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Silent cerebral infarct

MedGen UID:
927756
•Concept ID:
C4302087
•
Disease or Syndrome
SNOMED CT: Silent cerebral infarct (723082006)

Definition

The presence of infarcted brain tissue without a history of transient neurologic or stroke symptoms. The disorder occurs as a result of cessation of blood supply to the brain with subclinical and asymptomatic outcome due to the area of damage being very small or the cessation of supply occurring in a non-eloquent area of the brain. [from SNOMEDCT_US]

Professional guidelines

PubMed

Practice patterns for neuroimaging and transfusion therapy for management of neurologic complications in sickle cell anemia: DISPLACE consortium.
Phillips S, Schlenz AM, Mueller M, Melvin C, Adams RJ, Kanter J; (on behalf of the DISPLACE investigators)
Pediatr Blood Cancer 2020 Nov;67(11):e28569. Epub 2020 Sep 7 doi: 10.1002/pbc.28569. PMID: 32894002Free PMC Article
What is the place of hematopoietic stem cell transplantation in the management of cerebral vasculopathy in children with sickle cell anemia?
Bernaudin F
Hematol Oncol Stem Cell Ther 2020 Sep;13(3):121-130. Epub 2020 Mar 12 doi: 10.1016/j.hemonc.2019.12.002. PMID: 32202243
Subclinical Cerebrovascular Disease: Epidemiology and Treatment.
de Havenon A, Meyer C, McNally JS, Alexander M, Chung L
Curr Atheroscler Rep 2019 Jul 27;21(10):39. doi: 10.1007/s11883-019-0799-1. PMID: 31350593Free PMC Article

Recent clinical studies

Etiology

Nocturnal hypertension associated with stroke and silent cerebral infarcts in children with sickle cell disease.
Strumph K, Hafeman M, Ranabothu S, Gomes W, Benitez S, Kaskel F, Manwani D, Mahgerefteh J
Pediatr Blood Cancer 2021 May;68(5):e28883. Epub 2021 Jan 6 doi: 10.1002/pbc.28883. PMID: 33405393
Silent cerebral infarct in sickle cell anemia patients of southern Turkey.
Nafile Sayman E, Leblebİsatan G, Leblebisatan Ş, Bıçakcı YK, Kılınç Y, Barutçu A
Turk J Med Sci 2020 Dec 17;50(8):1887-1893. doi: 10.3906/sag-2003-192. PMID: 32599969Free PMC Article
Subclinical Cerebrovascular Disease: Epidemiology and Treatment.
de Havenon A, Meyer C, McNally JS, Alexander M, Chung L
Curr Atheroscler Rep 2019 Jul 27;21(10):39. doi: 10.1007/s11883-019-0799-1. PMID: 31350593Free PMC Article
Neurologic complications in children under five years with sickle cell disease.
Galadanci AA, DeBaun MR, Galadanci NA
Neurosci Lett 2019 Jul 27;706:201-206. Epub 2019 Apr 27 doi: 10.1016/j.neulet.2019.04.030. PMID: 31039424Free PMC Article
Obstructive sleep apnea and silent cerebral infarction in hypertensive individuals.
Alvarez-Sabín J, Romero O, Delgado P, Quintana M, Santamarina E, Ferré A, Maisterra O, Riba-Llena I, Montaner J, Sampol G
J Sleep Res 2018 Apr;27(2):232-239. Epub 2017 Jun 20 doi: 10.1111/jsr.12571. PMID: 28631309

