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Clear Cell Odontogenic Carcinoma

MedGen UID:
1371662
•Concept ID:
C4316837
•
Neoplastic Process
Synonyms: Clear Cell Ameloblastoma; Clear cell odontogenic carcinoma; Clear Cell Odontogenic Tumor
SNOMED CT: Clear cell odontogenic carcinoma (734032001)

Definition

A usually aggressive malignant neoplasm arising from tooth-forming tissues. It more often affects older females and more frequently occurs in the mandible. It is characterized by the presence of malignant epithelial cells with clear cytoplasm and a fibrotic stroma formation. It may recur and metastasize. Metastases may occur in the lymph nodes, lungs, and bones. Treatment of choice is resection with clean margins. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVClear Cell Odontogenic Carcinoma

Professional guidelines

PubMed

Glandular odontogenic cyst: analysis of 46 cases with special emphasis on microscopic criteria for diagnosis.
Fowler CB, Brannon RB, Kessler HP, Castle JT, Kahn MA
Head Neck Pathol 2011 Dec;5(4):364-75. Epub 2011 Sep 14 doi: 10.1007/s12105-011-0298-3. PMID: 21915706Free PMC Article
On the differential diagnosis of clear cell tumours of the head and neck.
Eversole LR
Eur J Cancer B Oral Oncol 1993 Jul;29B(3):173-9. doi: 10.1016/0964-1955(93)90019-b. PMID: 8298420

Recent clinical studies

Etiology

Clear Cell Odontogenic Carcinoma a Systematic Review.
Labrador AJP, Marin NRG, Valdez LHM, Valentina MP, Sanchez KBT, Ibazetta KAR, Johan B, Cesar AV, Wright JM
Head Neck Pathol 2022 Sep;16(3):838-848. Epub 2021 Oct 7 doi: 10.1007/s12105-021-01383-9. PMID: 34618301Free PMC Article
Clinico-pathological study of malignant odontogenic tumours from a national referral centre.
Sathasivam HP, Saw CL, Lau SH
BMC Oral Health 2021 Mar 18;21(1):129. doi: 10.1186/s12903-020-01365-3. PMID: 33736630Free PMC Article
Clear cell odontogenic carcinoma: evaluation of reported cases.
August M, Faquin W, Troulis M, Kaban L
J Oral Maxillofac Surg 2003 May;61(5):580-6. doi: 10.1053/joms.2003.50114. PMID: 12730837
Clear cell odontogenic carcinoma.
Iezzi G, Rubini C, Fioroni M, Piattelli A
Oral Oncol 2002 Feb;38(2):209-13. doi: 10.1016/s1368-8375(01)00038-0. PMID: 11854070
Malignant epithelial odontogenic tumors.
Eversole LR
Semin Diagn Pathol 1999 Nov;16(4):317-24. PMID: 10587275

Diagnosis

Clear Cell Odontogenic Carcinoma a Systematic Review.
Labrador AJP, Marin NRG, Valdez LHM, Valentina MP, Sanchez KBT, Ibazetta KAR, Johan B, Cesar AV, Wright JM
Head Neck Pathol 2022 Sep;16(3):838-848. Epub 2021 Oct 7 doi: 10.1007/s12105-021-01383-9. PMID: 34618301Free PMC Article
Clear Cell Odontogenic Carcinoma: a Clinicopathological and Immunocytochemical Analysis.
Liu L, Zhang JW, Zhu NS, Zhu Y, Guo B, Yang XH
Pathol Oncol Res 2020 Jul;26(3):1559-1564. Epub 2019 Sep 3 doi: 10.1007/s12253-019-00741-x. PMID: 31482399
Clear cell odontogenic carcinoma. A review.
Hadj Saïd M, Ordioni U, Benat G, Gomez-Brouchet A, Chossegros C, Catherine JH
J Stomatol Oral Maxillofac Surg 2017 Dec;118(6):363-370. Epub 2017 Aug 30 doi: 10.1016/j.jormas.2017.08.005. PMID: 28838775
Odontogenic Cysts and Neoplasms.
Bilodeau EA, Collins BM
Surg Pathol Clin 2017 Mar;10(1):177-222. Epub 2016 Dec 29 doi: 10.1016/j.path.2016.10.006. PMID: 28153133
Hyalinizing clear cell carcinoma of salivary gland: a review and update.
Weinreb I
Head Neck Pathol 2013 Jul;7 Suppl 1(Suppl 1):S20-9. Epub 2013 Jul 3 doi: 10.1007/s12105-013-0466-8. PMID: 23821218Free PMC Article

Therapy

Case of metastatic clear cell odontogenic carcinoma with response to chemoimmunotherapy.
Robertson IJ, Robbins QC, Li PC
BMJ Case Rep 2024 Apr 29;17(4) doi: 10.1136/bcr-2023-259568. PMID: 38684356Free PMC Article

