U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal perifollicular morphology

MedGen UID:
1615717
Concept ID:
C4531226
Anatomical Abnormality
HPO: HP:0031285

Definition

Any structural anomaly in the areas surrounding the hair follicles. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal perifollicular morphology

Conditions with this feature

Keratosis pilaris atrophicans
MedGen UID:
75520
Concept ID:
C0263428
Disease or Syndrome
Keratosis pilaris atrophicans (KPA) represents a group of rare genodermatoses characterized by perifollicular keratosis and inflammation that progresses to atrophy and scarring of the facial skin. Keratosis pilaris of extensor surfaces of limbs is a common associated finding. Affected individuals may present with features that overlap between 3 subtypes, keratosis pilaris atrophicans faciei (KPAF), keratosis follicularis spinulosa decalvans (KFSD), and atrophoderma vermiculata (AVA; see 209700) (summary by Klar et al., 2015).

Professional guidelines

PubMed

Kodali N, Patel VM, Schwartz RA
Ital J Dermatol Venerol 2023 Jun;158(3):217-223. Epub 2023 May 11 doi: 10.23736/S2784-8671.23.07594-1. PMID: 37166753
Kwiek B, Rożalski M, Sieczych J, Paluch Ł, Kowalewski C, Ambroziak M
Lasers Surg Med 2019 Sep;51(7):569-583. Epub 2019 Mar 12 doi: 10.1002/lsm.23083. PMID: 30860283
Sperling LC, Homoky C, Pratt L, Sau P
Arch Dermatol 2000 Apr;136(4):479-84. doi: 10.1001/archderm.136.4.479. PMID: 10768646

Recent clinical studies

Etiology

Lan X, Qiao R, Sun J, Song H, Gao M, Mo R, Song Z, Yang Y, Jiang Y
J Dermatol 2024 Feb;51(2):253-260. Epub 2023 Dec 12 doi: 10.1111/1346-8138.17026. PMID: 38087855
Al-Chaer RN, Bouazzi D, Jemec G, Mogensen M
Exp Dermatol 2023 Jul;32(7):945-954. Epub 2023 May 4 doi: 10.1111/exd.14830. PMID: 37140216
Miracco C, DE Piano E, Marruganti C, Baldino G, Sorrentino E, Batsikosta A, Rubegni P, Angotti R, Messina M, Cinotti E
Ital J Dermatol Venerol 2022 Aug;157(4):342-347. Epub 2022 Jun 6 doi: 10.23736/S2784-8671.22.07301-7. PMID: 35666664
George SM, Taylor MR, Farrant PB
Clin Exp Dermatol 2015 Oct;40(7):717-21. Epub 2015 Jul 23 doi: 10.1111/ced.12715. PMID: 26202646
Franks S, Roberts R, Hardy K
Reprod Biomed Online 2003 Mar;6(2):181-4. doi: 10.1016/s1472-6483(10)61708-7. PMID: 12675997

Diagnosis

Lan X, Qiao R, Sun J, Song H, Gao M, Mo R, Song Z, Yang Y, Jiang Y
J Dermatol 2024 Feb;51(2):253-260. Epub 2023 Dec 12 doi: 10.1111/1346-8138.17026. PMID: 38087855
Kodali N, Patel VM, Schwartz RA
Ital J Dermatol Venerol 2023 Jun;158(3):217-223. Epub 2023 May 11 doi: 10.23736/S2784-8671.23.07594-1. PMID: 37166753
Al-Chaer RN, Bouazzi D, Jemec G, Mogensen M
Exp Dermatol 2023 Jul;32(7):945-954. Epub 2023 May 4 doi: 10.1111/exd.14830. PMID: 37140216
Treichel AM, Pithadia DJ, Lee CR, Oyerinde O, Moss J, Darling TN
Histopathology 2021 Oct;79(4):619-628. Epub 2021 Jul 21 doi: 10.1111/his.14392. PMID: 33882161Free PMC Article
Andrés-Ramos I, Alegría-Landa V, Gimeno I, Pérez-Plaza A, Rütten A, Kutzner H, Requena L
Am J Dermatopathol 2019 Feb;41(2):85-117. doi: 10.1097/DAD.0000000000001275. PMID: 30688725

