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Thyroid cancer, nonmedullary, 5(NMTC5)

MedGen UID:
895900
Concept ID:
C4225292
Neoplastic Process
Synonym: NMTC5
 
Gene (location): HABP2 (10q25.3)
 
Monarch Initiative: MONDO:0014682
OMIM®: 616535

Definition

Nonmedullary thyroid cancer (NMTC) comprises cancer of follicular cell origin and accounts for more than 95% of all cases of thyroid cancer. Familial NMTC accounts for 3 to 9% of all cases of thyroid cancer and has an autosomal dominant mode of inheritance. Most cases of familial NMTC are papillary thyroid cancer (PTC), which is the most common type of thyroid cancer (summary by Gara et al., 2015). For a general phenotypic description and a discussion of genetic heterogeneity of NMTC, see NMTC1 (188550). [from OMIM]

Clinical features

From HPO
Familial nonmedullary thyroid carcinoma
MedGen UID:
502247
Concept ID:
C3501843
Neoplastic Process
A rare non-syndromic form of thyroid cancer characterized by occurrence of thyroid carcinoma (TC) as the primary feature in a familial setting.

Professional guidelines

PubMed

Kobaly K, Kim CS, Mandel SJ
Annu Rev Med 2022 Jan 27;73:517-528. Epub 2021 Aug 20 doi: 10.1146/annurev-med-042220-015032. PMID: 34416120
Grani G, Sponziello M, Pecce V, Ramundo V, Durante C
J Clin Endocrinol Metab 2020 Sep 1;105(9):2869-83. doi: 10.1210/clinem/dgaa322. PMID: 32491169Free PMC Article
Francis GL, Waguespack SG, Bauer AJ, Angelos P, Benvenga S, Cerutti JM, Dinauer CA, Hamilton J, Hay ID, Luster M, Parisi MT, Rachmiel M, Thompson GB, Yamashita S; American Thyroid Association Guidelines Task Force
Thyroid 2015 Jul;25(7):716-59. doi: 10.1089/thy.2014.0460. PMID: 25900731Free PMC Article

Curated

UK NICE Guideline NG230, Thyroid cancer: assessment and management

Recent clinical studies

Etiology

Li Y, Wu F, Ge W, Zhang Y, Hu Y, Zhao L, Gou W, Shi J, Ni Y, Li L, Fu W, Lin X, Yu Y, Han Z, Chen C, Xu R, Zhang S, Zhou L, Pan G, Peng Y, Mao L, Zhou T, Zheng J, Zheng H, Sun Y, Guo T, Luo D
Int J Surg 2024 Jan 1;110(1):372-384. doi: 10.1097/JS9.0000000000000814. PMID: 37916932Free PMC Article
Ali Hailan YM, Al-Dubai HN, Yassin MA
Oncology 2023;101(6):362-368. Epub 2023 May 9 doi: 10.1159/000530463. PMID: 37231874
Lee JS, Lee JS, Yun HJ, Kim SM, Chang H, Lee YS, Chang HS, Park CS
J Clin Endocrinol Metab 2023 May 17;108(6):1370-1375. doi: 10.1210/clinem/dgac739. PMID: 36546348Free PMC Article
Mao J, Zhang Q, Zhang H, Zheng K, Wang R, Wang G
Front Endocrinol (Lausanne) 2020;11:265. Epub 2020 May 15 doi: 10.3389/fendo.2020.00265. PMID: 32477264Free PMC Article
Bauer AJ
Front Horm Res 2013;41:141-8. Epub 2013 Mar 19 doi: 10.1159/000345674. PMID: 23652675

Diagnosis

Alzumaili B, Sadow PM
Genes (Basel) 2023 Jun 22;14(7) doi: 10.3390/genes14071314. PMID: 37510219Free PMC Article
Zhu X, Xue C, Kang X, Jia X, Wang L, Younis MH, Liu D, Huo N, Han Y, Chen Z, Fu J, Zhou C, Yao X, Du Y, Cai W, Kang L, Lyu Z
Int J Biol Sci 2022;18(11):4372-4387. Epub 2022 Jul 4 doi: 10.7150/ijbs.72397. PMID: 35864964Free PMC Article
Lam AK
Methods Mol Biol 2022;2534:1-15. doi: 10.1007/978-1-0716-2505-7_1. PMID: 35670964
Kant R, Davis A, Verma V
Am Fam Physician 2020 Sep 1;102(5):298-304. PMID: 32866364
Abdullah MI, Junit SM, Ng KL, Jayapalan JJ, Karikalan B, Hashim OH
Int J Med Sci 2019;16(3):450-460. Epub 2019 Feb 28 doi: 10.7150/ijms.29935. PMID: 30911279Free PMC Article