Prognosis

A Comparison of Clear Cell Sarcoma to Jaw and Salivary Tumors Bearing EWS Fusions.
Xhori O, Deol N, Rivera CM, Zavras J, Weil SG, Zafari H, Thierauf JC, Faquin WC, Choy E, Rivera MN, John Iafrate A, Jaquinet A, Troulis MJ
Head Neck Pathol 2024 Mar 25;18(1):25. doi: 10.1007/s12105-024-01625-6. PMID: 38526767Free PMC Article
Clear Cell Odontogenic Carcinoma a Systematic Review.
Labrador AJP, Marin NRG, Valdez LHM, Valentina MP, Sanchez KBT, Ibazetta KAR, Johan B, Cesar AV, Wright JM
Head Neck Pathol 2022 Sep;16(3):838-848. Epub 2021 Oct 7 doi: 10.1007/s12105-021-01383-9. PMID: 34618301Free PMC Article
Clear Cell Odontogenic Carcinoma: a Clinicopathological and Immunocytochemical Analysis.
Liu L, Zhang JW, Zhu NS, Zhu Y, Guo B, Yang XH
Pathol Oncol Res 2020 Jul;26(3):1559-1564. Epub 2019 Sep 3 doi: 10.1007/s12253-019-00741-x. PMID: 31482399
Clear cell odontogenic carcinoma. A review.
Hadj Saïd M, Ordioni U, Benat G, Gomez-Brouchet A, Chossegros C, Catherine JH
J Stomatol Oral Maxillofac Surg 2017 Dec;118(6):363-370. Epub 2017 Aug 30 doi: 10.1016/j.jormas.2017.08.005. PMID: 28838775
Odontogenic Cysts and Neoplasms.
Bilodeau EA, Collins BM
Surg Pathol Clin 2017 Mar;10(1):177-222. Epub 2016 Dec 29 doi: 10.1016/j.path.2016.10.006. PMID: 28153133

Clinical prediction guides

Carbon-ion radiotherapy for clear cell odontogenic carcinomas.
Ikawa H, Koto M, Fugo K, Takiyama H, Isozaki T, Shinoto M, Yamada S, Ishikawa H
World J Surg Oncol 2024 Jul 25;22(1):191. doi: 10.1186/s12957-024-03470-x. PMID: 39054550Free PMC Article
Detection of EWSR1 fusions in CCOC by targeted RNA-seq.
Rivera CM, Faquin WC, Thierauf J, Afrogheh AH, Jaquinet A, Iafrate AJ, Rivera MN, Troulis MJ
Oral Surg Oral Med Oral Pathol Oral Radiol 2022 Aug;134(2):240-244. Epub 2021 Dec 25 doi: 10.1016/j.oooo.2021.12.127. PMID: 35165059
Clear Cell Odontogenic Carcinoma: a Clinicopathological and Immunocytochemical Analysis.
Liu L, Zhang JW, Zhu NS, Zhu Y, Guo B, Yang XH
Pathol Oncol Res 2020 Jul;26(3):1559-1564. Epub 2019 Sep 3 doi: 10.1007/s12253-019-00741-x. PMID: 31482399
Establishment and characterization of a clear cell odontogenic carcinoma cell line with EWSR1-ATF1 fusion gene.
Kujiraoka S, Tsunematsu T, Sato Y, Yoshida M, Ishikawa A, Tohyama R, Tanaka M, Kobayashi Y, Kondo T, Ushio A, Otsuka K, Kurosawa M, Saito M, Yamada A, Arakaki R, Nagai H, Nikai H, Takeuchi K, Nagao T, Miyamoto Y, Ishimaru N, Kudo Y
Oral Oncol 2017 Jun;69:46-55. Epub 2017 Apr 10 doi: 10.1016/j.oraloncology.2017.04.003. PMID: 28559020
Clear cell odontogenic carcinoma: a comprehensive analysis of treatment strategies.
Ebert CS Jr, Dubin MG, Hart CF, Chalian AA, Shockley WW
Head Neck 2005 Jun;27(6):536-42. doi: 10.1002/hed.20181. PMID: 15772956

Recent systematic reviews

Clear Cell Odontogenic Carcinoma a Systematic Review.
Labrador AJP, Marin NRG, Valdez LHM, Valentina MP, Sanchez KBT, Ibazetta KAR, Johan B, Cesar AV, Wright JM
Head Neck Pathol 2022 Sep;16(3):838-848. Epub 2021 Oct 7 doi: 10.1007/s12105-021-01383-9. PMID: 34618301Free PMC Article
Clear cell odontogenic carcinoma: report of 7 new cases and systematic review of the current knowledge.
Loyola AM, Cardoso SV, de Faria PR, Servato JP, Barbosa de Paulo LF, Eisenberg AL, Dias FL, Gomes CC, Gomez RS
Oral Surg Oral Med Oral Pathol Oral Radiol 2015 Oct;120(4):483-96. Epub 2015 Jun 15 doi: 10.1016/j.oooo.2015.06.005. PMID: 26232924

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