Diagnosis

Cough Test Results during Screening for Silent Aspiration Are Affected by Risk Factors for Silent Cerebral Infarct in Older Adults with Chronic Disease.
Nakane A, Nakagawa K, Yamaguchi K, Yoshimi K, Hara Y, Tohara H
Int J Environ Res Public Health 2022 Aug 17;19(16) doi: 10.3390/ijerph191610202. PMID: 36011839Free PMC Article
Nocturnal hypertension associated with stroke and silent cerebral infarcts in children with sickle cell disease.
Strumph K, Hafeman M, Ranabothu S, Gomes W, Benitez S, Kaskel F, Manwani D, Mahgerefteh J
Pediatr Blood Cancer 2021 May;68(5):e28883. Epub 2021 Jan 6 doi: 10.1002/pbc.28883. PMID: 33405393
Brain-derived neurotrophic factor levels in pediatric sickle cell disease.
Lance EI, Barron-Casella E, Everett AD, Casella JF
Pediatr Blood Cancer 2020 Feb;67(2):e28076. Epub 2019 Nov 17 doi: 10.1002/pbc.28076. PMID: 31736231Free PMC Article
Silent cerebral infarct in child patients with beta thalassaemia intermedia.
Leblebisatan G, Bay A, Sirikci A, Kilincaslan H, Sonmezisik S, Leblebisatan S, Baspinar O, Dogan M, Yis U
Blood Coagul Fibrinolysis 2012 Oct;23(7):608-13. doi: 10.1097/MBC.0b013e3283566b0f. PMID: 22918039
Silent cerebral infarct and visual field progression in newly diagnosed normal-tension glaucoma: a cohort study.
Leung DY, Tham CC, Li FC, Kwong YY, Chi SC, Lam DS
Ophthalmology 2009 Jul;116(7):1250-6. Epub 2009 May 30 doi: 10.1016/j.ophtha.2009.02.003. PMID: 19481813

Therapy

Stroke in sickle cell disease and the promise of recent disease modifying agents.
Runge A, Brazel D, Pakbaz Z
J Neurol Sci 2022 Nov 15;442:120412. Epub 2022 Sep 9 doi: 10.1016/j.jns.2022.120412. PMID: 36150233
Economic evaluation of regular transfusions for cerebral infarct recurrence in the Silent Cerebral Infarct Transfusion Trial.
Hsu P, Gay JC, Lin CJ, Rodeghier M, DeBaun MR, Cronin RM
Blood Adv 2021 Dec 14;5(23):5032-5040. doi: 10.1182/bloodadvances.2021004864. PMID: 34607344Free PMC Article
Subclinical Cerebrovascular Disease: Epidemiology and Treatment.
de Havenon A, Meyer C, McNally JS, Alexander M, Chung L
Curr Atheroscler Rep 2019 Jul 27;21(10):39. doi: 10.1007/s11883-019-0799-1. PMID: 31350593Free PMC Article
Silent cerebral infarct definitions and full-scale IQ loss in children with sickle cell anemia.
Choudhury NA, DeBaun MR, Rodeghier M, King AA, Strouse JJ, McKinstry RC
Neurology 2018 Jan 16;90(3):e239-e246. Epub 2017 Dec 20 doi: 10.1212/WNL.0000000000004832. PMID: 29263226Free PMC Article
Silent cerebral infarction, income, and grade retention among students with sickle cell anemia.
King AA, Rodeghier MJ, Panepinto JA, Strouse JJ, Casella JF, Quinn CT, Dowling MM, Sarnaik SA, Thompson AA, Woods GM, Minniti CP, Redding-Lallinger RC, Kirby-Allen M, Kirkham FJ, McKinstry R, Noetzel MJ, White DA, Kwiatkowski JK, Howard TH, Kalinyak KA, Inusa B, Rhodes MM, Heiny ME, Fuh B, Fixler JM, Gordon MO, DeBaun MR
Am J Hematol 2014 Oct;89(10):E188-92. Epub 2014 Aug 4 doi: 10.1002/ajh.23805. PMID: 25042018Free PMC Article

Prognosis

Intracranial and Extracranial Vascular Stenosis as Risk Factors for Stroke in Sickle Cell Disease.
Schlotman AA, Donahue MJ, Kassim AA, Lee CA, Waddle SL, Pruthi S, Davis LT, Rodeghier M, DeBaun MR, Jordan LC
Pediatr Neurol 2021 Jan;114:29-34. Epub 2020 Oct 22 doi: 10.1016/j.pediatrneurol.2020.10.006. PMID: 33190070Free PMC Article
Brain-derived neurotrophic factor levels in pediatric sickle cell disease.
Lance EI, Barron-Casella E, Everett AD, Casella JF
Pediatr Blood Cancer 2020 Feb;67(2):e28076. Epub 2019 Nov 17 doi: 10.1002/pbc.28076. PMID: 31736231Free PMC Article
Silent cerebral infarct definitions and full-scale IQ loss in children with sickle cell anemia.
Choudhury NA, DeBaun MR, Rodeghier M, King AA, Strouse JJ, McKinstry RC
Neurology 2018 Jan 16;90(3):e239-e246. Epub 2017 Dec 20 doi: 10.1212/WNL.0000000000004832. PMID: 29263226Free PMC Article
Silent cerebral infarcts after cardiac catheterization: a randomized comparison of radial and femoral approaches.
Hamon M, Lipiecki J, Carrié D, Burzotta F, Durel N, Coutance G, Boudou N, Colosimo C, Trani C, Dumonteil N, Morello R, Viader F, Claise B, Hamon M
Am Heart J 2012 Oct;164(4):449-454.e1. Epub 2012 Jun 13 doi: 10.1016/j.ahj.2012.04.005. PMID: 23067900
Silent cerebral infarct and visual field progression in newly diagnosed normal-tension glaucoma: a cohort study.
Leung DY, Tham CC, Li FC, Kwong YY, Chi SC, Lam DS
Ophthalmology 2009 Jul;116(7):1250-6. Epub 2009 May 30 doi: 10.1016/j.ophtha.2009.02.003. PMID: 19481813

