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Immunoglobulin G subclass deficiency

MedGen UID:
1618515
•Concept ID:
C4520847
•
Finding
Synonyms: IgG deficiency; Reduced IgG levels
SNOMED CT: Immunoglobin G subclass deficiency (123785006); IgG subclass deficiency (123785006); Immunoglobulin G subclass deficiency (123785006)

Professional guidelines

PubMed

Humoral immune failure defined by immunoglobulin class and immunoglobulin G subclass deficiency is associated with shorter treatment-free and overall survival in Chronic Lymphocytic Leukaemia.
Crassini KR, Zhang E, Balendran S, Freeman JA, Best OG, Forsyth CJ, Mackinlay NJ, Han P, Stevenson WS, Mulligan SP
Br J Haematol 2018 Apr;181(1):97-101. Epub 2018 Feb 21 doi: 10.1111/bjh.15146. PMID: 29468645

Recent clinical studies

Etiology

Immunoglobulin G Subclass Deficiencies in Adult Patients with Chronic Airway Diseases.
Kim JH, Park S, Hwang YI, Jang SH, Jung KS, Sim YS, Kim CH, Kim C, Kim DG
J Korean Med Sci 2016 Oct;31(10):1560-5. doi: 10.3346/jkms.2016.31.10.1560. PMID: 27550483Free PMC Article
The Challenge of Immunoglobulin-G Subclass Deficiency and Specific Polysaccharide Antibody Deficiency--a Dutch Pediatric Cohort Study.
Schatorjé EJ, de Jong E, van Hout RW, García Vivas Y, de Vries E
J Clin Immunol 2016 Feb;36(2):141-8. Epub 2016 Feb 4 doi: 10.1007/s10875-016-0236-y. PMID: 26846287
Nasal polyposis and immunoglobulin-G subclass deficiency.
Tran Khai Hoan N, Karmochkine M, Laccourreye O, Bonfils P
Eur Ann Otorhinolaryngol Head Neck Dis 2014 Jun;131(3):171-5. Epub 2014 Apr 5 doi: 10.1016/j.anorl.2013.11.002. PMID: 24709408
Clinical significance of serum immunoglobulin G subclass deficiency in patients with chronic lymphocytic leukemia.
Svensson T, Höglund M, Cherif H
Scand J Infect Dis 2013 Jul;45(7):537-42. Epub 2013 Feb 21 doi: 10.3109/00365548.2013.769279. PMID: 23427875
Immunoglobulin G subclass deficiency and infection risk in 150 patients with chronic lymphocytic leukemia.
Freeman JA, Crassini KR, Best OG, Forsyth CJ, Mackinlay NJ, Han P, Stevenson W, Mulligan SP
Leuk Lymphoma 2013 Jan;54(1):99-104. Epub 2012 Sep 8 doi: 10.3109/10428194.2012.706285. PMID: 22738394

Diagnosis

Implanted ports in adults with primary immunodeficiency.
Barton JC, Barton JC, Bertoli LF
J Vasc Access 2018 Jul;19(4):375-377. Epub 2018 Mar 15 doi: 10.1177/1129729818757966. PMID: 29542377
Immunoglobulin G Subclass Deficiencies in Adult Patients with Chronic Airway Diseases.
Kim JH, Park S, Hwang YI, Jang SH, Jung KS, Sim YS, Kim CH, Kim C, Kim DG
J Korean Med Sci 2016 Oct;31(10):1560-5. doi: 10.3346/jkms.2016.31.10.1560. PMID: 27550483Free PMC Article
The Challenge of Immunoglobulin-G Subclass Deficiency and Specific Polysaccharide Antibody Deficiency--a Dutch Pediatric Cohort Study.
Schatorjé EJ, de Jong E, van Hout RW, García Vivas Y, de Vries E
J Clin Immunol 2016 Feb;36(2):141-8. Epub 2016 Feb 4 doi: 10.1007/s10875-016-0236-y. PMID: 26846287
Nasal polyposis and immunoglobulin-G subclass deficiency.
Tran Khai Hoan N, Karmochkine M, Laccourreye O, Bonfils P
Eur Ann Otorhinolaryngol Head Neck Dis 2014 Jun;131(3):171-5. Epub 2014 Apr 5 doi: 10.1016/j.anorl.2013.11.002. PMID: 24709408
Immunoglobulin G subclass deficiency and predisposition to infection in Down's syndrome.
Loh RK, Harth SC, Thong YH, Ferrante A
Pediatr Infect Dis J 1990 Aug;9(8):547-51. doi: 10.1097/00006454-199008000-00004. PMID: 2146585

