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Abnormal morphology of left ventricular trabeculae

MedGen UID:
1617226
•Concept ID:
C4531288
•
Anatomical Abnormality
HPO: HP:0031192

Definition

Any structural anomaly of the muscular columns which project from the inner surface of the left ventricle of the heart (cardiac trabeculae, trabeculae carneae). [from HPO]

Recent clinical studies

Etiology

Intra-Right Ventricle Course of the Coronary Arteries on Computed Tomography Angiography.
Tyczyński P, Skowroński J, Opolski MP, Pręgowski J, Kępka C, Kruk M, Orczykowski M, Łazarczyk H, Witkowski A, Michałowska I
J Comput Assist Tomogr 2020 Jul/Aug;44(4):586-590. doi: 10.1097/RCT.0000000000001021. PMID: 32697529
Nkx2-5 and Sarcospan genetically interact in the development of the muscular ventricular septum of the heart.
Panzer AA, Regmi SD, Cormier D, Danzo MT, Chen ID, Winston JB, Hutchinson AK, Salm D, Schulkey CE, Cochran RS, Wilson DB, Jay PY
Sci Rep 2017 Apr 13;7:46438. doi: 10.1038/srep46438. PMID: 28406175Free PMC Article
Fluorescein dye-guided intraoperative identification and closure of muscular ventricular septal defect.
Bishnoi AK, Garg P, Desai M, Sharma P, Patel J, Prajapati M, Malhotra A
World J Pediatr Congenit Heart Surg 2015 Jan;6(1):59-66. doi: 10.1177/2150135114559292. PMID: 25548345
Quantification of left ventricular trabeculae using fractal analysis.
Captur G, Muthurangu V, Cook C, Flett AS, Wilson R, Barison A, Sado DM, Anderson S, McKenna WJ, Mohun TJ, Elliott PM, Moon JC
J Cardiovasc Magn Reson 2013 May 10;15(1):36. doi: 10.1186/1532-429X-15-36. PMID: 23663522Free PMC Article
Pathology and pathogenesis of arrhythmogenic right ventricular cardiomyopathy.
Thiene G, Basso C, Calabrese F, Angelini A, Valente M
Herz 2000 May;25(3):210-5. doi: 10.1007/s000590050008. PMID: 10904840

Diagnosis

Supplementary Diagnostic Landmarks of Left Ventricular Non-Compaction on Magnetic Resonance Imaging.
Boban M, Pesa V, Beck N, Manola S, Zulj M, Rotim A, Vcev A
Yonsei Med J 2018 Jan;59(1):63-71. doi: 10.3349/ymj.2018.59.1.63. PMID: 29214778Free PMC Article
Left Ventricular Noncompaction: A Distinct Genetic Cardiomyopathy?
Arbustini E, Favalli V, Narula N, Serio A, Grasso M
J Am Coll Cardiol 2016 Aug 30;68(9):949-66. doi: 10.1016/j.jacc.2016.05.096. PMID: 27561770
Formation and Malformation of Cardiac Trabeculae: Biological Basis, Clinical Significance, and Special Yield of Magnetic Resonance Imaging in Assessment.
Captur G, Syrris P, Obianyo C, Limongelli G, Moon JC
Can J Cardiol 2015 Nov;31(11):1325-37. Epub 2015 Jul 8 doi: 10.1016/j.cjca.2015.07.003. PMID: 26440509
Quantification of left ventricular trabeculae using fractal analysis.
Captur G, Muthurangu V, Cook C, Flett AS, Wilson R, Barison A, Sado DM, Anderson S, McKenna WJ, Mohun TJ, Elliott PM, Moon JC
J Cardiovasc Magn Reson 2013 May 10;15(1):36. doi: 10.1186/1532-429X-15-36. PMID: 23663522Free PMC Article
Noncompaction syndrome of the myocardium: pathophysiology and imaging pearls.
Zenooz NA, Zahka KG, Siwik ES, Gilkeson RC
J Thorac Imaging 2010 Nov;25(4):326-32. doi: 10.1097/RTI.0b013e31819ca93e. PMID: 20216462

