U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Epstein-Barr virus-associated gastric carcinoma

MedGen UID:
896878
•Concept ID:
C4274414
•
Neoplastic Process
Synonyms: Carcinoma of stomach due to Epstein-Barr virus disease; EBV-Associated Gastric Carcinoma; EBV-associated gastric carcinoma; EBV-Related Gastric Carcinoma; EBVaGC; Epstein-Barr virus associated gastric carcinoma; Epstein-Barr Virus-Associated Gastric Carcinoma; Epstein-Barr Virus-Related Gastric Carcinoma; Gastric carcinoma due to Epstein-Barr virus disease
SNOMED CT: Epstein-Barr virus associated gastric carcinoma (716586009); Carcinoma of stomach due to Epstein-Barr virus disease (716586009); Gastric carcinoma due to Epstein-Barr virus disease (716586009)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
•Concept ID:
C0600599
•
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
Non-Mendelian inheritance (Orphanet)
 
Monarch Initiative: MONDO:0017784
Orphanet: ORPHA313920

Definition

A rare form of gastric carcinoma characterized by a latent EBV infection in gastric carcinoma cells, diffuse-type histology, a proximal location (in the body and cardia of the stomach) and a relatively favorable prognosis. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEpstein-Barr virus-associated gastric carcinoma

Professional guidelines

PubMed

Treatment of Epstein-Barr Virus infection in immunocompromised patients.
Pociupany M, Snoeck R, Dierickx D, Andrei G
Biochem Pharmacol 2024 Jul;225:116270. Epub 2024 May 10 doi: 10.1016/j.bcp.2024.116270. PMID: 38734316
The importance of Epstein-Barr virus infection in the systemic treatment of patients with gastric cancer.
Pikuła A, Kwietniewska M, Rawicz-Pruszyński K, Ciseł B, Skórzewska M, Gęca K, Franciszkiewicz-Pietrzak K, Kurylcio A, Mielko J, Polkowski WP
Semin Oncol 2020 Apr-Jun;47(2-3):127-137. Epub 2020 May 6 doi: 10.1053/j.seminoncol.2020.04.001. PMID: 32402473
Clinical utility of circulating cell-free Epstein-Barr virus DNA in patients with gastric cancer.
Shoda K, Ichikawa D, Fujita Y, Masuda K, Hiramoto H, Hamada J, Arita T, Konishi H, Kosuga T, Komatsu S, Shiozaki A, Okamoto K, Imoto I, Otsuji E
Oncotarget 2017 Apr 25;8(17):28796-28804. doi: 10.18632/oncotarget.15675. PMID: 28430637Free PMC Article

Recent clinical studies

Etiology

Sex-dependent different clinicopathological characterization of Epstein-Barr virus-associated gastric carcinoma: a large-scale study.
Kim JH, Kim N, Song DH, Choi Y, Jeon EB, Kim S, Jun YK, Yoon H, Shin CM, Park YS, Lee DH, Oh HJ, Lee HS, Park YS, Ahn SH, Suh YS, Park DJ, Kim HH, Kim JW, Kim JW, Lee KW, Chang W, Park JH, Lee YJ, Lee KH, Kim YH, Ahn S
Gastric Cancer 2024 Mar;27(2):221-234. Epub 2024 Jan 11 doi: 10.1007/s10120-023-01460-8. PMID: 38212543Free PMC Article
Prognostic Value of Tumor-Infiltrating Lymphocytes and Tertiary Lymphoid Structures in Epstein-Barr Virus-Associated and -Negative Gastric Carcinoma.
Cheng N, Li P, Cheng H, Zhao X, Dong M, Zhang Y, Zhao P, Chen J, Shao C
Front Immunol 2021;12:692859. Epub 2021 Jul 1 doi: 10.3389/fimmu.2021.692859. PMID: 34276684Free PMC Article
Clinicopathological features of Epstein-Barr virus-associated gastric carcinoma: A systematic review and meta-analysis.
Qiao YW, Zhao XQ, Liu J, Yang WJ
J BUON 2019 May-Jun;24(3):1092-1099. PMID: 31424666
Genome-wide analysis of Epstein-Barr virus identifies variants and genes associated with gastric carcinoma and population structure.
Yao Y, Xu M, Liang L, Zhang H, Xu R, Feng Q, Feng L, Luo B, Zeng YX
Tumour Biol 2017 Oct;39(10):1010428317714195. doi: 10.1177/1010428317714195. PMID: 29034771
Clinicopathological and molecular characteristics of Epstein-Barr virus-associated gastric carcinoma: a meta-analysis.
Lee JH, Kim SH, Han SH, An JS, Lee ES, Kim YS
J Gastroenterol Hepatol 2009 Mar;24(3):354-65. doi: 10.1111/j.1440-1746.2009.05775.x. PMID: 19335785

