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Medulloblastoma non-WNT/non-SHH

MedGen UID:
1387799
•Concept ID:
C4330667
•
Neoplastic Process
Synonyms: medulloblastoma non-WNT/non-SHH; Medulloblastoma, Non-WNT/Non-SHH
 
Monarch Initiative: MONDO:0850198

Definition

Medulloblastoma not associated with activation of the WNT pathway or sonic hedgehog (SHH) pathway. TP53 mutations are absent. This molecular subtype includes medulloblastomas numerically designated as ""group 3"" and ""group 4"". [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMedulloblastoma non-WNT/non-SHH

Professional guidelines

PubMed

Genetic Markers as Predictors for Response to Treatment and Possible Therapeutic Targets in Medulloblastoma.
Pérez-Pineda PL, Ortiz-Butrón R, Pérez-De Marcos JC, Hernández-Regino LM, Zapata-Tarrés MM, Torres-Espíndola LM
CNS Neurol Disord Drug Targets 2023;22(5):634-642. doi: 10.2174/1871527321666220509141030. PMID: 35579144

Recent clinical studies

Therapy

Clinicomorphological and molecular analysis of medulloblastoma and association with survival: A single tertiary care center experience.
Badiger S, Gudipati A, Uppin M, Konatam ML, Yeramneni VK, Bhattacharjee S, Saradhi MV, Patnaik S, Irukulla M
J Cancer Res Ther 2023 Jan 1;19(Suppl 2):S592-S602. Epub 2023 Apr 29 doi: 10.4103/jcrt.jcrt_1268_22. PMID: 38384024
Combination of PARP and WEE1 inhibitors in vitro: Potential for use in the treatment of SHH medulloblastoma.
Lukoseviciute M, Theodosopoulou A, Holzhauser S, Dalianis T, Kostopoulou ON
Oncol Rep 2023 Jun;49(6) Epub 2023 May 5 doi: 10.3892/or.2023.8562. PMID: 37144508Free PMC Article
Exclusive Hyperfractionated Radiation Therapy and Reduced Boost Volume for Standard-Risk Medulloblastoma: Pooled Analysis of the 2 French Multicentric Studies MSFOP98 and MSFOP 2007 and Correlation With Molecular Subgroups.
Carrie C, Kieffer V, Figarella-Branger D, Masliah-Planchon J, Bolle S, Bernier V, Laprie A, Supiot S, Leseur J, Habrand JL, Alapetite C, Kerr C, Dufour C, Claude L, Chapet S, Huchet A, Bondiau PY, Escande A, Truc G, Nguyen TD, Pasteuris C, Vigneron C, Muracciole X, Bourdeaut F, Appay R, Dubray B, Colin C, Ferlay C, Dussart S, Chabaud S, Padovani L; French Group of Pediatric Radiotherapy (GFRP); French Society of Pediatric Cancers (SFCE)
Int J Radiat Oncol Biol Phys 2020 Dec 1;108(5):1204-1217. Epub 2020 Aug 6 doi: 10.1016/j.ijrobp.2020.07.2324. PMID: 32768563
Association of Aggresomes with Survival Outcomes in Pediatric Medulloblastoma.
Yehia M, Taha H, Salama A, Amer N, Mosaab A, Hassanain O, Refaat A, Yassin D, El-Hemaly A, Ahmed S, El-Beltagy M, Shaalan O, El-Naggar S
Sci Rep 2019 Aug 30;9(1):12605. doi: 10.1038/s41598-019-49027-x. PMID: 31471537Free PMC Article
Molecular pathology of tumors of the central nervous system.
Kristensen BW, Priesterbach-Ackley LP, Petersen JK, Wesseling P
Ann Oncol 2019 Aug 1;30(8):1265-1278. doi: 10.1093/annonc/mdz164. PMID: 31124566Free PMC Article