Therapy

Right ventricular morphology on catheter angiography: variations and its implications for the diagnosis of arrhythmogenic right ventricular cardiomyopathy.
Ahmed J, Smith WM, Ruygrok PN, Occleshaw C
Heart Lung Circ 2012 Nov;21(11):700-5. Epub 2012 Jul 10 doi: 10.1016/j.hlc.2012.06.002. PMID: 22784484

Prognosis

Intra-Right Ventricle Course of the Coronary Arteries on Computed Tomography Angiography.
Tyczyński P, Skowroński J, Opolski MP, Pręgowski J, Kępka C, Kruk M, Orczykowski M, Łazarczyk H, Witkowski A, Michałowska I
J Comput Assist Tomogr 2020 Jul/Aug;44(4):586-590. doi: 10.1097/RCT.0000000000001021. PMID: 32697529
Nkx2-5 and Sarcospan genetically interact in the development of the muscular ventricular septum of the heart.
Panzer AA, Regmi SD, Cormier D, Danzo MT, Chen ID, Winston JB, Hutchinson AK, Salm D, Schulkey CE, Cochran RS, Wilson DB, Jay PY
Sci Rep 2017 Apr 13;7:46438. doi: 10.1038/srep46438. PMID: 28406175Free PMC Article
Fluorescein dye-guided intraoperative identification and closure of muscular ventricular septal defect.
Bishnoi AK, Garg P, Desai M, Sharma P, Patel J, Prajapati M, Malhotra A
World J Pediatr Congenit Heart Surg 2015 Jan;6(1):59-66. doi: 10.1177/2150135114559292. PMID: 25548345
Quantification of left ventricular trabeculae using fractal analysis.
Captur G, Muthurangu V, Cook C, Flett AS, Wilson R, Barison A, Sado DM, Anderson S, McKenna WJ, Mohun TJ, Elliott PM, Moon JC
J Cardiovasc Magn Reson 2013 May 10;15(1):36. doi: 10.1186/1532-429X-15-36. PMID: 23663522Free PMC Article
Noncompaction syndrome of the myocardium: pathophysiology and imaging pearls.
Zenooz NA, Zahka KG, Siwik ES, Gilkeson RC
J Thorac Imaging 2010 Nov;25(4):326-32. doi: 10.1097/RTI.0b013e31819ca93e. PMID: 20216462

Clinical prediction guides

Left Ventricular Noncompaction: A Distinct Genetic Cardiomyopathy?
Arbustini E, Favalli V, Narula N, Serio A, Grasso M
J Am Coll Cardiol 2016 Aug 30;68(9):949-66. doi: 10.1016/j.jacc.2016.05.096. PMID: 27561770
Fluorescein dye-guided intraoperative identification and closure of muscular ventricular septal defect.
Bishnoi AK, Garg P, Desai M, Sharma P, Patel J, Prajapati M, Malhotra A
World J Pediatr Congenit Heart Surg 2015 Jan;6(1):59-66. doi: 10.1177/2150135114559292. PMID: 25548345
Prediction of sarcomere mutations in subclinical hypertrophic cardiomyopathy.
Captur G, Lopes LR, Mohun TJ, Patel V, Li C, Bassett P, Finocchiaro G, Ferreira VM, Esteban MT, Muthurangu V, Sherrid MV, Day SM, Canter CE, McKenna WJ, Seidman CE, Bluemke DA, Elliott PM, Ho CY, Moon JC
Circ Cardiovasc Imaging 2014 Nov;7(6):863-71. Epub 2014 Sep 16 doi: 10.1161/CIRCIMAGING.114.002411. PMID: 25228707Free PMC Article
Quantification of left ventricular trabeculae using fractal analysis.
Captur G, Muthurangu V, Cook C, Flett AS, Wilson R, Barison A, Sado DM, Anderson S, McKenna WJ, Mohun TJ, Elliott PM, Moon JC
J Cardiovasc Magn Reson 2013 May 10;15(1):36. doi: 10.1186/1532-429X-15-36. PMID: 23663522Free PMC Article
Isolated left ventricular noncompaction syndrome.
Stanton C, Bruce C, Connolly H, Brady P, Syed I, Hodge D, Asirvatham S, Friedman P
Am J Cardiol 2009 Oct 15;104(8):1135-8. Epub 2009 Aug 28 doi: 10.1016/j.amjcard.2009.05.062. PMID: 19801037

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