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Insulin receptor antibody positivity

MedGen UID:
1379583
•Concept ID:
C4476973
•
Laboratory or Test Result
HPO: HP:0031104

Definition

The presence of autoantibodies (immunoglobulins) in the serum that react against the insulin receptor. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInsulin receptor antibody positivity

Professional guidelines

PubMed

Childhood screening for type 1 diabetes comparing automated multiplex Antibody Detection by Agglutination-PCR (ADAP) with single plex islet autoantibody radiobinding assays.
Lind A, Freyhult E, de Jesus Cortez F, Ramelius A, Bennet R, Robinson PV, Seftel D, Gebhart D, Tandel D, Maziarz M, Larsson HE, Lundgren M, Carlsson A, Nilsson AL, Fex M, Törn C, Agardh D, Tsai CT, Lernmark Å; Better Diabetes Diagnosis (BDD) study group
EBioMedicine 2024 Jun;104:105144. Epub 2024 May 8 doi: 10.1016/j.ebiom.2024.105144. PMID: 38723553Free PMC Article
Dulaglutide for the treatment of type 2 diabetes.
Scheen AJ
Expert Opin Biol Ther 2017 Apr;17(4):485-496. Epub 2017 Feb 28 doi: 10.1080/14712598.2017.1296131. PMID: 28274140
Albiglutide for the treatment of type 2 diabetes.
Muscogiuri G, Gastaldelli A
Drugs Today (Barc) 2014 Oct;50(10):665-78. doi: 10.1358/dot.2014.50.10.2214156. PMID: 25374965

Recent systematic reviews

PD-1 inhibitor-associated type 1 diabetes: A case report and systematic review.
Lin C, Li X, Qiu Y, Chen Z, Liu J
Front Public Health 2022;10:885001. Epub 2022 Aug 5 doi: 10.3389/fpubh.2022.885001. PMID: 35991054Free PMC Article
Type B insulin resistance syndrome: a systematic review.
Martins LM, Fernandes VO, Carvalho MMD, Gadelha DD, Queiroz PC, Montenegro Junior RM
Arch Endocrinol Metab 2020 Aug;64(4):337-348. Epub 2020 Jun 5 doi: 10.20945/2359-3997000000257. PMID: 32813762Free PMC Article

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