozaki E, Ohtake T, Takahashi Y
Neurosci Lett 2006 Feb 6;394(1):5-8. Epub 2005 Dec 20 doi: 10.1016/j.neulet.2005.08.070. PMID: 16364542
Asaoka K, Shoji H, Nishizaka S, Ayabe M, Abe T, Ohori N, Ichiyama T, Eizuru Y
Intern Med 2004 Jan;43(1):42-8. doi: 10.2169/internalmedicine.43.42. PMID: 14964578

Clinical prediction guides

Miyahara H, Ryufuku M, Fu YJ, Kitaura H, Murakami H, Masuda H, Kameyama S, Takahashi H, Kakita A
Seizure 2011 Jan;20(1):87-9. Epub 2010 Oct 14 doi: 10.1016/j.seizure.2010.09.013. PMID: 20951065
Okamoto K, Yamazaki T, Banno H, Sobue G, Yoshida M, Takatama M
Intern Med 2008;47(4):231-6. Epub 2008 Feb 15 doi: 10.2169/internalmedicine.47.0547. PMID: 18277022

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