U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Neurolymphomatosis

MedGen UID:
1642312
Concept ID:
C4553088
Neoplastic Process
Synonyms: Fowl Paralyses; Fowl Paralysis; Marek disease; Marek's Disease
SNOMED CT: Neurolymphomatosis (766752000)
 
Monarch Initiative: MONDO:0016101
Orphanet: ORPHA206586

Definition

A rare syndrome of peripheral and cranial nerve dysfunction in patients with haematologic malignancies, mostly non-Hodgkin''s lymphoma or acute leukaemia, characterised by painful or painless involvement of peripheral or cranial nerves or nerve roots. The clinical presentation is diverse depending on the site involved and includes plexopathy, mononeuritis multiplex, peripheral neuropathy, radiculopathy and cranial nerve palsies. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeurolymphomatosis

Professional guidelines

PubMed

Kaulen LD, Hielscher T, Doubrovinskaia S, Hoffmann DC, Kessler T, Traub BL, Baehring JM, Wick W
Neurology 2024 Aug 27;103(4):e209698. Epub 2024 Aug 5 doi: 10.1212/WNL.0000000000209698. PMID: 39102613
Keddie S, Nagendran A, Cox T, Bomsztyk J, Jaunmuktane Z, Brandner S, Manji H, Rees JH, Ramsay AD, Rossor A, D'Sa S, Reilly MM, Carr AS, Lunn MP
Muscle Nerve 2020 Nov;62(5):617-625. Epub 2020 Sep 10 doi: 10.1002/mus.27045. PMID: 32786031
Baehring JM, Batchelor TT
Cancer J 2012 Sep-Oct;18(5):463-8. doi: 10.1097/PPO.0b013e31826c5ad5. PMID: 23006953

Recent clinical studies

Etiology

Moshe-Lilie O, Ensrud E, Ragole T, Nizar C, Dimitrova D, Karam C
BMC Neurol 2021 Feb 28;21(1):94. doi: 10.1186/s12883-021-02118-7. PMID: 33639867Free PMC Article
Makranz C, Arkadir D, Nachmias B, Gatt ME, Eliahou R, Atlan K, Mordechai A, Goldshmit N, Lossos A
Neurol Sci 2021 May;42(5):1933-1940. Epub 2020 Sep 24 doi: 10.1007/s10072-020-04724-8. PMID: 32974798
Bourque PR, Warman Chardon J, Bryanton M, Toupin M, Burns BF, Torres C
Can J Neurol Sci 2018 Mar;45(2):137-143. Epub 2018 Jan 8 doi: 10.1017/cjn.2017.282. PMID: 29307326
Graus F, Dalmau J
Curr Opin Neurol 2013 Oct;26(5):489-95. doi: 10.1097/WCO.0b013e328364c020. PMID: 23892629
Baehring JM, Damek D, Martin EC, Betensky RA, Hochberg FH
Neuro Oncol 2003 Apr;5(2):104-15. doi: 10.1093/neuonc/nop021. PMID: 12672282Free PMC Article

Diagnosis

Patel DK, Gwathmey KG
Neurol Sci 2022 May;43(5):3019-3038. Epub 2022 Feb 23 doi: 10.1007/s10072-022-05951-x. PMID: 35195810
Lunn MP
Curr Opin Neurol 2019 Oct;32(5):658-665. doi: 10.1097/WCO.0000000000000726. PMID: 31313705
Gwathmey KG
Handb Clin Neurol 2018;149:257-279. doi: 10.1016/B978-0-12-811161-1.00017-7. PMID: 29307357
Graus F, Dalmau J
Curr Opin Neurol 2013 Oct;26(5):489-95. doi: 10.1097/WCO.0b013e328364c020. PMID: 23892629
Baehring JM, Batchelor TT
Cancer J 2012 Sep-Oct;18(5):463-8. doi: 10.1097/PPO.0b013e31826c5ad5. PMID: 23006953

