U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Chronic cerebrospinal venous insufficiency

MedGen UID:
1388537
•Concept ID:
C4511608
•
Disease or Syndrome
Synonym: CCSVI - chronic cerebrospinal venous insufficiency
SNOMED CT: Chronic cerebrospinal venous insufficiency (725958000); CCSVI - chronic cerebrospinal venous insufficiency (725958000)

Professional guidelines

PubMed

"Liberation treatment" for chronic cerebrospinal venous insufficiency in multiple sclerosis: the truth will set you free.
Tsivgoulis G, Faissner S, Voumvourakis K, Katsanos AH, Triantafyllou N, Grigoriadis N, Gold R, Krogias C
Brain Behav 2015 Jan;5(1):3-12. Epub 2014 Nov 21 doi: 10.1002/brb3.297. PMID: 25722945Free PMC Article
Reported outcomes after the endovascular treatment of chronic cerebrospinal venous insufficiency.
Hampson CO, Soares GM, Jaffan AA
Tech Vasc Interv Radiol 2012 Jun;15(2):144-9. doi: 10.1053/j.tvir.2012.02.007. PMID: 22640503
Screening for chronic cerebrospinal venous insufficiency (CCSVI) using ultrasound--recommendations for a protocol.
Zamboni P, Morovic S, Menegatti E, Viselner G, Nicolaides AN
Int Angiol 2011 Dec;30(6):571-97. PMID: 22233619

Recent clinical studies

Therapy

"Liberation treatment" for chronic cerebrospinal venous insufficiency in multiple sclerosis: the truth will set you free.
Tsivgoulis G, Faissner S, Voumvourakis K, Katsanos AH, Triantafyllou N, Grigoriadis N, Gold R, Krogias C
Brain Behav 2015 Jan;5(1):3-12. Epub 2014 Nov 21 doi: 10.1002/brb3.297. PMID: 25722945Free PMC Article
Percutaneous transluminal angioplasty for treatment of chronic cerebrospinal venous insufficiency (CCSVI) in multiple sclerosis patients.
van Zuuren EJ, Fedorowicz Z, Pucci E, Jagannath VA, Robak EW
Cochrane Database Syst Rev 2012 Dec 12;12:CD009903. doi: 10.1002/14651858.CD009903.pub2. PMID: 23235683
Chronic cerebrospinal venous insufficiency and multiple sclerosis.
Bagert BA, Marder E, Stüve O
Arch Neurol 2011 Nov;68(11):1379-84. Epub 2011 Jul 11 doi: 10.1001/archneurol.2011.179. PMID: 21747006
The chronic cerebrospinal venous insufficiency syndrome.
Zamboni P, Galeotti R
Phlebology 2010 Dec;25(6):269-79. doi: 10.1258/phleb.2010.009083. PMID: 21106999
Chronic cerebrospinal venous insufficiency and multiple sclerosis.
Khan O, Filippi M, Freedman MS, Barkhof F, Dore-Duffy P, Lassmann H, Trapp B, Bar-Or A, Zak I, Siegel MJ, Lisak R
Ann Neurol 2010 Mar;67(3):286-90. doi: 10.1002/ana.22001. PMID: 20373339

Prognosis

Chronic cerebrospinal venous insufficiency and menière's disease: Interventional versus medical therapy.
Attanasio G, Califano L, Bruno A, Giugliano V, Ralli M, Martellucci S, Milella C, de Vincentiis M, Russo FY, Greco A
Laryngoscope 2020 Aug;130(8):2040-2046. Epub 2019 Nov 11 doi: 10.1002/lary.28389. PMID: 31710712
Chronic cerebrospinal venous insufficiency in Ménière disease.
Di Berardino F, Alpini DC, Bavera PM, Cecconi P, Farabola M, Mattei V, Ambrosetti U, Cesarani A
Phlebology 2015 May;30(4):274-9. Epub 2014 Mar 4 doi: 10.1177/0268355514526871. PMID: 24594584
Meta-analysis of the correlation between chronic cerebrospinal venous insufficiency and multiple sclerosis.
Zwischenberger BA, Beasley MM, Davenport DL, Xenos ES
Vasc Endovascular Surg 2013 Nov;47(8):620-4. Epub 2013 Sep 4 doi: 10.1177/1538574413503562. PMID: 24005191
Reported outcomes after the endovascular treatment of chronic cerebrospinal venous insufficiency.
Hampson CO, Soares GM, Jaffan AA
Tech Vasc Interv Radiol 2012 Jun;15(2):144-9. doi: 10.1053/j.tvir.2012.02.007. PMID: 22640503
Screening for chronic cerebrospinal venous insufficiency (CCSVI) using ultrasound--recommendations for a protocol.
Zamboni P, Morovic S, Menegatti E, Viselner G, Nicolaides AN
Int Angiol 2011 Dec;30(6):571-97. PMID: 22233619

