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Severe fever with thrombocytopenia syndrome

MedGen UID:
924784
•Concept ID:
C4284413
•
Disease or Syndrome
Synonyms: Infection, SFTS Virus; Severe Fever with Thrombocytopenia Syndrome; Severe Fever with Thrombocytopenia Syndrome Bunyavirus Infection; SFTS Virus Infection; SFTS Virus Infections; Virus Infection, SFTS
SNOMED CT: SFTS - Severe Fever with Thrombocytopenia Syndrome (722401001); FTLS - Fever, thrombocytopenia, and leukopenia syndrome (722401001); Severe fever with thrombocytopenia syndrome (722401001)

Definition

Severe fever with thrombocytopenia syndrome (SFTS) is a newly emerging infectious disease. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSevere fever with thrombocytopenia syndrome

Professional guidelines

PubMed

Antiviral immunity of severe fever with thrombocytopenia syndrome: current understanding and implications for clinical treatment.
Niu Y, Liu Y, Huang L, Liu W, Cheng Q, Liu T, Ning Q, Chen T
Front Immunol 2024;15:1348836. Epub 2024 Apr 5 doi: 10.3389/fimmu.2024.1348836. PMID: 38646523Free PMC Article
Severe fever with thrombocytopenia syndrome virus genotype B in Thailand.
Rattanakomol P, Khongwichit S, Chuchaona W, Vongpunsawad S, Poovorawan Y
Arch Virol 2023 Oct 13;168(11):271. doi: 10.1007/s00705-023-05897-1. PMID: 37833439
Clinical efficacy of immunoglobulin on the treatment of severe fever with thrombocytopenia syndrome: a retrospective cohort study.
Zhang SS, Du J, Cui N, Yang X, Zhang L, Zhang WX, Yue M, Wu YX, Yang T, Zhang XA, Yang ZD, Lv HD, Lu QB, Liu W
EBioMedicine 2023 Oct;96:104807. Epub 2023 Sep 20 doi: 10.1016/j.ebiom.2023.104807. PMID: 37738834Free PMC Article

Recent clinical studies

Etiology

Epidemiology of Severe Fever with Thrombocytopenia Syndrome in Dogs and Cats in Taiwan.
Kuan CY, Ou SC, Chang CC, Kao PL, Tsai RS, Rattanapanadda P, Lin TL, Maeda K, Cheng TL, Lee YJ, Chuang ST, Lin SL, Liu HY, Lin FY, Lin JW, Hsu WL, Chou CC
Viruses 2023 Nov 28;15(12) doi: 10.3390/v15122338. PMID: 38140579Free PMC Article
Single-cell landscape of peripheral immune responses to fatal SFTS.
Li H, Li X, Lv S, Peng X, Cui N, Yang T, Yang Z, Yuan C, Yuan Y, Yao J, Yuan Z, Li J, Ye X, Zhang X, Zhu S, Peng K, Liu W
Cell Rep 2021 Nov 23;37(8):110039. doi: 10.1016/j.celrep.2021.110039. PMID: 34818556
Severe fever with thrombocytopenia syndrome virus: a highly lethal bunyavirus.
Li J, Li S, Yang L, Cao P, Lu J
Crit Rev Microbiol 2021 Feb;47(1):112-125. Epub 2020 Nov 27 doi: 10.1080/1040841X.2020.1847037. PMID: 33245676
Calcium channel blockers reduce severe fever with thrombocytopenia syndrome virus (SFTSV) related fatality.
Li H, Zhang LK, Li SF, Zhang SF, Wan WW, Zhang YL, Xin QL, Dai K, Hu YY, Wang ZB, Zhu XT, Fang YJ, Cui N, Zhang PH, Yuan C, Lu QB, Bai JY, Deng F, Xiao GF, Liu W, Peng K
Cell Res 2019 Sep;29(9):739-753. Epub 2019 Aug 23 doi: 10.1038/s41422-019-0214-z. PMID: 31444469Free PMC Article
Severe fever with thrombocytopenia syndrome, an emerging tick-borne zoonosis.
Liu Q, He B, Huang SY, Wei F, Zhu XQ
Lancet Infect Dis 2014 Aug;14(8):763-772. Epub 2014 May 15 doi: 10.1016/S1473-3099(14)70718-2. PMID: 24837566