Therapy

Tomkins O, Lunn MP
Curr Opin Neurol 2024 Oct 1;37(5):461-466. Epub 2024 Jun 10 doi: 10.1097/WCO.0000000000001291. PMID: 38861221
DeBoer SR, Lesche S, Rodriguez FJ, Ostrow LW
Neurology 2019 Sep 17;93(12):e1229-e1230. doi: 10.1212/WNL.0000000000008131. PMID: 31527110
Bourque PR, Warman Chardon J, Bryanton M, Toupin M, Burns BF, Torres C
Can J Neurol Sci 2018 Mar;45(2):137-143. Epub 2018 Jan 8 doi: 10.1017/cjn.2017.282. PMID: 29307326
Jiménez Zapata HD, Rojas Medina LM, Carrasco Moro R, Martínez Rodrigo A, García-Cosio Piqueras M
Neurocirugia (Astur : Engl Ed) 2018 May-Jun;29(3):138-142. Epub 2017 Sep 21 doi: 10.1016/j.neucir.2017.07.001. PMID: 28941783
Graus F, Dalmau J
Curr Opin Neurol 2013 Oct;26(5):489-95. doi: 10.1097/WCO.0b013e328364c020. PMID: 23892629

Prognosis

Patel DK, Gwathmey KG
Neurol Sci 2022 May;43(5):3019-3038. Epub 2022 Feb 23 doi: 10.1007/s10072-022-05951-x. PMID: 35195810
Makranz C, Arkadir D, Nachmias B, Gatt ME, Eliahou R, Atlan K, Mordechai A, Goldshmit N, Lossos A
Neurol Sci 2021 May;42(5):1933-1940. Epub 2020 Sep 24 doi: 10.1007/s10072-020-04724-8. PMID: 32974798
Bourque PR, Sampaio ML, Warman-Chardon J, Samaan S, Torres C
BMC Cancer 2019 Nov 27;19(1):1149. doi: 10.1186/s12885-019-6365-y. PMID: 31775683Free PMC Article
Briani C, Visentin A, Campagnolo M, Salvalaggio A, Ferrari S, Cavallaro T, Manara R, Gasparotti R, Piazza F
J Peripher Nerv Syst 2019 Mar;24(1):5-18. Epub 2019 Jan 8 doi: 10.1111/jns.12295. PMID: 30556258
Baehring JM, Damek D, Martin EC, Betensky RA, Hochberg FH
Neuro Oncol 2003 Apr;5(2):104-15. doi: 10.1093/neuonc/nop021. PMID: 12672282Free PMC Article

Clinical prediction guides

Skolka MP, Suanprasert N, Martinez-Thompson JM, King RL, Macon WR, Mauermann ML, Klein CJ, Habermann TM, Johnston PB, Micallef IN, Khurana A, Amrami K, Spinner RJ, Mandrekar J, Dyck PJ, Dyck PJB
Neurology 2024 Sep 24;103(6):e209777. Epub 2024 Sep 3 doi: 10.1212/WNL.0000000000209777. PMID: 39226481
Sato H, Hiroshima S, Anei R, Kamada K
Br J Neurosurg 2023 Aug;37(4):697-700. Epub 2019 Feb 11 doi: 10.1080/02688697.2019.1568391. PMID: 30741017
Terao T, Tsushima T, Ikeda D, Fukumoto A, Kamura Y, Kuzume A, Tabata R, Miura D, Narita K, Takeuchi M, Matsue K
Leuk Lymphoma 2022 Dec;63(14):3394-3401. Epub 2022 Sep 16 doi: 10.1080/10428194.2022.2123239. PMID: 36111741
Ando T, Kamoshita S, Riku Y, Ito A, Ozawa Y, Miyamura K, Fujino M, Ito M, Goto Y, Mano K, Akagi A, Miyahara H, Katsuno M, Yoshida M, Iwasaki Y
Neuropathology 2022 Aug;42(4):295-301. Epub 2022 May 23 doi: 10.1111/neup.12807. PMID: 35607714
Tomita M, Koike H, Kawagashira Y, Iijima M, Adachi H, Taguchi J, Abe T, Sako K, Tsuji Y, Nakagawa M, Kanda F, Takeda F, Sugawara M, Toyoshima I, Asano N, Sobue G
Brain 2013 Aug;136(Pt 8):2563-78. doi: 10.1093/brain/awt193. PMID: 23884813

Recent systematic reviews

Kaulen LD, Hielscher T, Doubrovinskaia S, Hoffmann DC, Kessler T, Traub BL, Baehring JM, Wick W
Neurology 2024 Aug 27;103(4):e209698. Epub 2024 Aug 5 doi: 10.1212/WNL.0000000000209698. PMID: 39102613

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...