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Hypertrophic obstructive cardiomyopathy

MedGen UID:
1645411
•Concept ID:
C4551472
•
Disease or Syndrome
Synonyms: Cardiomyopathies, Hypertrophic Obstructive; Cardiomyopathy, Hypertrophic Obstructive; Hypertrophic Obstructive Cardiomyopathies; Hypertrophic Obstructive Cardiomyopathy; Obstructive Cardiomyopathies, Hypertrophic; Obstructive Cardiomyopathy, Hypertrophic
SNOMED CT: Obstructive cardiomyopathy (45227007); HOCM - Hypertrophic obstructive cardiomyopathy (45227007); Hypertrophic obstructive cardiomyopathy (45227007)

Professional guidelines

PubMed

Efficacy and Safety of Mavacamten in the Treatment of Hypertrophic Cardiomyopathy: A Systematic Review.
Bishev D, Fabara S, Loseke I, Alok A, Al-Ani H, Bazikian Y
Heart Lung Circ 2023 Sep;32(9):1049-1056. Epub 2023 Jul 14 doi: 10.1016/j.hlc.2023.05.019. PMID: 37453852
Multi-modality management of hypertrophic cardiomyopathy.
Rao SJ, Iqbal SB, Kanwal AS, Aronow WS, Naidu SS
Hosp Pract (1995) 2023 Feb;51(1):2-11. Epub 2023 Jan 10 doi: 10.1080/21548331.2022.2162297. PMID: 36598161
Post-operative management of hypertrophic obstructive cardiomyopathy.
Mitra S, Ramanathan K, MacLaren G
Asian Cardiovasc Thorac Ann 2022 Jan;30(1):57-63. Epub 2022 Feb 15 doi: 10.1177/02184923211069189. PMID: 35167344

Recent clinical studies

Etiology

Post-operative management of hypertrophic obstructive cardiomyopathy.
Mitra S, Ramanathan K, MacLaren G
Asian Cardiovasc Thorac Ann 2022 Jan;30(1):57-63. Epub 2022 Feb 15 doi: 10.1177/02184923211069189. PMID: 35167344
Hypertrophic Obstructive Cardiomyopathy.
Batzner A, Schäfers HJ, Borisov KV, Seggewiß H
Dtsch Arztebl Int 2019 Jan 25;116(4):47-53. doi: 10.3238/arztebl.2019.0047. PMID: 30855006Free PMC Article
Surgical Approaches to Hypertrophic Obstructive Cardiomyopathy.
Solomon Z, Breton C, Rowin EJ, Maron BJ, Maron MS, Chen FY, Rastegar H
Semin Thorac Cardiovasc Surg 2018 Summer;30(2):125-128. Epub 2018 Mar 7 doi: 10.1053/j.semtcvs.2018.02.034. PMID: 29524602
Hypertrophic Obstructive Cardiomyopathy: Surgical Myectomy and Septal Ablation.
Nishimura RA, Seggewiss H, Schaff HV
Circ Res 2017 Sep 15;121(7):771-783. doi: 10.1161/CIRCRESAHA.116.309348. PMID: 28912182
Hypertrophic obstructive cardiomyopathy.
Veselka J, Anavekar NS, Charron P
Lancet 2017 Mar 25;389(10075):1253-1267. Epub 2016 Nov 30 doi: 10.1016/S0140-6736(16)31321-6. PMID: 27912983

Diagnosis

Interventions in Hypertrophic Obstructive Cardiomyopathy.
Ding WY, Meah MN, Stables R, Cooper RM
Can J Cardiol 2024 May;40(5):833-842. Epub 2023 Dec 8 doi: 10.1016/j.cjca.2023.12.001. PMID: 38070769
A Diagnostic Journey.
Thakker D, Kulkarni A, Hegde AV
J Assoc Physicians India 2023 May;71(5):11-12. doi: 10.5005/japi-11001-0227. PMID: 37355828
Percutaneous Intramyocardial Septal Radiofrequency Ablation for Hypertrophic Obstructive Cardiomyopathy.
Liu L, Li J, Zuo L, Zhang J, Zhou M, Xu B, Hahn RT, Leon MB, Hsi DH, Ge J, Zhou X, Zhang J, Ge S, Xiong L
J Am Coll Cardiol 2018 Oct 16;72(16):1898-1909. doi: 10.1016/j.jacc.2018.07.080. PMID: 30309466
Surgical Approaches to Hypertrophic Obstructive Cardiomyopathy.
Solomon Z, Breton C, Rowin EJ, Maron BJ, Maron MS, Chen FY, Rastegar H
Semin Thorac Cardiovasc Surg 2018 Summer;30(2):125-128. Epub 2018 Mar 7 doi: 10.1053/j.semtcvs.2018.02.034. PMID: 29524602
Hypertrophic obstructive cardiomyopathy.
Veselka J, Anavekar NS, Charron P
Lancet 2017 Mar 25;389(10075):1253-1267. Epub 2016 Nov 30 doi: 10.1016/S0140-6736(16)31321-6. PMID: 27912983

