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Toxemia of pregnancy

MedGen UID:
1638686
•Concept ID:
C4551893
•
Disease or Syndrome
Synonym: TOXEMIA OF PREGNANCY
 
HPO: HP:0100603
Monarch Initiative: MONDO:0045048
OMIM®: 189800

Definition

Pregnancy-induced toxic reactions of the mother that can be as harmless as slight Maternal hypertension or as life threatening as Eclampsia. [from HPO]

Professional guidelines

PubMed

The influence of fluid management on outcomes in preeclampsia: a systematic review and meta-analysis.
Pretorius T, van Rensburg G, Dyer RA, Biccard BM
Int J Obstet Anesth 2018 May;34:85-95. Epub 2017 Dec 20 doi: 10.1016/j.ijoa.2017.12.004. PMID: 29398426
Preeclampsia/eclampsia: an insight into the dilemma of treatment by the anesthesiologist.
Khan ZH
Acta Med Iran 2011;49(9):564-74. PMID: 22052138
Toxemia of pregnancy. Mechanism and therapeutic management.
Speroff L
Am J Cardiol 1973 Sep 20;32(4):582-91. doi: 10.1016/s0002-9149(73)80050-5. PMID: 4354111

Recent clinical studies

Etiology

Preeclampsia and eclampsia: the conceptual evolution of a syndrome.
Erez O, Romero R, Jung E, Chaemsaithong P, Bosco M, Suksai M, Gallo DM, Gotsch F
Am J Obstet Gynecol 2022 Feb;226(2S):S786-S803. doi: 10.1016/j.ajog.2021.12.001. PMID: 35177220Free PMC Article
Prediction of preeclampsia throughout gestation with maternal characteristics and biophysical and biochemical markers: a longitudinal study.
Tarca AL, Taran A, Romero R, Jung E, Paredes C, Bhatti G, Ghita C, Chaiworapongsa T, Than NG, Hsu CD
Am J Obstet Gynecol 2022 Jan;226(1):126.e1-126.e22. Epub 2021 Apr 16 doi: 10.1016/j.ajog.2021.01.020. PMID: 34998477Free PMC Article
The influence of fluid management on outcomes in preeclampsia: a systematic review and meta-analysis.
Pretorius T, van Rensburg G, Dyer RA, Biccard BM
Int J Obstet Anesth 2018 May;34:85-95. Epub 2017 Dec 20 doi: 10.1016/j.ijoa.2017.12.004. PMID: 29398426
Spectrum of changes in placenta in toxemia of pregnancy.
Narasimha A, Vasudeva DS
Indian J Pathol Microbiol 2011 Jan-Mar;54(1):15-20. doi: 10.4103/0377-4929.77317. PMID: 21393870
Adolescent pregnancy: a twenty year review.
Clark JF, Smith ES, Hopkins EL
J Natl Med Assoc 1982 Jan;74(1):39-42. PMID: 7120441Free PMC Article

Diagnosis

Preeclampsia and eclampsia: the conceptual evolution of a syndrome.
Erez O, Romero R, Jung E, Chaemsaithong P, Bosco M, Suksai M, Gallo DM, Gotsch F
Am J Obstet Gynecol 2022 Feb;226(2S):S786-S803. doi: 10.1016/j.ajog.2021.12.001. PMID: 35177220Free PMC Article
Pregnancy and liver disease.
Asimuakopoulos G
Rev Med Chir Soc Med Nat Iasi 2006 Apr-Jun;110(2):326-33. PMID: 17802941
Hypertensive choroidopathy.
Bourke K, Patel MR, Prisant LM, Marcus DM
J Clin Hypertens (Greenwich) 2004 Aug;6(8):471-2. doi: 10.1111/j.1524-6175.2004.3749.x. PMID: 15308890Free PMC Article
Visual loss from choroidal ischemia.
Kinyoun JL, Kalina RE
Am J Ophthalmol 1986 Jun 15;101(6):650-6. doi: 10.1016/0002-9394(86)90764-6. PMID: 3717247
Quintuplet pregnancy.
Schenker JG, Simha A
Obstet Gynecol 1975 May;45(5):590-3. PMID: 1124180

