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Peripheral resistance to thyroid hormones

MedGen UID:
902322
•Concept ID:
C4273673
•
Disease or Syndrome
Synonyms: Peripheral resistance to thyroid hormone; Peripheral Resistance to Thyroid Hormone; peripheral resistance to thyroid hormones; PRTH
SNOMED CT: Peripheral resistance to thyroid hormone (718193005)
 
Monarch Initiative: MONDO:0019995

Definition

Decreased response to thyroid hormones in peripheral tissues, with normal response in the pituitary gland. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPeripheral resistance to thyroid hormones

Professional guidelines

PubMed

Management of advanced medullary thyroid cancer.
Hadoux J, Pacini F, Tuttle RM, Schlumberger M
Lancet Diabetes Endocrinol 2016 Jan;4(1):64-71. Epub 2015 Oct 23 doi: 10.1016/S2213-8587(15)00337-X. PMID: 26608066
Molecular mechanisms of depression: perspectives on new treatment strategies.
Lang UE, Borgwardt S
Cell Physiol Biochem 2013;31(6):761-77. Epub 2013 May 31 doi: 10.1159/000350094. PMID: 23735822
Thyroid disorders in chronic heart failure: from prognostic set-up to therapeutic management.
Triggiani V, Iacoviello M
Endocr Metab Immune Disord Drug Targets 2013 Mar;13(1):22-37. doi: 10.2174/1871530311313010005. PMID: 23369135

Recent clinical studies

Etiology

Glycometabolic reprogramming-induced XRCC1 lactylation confers therapeutic resistance in ALDH1A3-overexpressing glioblastoma.
Li G, Wang D, Zhai Y, Pan C, Zhang J, Wang C, Huang R, Yu M, Li Y, Liu X, Liu Y, Wu F, Zhao Z, Hu H, Shi Z, Kahlert UD, Jiang T, Zhang W
Cell Metab 2024 Aug 6;36(8):1696-1710.e10. doi: 10.1016/j.cmet.2024.07.011. PMID: 39111285
Impaired sensitivity to thyroid hormone correlates to osteoporosis and fractures in euthyroid individuals.
Liu C, Hua L, Liu K, Xin Z
J Endocrinol Invest 2023 Oct;46(10):2017-2029. Epub 2023 Feb 16 doi: 10.1007/s40618-023-02035-1. PMID: 36795243
Environmental Exposure during Pregnancy: Influence on Prenatal Development and Early Life: A Comprehensive Review.
Gómez-Roig MD, Pascal R, Cahuana MJ, García-Algar O, Sebastiani G, Andreu-Fernández V, Martínez L, Rodríguez G, Iglesia I, Ortiz-Arrabal O, Mesa MD, Cabero MJ, Guerra L, Llurba E, Domínguez C, Zanini MJ, Foraster M, Larqué E, Cabañas F, Lopez-Azorín M, Pérez A, Loureiro B, Pallás-Alonso CR, Escuder-Vieco D, Vento M
Fetal Diagn Ther 2021;48(4):245-257. Epub 2021 Mar 18 doi: 10.1159/000514884. PMID: 33735860
Obesity and cancer risk: Emerging biological mechanisms and perspectives.
Avgerinos KI, Spyrou N, Mantzoros CS, Dalamaga M
Metabolism 2019 Mar;92:121-135. Epub 2018 Nov 13 doi: 10.1016/j.metabol.2018.11.001. PMID: 30445141
Molecular mechanisms of depression: perspectives on new treatment strategies.
Lang UE, Borgwardt S
Cell Physiol Biochem 2013;31(6):761-77. Epub 2013 May 31 doi: 10.1159/000350094. PMID: 23735822

Diagnosis

Exploring the association between triglyceride-glucose index and thyroid function.
Cheng H, Hu Y, Zhao H, Zhou G, Wang G, Ma C, Xu Y
Eur J Med Res 2023 Nov 10;28(1):508. doi: 10.1186/s40001-023-01501-z. PMID: 37946276Free PMC Article
Environmental Exposure during Pregnancy: Influence on Prenatal Development and Early Life: A Comprehensive Review.
Gómez-Roig MD, Pascal R, Cahuana MJ, García-Algar O, Sebastiani G, Andreu-Fernández V, Martínez L, Rodríguez G, Iglesia I, Ortiz-Arrabal O, Mesa MD, Cabero MJ, Guerra L, Llurba E, Domínguez C, Zanini MJ, Foraster M, Larqué E, Cabañas F, Lopez-Azorín M, Pérez A, Loureiro B, Pallás-Alonso CR, Escuder-Vieco D, Vento M
Fetal Diagn Ther 2021;48(4):245-257. Epub 2021 Mar 18 doi: 10.1159/000514884. PMID: 33735860
Obesity and cancer risk: Emerging biological mechanisms and perspectives.
Avgerinos KI, Spyrou N, Mantzoros CS, Dalamaga M
Metabolism 2019 Mar;92:121-135. Epub 2018 Nov 13 doi: 10.1016/j.metabol.2018.11.001. PMID: 30445141
Molecular mechanisms of depression: perspectives on new treatment strategies.
Lang UE, Borgwardt S
Cell Physiol Biochem 2013;31(6):761-77. Epub 2013 May 31 doi: 10.1159/000350094. PMID: 23735822
Thyroid disease and the heart.
Klein I, Danzi S
Circulation 2007 Oct 9;116(15):1725-35. doi: 10.1161/CIRCULATIONAHA.106.678326. PMID: 17923583