Diagnosis

MC180295 Inhibited Epstein-Barr Virus-Associated Gastric Carcinoma Cell Growth by Suppressing DNA Repair and the Cell Cycle.
Fujii T, Nishikawa J, Fukuda S, Kubota N, Nojima J, Fujisawa K, Ogawa R, Goto A, Hamabe K, Hashimoto S, Wai AP, Iizasa H, Yoshiyama H, Sakai K, Suehiro Y, Yamasaki T, Takami T
Int J Mol Sci 2022 Sep 13;23(18) doi: 10.3390/ijms231810597. PMID: 36142506Free PMC Article
Prognostic Value of Tumor-Infiltrating Lymphocytes and Tertiary Lymphoid Structures in Epstein-Barr Virus-Associated and -Negative Gastric Carcinoma.
Cheng N, Li P, Cheng H, Zhao X, Dong M, Zhang Y, Zhao P, Chen J, Shao C
Front Immunol 2021;12:692859. Epub 2021 Jul 1 doi: 10.3389/fimmu.2021.692859. PMID: 34276684Free PMC Article
Expression and prognostic roles of PIK3CA, JAK2, PD-L1, and PD-L2 in Epstein-Barr virus-associated gastric carcinoma.
Dong M, Wang HY, Zhao XX, Chen JN, Zhang YW, Huang Y, Xue L, Li HG, Du H, Wu XY, Shao CK
Hum Pathol 2016 Jul;53:25-34. Epub 2016 Mar 4 doi: 10.1016/j.humpath.2016.02.007. PMID: 26980034
Targeted therapy for Epstein-Barr virus-associated gastric carcinoma using low-dose gemcitabine-induced lytic activation.
Lee HG, Kim H, Kim EJ, Park PG, Dong SM, Choi TH, Kim H, Chong CR, Liu JO, Chen J, Ambinder RF, Hayward SD, Park JH, Lee JM
Oncotarget 2015 Oct 13;6(31):31018-29. doi: 10.18632/oncotarget.5041. PMID: 26427042Free PMC Article
Epstein-Barr virus associated gastric carcinoma: epidemiological and clinicopathological features.
Akiba S, Koriyama C, Herrera-Goepfert R, Eizuru Y
Cancer Sci 2008 Feb;99(2):195-201. doi: 10.1111/j.1349-7006.2007.00674.x. PMID: 18271915Free PMC Article

Therapy

Clinicopathological features of Epstein-Barr virus-associated gastric carcinoma: A systematic review and meta-analysis.
Qiao YW, Zhao XQ, Liu J, Yang WJ
J BUON 2019 May-Jun;24(3):1092-1099. PMID: 31424666
Epstein-Barr virus-associated gastric carcinoma.
Fukayama M, Ushiku T
Pathol Res Pract 2011 Sep 15;207(9):529-37. Epub 2011 Sep 23 doi: 10.1016/j.prp.2011.07.004. PMID: 21944426
Ganciclovir augments the lytic induction and apoptosis induced by chemotherapeutic agents in an Epstein-Barr virus-infected gastric carcinoma cell line.
Ji Jung E, Mie Lee Y, Lan Lee B, Soo Chang M, Ho Kim W
Anticancer Drugs 2007 Jan;18(1):79-85. doi: 10.1097/CAD.0b013e3280101006. PMID: 17159505