Clinical prediction guides

Cough Test Results during Screening for Silent Aspiration Are Affected by Risk Factors for Silent Cerebral Infarct in Older Adults with Chronic Disease.
Nakane A, Nakagawa K, Yamaguchi K, Yoshimi K, Hara Y, Tohara H
Int J Environ Res Public Health 2022 Aug 17;19(16) doi: 10.3390/ijerph191610202. PMID: 36011839Free PMC Article
Intracranial and Extracranial Vascular Stenosis as Risk Factors for Stroke in Sickle Cell Disease.
Schlotman AA, Donahue MJ, Kassim AA, Lee CA, Waddle SL, Pruthi S, Davis LT, Rodeghier M, DeBaun MR, Jordan LC
Pediatr Neurol 2021 Jan;114:29-34. Epub 2020 Oct 22 doi: 10.1016/j.pediatrneurol.2020.10.006. PMID: 33190070Free PMC Article
Silent cerebral infarct definitions and full-scale IQ loss in children with sickle cell anemia.
Choudhury NA, DeBaun MR, Rodeghier M, King AA, Strouse JJ, McKinstry RC
Neurology 2018 Jan 16;90(3):e239-e246. Epub 2017 Dec 20 doi: 10.1212/WNL.0000000000004832. PMID: 29263226Free PMC Article
A systematic review of the literature for severity predictors in children with sickle cell anemia.
Meier ER, Fasano RM, Levett PR
Blood Cells Mol Dis 2017 Jun;65:86-94. Epub 2017 Feb 2 doi: 10.1016/j.bcmd.2017.01.014. PMID: 28185829
Design of the silent cerebral infarct transfusion (SIT) trial.
Casella JF, King AA, Barton B, White DA, Noetzel MJ, Ichord RN, Terrill C, Hirtz D, McKinstry RC, Strouse JJ, Howard TH, Coates TD, Minniti CP, Campbell AD, Vendt BA, Lehmann H, Debaun MR
Pediatr Hematol Oncol 2010 Mar;27(2):69-89. doi: 10.3109/08880010903360367. PMID: 20201689Free PMC Article

Recent systematic reviews

Burden of central nervous system complications in sickle cell disease: A systematic review and meta-analysis.
Lee S, Lucas S, Proudman D, Nellesen D, Paulose J, Sheehan VA
Pediatr Blood Cancer 2022 Apr;69(4):e29493. Epub 2022 Jan 17 doi: 10.1002/pbc.29493. PMID: 35038214
Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease.
Estcourt LJ, Kohli R, Hopewell S, Trivella M, Wang WC
Cochrane Database Syst Rev 2020 Jul 27;7(7):CD003146. doi: 10.1002/14651858.CD003146.pub4. PMID: 32716555Free PMC Article
Red blood cell transfusion to treat or prevent complications in sickle cell disease: an overview of Cochrane reviews.
Fortin PM, Hopewell S, Estcourt LJ
Cochrane Database Syst Rev 2018 Aug 1;8(8):CD012082. doi: 10.1002/14651858.CD012082.pub2. PMID: 30067867Free PMC Article
A systematic review of the literature for severity predictors in children with sickle cell anemia.
Meier ER, Fasano RM, Levett PR
Blood Cells Mol Dis 2017 Jun;65:86-94. Epub 2017 Feb 2 doi: 10.1016/j.bcmd.2017.01.014. PMID: 28185829
Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease.
Estcourt LJ, Fortin PM, Hopewell S, Trivella M, Wang WC
Cochrane Database Syst Rev 2017 Jan 17;1(1):CD003146. doi: 10.1002/14651858.CD003146.pub3. PMID: 28094851Free PMC Article

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