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Taq1A POLYMORPHISM

MedGen UID:
1633370
•Concept ID:
C4694057
•
Disease or Syndrome
OMIM®: 608774

Professional guidelines

PubMed

The significant association of Taq1A genotypes in DRD2/ANKK1 with smoking cessation in a large-scale meta-analysis of Caucasian populations.
Ma Y, Wang M, Yuan W, Su K, Li MD
Transl Psychiatry 2015 Dec 1;5(12):e686. doi: 10.1038/tp.2015.176. PMID: 26624925Free PMC Article
Allele and genotype frequencies of serotonin and dopamine transporter and receptor polymorphisms in a Norwegian population.
Güzey C, Lopez-Rodriguez R, Myhre R, Spigset O
Genet Test Mol Biomarkers 2011 Jul-Aug;15(7-8):557-63. Epub 2011 Mar 31 doi: 10.1089/gtmb.2010.0210. PMID: 21453053
D2 receptor genetic variation and clinical response to antipsychotic drug treatment: a meta-analysis.
Zhang JP, Lencz T, Malhotra AK
Am J Psychiatry 2010 Jul;167(7):763-72. Epub 2010 Mar 1 doi: 10.1176/appi.ajp.2009.09040598. PMID: 20194480Free PMC Article

Recent clinical studies

Etiology

Taq1A polymorphism and medication effects on inhibitory action control in Parkinson disease.
McDonell KE, van Wouwe NC, Harrison MB, Wylie SA, Claassen DO
Brain Behav 2018 Jul;8(7):e01008. Epub 2018 Jun 1 doi: 10.1002/brb3.1008. PMID: 29856137Free PMC Article
Dopamine DRD2 polymorphism (DRD2/ANNK1-Taq1A) is not a significant risk factor in writer's cramp.
Zeuner KE, Acewicz A, Knutzen A, Dressler D, Lohmann K, Witt K
J Neurogenet 2016 Sep-Dec;30(3-4):276-279. Epub 2016 Oct 4 doi: 10.1080/01677063.2016.1238916. PMID: 27696930
The -141C Ins/Del and Taq1A polymorphism in the dopamine D2 receptor gene may confer susceptibility to schizophrenia in Asian populations.
Wang Y, Liu L, Xin L, Fan D, Ding N, Hu Y, Cai G, Wang L, Xia Q, Li X, Yang X, Zou Y, Pan F
J Clin Neurosci 2016 Aug;30:1-7. Epub 2016 Jun 6 doi: 10.1016/j.jocn.2015.10.052. PMID: 27283386
Lack of association between DRD2 Taq1A gene polymorphism and smoking cessation therapy: a meta-analysis.
Choi HD, Shin WG
Int J Clin Pharmacol Ther 2015 Jun;53(6):415-21. doi: 10.5414/CP202214. PMID: 25881752
Effects of aripiprazole and the Taq1A polymorphism in the dopamine D2 receptor gene on the clinical response and plasma monoamine metabolites level during the acute phase of schizophrenia.
Miura I, Takeuchi S, Katsumi A, Mori A, Kanno K, Yang Q, Mashiko H, Numata Y, Niwa S
J Clin Psychopharmacol 2012 Feb;32(1):106-9. doi: 10.1097/JCP.0b013e31823f87ac. PMID: 22198450

