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Decreased circulating inhibin B concentration

MedGen UID:: 1392759
•Concept ID:: C4476969
•: Finding

Synonym:	Decreased inhibin B level

HPO:	HP:0031100

Definition

The concentration of inhibin B in the blood circulation is below the lower limit of normal. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVDecreased circulating inhibin B concentration

Phenotypic abnormality
- Abnormality of the endocrine system
  - Abnormal circulating hormone concentration
    - Abnormal circulating inhibin level
      - Abnormal circulating inhibin B concentration
        Decreased circulating inhibin B concentration

Conditions with this feature

Premature ovarian failure 17

MedGen UID:: 1748767
•Concept ID:: C5436889
•: Disease or Syndrome

Premature ovarian failure-17 (POF17) is characterized by early cessation of menses after initial menarche, with small ovaries and uterus (Zhang et al., 2019). For a discussion of genetic heterogeneity of premature ovarian failure, see POF1 (311360).

See: Condition Record

Premature ovarian failure 17

Professional guidelines

PubMed

Serum INSL3 measured by LC-MS/MS in pubertal girls and in girls with precocious puberty during GnRH agonist treatment.

Albrethsen J, Hagen CP, Juul A
Front Endocrinol (Lausanne) 2024;15:1404320. Epub 2024 Jul 1 doi: 10.3389/fendo.2024.1404320. PMID: 39010900 Free PMC Article

See all (1)

Recent clinical studies

Etiology

Effects of Metabolic Syndrome on Semen Quality and Circulating Sex Hormones: A Systematic Review and Meta-Analysis.

Zhao L, Pang A
Front Endocrinol (Lausanne) 2020;11:428. Epub 2020 Aug 11 doi: 10.3389/fendo.2020.00428. PMID: 32849258 Free PMC Article

The biological aspects of risks of infertility due to age: the female side.

Gougeon A
Rev Epidemiol Sante Publique 2005 Nov;53 Spec No 2:2S37-45. PMID: 16471143

Decreased serum inhibin B/FSH ratio as a marker of Sertoli cell function in male survivors after chemotherapy in childhood and adolescence.

Bordallo MA, Guimarães MM, Pessoa CH, Carriço MK, Dimetz T, Gazolla HM, Dobbin J, Castilho IA
J Pediatr Endocrinol Metab 2004 Jun;17(6):879-87. doi: 10.1515/jpem.2004.17.6.879. PMID: 15270406

Inhibin B, follicle stimulating hormone, luteinizing hormone and testosterone during childhood and puberty in males: changes in serum concentrations in relation to age and stage of puberty.

Chada M, Průsa R, Bronský J, Kotaska K, Sídlová K, Pechová M, Lisá L
Physiol Res 2003;52(1):45-51. PMID: 12625806

Serum inhibin A, inhibin B, and pro-alphaC levels are altered after surgically or pharmacologically induced menopause.

Cobellis L, Luisi S, Pezzani I, Reis FM, De Leo V, Petraglia F
Fertil Steril 2002 Apr;77(4):745-9. doi: 10.1016/s0015-0282(01)03234-4. PMID: 11937127

See all (13)

Diagnosis

Lack of Improvement of Sperm Characteristics in Obese Males After Obesity Surgery Despite the Beneficial Changes Observed in Reproductive Hormones.

Calderón B, Huerta L, Galindo J, González Casbas JM, Escobar-Morreale HF, Martín-Hidalgo A, Botella-Carretero JI
Obes Surg 2019 Jul;29(7):2045-2050. doi: 10.1007/s11695-019-03798-4. PMID: 30806913

Phthalates might interfere with testicular function by reducing testosterone and insulin-like factor 3 levels.

Chang WH, Li SS, Wu MH, Pan HA, Lee CC
Hum Reprod 2015 Nov;30(11):2658-70. Epub 2015 Sep 18 doi: 10.1093/humrep/dev225. PMID: 26385792

Inhibin B in male reproduction: pathophysiology and clinical relevance.

Meachem SJ, Nieschlag E, Simoni M
Eur J Endocrinol 2001 Nov;145(5):561-71. doi: 10.1530/eje.0.1450561. PMID: 11720872

Serum inhibins A and B fall differentially as FSH rises in perimenopausal women.

Burger HG, Cahir N, Robertson DM, Groome NP, Dudley E, Green A, Dennerstein L
Clin Endocrinol (Oxf) 1998 Jun;48(6):809-13. doi: 10.1046/j.1365-2265.1998.00482.x. PMID: 9713572

Regulation of biologically active dimeric inhibin A and B from infancy to adulthood in the male.

Byrd W, Bennett MJ, Carr BR, Dong Y, Wians F, Rainey W
J Clin Endocrinol Metab 1998 Aug;83(8):2849-54. doi: 10.1210/jcem.83.8.5008. PMID: 9709958

See all (7)

Therapy

Effects of Metabolic Syndrome on Semen Quality and Circulating Sex Hormones: A Systematic Review and Meta-Analysis.