Clinical prediction guides

Association between chronic cerebrospinal venous insufficiency and multiple sclerosis: a systematic review and meta-analysis.
Yang J, Zhang N, Ding C, He X, Li M, Meng W, Ouyang T
BMJ Open 2023 Jun 28;13(6):e072319. doi: 10.1136/bmjopen-2023-072319. PMID: 37380203Free PMC Article
Chronic cerebrospinal venous insufficiency and menière's disease: Interventional versus medical therapy.
Attanasio G, Califano L, Bruno A, Giugliano V, Ralli M, Martellucci S, Milella C, de Vincentiis M, Russo FY, Greco A
Laryngoscope 2020 Aug;130(8):2040-2046. Epub 2019 Nov 11 doi: 10.1002/lary.28389. PMID: 31710712
Chronic cerebrospinal venous insufficiency in Ménière disease.
Di Berardino F, Alpini DC, Bavera PM, Cecconi P, Farabola M, Mattei V, Ambrosetti U, Cesarani A
Phlebology 2015 May;30(4):274-9. Epub 2014 Mar 4 doi: 10.1177/0268355514526871. PMID: 24594584
Screening for chronic cerebrospinal venous insufficiency (CCSVI) using ultrasound--recommendations for a protocol.
Zamboni P, Morovic S, Menegatti E, Viselner G, Nicolaides AN
Int Angiol 2011 Dec;30(6):571-97. PMID: 22233619
The chronic cerebrospinal venous insufficiency syndrome.
Zamboni P, Galeotti R
Phlebology 2010 Dec;25(6):269-79. doi: 10.1258/phleb.2010.009083. PMID: 21106999

Recent systematic reviews

Association between chronic cerebrospinal venous insufficiency and multiple sclerosis: a systematic review and meta-analysis.
Yang J, Zhang N, Ding C, He X, Li M, Meng W, Ouyang T
BMJ Open 2023 Jun 28;13(6):e072319. doi: 10.1136/bmjopen-2023-072319. PMID: 37380203Free PMC Article
Percutaneous transluminal angioplasty for treatment of chronic cerebrospinal venous insufficiency (CCSVI) in people with multiple sclerosis.
Jagannath VA, Pucci E, Asokan GV, Robak EW
Cochrane Database Syst Rev 2019 May 31;5(5):CD009903. doi: 10.1002/14651858.CD009903.pub3. PMID: 31150100Free PMC Article
Percutaneous transluminal angioplasty for treatment of chronic cerebrospinal venous insufficiency in people with multiple sclerosis: a summary of a Cochrane systematic review.
van Zuuren EJ, Fedorowicz Z, Pucci E, Jagannath V, Robak EW
J Neurol Neurosurg Psychiatry 2014 Apr;85(4):405-10. Epub 2013 Jun 18 doi: 10.1136/jnnp-2013-305481. PMID: 23781006
Percutaneous transluminal angioplasty for treatment of chronic cerebrospinal venous insufficiency (CCSVI) in multiple sclerosis patients.
van Zuuren EJ, Fedorowicz Z, Pucci E, Jagannath VA, Robak EW
Cochrane Database Syst Rev 2012 Dec 12;12:CD009903. doi: 10.1002/14651858.CD009903.pub2. PMID: 23235683
Systematic review of sonographic chronic cerebrospinal venous insufficiency findings in multiple sclerosis.
Thapar A, Lane T, Nicholas R, Friede T, Ellis M, Assenheim J, Franklin IJ, Davies AH
Phlebology 2011 Dec;26(8):319-25. Epub 2011 Oct 23 doi: 10.1258/phleb.2011.011098. PMID: 22021635

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...