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Ectopic pituitary adenoma

MedGen UID:: 1393057
•Concept ID:: C4518348
•: Neoplastic Process

SNOMED CT:

Ectopic pituitary adenoma (734037007)

Definition

A benign pituitary gland neoplasm occurring separately from and without involvement of the sella turcica. [from SNOMEDCT_US]

Professional guidelines

PubMed

Ectopic pituitary adenomas: clinical features, diagnostic challenges and management.

Zhu J, Wang Z, Zhang Y, Li X, Liu J, Deng K, Lu L, Pan H, Wang R, Yao Y, Zhu H
Pituitary 2020 Dec;23(6):648-664. doi: 10.1007/s11102-020-01071-x. PMID: 32757141

New developments in the medical treatment of Cushing's syndrome.

van der Pas R, de Herder WW, Hofland LJ, Feelders RA
Endocr Relat Cancer 2012 Dec;19(6):R205-23. Epub 2012 Nov 9 doi: 10.1530/ERC-12-0191. PMID: 22936543

Medical treatment of Cushing's syndrome: adrenal-blocking drugs and ketaconazole.

Feelders RA, Hofland LJ, de Herder WW
Neuroendocrinology 2010;92 Suppl 1:111-5. Epub 2010 Sep 10 doi: 10.1159/000314292. PMID: 20829630

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Recent clinical studies

Etiology

Ectopic pituitary adenomas: clinical features, diagnostic challenges and management.

Zhu J, Wang Z, Zhang Y, Li X, Liu J, Deng K, Lu L, Pan H, Wang R, Yao Y, Zhu H
Pituitary 2020 Dec;23(6):648-664. doi: 10.1007/s11102-020-01071-x. PMID: 32757141

Pituitary Adenoma Deposit in the Nasolabial Region Following Sublabial Transsphenoidal Surgery in the Setting of Nelson Syndrome.

Wallace A, Liu P, Cipriani NA, Ginat D, Portugal L
J Craniofac Surg 2020 Jan/Feb;31(1):e68-e69. doi: 10.1097/SCS.0000000000005913. PMID: 31633667

Ectopic pituitary adenomas: common presentations of a rare entity.

Agely A, Okromelidze L, Vilanilam GK, Chaichana KL, Middlebrooks EH, Gupta V
Pituitary 2019 Aug;22(4):339-343. doi: 10.1007/s11102-019-00954-y. PMID: 30895500

Ectopic Adrenocorticotropic Hormone-Secreting Pituitary Adenomas: An Underestimated Entity.

Knappe UJ, Jaspers C, Buschsieweke D, Reinbold WD, Alomari A, Saeger W, Ehlenz K, Mann WA, Kann PH, Feldkamp J
Neurosurgery 2017 Apr 1;80(4):525-533. doi: 10.1227/NEU.0000000000001319. PMID: 27352274

Ectopic sphenoid sinus pituitary adenoma (ESSPA) with normal anterior pituitary gland: a clinicopathologic and immunophenotypic study of 32 cases with a comprehensive review of the english literature.

Thompson LD, Seethala RR, Müller S
Head Neck Pathol 2012 Mar;6(1):75-100. Epub 2012 Mar 20 doi: 10.1007/s12105-012-0336-9. PMID: 22430769 Free PMC Article

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Diagnosis

Neuropathology Entities Involving the Sinonasal Tract.

Roberts KF, Dahiya SM
Surg Pathol Clin 2024 Dec;17(4):733-748. Epub 2024 Aug 17 doi: 10.1016/j.path.2024.07.011. PMID: 39489560

Imaging Features of Ectopic Tissues and Their Complications: Embryologic and Anatomic Approach.

Kurokawa M, Kurokawa R, Tamura K, Baba A, Ota Y, Nakaya M, Yokoyama K, Kim J, Moritani T, Abe O
Radiographics 2023 Jun;43(6):e220111. doi: 10.1148/rg.220111. PMID: 37141139

Case Report and Literature Review: Ectopic Thyrotropin-Secreting Pituitary Adenoma in the Suprasellar Region.

Li X, Zhao B, Hou B, Wang J, Zhu J, Yao Y, Lian X
Front Endocrinol (Lausanne) 2021;12:619161. Epub 2021 Mar 11 doi: 10.3389/fendo.2021.619161. PMID: 33776916 Free PMC Article

Ectopic pituitary adenomas: clinical features, diagnostic challenges and management.

Zhu J, Wang Z, Zhang Y, Li X, Liu J, Deng K, Lu L, Pan H, Wang R, Yao Y, Zhu H
Pituitary 2020 Dec;23(6):648-664. doi: 10.1007/s11102-020-01071-x. PMID: 32757141

Ectopic prolactinoma in the clivus: a case report.

Narese D, Virzì V, Virzì G, Narese F, Sciortino A, Culmone G, Virzì F, Maira G
Clin Ter 2015;166(4):176-8. doi: 10.7417/CT.2015.1866. PMID: 26378755

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Therapy

Ectopic pituitary adenoma of the TSH-secreting sphenoidal sinus with excellent response to somatostatin analogs. Theory of the embryogenesis and literature review from a clinical case.

