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TLR4 POLYMORPHISM

MedGen UID:
934882
•Concept ID:
C4310915
•
Finding
OMIM®: 603030

Professional guidelines

PubMed

Associations of Toll-like Receptor Gene Polymorphisms with NETosis Activity as Prognostic Criteria for the Severity of Pneumonia.
Karnaushkina MA, Guryev AS, Mironov KO, Dunaeva EA, Korchagin VI, Bobkova OY, Vasilyeva IS, Kassina DV, Litvinova MM
Sovrem Tekhnologii Med 2021;13(3):47-53. Epub 2021 Jun 28 doi: 10.17691/stm2021.13.3.06. PMID: 34603755Free PMC Article

Recent clinical studies

Therapy

Association between recent acetaminophen use and asthma: modification by polymorphism at TLR4.
Lee SH, Kang MJ, Yu HS, Hong K, Jung YH, Kim HY, Seo JH, Kwon JW, Kim BJ, Kim HJ, Kim YJ, Kim HS, Kim HB, Park KS, Lee SY, Hong SJ
J Korean Med Sci 2014 May;29(5):662-8. Epub 2014 Apr 25 doi: 10.3346/jkms.2014.29.5.662. PMID: 24851022Free PMC Article
TLR4 polymorphism is not associated with biopsy proven giant cell arteritis.
Dunstan E, Lester S, Rischmueller M, Chan H, Hewitt AW, Hill C
Clin Exp Rheumatol 2014 May-Jun;32(3 Suppl 82):S26-9. Epub 2014 Jan 20 PMID: 24447403
Toll-like receptor 4 gene polymorphism influences dendritic cell in vitro function and clinical outcomes in vaccinated melanoma patients.
Tittarelli A, González FE, Pereda C, Mora G, Muñoz L, Saffie C, García T, Díaz D, Falcón C, Hermoso M, López MN, Salazar-Onfray F
Cancer Immunol Immunother 2012 Nov;61(11):2067-77. Epub 2012 May 3 doi: 10.1007/s00262-012-1268-7. PMID: 22552381Free PMC Article
The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy.
Apetoh L, Ghiringhelli F, Tesniere A, Criollo A, Ortiz C, Lidereau R, Mariette C, Chaput N, Mira JP, Delaloge S, André F, Tursz T, Kroemer G, Zitvogel L
Immunol Rev 2007 Dec;220:47-59. doi: 10.1111/j.1600-065X.2007.00573.x. PMID: 17979839
TNF-alpha promoter, Nod2 and toll-like receptor-4 polymorphisms and the in vivo and ex vivo response to endotoxin.
Schippers EF, van 't Veer C, van Voorden S, Martina CA, le Cessie S, van Dissel JT
Cytokine 2004 Apr 7;26(1):16-24. doi: 10.1016/j.cyto.2003.12.003. PMID: 15016407

Prognosis

Clinical Implication of Toll-Like Receptors (TLR2 and TLR4) in Acute Myeloid Leukemia Patients.
Aref S, Abd Elmaksoud ASM, Abd Elaziz S, Mabed M, Ayed M
Asian Pac J Cancer Prev 2020 Nov 1;21(11):3177-3183. doi: 10.31557/APJCP.2020.21.11.3177. PMID: 33247673Free PMC Article
Toll-Like receptor 4 (TLR4) polymorphism rs2149356 and risk of gout in a Spanish cohort.
Torres RJ
Nucleosides Nucleotides Nucleic Acids 2020;39(10-12):1424-1431. Epub 2020 Jun 18 doi: 10.1080/15257770.2020.1780438. PMID: 32552358
Genetic polymorphism in patients with early and late onset of ulcerative colitis.
Dorofeyev AE, Dorofeyeva AA, Kiriyan EA, Rassokhina OA, Dynia YZ
Wiad Lek 2020;73(1):87-90. PMID: 32124813
Prognostic predictive value of TLR4 polymorphisms in Han Chinese population with hypertrophic cardiomyopathy.
Han K, Li YP
Kaohsiung J Med Sci 2018 Oct;34(10):569-575. Epub 2018 Jun 2 doi: 10.1016/j.kjms.2018.05.004. PMID: 30309485
The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy.
Apetoh L, Ghiringhelli F, Tesniere A, Criollo A, Ortiz C, Lidereau R, Mariette C, Chaput N, Mira JP, Delaloge S, André F, Tursz T, Kroemer G, Zitvogel L
Immunol Rev 2007 Dec;220:47-59. doi: 10.1111/j.1600-065X.2007.00573.x. PMID: 17979839

Clinical prediction guides

Interplay among differential exposure to Mycobacterium leprae and TLR4 polymorphism impacts the immune response in household contacts of leprosy patients.
Cunha EHM, Marçal PHF, Gama RS, de Oliveira LBP, Pinheiro RO, Sarno EN, Brito-de-Sousa JP, de Souza MLM, Fairley JK, Valente TNS, Velloso-Rodrigues C, Martins-Filho OA, de Oliveira DR, Fraga LAO
Front Immunol 2023;14:1130137. Epub 2023 Apr 28 doi: 10.3389/fimmu.2023.1130137. PMID: 37187734Free PMC Article
Toll-Like receptor 4 (TLR4) polymorphism rs2149356 and risk of gout in a Spanish cohort.
Torres RJ
Nucleosides Nucleotides Nucleic Acids 2020;39(10-12):1424-1431. Epub 2020 Jun 18 doi: 10.1080/15257770.2020.1780438. PMID: 32552358
Genetic polymorphism in patients with early and late onset of ulcerative colitis.
Dorofeyev AE, Dorofeyeva AA, Kiriyan EA, Rassokhina OA, Dynia YZ
Wiad Lek 2020;73(1):87-90. PMID: 32124813
TLR4 polymorphism is not associated with biopsy proven giant cell arteritis.
Dunstan E, Lester S, Rischmueller M, Chan H, Hewitt AW, Hill C
Clin Exp Rheumatol 2014 May-Jun;32(3 Suppl 82):S26-9. Epub 2014 Jan 20 PMID: 24447403
The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy.
Apetoh L, Ghiringhelli F, Tesniere A, Criollo A, Ortiz C, Lidereau R, Mariette C, Chaput N, Mira JP, Delaloge S, André F, Tursz T, Kroemer G, Zitvogel L
Immunol Rev 2007 Dec;220:47-59. doi: 10.1111/j.1600-065X.2007.00573.x. PMID: 17979839

Recent systematic reviews

An updated systematic review of the association between the TLR4 polymorphism rs4986790 and cancers risk.
Xiao Q, Chen J, Zeng S, Cai H, Zhu G
Medicine (Baltimore) 2022 Oct 21;101(42):e31247. doi: 10.1097/MD.0000000000031247. PMID: 36281200Free PMC Article
The association of toll-like receptor 4 gene polymorphisms with primary open angle glaucoma susceptibility: a meta-analysis.
Chaiwiang N, Poyomtip T
Biosci Rep 2019 Apr 30;39(4) Epub 2019 Apr 2 doi: 10.1042/BSR20190029. PMID: 30877182Free PMC Article

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