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Refractory Colorectal Carcinoma

MedGen UID:
1636913
•Concept ID:
C4688318
•
Neoplastic Process

Definition

Colorectal carcinoma that does not respond to treatment. [from NCI]

Professional guidelines

PubMed

Anti-PD-1/Her2 Bispecific Antibody IBI315 Enhances the Treatment Effect of Her2-Positive Gastric Cancer through Gasdermin B-Cleavage Induced Pyroptosis.
Lin W, Zhang Y, Yang Y, Lin B, Zhu M, Xu J, Chen Y, Wu W, Chen B, Chen X, Liu J, Wang H, Teng F, Yu X, Wang H, Lu J, Zhou Q, Teng L
Adv Sci (Weinh) 2023 Oct;10(30):e2303908. Epub 2023 Aug 16 doi: 10.1002/advs.202303908. PMID: 37587833Free PMC Article
Diagnosis and Treatment of ERBB2-Positive Metastatic Colorectal Cancer: A Review.
Strickler JH, Yoshino T, Graham RP, Siena S, Bekaii-Saab T
JAMA Oncol 2022 May 1;8(5):760-769. doi: 10.1001/jamaoncol.2021.8196. PMID: 35238866
The Management and Prevention of Anal Squamous Cell Carcinoma.
Eng C, Messick C, Glynne-Jones R
Am Soc Clin Oncol Educ Book 2019 Jan;39:216-225. Epub 2019 May 17 doi: 10.1200/EDBK_237433. PMID: 31099616

Recent clinical studies

Etiology

Raltitrexed and oxaliplatin hepatic arterial infusion for advanced colorectal cancer: a retrospective study.
Khouri C, Guiu B, Cercueil JP, Chauffert B, Ladoire S, Ghiringhelli F
Anticancer Drugs 2010 Jul;21(6):656-61. doi: 10.1097/CAD.0b013e328337d469. PMID: 20216061
Gefitinib in combination with oxaliplatin and 5-fluorouracil in irinotecan-refractory patients with colorectal cancer: a phase I study of the Arbeits gemeinschaft Internistische Onkologie (AIO).
Hartmann JT, Pintoffl JP, Kröning H, Bokemeyer C, Holtmann M, Höhler T
Onkologie 2008 May;31(5):237-41. Epub 2008 Apr 10 doi: 10.1159/000122029. PMID: 18497512
Selective chemoembolization in the management of hepatic metastases in refractory colorectal carcinoma: a phase II trial.
Sanz-Altamira PM, Spence LD, Huberman MS, Posner MR, Steele G Jr, Perry LJ, Stuart KE
Dis Colon Rectum 1997 Jul;40(7):770-5. doi: 10.1007/BF02055430. PMID: 9221850
Phase I and pharmacologic studies of the camptothecin analog irinotecan administered every 3 weeks in cancer patients.
Abigerges D, Chabot GG, Armand JP, Hérait P, Gouyette A, Gandia D
J Clin Oncol 1995 Jan;13(1):210-21. doi: 10.1200/JCO.1995.13.1.210. PMID: 7799022
Interleukin-2. A review of its pharmacological properties and therapeutic use in patients with cancer.
Whittington R, Faulds D
Drugs 1993 Sep;46(3):446-514. doi: 10.2165/00003495-199346030-00009. PMID: 7693434

Diagnosis

Gefitinib in combination with oxaliplatin and 5-fluorouracil in irinotecan-refractory patients with colorectal cancer: a phase I study of the Arbeits gemeinschaft Internistische Onkologie (AIO).
Hartmann JT, Pintoffl JP, Kröning H, Bokemeyer C, Holtmann M, Höhler T
Onkologie 2008 May;31(5):237-41. Epub 2008 Apr 10 doi: 10.1159/000122029. PMID: 18497512

Therapy

Tumour pharmacodynamics and circulating cell free DNA in patients with refractory colorectal carcinoma treated with regorafenib.
Wong AL, Lim JS, Sinha A, Gopinathan A, Lim R, Tan CS, Soh T, Venkatesh S, Titin C, Sapari NS, Lee SC, Yong WP, Tan DS, Pang B, Wang TT, Zee YK, Soong R, Trnkova Z, Lathia C, Thiery JP, Wilhelm S, Jeffers M, Goh BC
J Transl Med 2015 Feb 12;13:57. doi: 10.1186/s12967-015-0405-4. PMID: 25889309Free PMC Article
Raltitrexed and oxaliplatin hepatic arterial infusion for advanced colorectal cancer: a retrospective study.
Khouri C, Guiu B, Cercueil JP, Chauffert B, Ladoire S, Ghiringhelli F
Anticancer Drugs 2010 Jul;21(6):656-61. doi: 10.1097/CAD.0b013e328337d469. PMID: 20216061
Phase II trial of T138067, a novel microtubule inhibitor, in patients with metastatic, refractory colorectal carcinoma.
Berlin JD, Venook A, Bergsland E, Rothenberg M, Lockhart AC, Rosen L
Clin Colorectal Cancer 2008 Jan;7(1):44-7. doi: 10.3816/CCC.2008.n.006. PMID: 18279576
Cisplatin and chronic oral etoposide as salvage therapy for advanced colorectal carcinoma.
Stuart K, Posner M, Campbell K, Huberman M
Am J Clin Oncol 1995 Aug;18(4):300-2. doi: 10.1097/00000421-199508000-00006. PMID: 7625370
Interleukin-2. A review of its pharmacological properties and therapeutic use in patients with cancer.
Whittington R, Faulds D
Drugs 1993 Sep;46(3):446-514. doi: 10.2165/00003495-199346030-00009. PMID: 7693434