Ortiz E, Peldoza M, Monnier E, Gejman R, Henriquez M, Barra MI, Gayoso R, Sapunar J, Villaseca M, Guzmán P
Steroids 2020 Feb;154:108535. Epub 2019 Nov 6 doi: 10.1016/j.steroids.2019.108535. PMID: 31704334

Ectopic pituitary adenomas: common presentations of a rare entity.

Agely A, Okromelidze L, Vilanilam GK, Chaichana KL, Middlebrooks EH, Gupta V
Pituitary 2019 Aug;22(4):339-343. doi: 10.1007/s11102-019-00954-y. PMID: 30895500

Symptomatic hyperprolactinemia from an ectopic pituitary adenoma located in the clivus.

Rocque BG, Herold KA, Salamat MS, Shenker Y, Kuo JS
Endocr Pract 2009 Mar;15(2):143-8. doi: 10.4158/EP.15.2.143. PMID: 19289326

Pharyngeal pituitary non-functioning adenoma with normal intra-sellar gland: massive tumor shrinkage on octreotide therapy.

Pugnale N, Waridel F, Bouzourène H, Boubaker A, Pugnale M, Gaillard RC, Gomez F
Eur J Endocrinol 2003 Mar;148(3):357-64. doi: 10.1530/eje.0.1480357. PMID: 12611618

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Prognosis

First Report of Coexistence of Two Ectopic Pituitary Tumors: Rathke Cleft Cyst and Silent Adrenocorticotropic Hormone Adenoma.

Pojskić M, Zbytek B, Beckford NS, Boop FA, Arnautović KI
World Neurosurg 2017 Aug;104:1048.e1-1048.e7. Epub 2017 May 19 doi: 10.1016/j.wneu.2017.05.070. PMID: 28532906

Endoscopic Endonasal Surgery for Remission of Cushing Disease Caused by Ectopic Intracavernous Macroadenoma: Case Report and Literature Review.

Koutourousiou M, Winstead WI
World Neurosurg 2017 Feb;98:870.e5-870.e10. Epub 2016 Dec 18 doi: 10.1016/j.wneu.2016.12.021. PMID: 28003168

A pitfall in diagnosing Cushing's disease: ectopic ACTH-producing pituitary adenoma in the sphenoid sinus.

Flitsch J, Schmid SM, Bernreuther C, Winterberg B, Ritter MM, Lehnert H, Burkhardt T
Pituitary 2015 Apr;18(2):279-82. doi: 10.1007/s11102-014-0591-8. PMID: 25129688

A case report of FSH-producing nasal ectopic pituitary adenoma extending to the frontal cranial fossa.

Kitajiri S, Hosaka N, Tabuchi K, Hiraumi H, Nogaki H, Tatsumi S, Toki J, Ikehara S
Arch Otolaryngol Head Neck Surg 2000 Jun;126(6):782-4. doi: 10.1001/archotol.126.6.782. PMID: 10864117

Ectopic pituitary adenoma occurring in the interpeduncular cistern. Case report.

Takahata T, Katayama Y, Tsubokawa T, Oshima H, Yoshino A
J Neurosurg 1995 Dec;83(6):1092-4. doi: 10.3171/jns.1995.83.6.1092. PMID: 7490628

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Clinical prediction guides

Ectopic sphenoidal ACTH-secreting adenoma revealed by (11)C Methionine PET scan: case report.

Lurquin F, Constantinescu SM, Furnica RM, Duprez T, Raftopoulos C, Daoud L, Lammens M, Maiter D
BMC Endocr Disord 2023 Feb 16;23(1):43. doi: 10.1186/s12902-023-01298-2. PMID: 36797716 Free PMC Article

Cushing Syndrome Caused by Ectopic Adrenocorticotropic Hormone-Secreting Pituitary Adenomas: Case Report and Literature Review.

Sun X, Lu L, Feng M, Fan Y, Bao X, Dai C, Deng K, Guo D, Yao Y, Zhu H, Wang R
World Neurosurg 2020 Oct;142:75-86. Epub 2020 Jun 24 doi: 10.1016/j.wneu.2020.06.138. PMID: 32592962

Ectopic pituitary adenoma of the TSH-secreting sphenoidal sinus with excellent response to somatostatin analogs. Theory of the embryogenesis and literature review from a clinical case.

Three cases of ectopic sphenoid sinus pituitary adenoma.

Bobeff EJ, Wiśniewski K, Papierz W, Stefańczyk L, Jaskólski DJ
Folia Neuropathol 2017;55(1):60-66. doi: 10.5114/fn.2017.66714. PMID: 28430293

Suprasellar ectopic pituitary adenoma: case report and review of the literature.

Matsumura A, Meguro K, Doi M, Tsurushima H, Tomono Y
Neurosurgery 1990 Apr;26(4):681-5. PMID: 2184378

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