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Decreased CSF protein concentration

MedGen UID:
1387378
Concept ID:
C4476790
Finding
Synonym: Decreased CSF total protein
 
HPO: HP:0025457

Definition

CSF total protein level is below the lower limit of normal. [from HPO]

Term Hierarchy

Professional guidelines

PubMed

Ogasahara S, Nishikawa Y, Yorifuji S, Soga F, Nakamura Y, Takahashi M, Hashimoto S, Kono N, Tarui S
Neurology 1986 Jan;36(1):45-53. doi: 10.1212/wnl.36.1.45. PMID: 3941783

Recent clinical studies

Etiology

Sabatelli M, Cerri F, Zuccarino R, Patanella AK, Bernardo D, Bisogni G, Tanel R, Sansone V, Filosto M, Lattante S, Martello F, Doronzio PN, Stano S, Zanfini BA, Coccia M, Costantini EM, Lizio A, Lucioli G, Padovani A, Merlini GP, Conte A
J Neurol 2024 Aug;271(8):5177-5186. Epub 2024 Jun 3 doi: 10.1007/s00415-024-12437-7. PMID: 38829431
Barba L, Abu-Rumeileh S, Halbgebauer S, Bellomo G, Paolini Paoletti F, Gaetani L, Oeckl P, Steinacker P, Massa F, Parnetti L, Otto M
Neurology 2023 Jul 4;101(1):e50-e62. Epub 2023 May 15 doi: 10.1212/WNL.0000000000207371. PMID: 37188538Free PMC Article
Hua F, Zhu H, Yu W, Zheng Q, Zhang L, Liang W, Lin Y, Xiao F, Yi P, Xiong Y, Dong Y, Li H, Fang L, Liu H, Ying J, Wang X
J Neuroinflammation 2023 May 11;20(1):113. doi: 10.1186/s12974-023-02794-x. PMID: 37170230Free PMC Article
Lewczuk P, Łukaszewicz-Zając M, Mroczko P, Kornhuber J
Pharmacol Rep 2020 Jun;72(3):528-542. Epub 2020 May 8 doi: 10.1007/s43440-020-00107-0. PMID: 32385624Free PMC Article
Hyland K, Shoffner J, Heales SJ
J Inherit Metab Dis 2010 Oct;33(5):563-70. Epub 2010 Jul 29 doi: 10.1007/s10545-010-9159-6. PMID: 20668945

Diagnosis

Barba L, Abu-Rumeileh S, Halbgebauer S, Bellomo G, Paolini Paoletti F, Gaetani L, Oeckl P, Steinacker P, Massa F, Parnetti L, Otto M
Neurology 2023 Jul 4;101(1):e50-e62. Epub 2023 May 15 doi: 10.1212/WNL.0000000000207371. PMID: 37188538Free PMC Article
Okuyama T, Eto Y, Sakai N, Nakamura K, Yamamoto T, Yamaoka M, Ikeda T, So S, Tanizawa K, Sonoda H, Sato Y
Mol Ther 2021 Feb 3;29(2):671-679. Epub 2020 Sep 30 doi: 10.1016/j.ymthe.2020.09.039. PMID: 33038326Free PMC Article
Lewczuk P, Łukaszewicz-Zając M, Mroczko P, Kornhuber J
Pharmacol Rep 2020 Jun;72(3):528-542. Epub 2020 May 8 doi: 10.1007/s43440-020-00107-0. PMID: 32385624Free PMC Article
Schmid C, Neidert MC, Tschopp O, Sze L, Bernays RL
J Endocrinol 2013 Nov;219(2):R37-57. Epub 2013 Nov 1 doi: 10.1530/JOE-13-0285. PMID: 24096965
Hyland K, Shoffner J, Heales SJ
J Inherit Metab Dis 2010 Oct;33(5):563-70. Epub 2010 Jul 29 doi: 10.1007/s10545-010-9159-6. PMID: 20668945

Therapy

Morenas-Rodríguez E, Li Y, Nuscher B, Franzmeier N, Xiong C, Suárez-Calvet M, Fagan AM, Schultz S, Gordon BA, Benzinger TLS, Hassenstab J, McDade E, Feederle R, Karch CM, Schlepckow K, Morris JC, Kleinberger G, Nellgard B, Vöglein J, Blennow K, Zetterberg H, Ewers M, Jucker M, Levin J, Bateman RJ, Haass C; Dominantly Inherited Alzheimer Network
Lancet Neurol 2022 Apr;21(4):329-341. doi: 10.1016/S1474-4422(22)00027-8. PMID: 35305339Free PMC Article
Miller T, Cudkowicz M, Shaw PJ, Andersen PM, Atassi N, Bucelli RC, Genge A, Glass J, Ladha S, Ludolph AL, Maragakis NJ, McDermott CJ, Pestronk A, Ravits J, Salachas F, Trudell R, Van Damme P, Zinman L, Bennett CF, Lane R, Sandrock A, Runz H, Graham D, Houshyar H, McCampbell A, Nestorov I, Chang I, McNeill M, Fanning L, Fradette S, Ferguson TA
N Engl J Med 2020 Jul 9;383(2):109-119. doi: 10.1056/NEJMoa2003715. PMID: 32640130
Mullin S, Smith L, Lee K, D'Souza G, Woodgate P, Elflein J, Hällqvist J, Toffoli M, Streeter A, Hosking J, Heywood WE, Khengar R, Campbell P, Hehir J, Cable S, Mills K, Zetterberg H, Limousin P, Libri V, Foltynie T, Schapira AHV
JAMA Neurol 2020 Apr 1;77(4):427-434. doi: 10.1001/jamaneurol.2019.4611. PMID: 31930374Free PMC Article
Yang BB, Kido A
Clin Pharmacokinet 2011 May;50(5):295-306. doi: 10.2165/11586040-000000000-00000. PMID: 21456630
Hyland K, Shoffner J, Heales SJ
J Inherit Metab Dis 2010 Oct;33(5):563-70. Epub 2010 Jul 29 doi: 10.1007/s10545-010-9159-6. PMID: 20668945

