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Post-cardiac arrest syndrome

MedGen UID:
1672555
•Concept ID:
C4285706
•
Disease or Syndrome
Synonyms: Post Cardiac Arrest Syndrome; Post-Cardiac Arrest Syndrome; Post-Cardiac Arrest Syndromes; Postcardiac Arrest Syndrome; Postcardiac Arrest Syndromes; Postresuscitation Disease; Postresuscitation Diseases
 
Monarch Initiative: MONDO:0850092

Definition

A reperfusion syndrome characterized by various pathophysiological processes after CARDIAC ARREST. It may include post-cardiac arrest brain injury (HYPOXIA-ISCHEMIA, BRAIN), cardiocirculatory dysfunction, (e.g., systemic ISCHEMIA), HYPERGLYCEMIA; MULTIPLE ORGAN FAILURE and delayed death. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPost-cardiac arrest syndrome

Professional guidelines

PubMed

Pediatric Post-Cardiac Arrest Care: A Scientific Statement From the American Heart Association.
Topjian AA, de Caen A, Wainwright MS, Abella BS, Abend NS, Atkins DL, Bembea MM, Fink EL, Guerguerian AM, Haskell SE, Kilgannon JH, Lasa JJ, Hazinski MF
Circulation 2019 Aug 6;140(6):e194-e233. Epub 2019 Jun 27 doi: 10.1161/CIR.0000000000000697. PMID: 31242751
Multidisciplinary Management of the Post-Cardiac Arrest Patient.
Madder RD, Reynolds JC
Cardiol Clin 2018 Feb;36(1):85-101. doi: 10.1016/j.ccl.2017.08.005. PMID: 29173684
Post-cardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication. A Scientific Statement from the International Liaison Committee on Resuscitation; the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; the Council on Stroke.
Nolan JP, Neumar RW, Adrie C, Aibiki M, Berg RA, Böttiger BW, Callaway C, Clark RS, Geocadin RG, Jauch EC, Kern KB, Laurent I, Longstreth WT, Merchant RM, Morley P, Morrison LJ, Nadkarni V, Peberdy MA, Rivers EP, Rodriguez-Nunez A, Sellke FW, Spaulding C, Sunde K, Hoek TV
Resuscitation 2008 Dec;79(3):350-79. Epub 2008 Oct 28 doi: 10.1016/j.resuscitation.2008.09.017. PMID: 18963350

Recent clinical studies

Etiology

Prehospital high-dose methylprednisolone in resuscitated out-of-hospital cardiac arrest patients (STEROHCA): a randomized clinical trial.
Obling LER, Beske RP, Meyer MAS, Grand J, Wiberg S, Nyholm B, Josiassen J, Søndergaard FT, Mohr T, Damm-Hejmdal A, Bjerre M, Frikke-Schmidt R, Folke F, Møller JE, Kjaergaard J, Hassager C
Intensive Care Med 2023 Dec;49(12):1467-1478. Epub 2023 Nov 9 doi: 10.1007/s00134-023-07247-w. PMID: 37943300Free PMC Article
Blood Pressure and Oxygen Targets on Kidney Injury After Cardiac Arrest.
Rasmussen SB, Jeppesen KK, Kjaergaard J, Hassager C, Schmidt H, Mølstrøm S, Beske RP, Grand J, Ravn HB, Winther-Jensen M, Meyer MAS, Møller JE
Circulation 2023 Dec 5;148(23):1860-1869. Epub 2023 Oct 4 doi: 10.1161/CIRCULATIONAHA.123.066012. PMID: 37791480
Cytokine hemoadsorption with CytoSorb(®) in post-cardiac arrest syndrome, a pilot randomized controlled trial.
Monard C, Bianchi N, Poli E, Altarelli M, Debonneville A, Oddo M, Liaudet L, Schneider A
Crit Care 2023 Jan 23;27(1):36. doi: 10.1186/s13054-023-04323-x. PMID: 36691082Free PMC Article
Disseminated intravascular coagulation in cardiac arrest and resuscitation.
Gando S, Wada T
J Thromb Haemost 2019 Aug;17(8):1205-1216. Epub 2019 Jun 5 doi: 10.1111/jth.14480. PMID: 31102491
Post-cardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication. A Scientific Statement from the International Liaison Committee on Resuscitation; the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; the Council on Stroke.
Nolan JP, Neumar RW, Adrie C, Aibiki M, Berg RA, Böttiger BW, Callaway C, Clark RS, Geocadin RG, Jauch EC, Kern KB, Laurent I, Longstreth WT, Merchant RM, Morley P, Morrison LJ, Nadkarni V, Peberdy MA, Rivers EP, Rodriguez-Nunez A, Sellke FW, Spaulding C, Sunde K, Hoek TV
Resuscitation 2008 Dec;79(3):350-79. Epub 2008 Oct 28 doi: 10.1016/j.resuscitation.2008.09.017. PMID: 18963350

