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Non-small cell squamous lung carcinoma

MedGen UID:
1383559
•Concept ID:
C4509816
•
Neoplastic Process
Synonyms: Lung Non-Small Cell Squamous Carcinoma; non-small cell squamous lung cancer; Non-Small Cell Squamous Lung Carcinoma; non-small cell squamous lung carcinoma; Squamous non-small cell lung cancer; Squamous Non-Small Cell Lung Carcinoma; squamous non-small cell lung carcinoma; Squamous NSCLC (non-small cell lung cancer)
SNOMED CT: Squamous non-small cell lung cancer (723301009); Squamous NSCLC (non-small cell lung cancer) (723301009)
 
Monarch Initiative: MONDO:0056806

Definition

A squamous cell carcinoma that arises from the lung. It is characterized by the presence of large malignant cells. It includes the clear cell and papillary variants of squamous cell carcinoma. [from NCI]

Professional guidelines

PubMed

Integration of rapid PCR testing as an adjunct to NGS in diagnostic pathology services within the UK: evidence from a case series of non-squamous, non-small cell lung cancer (NSCLC) patients with follow-up.
Finall A, Davies G, Jones T, Emlyn G, Huey P, Mullard A
J Clin Pathol 2023 Jun;76(6):391-399. Epub 2022 Jan 18 doi: 10.1136/jclinpath-2021-207987. PMID: 35042754

Recent clinical studies

Etiology

The necroptosis signature and molecular mechanism of lung squamous cell carcinoma.
Song GQ, Wu HM, Ji KJ, He TL, Duan YM, Zhang JW, Hu GQ
Aging (Albany NY) 2023 Nov 15;15(22):12907-12926. doi: 10.18632/aging.205210. PMID: 37976123Free PMC Article
Machine learning analysis of lung squamous cell carcinoma gene expression datasets reveals novel prognostic signatures.
Joon HK, Thalor A, Gupta D
Comput Biol Med 2023 Oct;165:107430. Epub 2023 Aug 29 doi: 10.1016/j.compbiomed.2023.107430. PMID: 37703712
Cemiplimab Plus Chemotherapy Versus Chemotherapy Alone in Advanced NSCLC: 2-Year Follow-Up From the Phase 3 EMPOWER-Lung 3 Part 2 Trial.
Makharadze T, Gogishvili M, Melkadze T, Baramidze A, Giorgadze D, Penkov K, Laktionov K, Nemsadze G, Nechaeva M, Rozhkova I, Kalinka E, Li S, Li Y, Kaul M, Quek RGW, Pouliot JF, Seebach F, Lowy I, Gullo G, Rietschel P
J Thorac Oncol 2023 Jun;18(6):755-768. Epub 2023 Mar 29 doi: 10.1016/j.jtho.2023.03.008. PMID: 37001859
Integrated analysis of single-cell and bulk RNA-sequencing identifies a signature based on T-cell marker genes to predict prognosis and therapeutic response in lung squamous cell carcinoma.
Shi X, Dong A, Jia X, Zheng G, Wang N, Wang Y, Yang C, Lu J, Yang Y
Front Immunol 2022;13:992990. Epub 2022 Oct 14 doi: 10.3389/fimmu.2022.992990. PMID: 36311764Free PMC Article
Nivolumab Plus Ipilimumab vs Nivolumab for Previously Treated Patients With Stage IV Squamous Cell Lung Cancer: The Lung-MAP S1400I Phase 3 Randomized Clinical Trial.
Gettinger SN, Redman MW, Bazhenova L, Hirsch FR, Mack PC, Schwartz LH, Bradley JD, Stinchcombe TE, Leighl NB, Ramalingam SS, Tavernier SS, Yu H, Unger JM, Minichiello K, Highleyman L, Papadimitrakopoulou VA, Kelly K, Gandara DR, Herbst RS
JAMA Oncol 2021 Sep 1;7(9):1368-1377. doi: 10.1001/jamaoncol.2021.2209. PMID: 34264316Free PMC Article