Prognosis

Sabatelli M, Cerri F, Zuccarino R, Patanella AK, Bernardo D, Bisogni G, Tanel R, Sansone V, Filosto M, Lattante S, Martello F, Doronzio PN, Stano S, Zanfini BA, Coccia M, Costantini EM, Lizio A, Lucioli G, Padovani A, Merlini GP, Conte A
J Neurol 2024 Aug;271(8):5177-5186. Epub 2024 Jun 3 doi: 10.1007/s00415-024-12437-7. PMID: 38829431
Morenas-Rodríguez E, Li Y, Nuscher B, Franzmeier N, Xiong C, Suárez-Calvet M, Fagan AM, Schultz S, Gordon BA, Benzinger TLS, Hassenstab J, McDade E, Feederle R, Karch CM, Schlepckow K, Morris JC, Kleinberger G, Nellgard B, Vöglein J, Blennow K, Zetterberg H, Ewers M, Jucker M, Levin J, Bateman RJ, Haass C; Dominantly Inherited Alzheimer Network
Lancet Neurol 2022 Apr;21(4):329-341. doi: 10.1016/S1474-4422(22)00027-8. PMID: 35305339Free PMC Article
Lewczuk P, Łukaszewicz-Zając M, Mroczko P, Kornhuber J
Pharmacol Rep 2020 Jun;72(3):528-542. Epub 2020 May 8 doi: 10.1007/s43440-020-00107-0. PMID: 32385624Free PMC Article
Patel G, Greenberger PA
Allergy Asthma Proc 2019 Nov 1;40(6):421-424. doi: 10.2500/aap.2019.40.4262. PMID: 31690385
Yang BB, Kido A
Clin Pharmacokinet 2011 May;50(5):295-306. doi: 10.2165/11586040-000000000-00000. PMID: 21456630

Clinical prediction guides

Sabatelli M, Cerri F, Zuccarino R, Patanella AK, Bernardo D, Bisogni G, Tanel R, Sansone V, Filosto M, Lattante S, Martello F, Doronzio PN, Stano S, Zanfini BA, Coccia M, Costantini EM, Lizio A, Lucioli G, Padovani A, Merlini GP, Conte A
J Neurol 2024 Aug;271(8):5177-5186. Epub 2024 Jun 3 doi: 10.1007/s00415-024-12437-7. PMID: 38829431
Bellomo G, Paciotti S, Concha-Marambio L, Rizzo D, Wojdaƚa AL, Chiasserini D, Gatticchi L, Cerofolini L, Giuntini S, De Luca CMG, Ma Y, Farris CM, Pieraccini G, Bologna S, Filidei M, Ravera E, Lelli M, Moda F, Fragai M, Parnetti L, Luchinat C
Mol Neurodegener 2023 Apr 1;18(1):20. doi: 10.1186/s13024-023-00613-8. PMID: 37005644Free PMC Article
Piazza F, Caminiti SP, Zedde M, Presotto L, DiFrancesco JC, Pascarella R, Giossi A, Sessa M, Poli L, Basso G, Perani D
Neurology 2022 Sep 20;99(12):e1265-e1277. Epub 2022 Aug 8 doi: 10.1212/WNL.0000000000200892. PMID: 35940900Free PMC Article
Morenas-Rodríguez E, Li Y, Nuscher B, Franzmeier N, Xiong C, Suárez-Calvet M, Fagan AM, Schultz S, Gordon BA, Benzinger TLS, Hassenstab J, McDade E, Feederle R, Karch CM, Schlepckow K, Morris JC, Kleinberger G, Nellgard B, Vöglein J, Blennow K, Zetterberg H, Ewers M, Jucker M, Levin J, Bateman RJ, Haass C; Dominantly Inherited Alzheimer Network
Lancet Neurol 2022 Apr;21(4):329-341. doi: 10.1016/S1474-4422(22)00027-8. PMID: 35305339Free PMC Article
Yang BB, Kido A
Clin Pharmacokinet 2011 May;50(5):295-306. doi: 10.2165/11586040-000000000-00000. PMID: 21456630

Recent systematic reviews

Agah E, Mojtabavi H, Behkar A, Heidari A, Ajdari A, Shaka Z, Mousavi SV, Firoozeh N, Tafakhori A, Rezaei N
J Transl Med 2024 Oct 21;22(1):953. doi: 10.1186/s12967-024-05767-7. PMID: 39434139Free PMC Article
Saghazadeh A, Rezaei N
J Interferon Cytokine Res 2022 Mar;42(3):95-107. doi: 10.1089/jir.2021.0176. PMID: 35298290
Jiménez-Jiménez FJ, Alonso-Navarro H, García-Martín E, Agúndez JAG
Eur J Neurol 2021 Mar;28(3):1041-1055. Epub 2020 Dec 1 doi: 10.1111/ene.14607. PMID: 33098743
Reddy VS, Bukke S, Dutt N, Rana P, Pandey AK
J Trace Elem Med Biol 2017 Jul;42:68-75. Epub 2017 Apr 23 doi: 10.1016/j.jtemb.2017.04.005. PMID: 28595794
van Dongen RM, Zielman R, Noga M, Dekkers OM, Hankemeier T, van den Maagdenberg AM, Terwindt GM, Ferrari MD
Cephalalgia 2017 Jan;37(1):49-63. Epub 2016 Sep 30 doi: 10.1177/0333102415625614. PMID: 26888294

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