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Malignancy-associated membranous nephropathy

MedGen UID:
928526
•Concept ID:
C4302857
•
Disease or Syndrome
Synonym: Membranous glomerulonephritis due to malignant neoplastic disease
SNOMED CT: Membranous glomerulonephritis due to malignant neoplastic disease (722086002); Malignancy-associated membranous nephropathy (722086002)

Definition

Glomerulonephritis with electron dense deposits in the glomerular baseement membrane in a patient with cancer, after exclusion of other possible causes of membranous glomerulonephritis. [from SNOMEDCT_US]

Professional guidelines

PubMed

Malignancy-associated membranous nephropathy: focus on diagnosis and treatment.
Ai S, Yan X, Zhao X, Ye W, Wen Y, Wang J, Pan B, Dong J, Li X, Qin Y
J Nephrol 2023 Nov;36(8):2355-2363. Epub 2023 Sep 15 doi: 10.1007/s40620-023-01751-4. PMID: 37713160
Characterization of autoantibodies in primary membranous nephropathy and their clinical significance.
Stahl RA, Reinhard L, Hoxha E
Expert Rev Clin Immunol 2019 Feb;15(2):165-175. Epub 2018 Nov 27 doi: 10.1080/1744666X.2019.1548934. PMID: 30433832

Recent clinical studies

Etiology

Malignancy-associated membranous nephropathy: focus on diagnosis and treatment.
Ai S, Yan X, Zhao X, Ye W, Wen Y, Wang J, Pan B, Dong J, Li X, Qin Y
J Nephrol 2023 Nov;36(8):2355-2363. Epub 2023 Sep 15 doi: 10.1007/s40620-023-01751-4. PMID: 37713160
NELL1 is a target antigen in malignancy-associated membranous nephropathy.
Caza TN, Hassen SI, Dvanajscak Z, Kuperman M, Edmondson R, Herzog C, Storey A, Arthur J, Cossey LN, Sharma SG, Kenan DJ, Larsen CP
Kidney Int 2021 Apr;99(4):967-976. Epub 2020 Aug 20 doi: 10.1016/j.kint.2020.07.039. PMID: 32828756Free PMC Article
Antigen-Specific IgG Subclasses in Primary and Malignancy-Associated Membranous Nephropathy.
von Haxthausen F, Reinhard L, Pinnschmidt HO, Rink M, Soave A, Hoxha E, Stahl RAK
Front Immunol 2018;9:3035. Epub 2018 Dec 20 doi: 10.3389/fimmu.2018.03035. PMID: 30619370Free PMC Article
Absence of glomerular IgG4 deposition in patients with membranous nephropathy may indicate malignancy.
Qu Z, Liu G, Li J, Wu LH, Tan Y, Zheng X, Ao J, Zhao MH
Nephrol Dial Transplant 2012 May;27(5):1931-7. Epub 2011 Oct 5 doi: 10.1093/ndt/gfr534. PMID: 21976738
Distribution of glomerular IgG subclass deposits in malignancy-associated membranous nephropathy.
Ohtani H, Wakui H, Komatsuda A, Okuyama S, Masai R, Maki N, Kigawa A, Sawada K, Imai H
Nephrol Dial Transplant 2004 Mar;19(3):574-9. doi: 10.1093/ndt/gfg616. PMID: 14767011

Diagnosis

Malignancy-associated membranous nephropathy: focus on diagnosis and treatment.
Ai S, Yan X, Zhao X, Ye W, Wen Y, Wang J, Pan B, Dong J, Li X, Qin Y
J Nephrol 2023 Nov;36(8):2355-2363. Epub 2023 Sep 15 doi: 10.1007/s40620-023-01751-4. PMID: 37713160
Malignancy-associated membranous nephropathy with PLA2R double-positive for glomeruli and carcinoma.
Yasuda I, Tokuyama H, Hashiguchi A, Hasegawa K, Uchiyama K, Ryuzaki M, Yasuda M, Mizuno R, Ishidoya S, Wakino S, Itoh H
CEN Case Rep 2021 May;10(2):281-286. Epub 2021 Jan 3 doi: 10.1007/s13730-020-00556-9. PMID: 33393071Free PMC Article
Characterization of autoantibodies in primary membranous nephropathy and their clinical significance.
Stahl RA, Reinhard L, Hoxha E
Expert Rev Clin Immunol 2019 Feb;15(2):165-175. Epub 2018 Nov 27 doi: 10.1080/1744666X.2019.1548934. PMID: 30433832
Antigen-Specific IgG Subclasses in Primary and Malignancy-Associated Membranous Nephropathy.
von Haxthausen F, Reinhard L, Pinnschmidt HO, Rink M, Soave A, Hoxha E, Stahl RAK
Front Immunol 2018;9:3035. Epub 2018 Dec 20 doi: 10.3389/fimmu.2018.03035. PMID: 30619370Free PMC Article
Absence of glomerular IgG4 deposition in patients with membranous nephropathy may indicate malignancy.
Qu Z, Liu G, Li J, Wu LH, Tan Y, Zheng X, Ao J, Zhao MH
Nephrol Dial Transplant 2012 May;27(5):1931-7. Epub 2011 Oct 5 doi: 10.1093/ndt/gfr534. PMID: 21976738