Therapy

First-in-Human Transapical Beating-Heart Septal Myectomy in Patients With Hypertrophic Obstructive Cardiomyopathy.
Fang J, Liu Y, Zhu Y, Li R, Wang R, Wang DW, Song Y, Li C, Chen Y, Cheng L, Zheng K, Zhao Y, Li S, Cheng C, Xia L, Chen X, Wan S, Wei X
J Am Coll Cardiol 2023 Aug 15;82(7):575-586. doi: 10.1016/j.jacc.2023.05.052. PMID: 37558369
Efficacy and Safety of Mavacamten in the Treatment of Hypertrophic Cardiomyopathy: A Systematic Review.
Bishev D, Fabara S, Loseke I, Alok A, Al-Ani H, Bazikian Y
Heart Lung Circ 2023 Sep;32(9):1049-1056. Epub 2023 Jul 14 doi: 10.1016/j.hlc.2023.05.019. PMID: 37453852
Percutaneous Intramyocardial Septal Radiofrequency Ablation in Patients With Drug-Refractory Hypertrophic Obstructive Cardiomyopathy.
Zhou M, Ta S, Hahn RT, Hsi DH, Leon MB, Hu R, Zhang J, Zuo L, Li J, Wang J, Wang B, Zhu X, Liu J, Han Y, Li X, Xu B, Zhang L, Hou L, Han C, Liu J, Liu L
JAMA Cardiol 2022 May 1;7(5):529-538. doi: 10.1001/jamacardio.2022.0259. PMID: 35353129Free PMC Article
Randomized Trial of Metoprolol in Patients With Obstructive Hypertrophic Cardiomyopathy.
Dybro AM, Rasmussen TB, Nielsen RR, Andersen MJ, Jensen MK, Poulsen SH
J Am Coll Cardiol 2021 Dec 21;78(25):2505-2517. doi: 10.1016/j.jacc.2021.07.065. PMID: 34915981
Hypertrophic Obstructive Cardiomyopathy.
Batzner A, Schäfers HJ, Borisov KV, Seggewiß H
Dtsch Arztebl Int 2019 Jan 25;116(4):47-53. doi: 10.3238/arztebl.2019.0047. PMID: 30855006Free PMC Article

Prognosis

Hypertrophic obstructive cardiomyopathy-left ventricular outflow tract shapes and their hemodynamic influences applying CMR.
Mayr T, Riazy L, Trauzeddel RF, Bassenge JP, Wiesemann S, Blaszczyk E, Prothmann M, Hadler T, Schmitter S, Schulz-Menger J
Int J Cardiovasc Imaging 2024 Nov;40(11):2371-2381. Epub 2024 Sep 20 doi: 10.1007/s10554-024-03242-4. PMID: 39302632Free PMC Article
Mitral Valve Interventions for Hypertrophic Obstructive Cardiomyopathy.
Shuvy M, Postell YY, Carasso S, Marmor D, Strauss BH, Maisano F, Lapenna E
Can J Cardiol 2024 May;40(5):860-868. Epub 2023 Dec 16 doi: 10.1016/j.cjca.2023.12.009. PMID: 38110174
Childhood Hypertrophic Obstructive Cardiomyopathy and Its Relevant Surgical Outcome.
Zhu C, Wang S, Ma Y, Wang S, Zhou Z, Song Y, Yan J, Meng Y, Nie C
Ann Thorac Surg 2020 Jul;110(1):207-213. Epub 2019 Nov 28 doi: 10.1016/j.athoracsur.2019.10.016. PMID: 31785290
Surgical Approaches to Hypertrophic Obstructive Cardiomyopathy.
Solomon Z, Breton C, Rowin EJ, Maron BJ, Maron MS, Chen FY, Rastegar H
Semin Thorac Cardiovasc Surg 2018 Summer;30(2):125-128. Epub 2018 Mar 7 doi: 10.1053/j.semtcvs.2018.02.034. PMID: 29524602
Hypertrophic obstructive cardiomyopathy.
Messmer BJ, Klues HG, Reith S, Schoendube FA, Hanrath P
Adv Card Surg 1998;10:245-70. PMID: 9917908

