U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Peripheral arterial calcification

MedGen UID:
1613206
•Concept ID:
C4531217
•
Disease or Syndrome
Synonym: Peripheral artery calcification
 
HPO: HP:0031301

Definition

An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall. [from HPO]

Professional guidelines

PubMed

Distal Endarterectomy Combined With Endovascular Proximal Treatment: The Hybrid DEEP Retrograde Technique for High-Complexity Infrainguinal Disease.
García Domínguez LJ, Ramos Moreno I, Martinez López R, Ribé Bernal L, Hernández Sanfelix A, Miralles Hernández M
J Endovasc Ther 2023 Apr;30(2):232-240. Epub 2022 Feb 21 doi: 10.1177/15266028221079766. PMID: 35184612
2-Year Outcomes of the Eluvia Drug-Eluting Stent for the Treatment of Complex Femoropopliteal Lesions.
Stavroulakis K, Torsello G, Bosiers M, Argyriou A, Tsilimparis N, Bisdas T
JACC Cardiovasc Interv 2021 Mar 22;14(6):692-701. doi: 10.1016/j.jcin.2021.01.026. PMID: 33736776
Efficacy and safety of intravascular lithotripsy for the treatment of peripheral arterial disease: An individual patient-level pooled data analysis.
Madhavan MV, Shahim B, Mena-Hurtado C, Garcia L, Crowley A, Parikh SA
Catheter Cardiovasc Interv 2020 Apr 1;95(5):959-968. Epub 2020 Jan 20 doi: 10.1002/ccd.28729. PMID: 31957955Free PMC Article

Recent clinical studies

Etiology

Effect of high-dose vitamin D supplementation on peripheral arterial calcification: secondary analysis of a randomized controlled trial.
Billington EO, Burt LA, Plett R, Rose MS, Boyd SK, Hanley DA
Osteoporos Int 2020 Nov;31(11):2141-2150. Epub 2020 Jun 15 doi: 10.1007/s00198-020-05500-2. PMID: 32556518
Efficacy and safety of intravascular lithotripsy for the treatment of peripheral arterial disease: An individual patient-level pooled data analysis.
Madhavan MV, Shahim B, Mena-Hurtado C, Garcia L, Crowley A, Parikh SA
Catheter Cardiovasc Interv 2020 Apr 1;95(5):959-968. Epub 2020 Jan 20 doi: 10.1002/ccd.28729. PMID: 31957955Free PMC Article
Increased Peripheral Arterial Calcification in Patients Receiving Warfarin.
Han KH, O'Neill WC
J Am Heart Assoc 2016 Jan 25;5(1) doi: 10.1161/JAHA.115.002665. PMID: 26811161Free PMC Article
Peripheral arterial calcification: prevalence, mechanism, detection, and clinical implications.
Rocha-Singh KJ, Zeller T, Jaff MR
Catheter Cardiovasc Interv 2014 May 1;83(6):E212-20. Epub 2014 Feb 10 doi: 10.1002/ccd.25387. PMID: 24402839Free PMC Article
Breast arterial calcification: a marker of medial vascular calcification in chronic kidney disease.
Duhn V, D'Orsi ET, Johnson S, D'Orsi CJ, Adams AL, O'Neill WC
Clin J Am Soc Nephrol 2011 Feb;6(2):377-82. Epub 2011 Jan 21 doi: 10.2215/CJN.07190810. PMID: 21258037Free PMC Article

Diagnosis

A Plasma Pyrophosphate Cutoff Value for Diagnosing Pseudoxanthoma Elasticum.
Rubera I, Clotaire L, Laurain A, Destere A, Martin L, Duranton C, Leftheriotis G
Int J Mol Sci 2024 Jun 13;25(12) doi: 10.3390/ijms25126502. PMID: 38928212Free PMC Article
Efficacy and Safety of Intravascular Lithotripsy in Lower Extremity Peripheral Artery Disease: A Systematic Review and Meta-Analysis.
Wong CP, Chan LP, Au DM, Chan HWC, Chan YC
Eur J Vasc Endovasc Surg 2022 Mar;63(3):446-456. Epub 2021 Dec 6 doi: 10.1016/j.ejvs.2021.10.035. PMID: 34887206
Pulmonary hypertension - prevalence, risk factors, and its association with vascular calcification in chronic kidney disease and hemodialysis patients.
Nithiya N, Indhumathi E, Jagadeswaran D, Jayaprakash V, Jayakumar M
Saudi J Kidney Dis Transpl 2020 Mar-Apr;31(2):380-387. doi: 10.4103/1319-2442.284012. PMID: 32394910
Vascular calcification in patients with type 2 diabetes: the involvement of matrix Gla protein.
Liabeuf S, Bourron O, Olivier B, Vemeer C, Theuwissen E, Magdeleyns E, Aubert CE, Brazier M, Mentaverri R, Hartemann A, Massy ZA
Cardiovasc Diabetol 2014 Apr 24;13:85. doi: 10.1186/1475-2840-13-85. PMID: 24762216Free PMC Article
Peripheral arterial calcification: prevalence, mechanism, detection, and clinical implications.
Rocha-Singh KJ, Zeller T, Jaff MR
Catheter Cardiovasc Interv 2014 May 1;83(6):E212-20. Epub 2014 Feb 10 doi: 10.1002/ccd.25387. PMID: 24402839Free PMC Article