Diagnosis

European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2021: post-resuscitation care.
Nolan JP, Sandroni C, Böttiger BW, Cariou A, Cronberg T, Friberg H, Genbrugge C, Haywood K, Lilja G, Moulaert VRM, Nikolaou N, Olasveengen TM, Skrifvars MB, Taccone F, Soar J
Intensive Care Med 2021 Apr;47(4):369-421. Epub 2021 Mar 25 doi: 10.1007/s00134-021-06368-4. PMID: 33765189Free PMC Article
Comprehensive Cardiac Care After Cardiac Arrest.
Burstein B, Jentzer JC
Crit Care Clin 2020 Oct;36(4):771-786. Epub 2020 Aug 12 doi: 10.1016/j.ccc.2020.07.007. PMID: 32892828
Disseminated intravascular coagulation in cardiac arrest and resuscitation.
Gando S, Wada T
J Thromb Haemost 2019 Aug;17(8):1205-1216. Epub 2019 Jun 5 doi: 10.1111/jth.14480. PMID: 31102491
Neurology of cardiopulmonary resuscitation.
Mulder M, Geocadin RG
Handb Clin Neurol 2017;141:593-617. doi: 10.1016/B978-0-444-63599-0.00032-6. PMID: 28190437
Post-cardiac arrest syndrome.
Binks A, Nolan JP
Minerva Anestesiol 2010 May;76(5):362-8. PMID: 20395899

Therapy

Prehospital high-dose methylprednisolone in resuscitated out-of-hospital cardiac arrest patients (STEROHCA): a randomized clinical trial.
Obling LER, Beske RP, Meyer MAS, Grand J, Wiberg S, Nyholm B, Josiassen J, Søndergaard FT, Mohr T, Damm-Hejmdal A, Bjerre M, Frikke-Schmidt R, Folke F, Møller JE, Kjaergaard J, Hassager C
Intensive Care Med 2023 Dec;49(12):1467-1478. Epub 2023 Nov 9 doi: 10.1007/s00134-023-07247-w. PMID: 37943300Free PMC Article
Blood Pressure and Oxygen Targets on Kidney Injury After Cardiac Arrest.
Rasmussen SB, Jeppesen KK, Kjaergaard J, Hassager C, Schmidt H, Mølstrøm S, Beske RP, Grand J, Ravn HB, Winther-Jensen M, Meyer MAS, Møller JE
Circulation 2023 Dec 5;148(23):1860-1869. Epub 2023 Oct 4 doi: 10.1161/CIRCULATIONAHA.123.066012. PMID: 37791480
Nitric Oxide in Post-cardiac Arrest Syndrome.
Miyazaki Y, Ichinose F
J Cardiovasc Pharmacol 2020 Jun;75(6):508-515. doi: 10.1097/FJC.0000000000000765. PMID: 32421275
Pediatric Post-Cardiac Arrest Care: A Scientific Statement From the American Heart Association.
Topjian AA, de Caen A, Wainwright MS, Abella BS, Abend NS, Atkins DL, Bembea MM, Fink EL, Guerguerian AM, Haskell SE, Kilgannon JH, Lasa JJ, Hazinski MF
Circulation 2019 Aug 6;140(6):e194-e233. Epub 2019 Jun 27 doi: 10.1161/CIR.0000000000000697. PMID: 31242751
Neurology of cardiopulmonary resuscitation.
Mulder M, Geocadin RG
Handb Clin Neurol 2017;141:593-617. doi: 10.1016/B978-0-444-63599-0.00032-6. PMID: 28190437

Prognosis

The immunology of the post-cardiac arrest syndrome.
Cunningham CA, Coppler PJ, Skolnik AB
Resuscitation 2022 Oct;179:116-123. Epub 2022 Aug 24 doi: 10.1016/j.resuscitation.2022.08.013. PMID: 36028143
European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2021: post-resuscitation care.
Nolan JP, Sandroni C, Böttiger BW, Cariou A, Cronberg T, Friberg H, Genbrugge C, Haywood K, Lilja G, Moulaert VRM, Nikolaou N, Olasveengen TM, Skrifvars MB, Taccone F, Soar J
Intensive Care Med 2021 Apr;47(4):369-421. Epub 2021 Mar 25 doi: 10.1007/s00134-021-06368-4. PMID: 33765189Free PMC Article
Pediatric Post-Cardiac Arrest Care: A Scientific Statement From the American Heart Association.
Topjian AA, de Caen A, Wainwright MS, Abella BS, Abend NS, Atkins DL, Bembea MM, Fink EL, Guerguerian AM, Haskell SE, Kilgannon JH, Lasa JJ, Hazinski MF
Circulation 2019 Aug 6;140(6):e194-e233. Epub 2019 Jun 27 doi: 10.1161/CIR.0000000000000697. PMID: 31242751
Post-cardiac arrest syndrome.
Binks A, Nolan JP
Minerva Anestesiol 2010 May;76(5):362-8. PMID: 20395899
Post-cardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication. A Scientific Statement from the International Liaison Committee on Resuscitation; the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; the Council on Stroke.
Nolan JP, Neumar RW, Adrie C, Aibiki M, Berg RA, Böttiger BW, Callaway C, Clark RS, Geocadin RG, Jauch EC, Kern KB, Laurent I, Longstreth WT, Merchant RM, Morley P, Morrison LJ, Nadkarni V, Peberdy MA, Rivers EP, Rodriguez-Nunez A, Sellke FW, Spaulding C, Sunde K, Hoek TV
Resuscitation 2008 Dec;79(3):350-79. Epub 2008 Oct 28 doi: 10.1016/j.resuscitation.2008.09.017. PMID: 18963350