Prognosis

Tumour pharmacodynamics and circulating cell free DNA in patients with refractory colorectal carcinoma treated with regorafenib.
Wong AL, Lim JS, Sinha A, Gopinathan A, Lim R, Tan CS, Soh T, Venkatesh S, Titin C, Sapari NS, Lee SC, Yong WP, Tan DS, Pang B, Wang TT, Zee YK, Soong R, Trnkova Z, Lathia C, Thiery JP, Wilhelm S, Jeffers M, Goh BC
J Transl Med 2015 Feb 12;13:57. doi: 10.1186/s12967-015-0405-4. PMID: 25889309Free PMC Article
Cantuzumab mertansine, a maytansinoid immunoconjugate directed to the CanAg antigen: a phase I, pharmacokinetic, and biologic correlative study.
Tolcher AW, Ochoa L, Hammond LA, Patnaik A, Edwards T, Takimoto C, Smith L, de Bono J, Schwartz G, Mays T, Jonak ZL, Johnson R, DeWitte M, Martino H, Audette C, Maes K, Chari RV, Lambert JM, Rowinsky EK
J Clin Oncol 2003 Jan 15;21(2):211-22. doi: 10.1200/JCO.2003.05.137. PMID: 12525512
Improved survival in patients with advanced colorectal carcinoma failing 5-fluorouracil who received irinotecan hydrochloride and have high intratumor C-fos expression.
Singh A, Tong A, Ognoskie N, Meyer W, Nemunaitis J
Am J Clin Oncol 1998 Oct;21(5):466-9. doi: 10.1097/00000421-199810000-00009. PMID: 9781601
Selective chemoembolization in the management of hepatic metastases in refractory colorectal carcinoma: a phase II trial.
Sanz-Altamira PM, Spence LD, Huberman MS, Posner MR, Steele G Jr, Perry LJ, Stuart KE
Dis Colon Rectum 1997 Jul;40(7):770-5. doi: 10.1007/BF02055430. PMID: 9221850
Phase I and pharmacologic studies of the camptothecin analog irinotecan administered every 3 weeks in cancer patients.
Abigerges D, Chabot GG, Armand JP, Hérait P, Gouyette A, Gandia D
J Clin Oncol 1995 Jan;13(1):210-21. doi: 10.1200/JCO.1995.13.1.210. PMID: 7799022

Clinical prediction guides

Tumour pharmacodynamics and circulating cell free DNA in patients with refractory colorectal carcinoma treated with regorafenib.
Wong AL, Lim JS, Sinha A, Gopinathan A, Lim R, Tan CS, Soh T, Venkatesh S, Titin C, Sapari NS, Lee SC, Yong WP, Tan DS, Pang B, Wang TT, Zee YK, Soong R, Trnkova Z, Lathia C, Thiery JP, Wilhelm S, Jeffers M, Goh BC
J Transl Med 2015 Feb 12;13:57. doi: 10.1186/s12967-015-0405-4. PMID: 25889309Free PMC Article
Raltitrexed and oxaliplatin hepatic arterial infusion for advanced colorectal cancer: a retrospective study.
Khouri C, Guiu B, Cercueil JP, Chauffert B, Ladoire S, Ghiringhelli F
Anticancer Drugs 2010 Jul;21(6):656-61. doi: 10.1097/CAD.0b013e328337d469. PMID: 20216061
Phase I clinical trial and pharmacokinetic study of the spicamycin analog KRN5500 administered as a 1-hour intravenous infusion for five consecutive days to patients with refractory solid tumors.
Supko JG, Eder JP Jr, Ryan DP, Seiden MV, Lynch TJ, Amrein PC, Kufe DW, Clark JW
Clin Cancer Res 2003 Nov 1;9(14):5178-86. PMID: 14613997
9-Aminocamptothecin by 72-hour continuous intravenous infusion is inactive in the treatment of patients with 5-fluorouracil-refractory colorectal carcinoma.
Saltz LB, Kemeny NE, Tong W, Harrison J, Berkery R, Kelsen DP
Cancer 1997 Nov 1;80(9):1727-32. doi: 10.1002/(sici)1097-0142(19971101)80:9<1727::aid-cncr5>3.0.co;2-b. PMID: 9351540
Selective chemoembolization in the management of hepatic metastases in refractory colorectal carcinoma: a phase II trial.
Sanz-Altamira PM, Spence LD, Huberman MS, Posner MR, Steele G Jr, Perry LJ, Stuart KE
Dis Colon Rectum 1997 Jul;40(7):770-5. doi: 10.1007/BF02055430. PMID: 9221850

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