Diagnosis

The pathogenic and clinical characteristics of severe fever with thrombocytopenia syndrome patients with co-infections.
Song H, Zou S, Huang Y, Wang Y, Wang T, Wei W, Sun Z, Hou H
Front Cell Infect Microbiol 2023;13:1298050. Epub 2023 Dec 1 doi: 10.3389/fcimb.2023.1298050. PMID: 38106473Free PMC Article
Clinically differential diagnosis of human granulocytic anaplasmosis and severe fever with thrombocytopenia syndrome.
Kim DM, Yu BJ, Kim DY, Seo JW, Yun NR, Kim CM, Kim YK, Jung SI, Kim UJ, Kim SE, Kim HA, Kim ES, Hur J, Lee SH, Jeong HW, Heo JY, Jung DS, Kim J, Park SH, Kwak YG, Lee S, Lim S, Chatterjee S
Sci Rep 2023 Apr 26;13(1):6837. doi: 10.1038/s41598-023-32061-1. PMID: 37100782Free PMC Article
Clinical Update of Severe Fever with Thrombocytopenia Syndrome.
Seo JW, Kim D, Yun N, Kim DM
Viruses 2021 Jun 23;13(7) doi: 10.3390/v13071213. PMID: 34201811Free PMC Article
Current status of severe fever with thrombocytopenia syndrome in China.
Zhan J, Wang Q, Cheng J, Hu B, Li J, Zhan F, Song Y, Guo D
Virol Sin 2017 Feb;32(1):51-62. Epub 2017 Feb 27 doi: 10.1007/s12250-016-3931-1. PMID: 28251515Free PMC Article
Severe fever with thrombocytopenia syndrome, an emerging tick-borne zoonosis.
Liu Q, He B, Huang SY, Wei F, Zhu XQ
Lancet Infect Dis 2014 Aug;14(8):763-772. Epub 2014 May 15 doi: 10.1016/S1473-3099(14)70718-2. PMID: 24837566

Therapy

Coinfections in hospitalized patients with severe fever with thrombocytopenia syndrome: A retrospective study.
Ge HH, Wang G, Guo PJ, Zhao J, Zhang S, Xu YL, Liu YN, Ye XL, Wu YX, Li S, Yue M, Ji WJ, Geng SY, Li H, Zhang XA, Yang ZD, Cui N, Li W, Lin L, Liu W
J Med Virol 2022 Dec;94(12):5933-5942. Epub 2022 Sep 3 doi: 10.1002/jmv.28093. PMID: 36030552
The Endless Wars: Severe Fever With Thrombocytopenia Syndrome Virus, Host Immune and Genetic Factors.
Wang M, Tan W, Li J, Fang L, Yue M
Front Cell Infect Microbiol 2022;12:808098. Epub 2022 Jun 15 doi: 10.3389/fcimb.2022.808098. PMID: 35782112Free PMC Article
Clinical Update of Severe Fever with Thrombocytopenia Syndrome.
Seo JW, Kim D, Yun N, Kim DM
Viruses 2021 Jun 23;13(7) doi: 10.3390/v13071213. PMID: 34201811Free PMC Article
Calcium channel blockers reduce severe fever with thrombocytopenia syndrome virus (SFTSV) related fatality.
Li H, Zhang LK, Li SF, Zhang SF, Wan WW, Zhang YL, Xin QL, Dai K, Hu YY, Wang ZB, Zhu XT, Fang YJ, Cui N, Zhang PH, Yuan C, Lu QB, Bai JY, Deng F, Xiao GF, Liu W, Peng K
Cell Res 2019 Sep;29(9):739-753. Epub 2019 Aug 23 doi: 10.1038/s41422-019-0214-z. PMID: 31444469Free PMC Article
Pathophysiology of severe fever with thrombocytopenia syndrome and development of specific antiviral therapy.
Saijo M
J Infect Chemother 2018 Oct;24(10):773-781. Epub 2018 Aug 8 doi: 10.1016/j.jiac.2018.07.009. PMID: 30098914

Prognosis

Association of liver function and prognosis in patients with severe fever with thrombocytopenia syndrome.
Zhang S, Wang J, Zhang Q, Pan Y, Zhang Z, Geng Y, Jia B, Li Y, Xiong Y, Yan X, Li J, Wang H, Wu C, Huang R
PLoS Negl Trop Dis 2024 Apr;18(4):e0012068. Epub 2024 Apr 16 doi: 10.1371/journal.pntd.0012068. PMID: 38626222Free PMC Article
Pulmonary infection in patients with severe fever with thrombocytopenia syndrome: A multicentre observational study.
Zuo Y, Wang H, Huang J, Zhang F, Lv D, Meng T, Bibi A, Shen J, Wang L, Wang Z, Xu Y
J Med Virol 2023 Apr;95(4):e28712. doi: 10.1002/jmv.28712. PMID: 36991571
Severe fever with thrombocytopenia syndrome virus replicates in platelets and enhances platelet activation.
Fang L, Yu S, Tian X, Fu W, Su L, Chen Z, Yan C, He J, Hong J, Lian W, Liu G, Zhang Y, Zhou J, Hu L
J Thromb Haemost 2023 May;21(5):1336-1351. Epub 2023 Feb 13 doi: 10.1016/j.jtha.2023.02.006. PMID: 36792011
Single-cell landscape of peripheral immune responses to fatal SFTS.
Li H, Li X, Lv S, Peng X, Cui N, Yang T, Yang Z, Yuan C, Yuan Y, Yao J, Yuan Z, Li J, Ye X, Zhang X, Zhu S, Peng K, Liu W
Cell Rep 2021 Nov 23;37(8):110039. doi: 10.1016/j.celrep.2021.110039. PMID: 34818556
Severe fever with thrombocytopenia syndrome, an emerging tick-borne zoonosis.
Liu Q, He B, Huang SY, Wei F, Zhu XQ
Lancet Infect Dis 2014 Aug;14(8):763-772. Epub 2014 May 15 doi: 10.1016/S1473-3099(14)70718-2. PMID: 24837566