Diagnosis

The Ankyrin Repeat and Kinase Domain Containing 1 Gene Polymorphism (ANKK1Taq1A) and Personality Traits in Addicted Subjects.
Grzywacz A, Chmielowiec J, Chmielowiec K, Mroczek B, Masiak J, Suchanecka A, Sipak-Szmigiel O, Szumilas K, Trybek G
Int J Environ Res Public Health 2019 Jul 27;16(15) doi: 10.3390/ijerph16152687. PMID: 31357601Free PMC Article
Variants in the DRD2 locus and antipsychotic-related prolactin levels: A meta-analysis.
Miura I, Zhang JP, Hagi K, Lencz T, Kane JM, Yabe H, Malhotra AK, Correll CU
Psychoneuroendocrinology 2016 Oct;72:1-10. Epub 2016 Jun 6 doi: 10.1016/j.psyneuen.2016.06.002. PMID: 27333159Free PMC Article
A large-scale meta-analysis of the association between the ANKK1/DRD2 Taq1A polymorphism and alcohol dependence.
Wang F, Simen A, Arias A, Lu QW, Zhang H
Hum Genet 2013 Mar;132(3):347-58. Epub 2012 Dec 1 doi: 10.1007/s00439-012-1251-6. PMID: 23203481Free PMC Article
Dopamine-system genes, childhood abuse, and clinical manifestations in women with Bulimia-Spectrum Disorders.
Groleau P, Steiger H, Joober R, Bruce KR, Israel M, Badawi G, Zeramdini N, Sycz L
J Psychiatr Res 2012 Sep;46(9):1139-45. Epub 2012 Jun 23 doi: 10.1016/j.jpsychires.2012.05.018. PMID: 22733030
Meta-analysis of the association of the Taq1A polymorphism with the risk of alcohol dependency: a HuGE gene-disease association review.
Smith L, Watson M, Gates S, Ball D, Foxcroft D
Am J Epidemiol 2008 Jan 15;167(2):125-38. Epub 2007 Nov 7 doi: 10.1093/aje/kwm281. PMID: 17989061

Therapy

Taq1A polymorphism and medication effects on inhibitory action control in Parkinson disease.
McDonell KE, van Wouwe NC, Harrison MB, Wylie SA, Claassen DO
Brain Behav 2018 Jul;8(7):e01008. Epub 2018 Jun 1 doi: 10.1002/brb3.1008. PMID: 29856137Free PMC Article
Variants in the DRD2 locus and antipsychotic-related prolactin levels: A meta-analysis.
Miura I, Zhang JP, Hagi K, Lencz T, Kane JM, Yabe H, Malhotra AK, Correll CU
Psychoneuroendocrinology 2016 Oct;72:1-10. Epub 2016 Jun 6 doi: 10.1016/j.psyneuen.2016.06.002. PMID: 27333159Free PMC Article
Lack of association between DRD2 Taq1A gene polymorphism and smoking cessation therapy: a meta-analysis.
Choi HD, Shin WG
Int J Clin Pharmacol Ther 2015 Jun;53(6):415-21. doi: 10.5414/CP202214. PMID: 25881752
Effects of aripiprazole and the Taq1A polymorphism in the dopamine D2 receptor gene on the clinical response and plasma monoamine metabolites level during the acute phase of schizophrenia.
Miura I, Takeuchi S, Katsumi A, Mori A, Kanno K, Yang Q, Mashiko H, Numata Y, Niwa S
J Clin Psychopharmacol 2012 Feb;32(1):106-9. doi: 10.1097/JCP.0b013e31823f87ac. PMID: 22198450
Association of the DRD2 gene Taq1A polymorphism and smoking behavior: a meta-analysis and new data.
Munafò MR, Timpson NJ, David SP, Ebrahim S, Lawlor DA
Nicotine Tob Res 2009 Jan;11(1):64-76. Epub 2009 Jan 27 doi: 10.1093/ntr/ntn012. PMID: 19246443Free PMC Article