Diagnosis

Single-cell and spatial transcriptomics analysis of non-small cell lung cancer.
De Zuani M, Xue H, Park JS, Dentro SC, Seferbekova Z, Tessier J, Curras-Alonso S, Hadjipanayis A, Athanasiadis EI, Gerstung M, Bayraktar O, Cvejic A
Nat Commun 2024 May 23;15(1):4388. doi: 10.1038/s41467-024-48700-8. PMID: 38782901Free PMC Article
IASLC Lung Cancer Staging Project: The New Database to Inform Revisions in the Ninth Edition of the TNM Classification of Lung Cancer.
Asamura H, Nishimura KK, Giroux DJ, Chansky K, Hoering A, Rusch V, Rami-Porta R; Members of the IASLC Staging and Prognostic Factors Committee and of the Advisory Boards, and Participating Institutions
J Thorac Oncol 2023 May;18(5):564-575. Epub 2023 Feb 10 doi: 10.1016/j.jtho.2023.01.088. PMID: 36773775
Integrated analysis of single-cell and bulk RNA-sequencing identifies a signature based on T-cell marker genes to predict prognosis and therapeutic response in lung squamous cell carcinoma.
Shi X, Dong A, Jia X, Zheng G, Wang N, Wang Y, Yang C, Lu J, Yang Y
Front Immunol 2022;13:992990. Epub 2022 Oct 14 doi: 10.3389/fimmu.2022.992990. PMID: 36311764Free PMC Article
Can cytology reliably subtype non-small cell lung carcinomas?
Jain D, Bubendorf L
Cytopathology 2022 Jan;33(1):8-13. Epub 2021 Sep 21 doi: 10.1111/cyt.13056. PMID: 34494327
Progress and prospects of early detection in lung cancer.
Blandin Knight S, Crosbie PA, Balata H, Chudziak J, Hussell T, Dive C
Open Biol 2017 Sep;7(9) doi: 10.1098/rsob.170070. PMID: 28878044Free PMC Article

Therapy

Divergent tumor and immune cell reprogramming underlying immunotherapy response and immune-related adverse events in lung squamous cell carcinoma.
Chen M, Ma P, Zhang Y, Wang D, Yu Z, Fu Y, Zhao X, Wang M, Zhuang G, Jing Y
J Immunother Cancer 2023 Oct;11(10) doi: 10.1136/jitc-2023-007305. PMID: 37857527Free PMC Article
First-line cemiplimab monotherapy and continued cemiplimab beyond progression plus chemotherapy for advanced non-small-cell lung cancer with PD-L1 50% or more (EMPOWER-Lung 1): 35-month follow-up from a mutlicentre, open-label, randomised, phase 3 trial.
Özgüroğlu M, Kilickap S, Sezer A, Gümüş M, Bondarenko I, Gogishvili M, Nechaeva M, Schenker M, Cicin I, Ho GF, Kulyaba Y, Zyuhal K, Scheusan RI, Garassino MC, He X, Kaul M, Okoye E, Li Y, Li S, Pouliot JF, Seebach F, Lowy I, Gullo G, Rietschel P
Lancet Oncol 2023 Sep;24(9):989-1001. Epub 2023 Aug 14 doi: 10.1016/S1470-2045(23)00329-7. PMID: 37591293
Nivolumab Plus Ipilimumab vs Nivolumab for Previously Treated Patients With Stage IV Squamous Cell Lung Cancer: The Lung-MAP S1400I Phase 3 Randomized Clinical Trial.
Gettinger SN, Redman MW, Bazhenova L, Hirsch FR, Mack PC, Schwartz LH, Bradley JD, Stinchcombe TE, Leighl NB, Ramalingam SS, Tavernier SS, Yu H, Unger JM, Minichiello K, Highleyman L, Papadimitrakopoulou VA, Kelly K, Gandara DR, Herbst RS
JAMA Oncol 2021 Sep 1;7(9):1368-1377. doi: 10.1001/jamaoncol.2021.2209. PMID: 34264316Free PMC Article
Lung adenocarcinoma and lung squamous cell carcinoma cancer classification, biomarker identification, and gene expression analysis using overlapping feature selection methods.
Chen JW, Dhahbi J
Sci Rep 2021 Jun 25;11(1):13323. doi: 10.1038/s41598-021-92725-8. PMID: 34172784Free PMC Article
Lung Cancer Incidence and Mortality with Extended Follow-up in the National Lung Screening Trial.
National Lung Screening Trial Research Team
J Thorac Oncol 2019 Oct;14(10):1732-1742. Epub 2019 Jun 28 doi: 10.1016/j.jtho.2019.05.044. PMID: 31260833Free PMC Article