Therapy

Environmental Exposure during Pregnancy: Influence on Prenatal Development and Early Life: A Comprehensive Review.
Gómez-Roig MD, Pascal R, Cahuana MJ, García-Algar O, Sebastiani G, Andreu-Fernández V, Martínez L, Rodríguez G, Iglesia I, Ortiz-Arrabal O, Mesa MD, Cabero MJ, Guerra L, Llurba E, Domínguez C, Zanini MJ, Foraster M, Larqué E, Cabañas F, Lopez-Azorín M, Pérez A, Loureiro B, Pallás-Alonso CR, Escuder-Vieco D, Vento M
Fetal Diagn Ther 2021;48(4):245-257. Epub 2021 Mar 18 doi: 10.1159/000514884. PMID: 33735860
Thyroid Hormone and Cardioprotection.
Gerdes AM, Ojamaa K
Compr Physiol 2016 Jun 13;6(3):1199-219. doi: 10.1002/cphy.c150012. PMID: 27347890
Molecular mechanisms of depression: perspectives on new treatment strategies.
Lang UE, Borgwardt S
Cell Physiol Biochem 2013;31(6):761-77. Epub 2013 May 31 doi: 10.1159/000350094. PMID: 23735822
Thyroid hormone resistance.
Agrawal NK, Goyal R, Rastogi A, Naik D, Singh SK
Postgrad Med J 2008 Sep;84(995):473-7. doi: 10.1136/pgmj.2008.069740. PMID: 18940949
Euthyroid hyperthyroxinemia.
Borst GC, Eil C, Burman KD
Ann Intern Med 1983 Mar;98(3):366-78. doi: 10.7326/0003-4819-98-3-366. PMID: 6187257

Prognosis

Sensitivity to Thyroid Hormones and Risk of Prediabetes: A Cross-Sectional Study.
Liu B, Wang Z, Fu J, Guan H, Lyu Z, Wang W
Front Endocrinol (Lausanne) 2021;12:657114. Epub 2021 May 4 doi: 10.3389/fendo.2021.657114. PMID: 34017311Free PMC Article
Dyslipidemia, Insulin Resistance, Ectopic Lipid Accumulation, and Vascular Function in Resistance to Thyroid Hormone β.
Moran C, McEniery CM, Schoenmakers N, Mitchell C, Sleigh A, Watson L, Lyons G, Burling K, Barker P, Chatterjee K
J Clin Endocrinol Metab 2021 Apr 23;106(5):e2005-e2014. doi: 10.1210/clinem/dgab002. PMID: 33524107Free PMC Article
Screening for New Markers to Assess Thyroid Hormone Action by OMICs Analysis of Human Samples.
Friedrich N, Pietzner M, Engelmann B, Homuth G, Führer D, Brabant G, Wallaschofski H, Völker U
Exp Clin Endocrinol Diabetes 2020 Jun;128(6-07):479-487. Epub 2020 Jun 16 doi: 10.1055/a-1144-2636. PMID: 32544978
Thyroid hormone and heart failure.
Schmidt-Ott UM, Ascheim DD
Curr Heart Fail Rep 2006 Sep;3(3):114-9. doi: 10.1007/s11897-006-0010-1. PMID: 16914103
Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress.
Tsigos C, Chrousos GP
J Psychosom Res 2002 Oct;53(4):865-71. doi: 10.1016/s0022-3999(02)00429-4. PMID: 12377295

Clinical prediction guides

Impaired Sensitivity to Thyroid Hormones is Associated with Mild Cognitive Impairment in Euthyroid Patients with Type 2 Diabetes.
Yu ZW, Pu SD, Sun XT, Wang XC, Gao XY, Shan ZY
Clin Interv Aging 2023;18:1263-1274. Epub 2023 Aug 3 doi: 10.2147/CIA.S413584. PMID: 37554512Free PMC Article
Molecular mechanisms of depression: perspectives on new treatment strategies.
Lang UE, Borgwardt S
Cell Physiol Biochem 2013;31(6):761-77. Epub 2013 May 31 doi: 10.1159/000350094. PMID: 23735822
Thyroid disease and the heart.
Klein I, Danzi S
Circulation 2007 Oct 9;116(15):1725-35. doi: 10.1161/CIRCULATIONAHA.106.678326. PMID: 17923583
Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress.
Tsigos C, Chrousos GP
J Psychosom Res 2002 Oct;53(4):865-71. doi: 10.1016/s0022-3999(02)00429-4. PMID: 12377295
Stress-induced hormonal alterations.
Weinmann M
Crit Care Clin 2001 Jan;17(1):1-10. doi: 10.1016/s0749-0704(05)70148-2. PMID: 11219222

Recent systematic reviews

Effect of Levothyroxine Supplementation on the Cardiac Morphology and Function in Patients With Subclinical Hypothyroidism: A Systematic Review and Meta-analysis.
Wang X, Wang H, Li Q, Wang P, Xing Y, Zhang F, Li J, Shan Z
J Clin Endocrinol Metab 2022 Aug 18;107(9):2674-2683. doi: 10.1210/clinem/dgac417. PMID: 35810404
Clinical review: Thyroid hormone therapy for postoperative nonthyroidal illnesses: a systematic review and synthesis.
Kaptein EM, Sanchez A, Beale E, Chan LS
J Clin Endocrinol Metab 2010 Oct;95(10):4526-34. Epub 2010 Jul 28 doi: 10.1210/jc.2010-1052. PMID: 20668034
Thyroid hormone therapy for obesity and nonthyroidal illnesses: a systematic review.
Kaptein EM, Beale E, Chan LS
J Clin Endocrinol Metab 2009 Oct;94(10):3663-75. Epub 2009 Sep 8 doi: 10.1210/jc.2009-0899. PMID: 19737920

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