Therapy

Efficacy and Safety of Intravascular Lithotripsy in Lower Extremity Peripheral Artery Disease: A Systematic Review and Meta-Analysis.
Wong CP, Chan LP, Au DM, Chan HWC, Chan YC
Eur J Vasc Endovasc Surg 2022 Mar;63(3):446-456. Epub 2021 Dec 6 doi: 10.1016/j.ejvs.2021.10.035. PMID: 34887206
Effect of high-dose vitamin D supplementation on peripheral arterial calcification: secondary analysis of a randomized controlled trial.
Billington EO, Burt LA, Plett R, Rose MS, Boyd SK, Hanley DA
Osteoporos Int 2020 Nov;31(11):2141-2150. Epub 2020 Jun 15 doi: 10.1007/s00198-020-05500-2. PMID: 32556518
Pulmonary hypertension - prevalence, risk factors, and its association with vascular calcification in chronic kidney disease and hemodialysis patients.
Nithiya N, Indhumathi E, Jagadeswaran D, Jayaprakash V, Jayakumar M
Saudi J Kidney Dis Transpl 2020 Mar-Apr;31(2):380-387. doi: 10.4103/1319-2442.284012. PMID: 32394910
Efficacy and safety of intravascular lithotripsy for the treatment of peripheral arterial disease: An individual patient-level pooled data analysis.
Madhavan MV, Shahim B, Mena-Hurtado C, Garcia L, Crowley A, Parikh SA
Catheter Cardiovasc Interv 2020 Apr 1;95(5):959-968. Epub 2020 Jan 20 doi: 10.1002/ccd.28729. PMID: 31957955Free PMC Article
Increased Peripheral Arterial Calcification in Patients Receiving Warfarin.
Han KH, O'Neill WC
J Am Heart Assoc 2016 Jan 25;5(1) doi: 10.1161/JAHA.115.002665. PMID: 26811161Free PMC Article

Prognosis

Peripheral arterial calcification: prevalence, mechanism, detection, and clinical implications.
Rocha-Singh KJ, Zeller T, Jaff MR
Catheter Cardiovasc Interv 2014 May 1;83(6):E212-20. Epub 2014 Feb 10 doi: 10.1002/ccd.25387. PMID: 24402839Free PMC Article
Breast arterial calcification: a marker of medial vascular calcification in chronic kidney disease.
Duhn V, D'Orsi ET, Johnson S, D'Orsi CJ, Adams AL, O'Neill WC
Clin J Am Soc Nephrol 2011 Feb;6(2):377-82. Epub 2011 Jan 21 doi: 10.2215/CJN.07190810. PMID: 21258037Free PMC Article
Intensive treatment of diabetes is associated with a reduced rate of peripheral arterial calcification in the diabetes control and complications trial.
Carter RE, Lackland DT, Cleary PA, Yim E, Lopes-Virella MF, Gilbert GE, Orchard TJ; Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research Group
Diabetes Care 2007 Oct;30(10):2646-8. Epub 2007 Jul 10 doi: 10.2337/dc07-0517. PMID: 17623823Free PMC Article

Clinical prediction guides

A Plasma Pyrophosphate Cutoff Value for Diagnosing Pseudoxanthoma Elasticum.
Rubera I, Clotaire L, Laurain A, Destere A, Martin L, Duranton C, Leftheriotis G
Int J Mol Sci 2024 Jun 13;25(12) doi: 10.3390/ijms25126502. PMID: 38928212Free PMC Article
Vascular calcification in patients with type 2 diabetes: the involvement of matrix Gla protein.
Liabeuf S, Bourron O, Olivier B, Vemeer C, Theuwissen E, Magdeleyns E, Aubert CE, Brazier M, Mentaverri R, Hartemann A, Massy ZA
Cardiovasc Diabetol 2014 Apr 24;13:85. doi: 10.1186/1475-2840-13-85. PMID: 24762216Free PMC Article
Peripheral arterial calcification: prevalence, mechanism, detection, and clinical implications.
Rocha-Singh KJ, Zeller T, Jaff MR
Catheter Cardiovasc Interv 2014 May 1;83(6):E212-20. Epub 2014 Feb 10 doi: 10.1002/ccd.25387. PMID: 24402839Free PMC Article
Breast arterial calcification: a marker of medial vascular calcification in chronic kidney disease.
Duhn V, D'Orsi ET, Johnson S, D'Orsi CJ, Adams AL, O'Neill WC
Clin J Am Soc Nephrol 2011 Feb;6(2):377-82. Epub 2011 Jan 21 doi: 10.2215/CJN.07190810. PMID: 21258037Free PMC Article

Recent systematic reviews

Efficacy and Safety of Intravascular Lithotripsy in Lower Extremity Peripheral Artery Disease: A Systematic Review and Meta-Analysis.
Wong CP, Chan LP, Au DM, Chan HWC, Chan YC
Eur J Vasc Endovasc Surg 2022 Mar;63(3):446-456. Epub 2021 Dec 6 doi: 10.1016/j.ejvs.2021.10.035. PMID: 34887206

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...