U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gluten intolerance

MedGen UID:
1370572
•Concept ID:
C4317045
•
Disease or Syndrome
Synonym: Gluten sensitivity
SNOMED CT: Gluten intolerance (1269424006)
 
HPO: HP:0012538

Definition

A detrimental reaction to the presence of gluten in food, which may include abdominal pain, fatigue, headaches and paresthesia, or celiac disease. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGluten intolerance

Professional guidelines

PubMed

Advances in understanding and managing celiac disease: Pathophysiology and treatment strategies.
Ge HJ, Chen XL
World J Gastroenterol 2024 Sep 21;30(35):3932-3941. doi: 10.3748/wjg.v30.i35.3932. PMID: 39351055Free PMC Article
THE MANAGEMENT OF DERMATITIS HERPETIFORMIS BY THE GASTROENTEROLOGIST. A SERIES OF CASES.
Kotze LMDS, Kotze LR, Purim KSM, Nisihara R
Arq Gastroenterol 2021 Oct-Dec;58(4):429-432. doi: 10.1590/S0004-2803.202100000-78. PMID: 34909845
Probiotic: effectiveness nutrition in cancer treatment and prevention.
Kich DM, Vincenzi A, Majolo F, Volken de Souza CF, Goettert MI
Nutr Hosp 2016 Nov 29;33(6):1430-1437. doi: 10.20960/nh.806. PMID: 28000477

Recent clinical studies

Therapy

Manipulation of the gut microbiome in gluten-intolerance.
Olivares M, Flor-Duro A, Sanz Y
Curr Opin Clin Nutr Metab Care 2021 Nov 1;24(6):536-542. doi: 10.1097/MCO.0000000000000791. PMID: 34622826
Properties of Gluten Intolerance: Gluten Structure, Evolution, Pathogenicity and Detoxification Capabilities.
Balakireva AV, Zamyatnin AA
Nutrients 2016 Oct 18;8(10) doi: 10.3390/nu8100644. PMID: 27763541Free PMC Article
Microbiome and Gluten.
Sanz Y
Ann Nutr Metab 2015;67 Suppl 2:28-41. Epub 2015 Nov 26 doi: 10.1159/000440991. PMID: 26605783
The Oslo definitions for coeliac disease and related terms.
Ludvigsson JF, Leffler DA, Bai JC, Biagi F, Fasano A, Green PH, Hadjivassiliou M, Kaukinen K, Kelly CP, Leonard JN, Lundin KE, Murray JA, Sanders DS, Walker MM, Zingone F, Ciacci C
Gut 2013 Jan;62(1):43-52. Epub 2012 Feb 16 doi: 10.1136/gutjnl-2011-301346. PMID: 22345659Free PMC Article
Coeliac disease.
Leeds JS, Hopper AD, Sanders DS
Br Med Bull 2008;88(1):157-70. Epub 2008 Dec 10 doi: 10.1093/bmb/ldn044. PMID: 19073695

Prognosis

Discontinuing semaglutide after weight loss: strategy for weight maintenance and a possible new side effect.
Carris NW, Wallace S, DuCoin CG, Mhaskar R, Stern M, Bunnell B
Can J Physiol Pharmacol 2024 Jun 1;102(6):391-395. Epub 2024 Apr 8 doi: 10.1139/cjpp-2023-0464. PMID: 38587178
Dermatitis herpetiformis: a cutaneous manifestation of coeliac disease.
Collin P, Salmi TT, Hervonen K, Kaukinen K, Reunala T
Ann Med 2017 Feb;49(1):23-31. Epub 2016 Dec 14 doi: 10.1080/07853890.2016.1222450. PMID: 27499257
Non-celiac gluten sensitivity: literature review.
Mansueto P, Seidita A, D'Alcamo A, Carroccio A
J Am Coll Nutr 2014;33(1):39-54. doi: 10.1080/07315724.2014.869996. PMID: 24533607
Gluten intolerance and skin diseases.
Humbert P, Pelletier F, Dreno B, Puzenat E, Aubin F
Eur J Dermatol 2006 Jan-Feb;16(1):4-11. PMID: 16436335
Gluten intolerance: gender- and age-related differences in symptoms.
Bardella MT, Fredella C, Saladino V, Trovato C, Cesana BM, Quatrini M, Prampolini L
Scand J Gastroenterol 2005 Jan;40(1):15-9. doi: 10.1080/00365520410008169. PMID: 15841709

Clinical prediction guides

THE MANAGEMENT OF DERMATITIS HERPETIFORMIS BY THE GASTROENTEROLOGIST. A SERIES OF CASES.
Kotze LMDS, Kotze LR, Purim KSM, Nisihara R
Arq Gastroenterol 2021 Oct-Dec;58(4):429-432. doi: 10.1590/S0004-2803.202100000-78. PMID: 34909845
Manipulation of the gut microbiome in gluten-intolerance.
Olivares M, Flor-Duro A, Sanz Y
Curr Opin Clin Nutr Metab Care 2021 Nov 1;24(6):536-542. doi: 10.1097/MCO.0000000000000791. PMID: 34622826
Interaction between ingested nutrients and gut endocrine cells in patients with irritable bowel syndrome (review).
El-Salhy M, Gilja OH, Gundersen D, Hatlebakk JG, Hausken T
Int J Mol Med 2014 Aug;34(2):363-71. Epub 2014 Jun 17 doi: 10.3892/ijmm.2014.1811. PMID: 24939595Free PMC Article
Clinical features of celiac disease today.
Collin P, Kaukinen K, Mäki M
Dig Dis 1999;17(2):100-6. doi: 10.1159/000016911. PMID: 10545715
The contribution of some constitutional factors to the development of cow's milk and gluten intolerance in children.
Kaczmarski M, Kurzatkowska B
Rocz Akad Med Bialymst (1989) 1988-1989;33-34:167-76. PMID: 3154973

Recent systematic reviews

Is it time to rethink the burden of non-coeliac gluten sensitivity? A systematic review.
Borrelli DE Andreis F, Schiepatti A, Gibiino G, Fabbri C, Baiardi P, Biagi F
Minerva Gastroenterol (Torino) 2022 Dec;68(4):442-449. Epub 2021 Dec 21 doi: 10.23736/S2724-5985.21.03077-1. PMID: 34929997
Systematic review: noncoeliac gluten sensitivity.
Molina-Infante J, Santolaria S, Sanders DS, Fernández-Bañares F
Aliment Pharmacol Ther 2015 May;41(9):807-20. Epub 2015 Mar 6 doi: 10.1111/apt.13155. PMID: 25753138

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...