Prognosis

Cemiplimab Plus Chemotherapy Versus Chemotherapy Alone in Advanced NSCLC: 2-Year Follow-Up From the Phase 3 EMPOWER-Lung 3 Part 2 Trial.
Makharadze T, Gogishvili M, Melkadze T, Baramidze A, Giorgadze D, Penkov K, Laktionov K, Nemsadze G, Nechaeva M, Rozhkova I, Kalinka E, Li S, Li Y, Kaul M, Quek RGW, Pouliot JF, Seebach F, Lowy I, Gullo G, Rietschel P
J Thorac Oncol 2023 Jun;18(6):755-768. Epub 2023 Mar 29 doi: 10.1016/j.jtho.2023.03.008. PMID: 37001859
IASLC Lung Cancer Staging Project: The New Database to Inform Revisions in the Ninth Edition of the TNM Classification of Lung Cancer.
Asamura H, Nishimura KK, Giroux DJ, Chansky K, Hoering A, Rusch V, Rami-Porta R; Members of the IASLC Staging and Prognostic Factors Committee and of the Advisory Boards, and Participating Institutions
J Thorac Oncol 2023 May;18(5):564-575. Epub 2023 Feb 10 doi: 10.1016/j.jtho.2023.01.088. PMID: 36773775
Integrated analysis of single-cell and bulk RNA-sequencing identifies a signature based on T-cell marker genes to predict prognosis and therapeutic response in lung squamous cell carcinoma.
Shi X, Dong A, Jia X, Zheng G, Wang N, Wang Y, Yang C, Lu J, Yang Y
Front Immunol 2022;13:992990. Epub 2022 Oct 14 doi: 10.3389/fimmu.2022.992990. PMID: 36311764Free PMC Article
Lung adenocarcinoma and lung squamous cell carcinoma cancer classification, biomarker identification, and gene expression analysis using overlapping feature selection methods.
Chen JW, Dhahbi J
Sci Rep 2021 Jun 25;11(1):13323. doi: 10.1038/s41598-021-92725-8. PMID: 34172784Free PMC Article
Lung Cancer Incidence and Mortality with Extended Follow-up in the National Lung Screening Trial.
National Lung Screening Trial Research Team
J Thorac Oncol 2019 Oct;14(10):1732-1742. Epub 2019 Jun 28 doi: 10.1016/j.jtho.2019.05.044. PMID: 31260833Free PMC Article