Therapy

Kwiek B, Rożalski M, Sieczych J, Paluch Ł, Kowalewski C, Ambroziak M
Lasers Surg Med 2019 Sep;51(7):569-583. Epub 2019 Mar 12 doi: 10.1002/lsm.23083. PMID: 30860283
George SM, Taylor MR, Farrant PB
Clin Exp Dermatol 2015 Oct;40(7):717-21. Epub 2015 Jul 23 doi: 10.1111/ced.12715. PMID: 26202646
Gonzalez ME, Cantatore-Francis J, Orlow SJ
Br J Dermatol 2010 Aug;163(2):378-85. Epub 2010 Mar 23 doi: 10.1111/j.1365-2133.2010.09777.x. PMID: 20346026
Ubaldi F, Rienzi L
Placenta 2008 Oct;29 Suppl B:115-20. Epub 2008 Aug 31 doi: 10.1016/j.placenta.2008.08.009. PMID: 18762336
Franks S, Roberts R, Hardy K
Reprod Biomed Online 2003 Mar;6(2):181-4. doi: 10.1016/s1472-6483(10)61708-7. PMID: 12675997

Prognosis

Kwiek B, Rożalski M, Sieczych J, Paluch Ł, Kowalewski C, Ambroziak M
Lasers Surg Med 2019 Sep;51(7):569-583. Epub 2019 Mar 12 doi: 10.1002/lsm.23083. PMID: 30860283
Lis-Święty A, Miziołek B, Ranosz-Janicka I, Bierzyńska-Macyszyn G, Brzezińska-Wcisło L
J Cosmet Dermatol 2018 Apr;17(2):268-273. Epub 2017 Jul 20 doi: 10.1111/jocd.12379. PMID: 28727235
Ubaldi F, Rienzi L
Placenta 2008 Oct;29 Suppl B:115-20. Epub 2008 Aug 31 doi: 10.1016/j.placenta.2008.08.009. PMID: 18762336
Carbillon L, Perrot N, Uzan M, Uzan S
Fetal Diagn Ther 2001 Nov-Dec;16(6):327-32. doi: 10.1159/000053936. PMID: 11694734
Sladkevicius P, Campbell S
Br Med Bull 2000;56(3):691-703. doi: 10.1258/0007142001903472. PMID: 11255554

Clinical prediction guides

Lan X, Qiao R, Sun J, Song H, Gao M, Mo R, Song Z, Yang Y, Jiang Y
J Dermatol 2024 Feb;51(2):253-260. Epub 2023 Dec 12 doi: 10.1111/1346-8138.17026. PMID: 38087855
Miracco C, DE Piano E, Marruganti C, Baldino G, Sorrentino E, Batsikosta A, Rubegni P, Angotti R, Messina M, Cinotti E
Ital J Dermatol Venerol 2022 Aug;157(4):342-347. Epub 2022 Jun 6 doi: 10.23736/S2784-8671.22.07301-7. PMID: 35666664
Treichel AM, Pithadia DJ, Lee CR, Oyerinde O, Moss J, Darling TN
Histopathology 2021 Oct;79(4):619-628. Epub 2021 Jul 21 doi: 10.1111/his.14392. PMID: 33882161Free PMC Article
Ubaldi F, Rienzi L
Placenta 2008 Oct;29 Suppl B:115-20. Epub 2008 Aug 31 doi: 10.1016/j.placenta.2008.08.009. PMID: 18762336
Sladkevicius P, Campbell S
Br Med Bull 2000;56(3):691-703. doi: 10.1258/0007142001903472. PMID: 11255554

Recent systematic reviews

Al-Chaer RN, Bouazzi D, Jemec G, Mogensen M
Exp Dermatol 2023 Jul;32(7):945-954. Epub 2023 May 4 doi: 10.1111/exd.14830. PMID: 37140216

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...