Therapy

Characterization of autoantibodies in primary membranous nephropathy and their clinical significance.
Stahl RA, Reinhard L, Hoxha E
Expert Rev Clin Immunol 2019 Feb;15(2):165-175. Epub 2018 Nov 27 doi: 10.1080/1744666X.2019.1548934. PMID: 30433832
Distribution of glomerular IgG subclass deposits in malignancy-associated membranous nephropathy.
Ohtani H, Wakui H, Komatsuda A, Okuyama S, Masai R, Maki N, Kigawa A, Sawada K, Imai H
Nephrol Dial Transplant 2004 Mar;19(3):574-9. doi: 10.1093/ndt/gfg616. PMID: 14767011

Prognosis

Antigen-Specific IgG Subclasses in Primary and Malignancy-Associated Membranous Nephropathy.
von Haxthausen F, Reinhard L, Pinnschmidt HO, Rink M, Soave A, Hoxha E, Stahl RAK
Front Immunol 2018;9:3035. Epub 2018 Dec 20 doi: 10.3389/fimmu.2018.03035. PMID: 30619370Free PMC Article
Absence of glomerular IgG4 deposition in patients with membranous nephropathy may indicate malignancy.
Qu Z, Liu G, Li J, Wu LH, Tan Y, Zheng X, Ao J, Zhao MH
Nephrol Dial Transplant 2012 May;27(5):1931-7. Epub 2011 Oct 5 doi: 10.1093/ndt/gfr534. PMID: 21976738
Distribution of glomerular IgG subclass deposits in malignancy-associated membranous nephropathy.
Ohtani H, Wakui H, Komatsuda A, Okuyama S, Masai R, Maki N, Kigawa A, Sawada K, Imai H
Nephrol Dial Transplant 2004 Mar;19(3):574-9. doi: 10.1093/ndt/gfg616. PMID: 14767011

Clinical prediction guides

Malignancy-associated membranous nephropathy: focus on diagnosis and treatment.
Ai S, Yan X, Zhao X, Ye W, Wen Y, Wang J, Pan B, Dong J, Li X, Qin Y
J Nephrol 2023 Nov;36(8):2355-2363. Epub 2023 Sep 15 doi: 10.1007/s40620-023-01751-4. PMID: 37713160
Features of phospholipase A2 receptor and thrombospondin type-1 domain-containing 7A in malignancy-associated membranous nephropathy.
Zhang C, Zhang M, Chen D, Ren Q, Xu W, Zeng C, Qin W, Liu Z
J Clin Pathol 2019 Oct;72(10):705-711. Epub 2019 Jun 26 doi: 10.1136/jclinpath-2019-205852. PMID: 31243053
Antigen-Specific IgG Subclasses in Primary and Malignancy-Associated Membranous Nephropathy.
von Haxthausen F, Reinhard L, Pinnschmidt HO, Rink M, Soave A, Hoxha E, Stahl RAK
Front Immunol 2018;9:3035. Epub 2018 Dec 20 doi: 10.3389/fimmu.2018.03035. PMID: 30619370Free PMC Article
Absence of glomerular IgG4 deposition in patients with membranous nephropathy may indicate malignancy.
Qu Z, Liu G, Li J, Wu LH, Tan Y, Zheng X, Ao J, Zhao MH
Nephrol Dial Transplant 2012 May;27(5):1931-7. Epub 2011 Oct 5 doi: 10.1093/ndt/gfr534. PMID: 21976738
Distribution of glomerular IgG subclass deposits in malignancy-associated membranous nephropathy.
Ohtani H, Wakui H, Komatsuda A, Okuyama S, Masai R, Maki N, Kigawa A, Sawada K, Imai H
Nephrol Dial Transplant 2004 Mar;19(3):574-9. doi: 10.1093/ndt/gfg616. PMID: 14767011

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