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Inherited isolated adrenal insufficiency due to partial CYP11A1 deficiency

MedGen UID:
1643960
Concept ID:
C4707238
Disease or Syndrome
Synonyms: inherited isolated adrenal insufficiency due to partial CYP11A1 deficiency; Inherited isolated adrenal insufficiency due to partial cytochrome P450 family 11 subfamily A member 1 deficiency
SNOMED CT: Inherited isolated adrenal insufficiency due to partial cytochrome P450 family 11 subfamily A member 1 deficiency (764960005); Inherited isolated adrenal insufficiency due to partial CYP11A1 deficiency (764960005)
Modes of inheritance:
Autosomal recessive inheritance
MedGen UID:
141025
Concept ID:
C0441748
Intellectual Product
Source: Orphanet
A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in individuals with two pathogenic alleles, either homozygotes (two copies of the same mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele).
 
Monarch Initiative: MONDO:0017337
Orphanet: ORPHA289548

Definition

A rare genetic chronic primary adrenal insufficiency disorder due to partial loss-of-function CYP11A1 mutations. The disease has characteristics of early-onset adrenal insufficiency without associated abnormal external male genitalia. Patients present with signs of adrenal crisis, including electrolyte abnormalities, severe weakness, recurrent vomiting and seizures. Ultrasound reveals absent (or very small) adrenal glands. [from SNOMEDCT_US]

Recent clinical studies

Prognosis

Ali N, Maharaj AV, Buonocore F, Achermann JC, Metherell LA
Front Endocrinol (Lausanne) 2022;13:860055. Epub 2022 Mar 28 doi: 10.3389/fendo.2022.860055. PMID: 35418949Free PMC Article

Clinical prediction guides

Ali N, Maharaj AV, Buonocore F, Achermann JC, Metherell LA
Front Endocrinol (Lausanne) 2022;13:860055. Epub 2022 Mar 28 doi: 10.3389/fendo.2022.860055. PMID: 35418949Free PMC Article

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