Zhao L, Pang A
Front Endocrinol (Lausanne) 2020;11:428. Epub 2020 Aug 11 doi: 10.3389/fendo.2020.00428. PMID: 32849258 Free PMC Article

Decreased serum inhibin B/FSH ratio as a marker of Sertoli cell function in male survivors after chemotherapy in childhood and adolescence.

Bordallo MA, Guimarães MM, Pessoa CH, Carriço MK, Dimetz T, Gazolla HM, Dobbin J, Castilho IA
J Pediatr Endocrinol Metab 2004 Jun;17(6):879-87. doi: 10.1515/jpem.2004.17.6.879. PMID: 15270406

Sex differences in FSH-regulatory peptides in pubertal age boys and girls and effects of sex steroid treatment.

Foster CM, Olton PR, Racine MS, Phillips DJ, Padmanabhan V
Hum Reprod 2004 Jul;19(7):1668-76. Epub 2004 May 20 doi: 10.1093/humrep/deh284. PMID: 15155605

Serum inhibin A, inhibin B, and pro-alphaC levels are altered after surgically or pharmacologically induced menopause.

Cobellis L, Luisi S, Pezzani I, Reis FM, De Leo V, Petraglia F
Fertil Steril 2002 Apr;77(4):745-9. doi: 10.1016/s0015-0282(01)03234-4. PMID: 11937127

Serum inhibins A and B fall differentially as FSH rises in perimenopausal women.

Burger HG, Cahir N, Robertson DM, Groome NP, Dudley E, Green A, Dennerstein L
Clin Endocrinol (Oxf) 1998 Jun;48(6):809-13. doi: 10.1046/j.1365-2265.1998.00482.x. PMID: 9713572

See all (6)

Prognosis

Lack of Improvement of Sperm Characteristics in Obese Males After Obesity Surgery Despite the Beneficial Changes Observed in Reproductive Hormones.

Calderón B, Huerta L, Galindo J, González Casbas JM, Escobar-Morreale HF, Martín-Hidalgo A, Botella-Carretero JI
Obes Surg 2019 Jul;29(7):2045-2050. doi: 10.1007/s11695-019-03798-4. PMID: 30806913

The biological aspects of risks of infertility due to age: the female side.

Gougeon A
Rev Epidemiol Sante Publique 2005 Nov;53 Spec No 2:2S37-45. PMID: 16471143

Decreased serum inhibin B/FSH ratio as a marker of Sertoli cell function in male survivors after chemotherapy in childhood and adolescence.

Bordallo MA, Guimarães MM, Pessoa CH, Carriço MK, Dimetz T, Gazolla HM, Dobbin J, Castilho IA
J Pediatr Endocrinol Metab 2004 Jun;17(6):879-87. doi: 10.1515/jpem.2004.17.6.879. PMID: 15270406

Serum inhibin A, inhibin B, and pro-alphaC levels are altered after surgically or pharmacologically induced menopause.

Cobellis L, Luisi S, Pezzani I, Reis FM, De Leo V, Petraglia F
Fertil Steril 2002 Apr;77(4):745-9. doi: 10.1016/s0015-0282(01)03234-4. PMID: 11937127

Inhibin B in male reproduction: pathophysiology and clinical relevance.

Meachem SJ, Nieschlag E, Simoni M
Eur J Endocrinol 2001 Nov;145(5):561-71. doi: 10.1530/eje.0.1450561. PMID: 11720872

See all (7)

Clinical prediction guides

The biological aspects of risks of infertility due to age: the female side.

Gougeon A
Rev Epidemiol Sante Publique 2005 Nov;53 Spec No 2:2S37-45. PMID: 16471143

Decreased serum inhibin B/FSH ratio as a marker of Sertoli cell function in male survivors after chemotherapy in childhood and adolescence.

Bordallo MA, Guimarães MM, Pessoa CH, Carriço MK, Dimetz T, Gazolla HM, Dobbin J, Castilho IA
J Pediatr Endocrinol Metab 2004 Jun;17(6):879-87. doi: 10.1515/jpem.2004.17.6.879. PMID: 15270406

Serum inhibin A, inhibin B, and pro-alphaC levels are altered after surgically or pharmacologically induced menopause.

Cobellis L, Luisi S, Pezzani I, Reis FM, De Leo V, Petraglia F
Fertil Steril 2002 Apr;77(4):745-9. doi: 10.1016/s0015-0282(01)03234-4. PMID: 11937127

Inhibin B in male reproduction: pathophysiology and clinical relevance.

Meachem SJ, Nieschlag E, Simoni M
Eur J Endocrinol 2001 Nov;145(5):561-71. doi: 10.1530/eje.0.1450561. PMID: 11720872

Role of inhibins in childhood and puberty.

Bergadá I, Bergadá C, Campo S
J Pediatr Endocrinol Metab 2001 Apr;14(4):343-53. doi: 10.1515/jpem.2001.14.4.343. PMID: 11327369

See all (14)