Clinical prediction guides

Efficacy and Safety of Mavacamten in the Treatment of Hypertrophic Cardiomyopathy: A Systematic Review.
Bishev D, Fabara S, Loseke I, Alok A, Al-Ani H, Bazikian Y
Heart Lung Circ 2023 Sep;32(9):1049-1056. Epub 2023 Jul 14 doi: 10.1016/j.hlc.2023.05.019. PMID: 37453852
Effects of Metoprolol on Exercise Hemodynamics in Patients With Obstructive Hypertrophic Cardiomyopathy.
Dybro AM, Rasmussen TB, Nielsen RR, Ladefoged BT, Andersen MJ, Jensen MK, Poulsen SH
J Am Coll Cardiol 2022 Apr 26;79(16):1565-1575. doi: 10.1016/j.jacc.2022.02.024. PMID: 35450573
Randomized Trial of Metoprolol in Patients With Obstructive Hypertrophic Cardiomyopathy.
Dybro AM, Rasmussen TB, Nielsen RR, Andersen MJ, Jensen MK, Poulsen SH
J Am Coll Cardiol 2021 Dec 21;78(25):2505-2517. doi: 10.1016/j.jacc.2021.07.065. PMID: 34915981
Surgical Approaches to Hypertrophic Obstructive Cardiomyopathy.
Solomon Z, Breton C, Rowin EJ, Maron BJ, Maron MS, Chen FY, Rastegar H
Semin Thorac Cardiovasc Surg 2018 Summer;30(2):125-128. Epub 2018 Mar 7 doi: 10.1053/j.semtcvs.2018.02.034. PMID: 29524602
Collapse in the scrum.
Donnelly D, Patrick D, Weir RA
Emerg Med J 2018 Dec;35(12):764-772. Epub 2018 Mar 5 doi: 10.1136/emermed-2017-207434. PMID: 29507049

Recent systematic reviews

Radiofrequency ablation in patients with obstructive hypertrophic cardiomyopathy: An updated comprehensive review and meta-analysis.
da Silva Menezes A Jr, Sanches MR, de Oliveira Filho E, de Oliveira EJR, Oliveira VMR, Moraes VRY
Catheter Cardiovasc Interv 2024 Nov;104(5):1096-1106. Epub 2024 Jun 21 doi: 10.1002/ccd.31125. PMID: 39031814
Gender-Based Outcome Discrepancies in Patients Who Underwent Alcohol Septal Ablation or Septal Myectomy for Hypertrophic Obstructive Cardiomyopathy: A Systematic Review and Meta-Analysis.
Saravanabavanandan R, Jaimalani A, Khan MAN, Riaz S, Mangas GM, Ahsan SM, Posani S, Patel T, Fawad M, Al-Tawil M
Am J Cardiol 2023 Dec 1;208:134-142. Epub 2023 Oct 13 doi: 10.1016/j.amjcard.2023.09.033. PMID: 37839170
Efficacy and Safety of Mavacamten in the Treatment of Hypertrophic Cardiomyopathy: A Systematic Review.
Bishev D, Fabara S, Loseke I, Alok A, Al-Ani H, Bazikian Y
Heart Lung Circ 2023 Sep;32(9):1049-1056. Epub 2023 Jul 14 doi: 10.1016/j.hlc.2023.05.019. PMID: 37453852
Efficacy and safety of radiofrequency ablation for hypertrophic obstructive cardiomyopathy: A systematic review and meta-analysis.
Yang H, Yang Y, Xue Y, Luo S
Clin Cardiol 2020 May;43(5):450-458. Epub 2020 Feb 7 doi: 10.1002/clc.23341. PMID: 32034788Free PMC Article
Alcohol septal ablation for hypertrophic obstructive cardiomyopathy: a systematic review of published studies.
Alam M, Dokainish H, Lakkis N
J Interv Cardiol 2006 Aug;19(4):319-27. doi: 10.1111/j.1540-8183.2006.00153.x. PMID: 16881978

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