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SPITZ NEVUS, SOMATIC

MedGen UID:
902704
•Concept ID:
C4225656
•
Neoplastic Process
OMIM®: 190020

Recent clinical studies

Etiology

An Atypical Deep Penetrating Nevus With Mutations in Beta Catenin , BRAFV600E , and IDH1R132C in an 8-Year-Old Boy.
Ireland AM, Wood BA, Whitfield J, Amanuel B, Harvey NT, Mesbah Ardakani N
Am J Dermatopathol 2022 Aug 1;44(8):607-610. Epub 2022 Apr 6 doi: 10.1097/DAD.0000000000002198. PMID: 35385855
Genetic analysis of multiple primary melanomas arising within the boundaries of congenital nevi depigmentosa.
Fuiten AM, Fankhauser RG, Smit DJ, Stark MS, Enright TF, Wood MA, DePatie NA, Pivik K, Sturm RA, Berry EG, Kulkarni RP
Pigment Cell Melanoma Res 2021 Nov;34(6):1123-1130. Epub 2021 May 7 doi: 10.1111/pcmr.12979. PMID: 33884765
The genomic landscape of childhood and adolescent melanoma.
Lu C, Zhang J, Nagahawatte P, Easton J, Lee S, Liu Z, Ding L, Wyczalkowski MA, Valentine M, Navid F, Mulder H, Tatevossian RG, Dalton J, Davenport J, Yin Z, Edmonson M, Rusch M, Wu G, Li Y, Parker M, Hedlund E, Shurtleff S, Raimondi S, Bhavin V, Donald Y, Mardis ER, Wilson RK, Evans WE, Ellison DW, Pounds S, Dyer M, Downing JR, Pappo A, Bahrami A
J Invest Dermatol 2015 Mar;135(3):816-823. Epub 2014 Sep 30 doi: 10.1038/jid.2014.425. PMID: 25268584Free PMC Article
Evaluation of DNA ploidy and degree of DNA abnormality in benign and malignant melanocytic lesions of the skin using video imaging.
Pilch H, Günzel S, Schäffer U, Tanner B, Heine M
Cancer 2000 Mar 15;88(6):1370-7. PMID: 10717619

Diagnosis

Biology and genetics of acquired and congenital melanocytic naevi.
Maher NG, Scolyer RA, Colebatch AJ
Pathology 2023 Mar;55(2):169-177. Epub 2022 Dec 29 doi: 10.1016/j.pathol.2022.12.344. PMID: 36635156
Single-Nucleotide Polymorphism Array for Histologically Ambiguous Melanocytic Tumors.
Geiersbach KB, Gliem TJ, Jenkins SM, Gaitatzes AG, Brodersen PR, Negro ME, Clees MJ, Swanson KE, Boeckman RM, Natrop TJ, Sukov WR, Shah KK, Greipp PT, Rowsey RA, Flotte TJ, Erickson LA, Guo R
J Mol Diagn 2022 Nov;24(11):1160-1170. Epub 2022 Sep 14 doi: 10.1016/j.jmoldx.2022.08.004. PMID: 36115511
Evaluation of Crizotinib Treatment in a Patient With Unresectable GOPC-ROS1 Fusion Agminated Spitz Nevi.
Robertson SJ, Orme L, Teixeira R, Shamassi M, Newell F, Patch AM, Yeh I, Gard G, Wilmott J, Jackett L, LeBoit P, Fellowes A, MacArthur G, Fox S, Hayward NK, Bastian B, Scolyer R, Waddell N, Penington A, Shackleton M
JAMA Dermatol 2021 Jul 1;157(7):836-841. doi: 10.1001/jamadermatol.2021.0025. PMID: 34076666Free PMC Article
Tumours associated with BAP1 mutations.
Murali R, Wiesner T, Scolyer RA
Pathology 2013 Feb;45(2):116-26. doi: 10.1097/PAT.0b013e32835d0efb. PMID: 23277170
Update in molecular diagnostics in melanocytic neoplasms.
Cooper C, Sorrell J, Gerami P
Adv Anat Pathol 2012 Nov;19(6):410-6. doi: 10.1097/PAP.0b013e318271a5cb. PMID: 23060066

Therapy

Evaluation of Crizotinib Treatment in a Patient With Unresectable GOPC-ROS1 Fusion Agminated Spitz Nevi.
Robertson SJ, Orme L, Teixeira R, Shamassi M, Newell F, Patch AM, Yeh I, Gard G, Wilmott J, Jackett L, LeBoit P, Fellowes A, MacArthur G, Fox S, Hayward NK, Bastian B, Scolyer R, Waddell N, Penington A, Shackleton M
JAMA Dermatol 2021 Jul 1;157(7):836-841. doi: 10.1001/jamadermatol.2021.0025. PMID: 34076666Free PMC Article
Personalized and targeted mutational analysis of multiple second primary melanomas under kinase inhibitors.
Donati M, Zelano G, Coppola R, Cinelli E, Verri M, Persichetti P, Perrella E, Devirgiliis V, Calvieri S, Crescenzi A, Panasiti V
Ital J Dermatol Venerol 2021 Oct;156(5):593-598. Epub 2019 Dec 4 doi: 10.23736/S2784-8671.19.06516-7. PMID: 31804055
The genomic landscape of childhood and adolescent melanoma.
Lu C, Zhang J, Nagahawatte P, Easton J, Lee S, Liu Z, Ding L, Wyczalkowski MA, Valentine M, Navid F, Mulder H, Tatevossian RG, Dalton J, Davenport J, Yin Z, Edmonson M, Rusch M, Wu G, Li Y, Parker M, Hedlund E, Shurtleff S, Raimondi S, Bhavin V, Donald Y, Mardis ER, Wilson RK, Evans WE, Ellison DW, Pounds S, Dyer M, Downing JR, Pappo A, Bahrami A
J Invest Dermatol 2015 Mar;135(3):816-823. Epub 2014 Sep 30 doi: 10.1038/jid.2014.425. PMID: 25268584Free PMC Article
Update in molecular diagnostics in melanocytic neoplasms.
Cooper C, Sorrell J, Gerami P
Adv Anat Pathol 2012 Nov;19(6):410-6. doi: 10.1097/PAP.0b013e318271a5cb. PMID: 23060066

