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Abnormal mitral valve physiology

MedGen UID:
1624687
•Concept ID:
C4531094
•
Anatomical Abnormality
HPO: HP:0031481

Definition

Any functional anomaly of the mitral valve. [from HPO]

Professional guidelines

PubMed

Floppy mitral valve/mitral valve prolapse: A complex entity with multiple genotypes and phenotypes.
Boudoulas KD, Pitsis AA, Mazzaferri EL, Gumina RJ, Triposkiadis F, Boudoulas H
Prog Cardiovasc Dis 2020 May-Jun;63(3):308-326. Epub 2020 Mar 19 doi: 10.1016/j.pcad.2020.03.004. PMID: 32201287
Role of echocardiography in the diagnosis and management of hypertrophic cardiomyopathy.
Dominguez F, González-López E, Padron-Barthe L, Cavero MA, Garcia-Pavia P
Heart 2018 Feb;104(3):261-273. Epub 2017 Sep 19 doi: 10.1136/heartjnl-2016-310559. PMID: 28928240
Antithrombotic and thrombolytic therapy for valvular disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.
Whitlock RP, Sun JC, Fremes SE, Rubens FD, Teoh KH
Chest 2012 Feb;141(2 Suppl):e576S-e600S. doi: 10.1378/chest.11-2305. PMID: 22315272Free PMC Article

Recent clinical studies

Etiology

Accessory mitral valve tissue: anatomical and clinical perspectives.
Yetkin E, Cuglan B, Turhan H, Yalta K
Cardiovasc Pathol 2021 Jan-Feb;50:107277. Epub 2020 Aug 31 doi: 10.1016/j.carpath.2020.107277. PMID: 32882373
Proportionate and Disproportionate Functional Mitral Regurgitation: A New Conceptual Framework That Reconciles the Results of the MITRA-FR and COAPT Trials.
Grayburn PA, Sannino A, Packer M
JACC Cardiovasc Imaging 2019 Feb;12(2):353-362. Epub 2018 Dec 12 doi: 10.1016/j.jcmg.2018.11.006. PMID: 30553663
Mitral Annulus Calcification.
Abramowitz Y, Jilaihawi H, Chakravarty T, Mack MJ, Makkar RR
J Am Coll Cardiol 2015 Oct 27;66(17):1934-41. doi: 10.1016/j.jacc.2015.08.872. PMID: 26493666
Mitral regurgitation.
Ahmed MI, McGiffin DC, O'Rourke RA, Dell'Italia LJ
Curr Probl Cardiol 2009 Mar;34(3):93-136. doi: 10.1016/j.cpcardiol.2008.11.002. PMID: 19232244
Ischemic mitral regurgitation.
Le HC, Thys DM
Semin Cardiothorac Vasc Anesth 2006 Mar;10(1):73-7. doi: 10.1177/108925320601000113. PMID: 16703238

Diagnosis

Accessory mitral valve tissue: anatomical and clinical perspectives.
Yetkin E, Cuglan B, Turhan H, Yalta K
Cardiovasc Pathol 2021 Jan-Feb;50:107277. Epub 2020 Aug 31 doi: 10.1016/j.carpath.2020.107277. PMID: 32882373
Proportionate and Disproportionate Functional Mitral Regurgitation: A New Conceptual Framework That Reconciles the Results of the MITRA-FR and COAPT Trials.
Grayburn PA, Sannino A, Packer M
JACC Cardiovasc Imaging 2019 Feb;12(2):353-362. Epub 2018 Dec 12 doi: 10.1016/j.jcmg.2018.11.006. PMID: 30553663
Mitral Valve Prolapse: Multimodality Imaging and Genetic Insights.
Parwani P, Avierinos JF, Levine RA, Delling FN
Prog Cardiovasc Dis 2017 Nov-Dec;60(3):361-369. Epub 2017 Nov 6 doi: 10.1016/j.pcad.2017.10.007. PMID: 29122631Free PMC Article
Mitral Annulus Calcification.
Abramowitz Y, Jilaihawi H, Chakravarty T, Mack MJ, Makkar RR
J Am Coll Cardiol 2015 Oct 27;66(17):1934-41. doi: 10.1016/j.jacc.2015.08.872. PMID: 26493666
Mitral regurgitation.
Ahmed MI, McGiffin DC, O'Rourke RA, Dell'Italia LJ
Curr Probl Cardiol 2009 Mar;34(3):93-136. doi: 10.1016/j.cpcardiol.2008.11.002. PMID: 19232244

Therapy

Proportionate and Disproportionate Functional Mitral Regurgitation: A New Conceptual Framework That Reconciles the Results of the MITRA-FR and COAPT Trials.
Grayburn PA, Sannino A, Packer M
JACC Cardiovasc Imaging 2019 Feb;12(2):353-362. Epub 2018 Dec 12 doi: 10.1016/j.jcmg.2018.11.006. PMID: 30553663
Antithrombotic and thrombolytic therapy for valvular disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.
Whitlock RP, Sun JC, Fremes SE, Rubens FD, Teoh KH
Chest 2012 Feb;141(2 Suppl):e576S-e600S. doi: 10.1378/chest.11-2305. PMID: 22315272Free PMC Article
Mitral regurgitation.
Ahmed MI, McGiffin DC, O'Rourke RA, Dell'Italia LJ
Curr Probl Cardiol 2009 Mar;34(3):93-136. doi: 10.1016/j.cpcardiol.2008.11.002. PMID: 19232244
Idiopathic ventricular tachycardia.
Altemose GT, Buxton AE
Annu Rev Med 1999;50:159-77. doi: 10.1146/annurev.med.50.1.159. PMID: 10073270
Hydralazine in heart failure.
Chatterjee K
Herz 1983 Aug;8(4):187-98. PMID: 6413340