Therapy

Fatigue Is Common in Immunoglobulin G Subclass Deficiency and Correlates With Inflammatory Response and Need for Immunoglobulin Replacement Therapy.
Wågström P, Nilsdotter-Augustinsson Å, Nilsson M, Björkander J, Dahle C, Nyström S
Front Immunol 2021;12:797336. Epub 2022 Jan 10 doi: 10.3389/fimmu.2021.797336. PMID: 35082787Free PMC Article
Implanted ports in adults with primary immunodeficiency.
Barton JC, Barton JC, Bertoli LF
J Vasc Access 2018 Jul;19(4):375-377. Epub 2018 Mar 15 doi: 10.1177/1129729818757966. PMID: 29542377
Nasal polyposis and immunoglobulin-G subclass deficiency.
Tran Khai Hoan N, Karmochkine M, Laccourreye O, Bonfils P
Eur Ann Otorhinolaryngol Head Neck Dis 2014 Jun;131(3):171-5. Epub 2014 Apr 5 doi: 10.1016/j.anorl.2013.11.002. PMID: 24709408
Immunoglobulin subclasses and prophylactic use of immunoglobulin in immunoglobulin G subclass deficiency.
Söderström T, Söderström R, Enskog A
Cancer 1991 Sep 15;68(6 Suppl):1426-9. doi: 10.1002/1097-0142(19910915)68:6+<1426::aid-cncr2820681404>3.0.co;2-r. PMID: 1908745
Immunoglobulin G subclass deficiency and pneumococcal infection after allogeneic bone marrow transplantation.
Sheridan JF, Tutschka PJ, Sedmak DD, Copelan EA
Blood 1990 Apr 1;75(7):1583-6. PMID: 2317564

Prognosis

Humoral immune failure defined by immunoglobulin class and immunoglobulin G subclass deficiency is associated with shorter treatment-free and overall survival in Chronic Lymphocytic Leukaemia.
Crassini KR, Zhang E, Balendran S, Freeman JA, Best OG, Forsyth CJ, Mackinlay NJ, Han P, Stevenson WS, Mulligan SP
Br J Haematol 2018 Apr;181(1):97-101. Epub 2018 Feb 21 doi: 10.1111/bjh.15146. PMID: 29468645
Immunoglobulin G Subclass Deficiencies in Adult Patients with Chronic Airway Diseases.
Kim JH, Park S, Hwang YI, Jang SH, Jung KS, Sim YS, Kim CH, Kim C, Kim DG
J Korean Med Sci 2016 Oct;31(10):1560-5. doi: 10.3346/jkms.2016.31.10.1560. PMID: 27550483Free PMC Article
The Challenge of Immunoglobulin-G Subclass Deficiency and Specific Polysaccharide Antibody Deficiency--a Dutch Pediatric Cohort Study.
Schatorjé EJ, de Jong E, van Hout RW, García Vivas Y, de Vries E
J Clin Immunol 2016 Feb;36(2):141-8. Epub 2016 Feb 4 doi: 10.1007/s10875-016-0236-y. PMID: 26846287
A case of IgG subclass deficiency with the initial presentation of transient hypogammaimmuno-globulinemia of infancy and a review of IgG subclass deficiencies.
Nettagul R, Visitsunthorn N, Vichyanond P
J Med Assoc Thai 2003 Jul;86(7):686-92. PMID: 12948264
Hepatitis C virus infection in Italian patients with hypogammaglobulinemia.
Quinti I, Pandolfi F, Paganelli R, Giovannetti A, Sacco G, Oliva A, Aiuti F
Clin Ther 1996;18 Suppl B:96-107. doi: 10.1016/s0149-2918(96)80201-3. PMID: 8930447

Clinical prediction guides

The Challenge of Immunoglobulin-G Subclass Deficiency and Specific Polysaccharide Antibody Deficiency--a Dutch Pediatric Cohort Study.
Schatorjé EJ, de Jong E, van Hout RW, García Vivas Y, de Vries E
J Clin Immunol 2016 Feb;36(2):141-8. Epub 2016 Feb 4 doi: 10.1007/s10875-016-0236-y. PMID: 26846287
Nasal polyposis and immunoglobulin-G subclass deficiency.
Tran Khai Hoan N, Karmochkine M, Laccourreye O, Bonfils P
Eur Ann Otorhinolaryngol Head Neck Dis 2014 Jun;131(3):171-5. Epub 2014 Apr 5 doi: 10.1016/j.anorl.2013.11.002. PMID: 24709408
Immunoglobulin G subclass deficiency and infection risk in 150 patients with chronic lymphocytic leukemia.
Freeman JA, Crassini KR, Best OG, Forsyth CJ, Mackinlay NJ, Han P, Stevenson W, Mulligan SP
Leuk Lymphoma 2013 Jan;54(1):99-104. Epub 2012 Sep 8 doi: 10.3109/10428194.2012.706285. PMID: 22738394
Immunoglobulin G subclass deficiency: fact or fancy?
Buckley RH
Curr Allergy Asthma Rep 2002 Sep;2(5):356-60. doi: 10.1007/s11882-002-0067-1. PMID: 12165200
Immunoglobulin subclasses and prophylactic use of immunoglobulin in immunoglobulin G subclass deficiency.
Söderström T, Söderström R, Enskog A
Cancer 1991 Sep 15;68(6 Suppl):1426-9. doi: 10.1002/1097-0142(19910915)68:6+<1426::aid-cncr2820681404>3.0.co;2-r. PMID: 1908745

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