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Neonatal thrombosis of cerebral venous sinus

MedGen UID:
927874
•Concept ID:
C4302205
•
Disease or Syndrome
Synonym: Neonatal cerebral sinovenous thrombosis
SNOMED CT: Neonatal thrombosis of cerebral venous sinus (722930000); Neonatal cerebral sinovenous thrombosis (722930000)

Professional guidelines

PubMed

Perinatal stroke syndromes: Similarities and diversities in aetiology, outcome and management.
Fluss J, Dinomais M, Chabrier S
Eur J Paediatr Neurol 2019 May;23(3):368-383. Epub 2019 Feb 27 doi: 10.1016/j.ejpn.2019.02.013. PMID: 30879961
Neonatal cerebral sinovenous thrombosis: sifting the evidence for a diagnostic plan and treatment strategy.
Yang JY, Chan AK, Callen DJ, Paes BA
Pediatrics 2010 Sep;126(3):e693-700. Epub 2010 Aug 9 doi: 10.1542/peds.2010-1035. PMID: 20696732
Perinatal stroke--risk factors and management.
Chalmers EA
Br J Haematol 2005 Aug;130(3):333-43. doi: 10.1111/j.1365-2141.2005.05554.x. PMID: 16042683

Recent clinical studies

Etiology

Cerebral venous sinus thrombosis.
Capecchi M, Abbattista M, Martinelli I
J Thromb Haemost 2018 Oct;16(10):1918-1931. Epub 2018 Jul 11 doi: 10.1111/jth.14210. PMID: 29923367
Thrombophilic states.
Martinelli I, Passamonti SM, Bucciarelli P
Handb Clin Neurol 2014;120:1061-71. doi: 10.1016/B978-0-7020-4087-0.00071-1. PMID: 24365371
Pediatric thrombophilia.
Yang JY, Chan AK
Pediatr Clin North Am 2013 Dec;60(6):1443-62. doi: 10.1016/j.pcl.2013.09.004. PMID: 24237981
Cerebral sinus-venous thrombosis.
Martinelli I, Passamonti SM, Rossi E, De Stefano V
Intern Emerg Med 2012 Oct;7 Suppl 3:S221-5. doi: 10.1007/s11739-012-0806-9. PMID: 23073861
Neonatal stroke.
Rutherford MA, Ramenghi LA, Cowan FM
Arch Dis Child Fetal Neonatal Ed 2012 Sep;97(5):F377-84. doi: 10.1136/fetalneonatal-2010-196451. PMID: 22933099

Diagnosis

Neonatal cerebral sinovenous thrombosis.
Ramenghi LA, Cardiello V, Rossi A
Handb Clin Neurol 2019;162:267-280. doi: 10.1016/B978-0-444-64029-1.00012-6. PMID: 31324314
Cerebral venous sinus thrombosis.
Capecchi M, Abbattista M, Martinelli I
J Thromb Haemost 2018 Oct;16(10):1918-1931. Epub 2018 Jul 11 doi: 10.1111/jth.14210. PMID: 29923367
Intracranial hemorrhage in neonates: A review of etiologies, patterns and predicted clinical outcomes.
Tan AP, Svrckova P, Cowan F, Chong WK, Mankad K
Eur J Paediatr Neurol 2018 Jul;22(4):690-717. Epub 2018 Apr 24 doi: 10.1016/j.ejpn.2018.04.008. PMID: 29731328
Neonatal stroke.
Rutherford MA, Ramenghi LA, Cowan FM
Arch Dis Child Fetal Neonatal Ed 2012 Sep;97(5):F377-84. doi: 10.1136/fetalneonatal-2010-196451. PMID: 22933099
Sonographic stroke templates.
Govaert P
Semin Fetal Neonatal Med 2009 Oct;14(5):284-98. Epub 2009 Aug 13 doi: 10.1016/j.siny.2009.07.006. PMID: 19682961

Therapy

Cerebral Venous Sinus Thrombosis in Preterm Infants.
Christensen R, Krishnan P, deVeber G, Dlamini N, MacGregor D, Pulcine E, Moharir M
Stroke 2022 Jul;53(7):2241-2248. Epub 2022 Apr 18 doi: 10.1161/STROKEAHA.121.037621. PMID: 35430899
Neonatal cerebral sinovenous thrombosis.
Ramenghi LA, Cardiello V, Rossi A
Handb Clin Neurol 2019;162:267-280. doi: 10.1016/B978-0-444-64029-1.00012-6. PMID: 31324314
Cerebral venous sinus thrombosis.
Capecchi M, Abbattista M, Martinelli I
J Thromb Haemost 2018 Oct;16(10):1918-1931. Epub 2018 Jul 11 doi: 10.1111/jth.14210. PMID: 29923367
Cerebral sinus-venous thrombosis.
Martinelli I, Passamonti SM, Rossi E, De Stefano V
Intern Emerg Med 2012 Oct;7 Suppl 3:S221-5. doi: 10.1007/s11739-012-0806-9. PMID: 23073861
Impact of thrombophilia on risk of arterial ischemic stroke or cerebral sinovenous thrombosis in neonates and children: a systematic review and meta-analysis of observational studies.
Kenet G, Lütkhoff LK, Albisetti M, Bernard T, Bonduel M, Brandao L, Chabrier S, Chan A, deVeber G, Fiedler B, Fullerton HJ, Goldenberg NA, Grabowski E, Günther G, Heller C, Holzhauer S, Iorio A, Journeycake J, Junker R, Kirkham FJ, Kurnik K, Lynch JK, Male C, Manco-Johnson M, Mesters R, Monagle P, van Ommen CH, Raffini L, Rostásy K, Simioni P, Sträter RD, Young G, Nowak-Göttl U
Circulation 2010 Apr 27;121(16):1838-47. Epub 2010 Apr 12 doi: 10.1161/CIRCULATIONAHA.109.913673. PMID: 20385928