Prognosis

Accessory mitral valve tissue: anatomical and clinical perspectives.
Yetkin E, Cuglan B, Turhan H, Yalta K
Cardiovasc Pathol 2021 Jan-Feb;50:107277. Epub 2020 Aug 31 doi: 10.1016/j.carpath.2020.107277. PMID: 32882373
Atrial functional mitral regurgitation.
Hoit BD
Curr Opin Cardiol 2020 Sep;35(5):474-481. doi: 10.1097/HCO.0000000000000761. PMID: 32649349
Proportionate and Disproportionate Functional Mitral Regurgitation: A New Conceptual Framework That Reconciles the Results of the MITRA-FR and COAPT Trials.
Grayburn PA, Sannino A, Packer M
JACC Cardiovasc Imaging 2019 Feb;12(2):353-362. Epub 2018 Dec 12 doi: 10.1016/j.jcmg.2018.11.006. PMID: 30553663
Mitral Valve Prolapse: Multimodality Imaging and Genetic Insights.
Parwani P, Avierinos JF, Levine RA, Delling FN
Prog Cardiovasc Dis 2017 Nov-Dec;60(3):361-369. Epub 2017 Nov 6 doi: 10.1016/j.pcad.2017.10.007. PMID: 29122631Free PMC Article
STRUCTURAL HEART ANOMALIES (REVIEW).
Osovska N, Kuzminova N, Ovcharuk M, Serhiychuk O
Georgian Med News 2016 Jun;(255):66-77. PMID: 27441539

Clinical prediction guides

Accessory mitral valve tissue: anatomical and clinical perspectives.
Yetkin E, Cuglan B, Turhan H, Yalta K
Cardiovasc Pathol 2021 Jan-Feb;50:107277. Epub 2020 Aug 31 doi: 10.1016/j.carpath.2020.107277. PMID: 32882373
Proportionate and Disproportionate Functional Mitral Regurgitation: A New Conceptual Framework That Reconciles the Results of the MITRA-FR and COAPT Trials.
Grayburn PA, Sannino A, Packer M
JACC Cardiovasc Imaging 2019 Feb;12(2):353-362. Epub 2018 Dec 12 doi: 10.1016/j.jcmg.2018.11.006. PMID: 30553663
Assessment of the severity of native mitral valve regurgitation.
El-Tallawi KC, Messika-Zeitoun D, Zoghbi WA
Prog Cardiovasc Dis 2017 Nov-Dec;60(3):322-333. Epub 2017 Nov 22 doi: 10.1016/j.pcad.2017.11.005. PMID: 29174559
Mitral Valve Prolapse: Multimodality Imaging and Genetic Insights.
Parwani P, Avierinos JF, Levine RA, Delling FN
Prog Cardiovasc Dis 2017 Nov-Dec;60(3):361-369. Epub 2017 Nov 6 doi: 10.1016/j.pcad.2017.10.007. PMID: 29122631Free PMC Article
Interventional imaging: the role of echocardiography.
Maragiannis D, Little SH
Methodist Debakey Cardiovasc J 2014 Jul-Sep;10(3):172-7. doi: 10.14797/mdcj-10-3-172. PMID: 25574345Free PMC Article

Recent systematic reviews

The relationship between mitral valve prolapse and thoracic skeletal abnormalities in clinical practice: a systematic review.
Sonaglioni A, Nicolosi GL, Lombardo M
J Cardiovasc Med (Hagerstown) 2024 May 1;25(5):353-363. Epub 2024 Mar 19 doi: 10.2459/JCM.0000000000001614. PMID: 38526955
Clinical features and complications of Loeys-Dietz syndrome: A systematic review.
Gouda P, Kay R, Habib M, Aziz A, Aziza E, Welsh R
Int J Cardiol 2022 Sep 1;362:158-167. Epub 2022 Jun 1 doi: 10.1016/j.ijcard.2022.05.065. PMID: 35662564
Mitral valve prolapse and sudden cardiac death: a systematic review and meta-analysis.
Nalliah CJ, Mahajan R, Elliott AD, Haqqani H, Lau DH, Vohra JK, Morton JB, Semsarian C, Marwick T, Kalman JM, Sanders P
Heart 2019 Jan;105(2):144-151. Epub 2018 Sep 21 doi: 10.1136/heartjnl-2017-312932. PMID: 30242141
Genomic analysis in patients with myxomatous mitral valve prolapse: current state of knowledge.
Gasser S, Reichenspurner H, Girdauskas E
BMC Cardiovasc Disord 2018 Feb 27;18(1):41. doi: 10.1186/s12872-018-0755-y. PMID: 29486707Free PMC Article
Risk Factors for Coarctation of the Aorta on Prenatal Ultrasound: A Systematic Review and Meta-Analysis.
Familiari A, Morlando M, Khalil A, Sonesson SE, Scala C, Rizzo G, Del Sordo G, Vassallo C, Elena Flacco M, Manzoli L, Lanzone A, Scambia G, Acharya G, D'Antonio F
Circulation 2017 Feb 21;135(8):772-785. Epub 2016 Dec 29 doi: 10.1161/CIRCULATIONAHA.116.024068. PMID: 28034902

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