Prognosis

Genomic Assessment of Blitz Nevi Suggests Classification as a Subset of Blue Nevus Rather Than Spitz Nevus: Clinical, Histopathologic, and Molecular Analysis of 18 Cases.
Isales MC, Haugh AM, Bubley J, Verzì AE, Zhang B, Kudalkar E, Lee CY, Yazdan P, Guitart J, Gerami P
Am J Dermatopathol 2018 Feb;40(2):118-124. doi: 10.1097/DAD.0000000000000918. PMID: 28475519
The genomic landscape of childhood and adolescent melanoma.
Lu C, Zhang J, Nagahawatte P, Easton J, Lee S, Liu Z, Ding L, Wyczalkowski MA, Valentine M, Navid F, Mulder H, Tatevossian RG, Dalton J, Davenport J, Yin Z, Edmonson M, Rusch M, Wu G, Li Y, Parker M, Hedlund E, Shurtleff S, Raimondi S, Bhavin V, Donald Y, Mardis ER, Wilson RK, Evans WE, Ellison DW, Pounds S, Dyer M, Downing JR, Pappo A, Bahrami A
J Invest Dermatol 2015 Mar;135(3):816-823. Epub 2014 Sep 30 doi: 10.1038/jid.2014.425. PMID: 25268584Free PMC Article
Tumours associated with BAP1 mutations.
Murali R, Wiesner T, Scolyer RA
Pathology 2013 Feb;45(2):116-26. doi: 10.1097/PAT.0b013e32835d0efb. PMID: 23277170
Update in molecular diagnostics in melanocytic neoplasms.
Cooper C, Sorrell J, Gerami P
Adv Anat Pathol 2012 Nov;19(6):410-6. doi: 10.1097/PAP.0b013e318271a5cb. PMID: 23060066
Evaluation of DNA ploidy and degree of DNA abnormality in benign and malignant melanocytic lesions of the skin using video imaging.
Pilch H, Günzel S, Schäffer U, Tanner B, Heine M
Cancer 2000 Mar 15;88(6):1370-7. PMID: 10717619

Clinical prediction guides

Evaluation of Crizotinib Treatment in a Patient With Unresectable GOPC-ROS1 Fusion Agminated Spitz Nevi.
Robertson SJ, Orme L, Teixeira R, Shamassi M, Newell F, Patch AM, Yeh I, Gard G, Wilmott J, Jackett L, LeBoit P, Fellowes A, MacArthur G, Fox S, Hayward NK, Bastian B, Scolyer R, Waddell N, Penington A, Shackleton M
JAMA Dermatol 2021 Jul 1;157(7):836-841. doi: 10.1001/jamadermatol.2021.0025. PMID: 34076666Free PMC Article
Personalized and targeted mutational analysis of multiple second primary melanomas under kinase inhibitors.
Donati M, Zelano G, Coppola R, Cinelli E, Verri M, Persichetti P, Perrella E, Devirgiliis V, Calvieri S, Crescenzi A, Panasiti V
Ital J Dermatol Venerol 2021 Oct;156(5):593-598. Epub 2019 Dec 4 doi: 10.23736/S2784-8671.19.06516-7. PMID: 31804055
Melanoma mimic: a case of multiple pagetoid Spitz nevi.
Harris K, Florell SR, Papenfuss J, Kohlmann W, Jahromi M, Schiffman JD, Quackenbush J, Cassidy P, Leachman S
Arch Dermatol 2012 Mar;148(3):370-4. Epub 2011 Nov 21 doi: 10.1001/archdermatol.2011.356. PMID: 22105811
Two cases of multiple spitz nevi: correlating clinical, histologic, and fluorescence in situ hybridization findings.
Boone SL, Busam KJ, Marghoob AA, Fang Y, Guitart J, Martini M, Gerami P
Arch Dermatol 2011 Feb;147(2):227-31. doi: 10.1001/archdermatol.2010.439. PMID: 21339450
Evaluation of DNA ploidy and degree of DNA abnormality in benign and malignant melanocytic lesions of the skin using video imaging.
Pilch H, Günzel S, Schäffer U, Tanner B, Heine M
Cancer 2000 Mar 15;88(6):1370-7. PMID: 10717619

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