Prognosis

Neonatal cerebral sinovenous thrombosis.
Ramenghi LA, Cardiello V, Rossi A
Handb Clin Neurol 2019;162:267-280. doi: 10.1016/B978-0-444-64029-1.00012-6. PMID: 31324314
Cerebral venous sinus thrombosis.
Capecchi M, Abbattista M, Martinelli I
J Thromb Haemost 2018 Oct;16(10):1918-1931. Epub 2018 Jul 11 doi: 10.1111/jth.14210. PMID: 29923367
Intracranial hemorrhage in neonates: A review of etiologies, patterns and predicted clinical outcomes.
Tan AP, Svrckova P, Cowan F, Chong WK, Mankad K
Eur J Paediatr Neurol 2018 Jul;22(4):690-717. Epub 2018 Apr 24 doi: 10.1016/j.ejpn.2018.04.008. PMID: 29731328
Cerebral sinus-venous thrombosis.
Martinelli I, Passamonti SM, Rossi E, De Stefano V
Intern Emerg Med 2012 Oct;7 Suppl 3:S221-5. doi: 10.1007/s11739-012-0806-9. PMID: 23073861
Sonographic stroke templates.
Govaert P
Semin Fetal Neonatal Med 2009 Oct;14(5):284-98. Epub 2009 Aug 13 doi: 10.1016/j.siny.2009.07.006. PMID: 19682961

Clinical prediction guides

Hemorrhagic Transformation of Arterial Ischemic and Venous Stroke in Children.
Hutchinson ML, Beslow LA
Pediatr Neurol 2019 Jun;95:26-33. Epub 2019 Feb 8 doi: 10.1016/j.pediatrneurol.2019.01.023. PMID: 30904397
Intracranial hemorrhage in neonates: A review of etiologies, patterns and predicted clinical outcomes.
Tan AP, Svrckova P, Cowan F, Chong WK, Mankad K
Eur J Paediatr Neurol 2018 Jul;22(4):690-717. Epub 2018 Apr 24 doi: 10.1016/j.ejpn.2018.04.008. PMID: 29731328
Impact of thrombophilia on risk of arterial ischemic stroke or cerebral sinovenous thrombosis in neonates and children: a systematic review and meta-analysis of observational studies.
Kenet G, Lütkhoff LK, Albisetti M, Bernard T, Bonduel M, Brandao L, Chabrier S, Chan A, deVeber G, Fiedler B, Fullerton HJ, Goldenberg NA, Grabowski E, Günther G, Heller C, Holzhauer S, Iorio A, Journeycake J, Junker R, Kirkham FJ, Kurnik K, Lynch JK, Male C, Manco-Johnson M, Mesters R, Monagle P, van Ommen CH, Raffini L, Rostásy K, Simioni P, Sträter RD, Young G, Nowak-Göttl U
Circulation 2010 Apr 27;121(16):1838-47. Epub 2010 Apr 12 doi: 10.1161/CIRCULATIONAHA.109.913673. PMID: 20385928
Sonographic stroke templates.
Govaert P
Semin Fetal Neonatal Med 2009 Oct;14(5):284-98. Epub 2009 Aug 13 doi: 10.1016/j.siny.2009.07.006. PMID: 19682961
Independent walking after neonatal arterial ischemic stroke and sinovenous thrombosis.
Golomb MR, deVeber GA, MacGregor DL, Domi T, Whyte H, Stephens D, Dick PT
J Child Neurol 2003 Aug;18(8):530-6. doi: 10.1177/08830738030180080901. PMID: 13677578

Recent systematic reviews

Risk factors of neonatal stroke from different origins: a systematic review and meta-analysis.
Song Y, Li S, Hao L, Han Y, Wu W, Fan Y, Gao X, Li X, Ren C, Chen Y
Eur J Pediatr 2024 Jul;183(7):3073-3083. Epub 2024 Apr 25 doi: 10.1007/s00431-024-05531-5. PMID: 38661815
The incidence of pediatric ischemic stroke: A systematic review and meta-analysis.
Gao L, Lim M, Nguyen D, Bowe S, MacKay MT, Stojanovski B, Moodie M
Int J Stroke 2023 Aug;18(7):765-772. Epub 2023 Feb 7 doi: 10.1177/17474930231155336. PMID: 36691675
Impact of thrombophilia on risk of arterial ischemic stroke or cerebral sinovenous thrombosis in neonates and children: a systematic review and meta-analysis of observational studies.
Kenet G, Lütkhoff LK, Albisetti M, Bernard T, Bonduel M, Brandao L, Chabrier S, Chan A, deVeber G, Fiedler B, Fullerton HJ, Goldenberg NA, Grabowski E, Günther G, Heller C, Holzhauer S, Iorio A, Journeycake J, Junker R, Kirkham FJ, Kurnik K, Lynch JK, Male C, Manco-Johnson M, Mesters R, Monagle P, van Ommen CH, Raffini L, Rostásy K, Simioni P, Sträter RD, Young G, Nowak-Göttl U
Circulation 2010 Apr 27;121(16):1838-47. Epub 2010 Apr 12 doi: 10.1161/CIRCULATIONAHA.109.913673. PMID: 20385928

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