Therapy

The influence of fluid management on outcomes in preeclampsia: a systematic review and meta-analysis.
Pretorius T, van Rensburg G, Dyer RA, Biccard BM
Int J Obstet Anesth 2018 May;34:85-95. Epub 2017 Dec 20 doi: 10.1016/j.ijoa.2017.12.004. PMID: 29398426
Will treatment with digoxin antibody benefit pregnant patients with toxemia and elevated digoxin like factor?
Goodlin RC
Med Hypotheses 1987 Sep;24(1):107-10. doi: 10.1016/0306-9877(87)90053-3. PMID: 3670128
Clinical chemistry of thiamin.
Davis RE, Icke GC
Adv Clin Chem 1983;23:93-140. doi: 10.1016/s0065-2423(08)60399-6. PMID: 6398618
Hypocalcemia after therapeutic use of magnesium sulfate.
Eisenbud E, LoBue CC
Arch Intern Med 1976 Jun;136(6):688-91. PMID: 1275625
Quintuplet pregnancy.
Schenker JG, Simha A
Obstet Gynecol 1975 May;45(5):590-3. PMID: 1124180

Prognosis

Preeclampsia and eclampsia: the conceptual evolution of a syndrome.
Erez O, Romero R, Jung E, Chaemsaithong P, Bosco M, Suksai M, Gallo DM, Gotsch F
Am J Obstet Gynecol 2022 Feb;226(2S):S786-S803. doi: 10.1016/j.ajog.2021.12.001. PMID: 35177220Free PMC Article
Prediction of preeclampsia throughout gestation with maternal characteristics and biophysical and biochemical markers: a longitudinal study.
Tarca AL, Taran A, Romero R, Jung E, Paredes C, Bhatti G, Ghita C, Chaiworapongsa T, Than NG, Hsu CD
Am J Obstet Gynecol 2022 Jan;226(1):126.e1-126.e22. Epub 2021 Apr 16 doi: 10.1016/j.ajog.2021.01.020. PMID: 34998477Free PMC Article
Posterior reversible encephalopathy syndrome.
Staykov D, Schwab S
J Intensive Care Med 2012 Feb;27(1):11-24. Epub 2011 Jan 21 doi: 10.1177/0885066610393634. PMID: 21257628
Bell palsy complicating pregnancy: a review.
Cohen Y, Lavie O, Granovsky-Grisaru S, Aboulafia Y, Diamant YZ
Obstet Gynecol Surv 2000 Mar;55(3):184-8. doi: 10.1097/00006254-200003000-00027. PMID: 10713984
Toxemia of pregnancy.
Yussman MA
J Ky Med Assoc 1970 Apr;68(4):212-6. PMID: 5442288

Clinical prediction guides

Preeclampsia and eclampsia: the conceptual evolution of a syndrome.
Erez O, Romero R, Jung E, Chaemsaithong P, Bosco M, Suksai M, Gallo DM, Gotsch F
Am J Obstet Gynecol 2022 Feb;226(2S):S786-S803. doi: 10.1016/j.ajog.2021.12.001. PMID: 35177220Free PMC Article
Prediction of preeclampsia throughout gestation with maternal characteristics and biophysical and biochemical markers: a longitudinal study.
Tarca AL, Taran A, Romero R, Jung E, Paredes C, Bhatti G, Ghita C, Chaiworapongsa T, Than NG, Hsu CD
Am J Obstet Gynecol 2022 Jan;226(1):126.e1-126.e22. Epub 2021 Apr 16 doi: 10.1016/j.ajog.2021.01.020. PMID: 34998477Free PMC Article
Cerebral tuberculoma in pregnancy: overview of the literature and report of a case.
Ahmadi SA, Roozbeh H, Abbasi A, Bahadori M, Moghaddam KG, Ketabchi SE
Acta Med Iran 2011;49(1):64-9. PMID: 21425075
Visual loss from choroidal ischemia.
Kinyoun JL, Kalina RE
Am J Ophthalmol 1986 Jun 15;101(6):650-6. doi: 10.1016/0002-9394(86)90764-6. PMID: 3717247
Fat-containing uterine smooth muscle cells in "toxemia": possible relevance to atherosclerosis?
Haust MD, Las Heras J, Harding PG
Science 1977 Mar 25;195(4284):1353-4. doi: 10.1126/science.841334. PMID: 841334

Recent systematic reviews

The influence of fluid management on outcomes in preeclampsia: a systematic review and meta-analysis.
Pretorius T, van Rensburg G, Dyer RA, Biccard BM
Int J Obstet Anesth 2018 May;34:85-95. Epub 2017 Dec 20 doi: 10.1016/j.ijoa.2017.12.004. PMID: 29398426

Supplemental Content

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    Clinical resources

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