Prognosis

Expression of MAP9 in Epstein-Barr virus-associated gastric carcinoma.
Xiao H, Sun J, Huang W, Liu W, Zhang Y, Wang H, Luo B
Virus Res 2021 Feb;293:198253. Epub 2020 Dec 10 doi: 10.1016/j.virusres.2020.198253. PMID: 33309912
Update on Epstein-Barr virus and gastric cancer (review).
Shinozaki-Ushiku A, Kunita A, Fukayama M
Int J Oncol 2015 Apr;46(4):1421-34. Epub 2015 Jan 28 doi: 10.3892/ijo.2015.2856. PMID: 25633561
Epigenetic dysregulation in Epstein-Barr virus-associated gastric carcinoma: disease and treatments.
Yau TO, Tang CM, Yu J
World J Gastroenterol 2014 Jun 7;20(21):6448-56. doi: 10.3748/wjg.v20.i21.6448. PMID: 24914366Free PMC Article
Clinicopathological and molecular characteristics of Epstein-Barr virus-associated gastric carcinoma: a meta-analysis.
Lee JH, Kim SH, Han SH, An JS, Lee ES, Kim YS
J Gastroenterol Hepatol 2009 Mar;24(3):354-65. doi: 10.1111/j.1440-1746.2009.05775.x. PMID: 19335785
Epstein-Barr virus associated gastric carcinoma: epidemiological and clinicopathological features.
Akiba S, Koriyama C, Herrera-Goepfert R, Eizuru Y
Cancer Sci 2008 Feb;99(2):195-201. doi: 10.1111/j.1349-7006.2007.00674.x. PMID: 18271915Free PMC Article

Clinical prediction guides

Prognostic Effect of Tertiary Lymphoid Structures in Epstein-Barr Virus-Associated Gastric Carcinomas Measured by Digital Image Analysis.
Cho YJ, Hwang I, Park S, Lee S, Kang SY, Kim MJ, Ahn S, Kim KM
Lab Invest 2024 Jul;104(7):102071. Epub 2024 Apr 26 doi: 10.1016/j.labinv.2024.102071. PMID: 38677591
MC180295 Inhibited Epstein-Barr Virus-Associated Gastric Carcinoma Cell Growth by Suppressing DNA Repair and the Cell Cycle.
Fujii T, Nishikawa J, Fukuda S, Kubota N, Nojima J, Fujisawa K, Ogawa R, Goto A, Hamabe K, Hashimoto S, Wai AP, Iizasa H, Yoshiyama H, Sakai K, Suehiro Y, Yamasaki T, Takami T
Int J Mol Sci 2022 Sep 13;23(18) doi: 10.3390/ijms231810597. PMID: 36142506Free PMC Article
The implication of tumor-infiltrating lymphocytes in Epstein-Barr virus-associated gastric carcinoma.
Gong LP, Chen JN, Xiao L, He Q, Feng ZY, Zhang ZG, Liu JP, Wei HB, Shao CK
Hum Pathol 2019 Mar;85:82-91. Epub 2018 Nov 15 doi: 10.1016/j.humpath.2018.11.002. PMID: 30448221
Radiation-induced Epstein-Barr virus reactivation in gastric cancer cells with latent EBV infection.
Nandakumar A, Uwatoko F, Yamamoto M, Tomita K, Majima HJ, Akiba S, Koriyama C
Tumour Biol 2017 Jul;39(7):1010428317717718. doi: 10.1177/1010428317717718. PMID: 28675108
Epstein-Barr virus associated gastric carcinoma: epidemiological and clinicopathological features.
Akiba S, Koriyama C, Herrera-Goepfert R, Eizuru Y
Cancer Sci 2008 Feb;99(2):195-201. doi: 10.1111/j.1349-7006.2007.00674.x. PMID: 18271915Free PMC Article

Recent systematic reviews

Clinicopathological features of Epstein-Barr virus-associated gastric carcinoma: A systematic review and meta-analysis.
Qiao YW, Zhao XQ, Liu J, Yang WJ
J BUON 2019 May-Jun;24(3):1092-1099. PMID: 31424666

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...