Prognosis

Primary microcephaly gene CENPE is a novel biomarker and potential therapeutic target for non-WNT/non-SHH medulloblastoma.
Fang H, Zhang Y, Lin C, Sun Z, Wen W, Sheng H, Lin J
Front Immunol 2023;14:1227143. Epub 2023 Aug 1 doi: 10.3389/fimmu.2023.1227143. PMID: 37593739Free PMC Article
Transcriptome analysis stratifies second-generation non-WNT/non-SHH medulloblastoma subgroups into clinically tractable subtypes.
Korshunov A, Okonechnikov K, Schrimpf D, Tonn S, Mynarek M, Koster J, Sievers P, Milde T, Sahm F, Jones DTW, von Deimling A, Pfister SM, Kool M
Acta Neuropathol 2023 Jun;145(6):829-842. Epub 2023 Apr 24 doi: 10.1007/s00401-023-02575-z. PMID: 37093271
Timing is everything: A connection between medulloblastoma prognosis and foetal cerebellar development.
Williamson D, Schwalbe EC, Bailey S, Clifford SC
Neuropathol Appl Neurobiol 2023 Jun;49(3):e12903. doi: 10.1111/nan.12903. PMID: 37021628Free PMC Article
Molecular Stratification of Medulloblastoma: Clinical Outcomes and Therapeutic Interventions.
Sursal T, Ronecker JS, Dicpinigaitis AJ, Mohan AL, Tobias ME, Gandhi CD, Jhanwar-Uniyal M
Anticancer Res 2022 May;42(5):2225-2239. doi: 10.21873/anticanres.15703. PMID: 35489737
Molecular pathology of tumors of the central nervous system.
Kristensen BW, Priesterbach-Ackley LP, Petersen JK, Wesseling P
Ann Oncol 2019 Aug 1;30(8):1265-1278. doi: 10.1093/annonc/mdz164. PMID: 31124566Free PMC Article

Clinical prediction guides

Clinicomorphological and molecular analysis of medulloblastoma and association with survival: A single tertiary care center experience.
Badiger S, Gudipati A, Uppin M, Konatam ML, Yeramneni VK, Bhattacharjee S, Saradhi MV, Patnaik S, Irukulla M
J Cancer Res Ther 2023 Jan 1;19(Suppl 2):S592-S602. Epub 2023 Apr 29 doi: 10.4103/jcrt.jcrt_1268_22. PMID: 38384024
Transcriptome analysis stratifies second-generation non-WNT/non-SHH medulloblastoma subgroups into clinically tractable subtypes.
Korshunov A, Okonechnikov K, Schrimpf D, Tonn S, Mynarek M, Koster J, Sievers P, Milde T, Sahm F, Jones DTW, von Deimling A, Pfister SM, Kool M
Acta Neuropathol 2023 Jun;145(6):829-842. Epub 2023 Apr 24 doi: 10.1007/s00401-023-02575-z. PMID: 37093271
Timing is everything: A connection between medulloblastoma prognosis and foetal cerebellar development.
Williamson D, Schwalbe EC, Bailey S, Clifford SC
Neuropathol Appl Neurobiol 2023 Jun;49(3):e12903. doi: 10.1111/nan.12903. PMID: 37021628Free PMC Article
Molecular characterisation defines clinically-actionable heterogeneity within Group 4 medulloblastoma and improves disease risk-stratification.
Goddard J, Castle J, Southworth E, Fletcher A, Crosier S, Martin-Guerrero I, García-Ariza M, Navajas A, Masliah-Planchon J, Bourdeaut F, Dufour C, Ayrault O, Goschzik T, Pietsch T, Sill M, Pfister SM, Rutkowski S, Richardson S, Hill RM, Williamson D, Bailey S, Schwalbe EC, Clifford SC, Hicks D
Acta Neuropathol 2023 May;145(5):651-666. Epub 2023 Apr 4 doi: 10.1007/s00401-023-02566-0. PMID: 37014508Free PMC Article
Clinically Tractable Outcome Prediction of Non-WNT/Non-SHH Medulloblastoma Based on TPD52 IHC in a Multicohort Study.
Delaidelli A, Dunham C, Santi M, Negri GL, Triscott J, Zheludkova O, Golanov A, Ryzhova M, Okonechnikov K, Schrimpf D, Stichel D, Ellison DW, von Deimling A, Kool M, Pfister SM, Ramaswamy V, Korshunov A, Taylor MD, Sorensen PH
Clin Cancer Res 2022 Jan 1;28(1):116-128. Epub 2021 Oct 26 doi: 10.1158/1078-0432.CCR-21-2057. PMID: 34702771

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