Clinical prediction guides

Single-cell and spatial transcriptomics analysis of non-small cell lung cancer.
De Zuani M, Xue H, Park JS, Dentro SC, Seferbekova Z, Tessier J, Curras-Alonso S, Hadjipanayis A, Athanasiadis EI, Gerstung M, Bayraktar O, Cvejic A
Nat Commun 2024 May 23;15(1):4388. doi: 10.1038/s41467-024-48700-8. PMID: 38782901Free PMC Article
Tumor-immune microenvironment and NRF2 associate with clinical efficacy of PD-1 blockade combined with chemotherapy in lung squamous cell carcinoma.
Duan J, Zhang Y, Chen R, Liang L, Huo Y, Lu S, Zhao J, Hu C, Sun Y, Yang K, Chen M, Yu Y, Ying J, Huang R, Ma X, Leaw S, Bai F, Shen Z, Cai S, Gao D, Wang J, Wang Z
Cell Rep Med 2023 Dec 19;4(12):101302. Epub 2023 Dec 4 doi: 10.1016/j.xcrm.2023.101302. PMID: 38052215Free PMC Article
Divergent tumor and immune cell reprogramming underlying immunotherapy response and immune-related adverse events in lung squamous cell carcinoma.
Chen M, Ma P, Zhang Y, Wang D, Yu Z, Fu Y, Zhao X, Wang M, Zhuang G, Jing Y
J Immunother Cancer 2023 Oct;11(10) doi: 10.1136/jitc-2023-007305. PMID: 37857527Free PMC Article
Integrated analysis of single-cell and bulk RNA-sequencing identifies a signature based on T-cell marker genes to predict prognosis and therapeutic response in lung squamous cell carcinoma.
Shi X, Dong A, Jia X, Zheng G, Wang N, Wang Y, Yang C, Lu J, Yang Y
Front Immunol 2022;13:992990. Epub 2022 Oct 14 doi: 10.3389/fimmu.2022.992990. PMID: 36311764Free PMC Article
Nivolumab Plus Ipilimumab vs Nivolumab for Previously Treated Patients With Stage IV Squamous Cell Lung Cancer: The Lung-MAP S1400I Phase 3 Randomized Clinical Trial.
Gettinger SN, Redman MW, Bazhenova L, Hirsch FR, Mack PC, Schwartz LH, Bradley JD, Stinchcombe TE, Leighl NB, Ramalingam SS, Tavernier SS, Yu H, Unger JM, Minichiello K, Highleyman L, Papadimitrakopoulou VA, Kelly K, Gandara DR, Herbst RS
JAMA Oncol 2021 Sep 1;7(9):1368-1377. doi: 10.1001/jamaoncol.2021.2209. PMID: 34264316Free PMC Article

Recent systematic reviews

MET Exon 14 Skipping in NSCLC: A Systematic Literature Review of Epidemiology, Clinical Characteristics, and Outcomes.
Mazieres J, Vioix H, Pfeiffer BM, Campden RI, Chen Z, Heeg B, Cortot AB
Clin Lung Cancer 2023 Sep;24(6):483-497. Epub 2023 Jun 18 doi: 10.1016/j.cllc.2023.06.008. PMID: 37451931
Efficacy and safety of first-line checkpoint inhibitors-based treatments for non-oncogene-addicted non-small-cell lung cancer: a systematic review and meta-analysis.
Siciliano MA, Caridà G, Ciliberto D, d'Apolito M, Pelaia C, Caracciolo D, Riillo C, Correale P, Galvano A, Russo A, Barbieri V, Tassone P, Tagliaferri P
ESMO Open 2022 Jun;7(3):100465. Epub 2022 Apr 12 doi: 10.1016/j.esmoop.2022.100465. PMID: 35427835Free PMC Article
Comparison of the toxicity profile of PD-1 versus PD-L1 inhibitors in non-small cell lung cancer: A systematic analysis of the literature.
Pillai RN, Behera M, Owonikoko TK, Kamphorst AO, Pakkala S, Belani CP, Khuri FR, Ahmed R, Ramalingam SS
Cancer 2018 Jan 15;124(2):271-277. Epub 2017 Sep 28 doi: 10.1002/cncr.31043. PMID: 28960263Free PMC Article
Comparison of gefitinib, erlotinib and afatinib in non-small cell lung cancer: A meta-analysis.
Yang Z, Hackshaw A, Feng Q, Fu X, Zhang Y, Mao C, Tang J
Int J Cancer 2017 Jun 15;140(12):2805-2819. Epub 2017 Mar 27 doi: 10.1002/ijc.30691. PMID: 28295308
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

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