Clinical prediction guides

Prehospital high-dose methylprednisolone in resuscitated out-of-hospital cardiac arrest patients (STEROHCA): a randomized clinical trial.
Obling LER, Beske RP, Meyer MAS, Grand J, Wiberg S, Nyholm B, Josiassen J, Søndergaard FT, Mohr T, Damm-Hejmdal A, Bjerre M, Frikke-Schmidt R, Folke F, Møller JE, Kjaergaard J, Hassager C
Intensive Care Med 2023 Dec;49(12):1467-1478. Epub 2023 Nov 9 doi: 10.1007/s00134-023-07247-w. PMID: 37943300Free PMC Article
Somatosensory Evoked Potentials and Neuroprognostication After Cardiac Arrest.
Lachance B, Wang Z, Badjatia N, Jia X
Neurocrit Care 2020 Jun;32(3):847-857. doi: 10.1007/s12028-019-00903-4. PMID: 31907802Free PMC Article
Disseminated intravascular coagulation in cardiac arrest and resuscitation.
Gando S, Wada T
J Thromb Haemost 2019 Aug;17(8):1205-1216. Epub 2019 Jun 5 doi: 10.1111/jth.14480. PMID: 31102491
The post-cardiac arrest syndrome: A case for lung-brain coupling and opportunities for neuroprotection.
Mai N, Miller-Rhodes K, Knowlden S, Halterman MW
J Cereb Blood Flow Metab 2019 Jun;39(6):939-958. Epub 2019 Mar 13 doi: 10.1177/0271678X19835552. PMID: 30866740Free PMC Article
Neurology of cardiopulmonary resuscitation.
Mulder M, Geocadin RG
Handb Clin Neurol 2017;141:593-617. doi: 10.1016/B978-0-444-63599-0.00032-6. PMID: 28190437

Recent systematic reviews

Monitoring of Cerebral Blood Flow Autoregulation after Cardiac Arrest.
Petrovčič R, Rakusa M, Markota A
Medicina (Kaunas) 2024 Aug 23;60(9) doi: 10.3390/medicina60091381. PMID: 39336422Free PMC Article
Procalcitonin as a prognostic marker for outcomes in post-cardiac arrest patients: A systematic review and meta-analysis.
Shin H, Kim JG, Kim W, Lim TH, Jang BH, Cho Y, Choi KS, Ahn C, Lee J, Na MK
Resuscitation 2019 May;138:160-167. Epub 2019 Mar 11 doi: 10.1016/j.resuscitation.2019.02.041. PMID: 30872069
Effects of PaCO2 derangements on clinical outcomes after cerebral injury: A systematic review.
Roberts BW, Karagiannis P, Coletta M, Kilgannon JH, Chansky ME, Trzeciak S
Resuscitation 2015 Jun;91:32-41. Epub 2015 Mar 28 doi: 10.1016/j.resuscitation.2015.03.015. PMID: 25828950
Outcome measures utilized in clinical trials of interventions for post-cardiac arrest syndrome: a systematic review.
Trzeciak S, Jones AE, Kilgannon JH, Fuller BM, Roberts BW, Parrillo JE, Farrar JT
Resuscitation 2009 Jun;80(6):617-23. Epub 2009 Apr 21 doi: 10.1016/j.resuscitation.2009.03.014. PMID: 19386408Free PMC Article
Goal-directed hemodynamic optimization in the post-cardiac arrest syndrome: a systematic review.
Jones AE, Shapiro NI, Kilgannon JH, Trzeciak S; Emergency Medicine Shock Research Network (EMSHOCKNET) investigators
Resuscitation 2008 Apr;77(1):26-9. Epub 2007 Dec 27 doi: 10.1016/j.resuscitation.2007.10.021. PMID: 18164117

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