Clinical prediction guides

Epidemiology of Severe Fever with Thrombocytopenia Syndrome in Dogs and Cats in Taiwan.
Kuan CY, Ou SC, Chang CC, Kao PL, Tsai RS, Rattanapanadda P, Lin TL, Maeda K, Cheng TL, Lee YJ, Chuang ST, Lin SL, Liu HY, Lin FY, Lin JW, Hsu WL, Chou CC
Viruses 2023 Nov 28;15(12) doi: 10.3390/v15122338. PMID: 38140579Free PMC Article
Clinical Characteristics and Diagnostic Prediction of Severe Fever with Thrombocytopenia Syndrome and Rickettsiosis in the Co-Endemic Wakayama Prefecture, Japan.
Teramoto K, Tamura S, Yoshida K, Inada Y, Yamashita Y, Morimoto M, Mushino T, Koreeda D, Miyamoto K, Komiya N, Nakano Y, Takagaki Y, Koizumi Y
Medicina (Kaunas) 2023 Nov 17;59(11) doi: 10.3390/medicina59112024. PMID: 38004073Free PMC Article
Severe fever with thrombocytopenia syndrome virus induces platelet activation and apoptosis via a reactive oxygen species-dependent pathway.
Li YH, Wang XH, Huang WW, Tian RR, Pang W, Zheng YT
Redox Biol 2023 Sep;65:102837. Epub 2023 Aug 1 doi: 10.1016/j.redox.2023.102837. PMID: 37544244Free PMC Article
Effect of genomic variations in severe fever with thrombocytopenia syndrome virus on the disease lethality.
Dai ZN, Peng XF, Li JC, Zhao J, Wu YX, Yang X, Yang T, Zhang SF, Dai K, Guan XG, Yuan C, Yang ZD, Cui N, Lu QB, Huang Y, Fan H, Zhang XA, Xiao GF, Peng K, Zhang LK, Liu W, Li H
Emerg Microbes Infect 2022 Dec;11(1):1672-1682. doi: 10.1080/22221751.2022.2081617. PMID: 35603493Free PMC Article
SFTSV Infection Induces BAK/BAX-Dependent Mitochondrial DNA Release to Trigger NLRP3 Inflammasome Activation.
Li S, Li H, Zhang YL, Xin QL, Guan ZQ, Chen X, Zhang XA, Li XK, Xiao GF, Lozach PY, Cui J, Liu W, Zhang LK, Peng K
Cell Rep 2020 Mar 31;30(13):4370-4385.e7. doi: 10.1016/j.celrep.2020.02.105. PMID: 32234474

Recent systematic reviews

Comprehensive meta-analysis of severe fever with thrombocytopenia syndrome virus infections in humans, vertebrate hosts and questing ticks.
Xu AL, Xue H, Li Y, Wang X, Zheng JX, Shi FY, Cui QX, Lu Y, Cun DJ, Li LH
Parasit Vectors 2024 Jun 20;17(1):265. doi: 10.1186/s13071-024-06341-2. PMID: 38902842Free PMC Article
Clinical laboratory parameters and fatality of Severe fever with thrombocytopenia syndrome patients: A systematic review and meta-analysis.
Wang Y, Song Z, Wei X, Yuan H, Xu X, Liang H, Wen H
PLoS Negl Trop Dis 2022 Jun;16(6):e0010489. Epub 2022 Jun 17 doi: 10.1371/journal.pntd.0010489. PMID: 35714138Free PMC Article
Severe fever with thrombocytopenia syndrome virus: a systematic review and meta-analysis of transmission mode.
Huang XY, He ZQ, Wang BH, Hu K, Li Y, Guo WS
Epidemiol Infect 2020 Sep 30;148:e239. doi: 10.1017/S0950268820002290. PMID: 32993819Free PMC Article
Seroprevalence of severe fever with thrombocytopenia syndrome virus in China: A systematic review and meta-analysis.
Li P, Tong ZD, Li KF, Tang A, Dai YX, Yan JB
PLoS One 2017;12(4):e0175592. Epub 2017 Apr 11 doi: 10.1371/journal.pone.0175592. PMID: 28399161Free PMC Article
Systematic review of severe fever with thrombocytopenia syndrome: virology, epidemiology, and clinical characteristics.
Liu S, Chai C, Wang C, Amer S, Lv H, He H, Sun J, Lin J
Rev Med Virol 2014 Mar;24(2):90-102. Epub 2013 Dec 6 doi: 10.1002/rmv.1776. PMID: 24310908Free PMC Article

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