Prognosis

Blocking D2/D3 dopamine receptors in male participants increases volatility of beliefs when learning to trust others.
Mikus N, Eisenegger C, Mathys C, Clark L, Müller U, Robbins TW, Lamm C, Naef M
Nat Commun 2023 Jul 8;14(1):4049. doi: 10.1038/s41467-023-39823-5. PMID: 37422466Free PMC Article
Polymorphisms influencing olanzapine metabolism and adverse effects in healthy subjects.
Cabaleiro T, López-Rodríguez R, Ochoa D, Román M, Novalbos J, Abad-Santos F
Hum Psychopharmacol 2013 May;28(3):205-14. Epub 2013 Apr 5 doi: 10.1002/hup.2308. PMID: 23559402
D2 dopamine receptor Taq1A polymorphism, body weight, and dietary intake in type 2 diabetes.
Barnard ND, Noble EP, Ritchie T, Cohen J, Jenkins DJ, Turner-McGrievy G, Gloede L, Green AA, Ferdowsian H
Nutrition 2009 Jan;25(1):58-65. Epub 2008 Oct 2 doi: 10.1016/j.nut.2008.07.012. PMID: 18834717Free PMC Article
Taq1A polymorphism in the dopamine D2 receptor gene predicts brain metabolic response to aripiprazole in healthy male volunteers.
Kim E, Kwon JS, Shin YW, Lee JS, Kang WJ, Jo HJ, Lee JM, Yu KS, Kang DH, Cho JY, Jang IJ, Shin SG
Pharmacogenet Genomics 2008 Feb;18(2):91-7. doi: 10.1097/FPC.0b013e3282f3ef8c. PMID: 18192895
Bupropion efficacy for smoking cessation is influenced by the DRD2 Taq1A polymorphism: analysis of pooled data from two clinical trials.
David SP, Strong DR, Munafò MR, Brown RA, Lloyd-Richardson EE, Wileyto PE, Evins AE, Shields PG, Lerman C, Niaura R
Nicotine Tob Res 2007 Dec;9(12):1251-7. doi: 10.1080/14622200701705027. PMID: 18058343Free PMC Article

Clinical prediction guides

Taq1A polymorphism and medication effects on inhibitory action control in Parkinson disease.
McDonell KE, van Wouwe NC, Harrison MB, Wylie SA, Claassen DO
Brain Behav 2018 Jul;8(7):e01008. Epub 2018 Jun 1 doi: 10.1002/brb3.1008. PMID: 29856137Free PMC Article
Influence of the DRD2/ANKK1 Taq1A polymorphism on caudate volume in older adults without dementia.
Li X, Papenberg G, Kalpouzos G, Bäckman L, Persson J
Brain Struct Funct 2018 Jul;223(6):2653-2662. Epub 2018 Mar 21 doi: 10.1007/s00429-018-1650-0. PMID: 29564530Free PMC Article
The significant association of Taq1A genotypes in DRD2/ANKK1 with smoking cessation in a large-scale meta-analysis of Caucasian populations.
Ma Y, Wang M, Yuan W, Su K, Li MD
Transl Psychiatry 2015 Dec 1;5(12):e686. doi: 10.1038/tp.2015.176. PMID: 26624925Free PMC Article
Lack of association between DRD2 Taq1A gene polymorphism and smoking cessation therapy: a meta-analysis.
Choi HD, Shin WG
Int J Clin Pharmacol Ther 2015 Jun;53(6):415-21. doi: 10.5414/CP202214. PMID: 25881752
Association of the DRD2 gene Taq1A polymorphism and smoking behavior: a meta-analysis and new data.
Munafò MR, Timpson NJ, David SP, Ebrahim S, Lawlor DA
Nicotine Tob Res 2009 Jan;11(1):64-76. Epub 2009 Jan 27 doi: 10.1093/ntr/ntn012. PMID: 19246443Free PMC Article

Recent systematic reviews

The effect of ANKK1 Taq1A and DRD2 C957T polymorphisms on executive function: A systematic review and meta-analysis.
Klaus K, Butler K, Curtis F, Bridle C, Pennington K
Neurosci Biobehav Rev 2019 May;100:224-236. Epub 2019 Mar 2 doi: 10.1016/j.neubiorev.2019.01.021. PMID: 30836122
A meta-analysis of the relationship between brain dopamine receptors and obesity: a matter of changes in behavior rather than food addiction?
Benton D, Young HA
Int J Obes (Lond) 2016 Mar;40 Suppl 1(Suppl 1):S12-21. doi: 10.1038/ijo.2016.9. PMID: 27001642Free PMC Article
The genetic basis for smoking behavior: a systematic review and meta-analysis.
Munafò M, Clark T, Johnstone E, Murphy M, Walton R
Nicotine Tob Res 2004 Aug;6(4):583-97. doi: 10.1080/14622200410001734030. PMID: 15370155

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