Therapy

Tahara M, Kiyota N, Imai H, Takahashi S, Nishiyama A, Tamura S, Shimizu Y, Kadowaki S, Ito KI, Toyoshima M, Hirashima Y, Ueno S, Sugitani I
Thyroid 2024 Apr;34(4):467-476. Epub 2024 Mar 14 doi: 10.1089/thy.2023.0547. PMID: 38343359
Xu S, Huang H, Huang Y, Qian J, Wang X, Xu Z, Liu S, Liu J
JAMA Surg 2023 Jan 1;158(1):73-79. doi: 10.1001/jamasurg.2022.5781. PMID: 36449303Free PMC Article
Gordon AJ, Dublin JC, Patel E, Papazian M, Chow MS, Persky MJ, Jacobson AS, Patel KN, Suh I, Morris LGT, Givi B
JAMA Otolaryngol Head Neck Surg 2022 Dec 1;148(12):1156-1163. doi: 10.1001/jamaoto.2022.3360. PMID: 36326739Free PMC Article
Fallahi P, Ferrari SM, Galdiero MR, Varricchi G, Elia G, Ragusa F, Paparo SR, Benvenga S, Antonelli A
Semin Cancer Biol 2022 Feb;79:180-196. Epub 2020 Nov 26 doi: 10.1016/j.semcancer.2020.11.013. PMID: 33249201
Lee YA, Lee H, Im SW, Song YS, Oh DY, Kang HJ, Won JK, Jung KC, Kwon D, Chung EJ, Hah JH, Paeng JC, Kim JH, Choi J, Kim OH, Oh JM, Ahn BC, Wirth LJ, Shin CH, Kim JI, Park YJ
J Clin Invest 2021 Sep 15;131(18) doi: 10.1172/JCI144847. PMID: 34237031Free PMC Article

Prognosis

Alzumaili B, Sadow PM
Genes (Basel) 2023 Jun 22;14(7) doi: 10.3390/genes14071314. PMID: 37510219Free PMC Article
Megwalu UC, Moon PK
Thyroid 2022 May;32(5):560-570. Epub 2022 Mar 15 doi: 10.1089/thy.2021.0662. PMID: 35132899
He J, Zhou M, Yin J, Wan J, Chu J, Jia J, Sheng J, Wang C, Yin H, He F
Mol Ther 2021 May 5;29(5):1821-1837. Epub 2021 Jan 21 doi: 10.1016/j.ymthe.2021.01.019. PMID: 33484966Free PMC Article
Kant R, Davis A, Verma V
Am Fam Physician 2020 Sep 1;102(5):298-304. PMID: 32866364
Abdullah MI, Junit SM, Ng KL, Jayapalan JJ, Karikalan B, Hashim OH
Int J Med Sci 2019;16(3):450-460. Epub 2019 Feb 28 doi: 10.7150/ijms.29935. PMID: 30911279Free PMC Article

Clinical prediction guides

Li Y, Wu F, Ge W, Zhang Y, Hu Y, Zhao L, Gou W, Shi J, Ni Y, Li L, Fu W, Lin X, Yu Y, Han Z, Chen C, Xu R, Zhang S, Zhou L, Pan G, Peng Y, Mao L, Zhou T, Zheng J, Zheng H, Sun Y, Guo T, Luo D
Int J Surg 2024 Jan 1;110(1):372-384. doi: 10.1097/JS9.0000000000000814. PMID: 37916932Free PMC Article
Lee JS, Lee JS, Yun HJ, Kim SM, Chang H, Lee YS, Chang HS, Park CS
J Clin Endocrinol Metab 2023 May 17;108(6):1370-1375. doi: 10.1210/clinem/dgac739. PMID: 36546348Free PMC Article
Zhu X, Xue C, Kang X, Jia X, Wang L, Younis MH, Liu D, Huo N, Han Y, Chen Z, Fu J, Zhou C, Yao X, Du Y, Cai W, Kang L, Lyu Z
Int J Biol Sci 2022;18(11):4372-4387. Epub 2022 Jul 4 doi: 10.7150/ijbs.72397. PMID: 35864964Free PMC Article
Kant R, Davis A, Verma V
Am Fam Physician 2020 Sep 1;102(5):298-304. PMID: 32866364
Mao J, Zhang Q, Zhang H, Zheng K, Wang R, Wang G
Front Endocrinol (Lausanne) 2020;11:265. Epub 2020 May 15 doi: 10.3389/fendo.2020.00265. PMID: 32477264Free PMC Article

Recent systematic reviews

Silverii GA, Monami M, Gallo M, Ragni A, Prattichizzo F, Renzelli V, Ceriello A, Mannucci E
Diabetes Obes Metab 2024 Mar;26(3):891-900. Epub 2023 Nov 29 doi: 10.1111/dom.15382. PMID: 38018310
Moleti M, Aversa T, Crisafulli S, Trifirò G, Corica D, Pepe G, Cannavò L, Di Mauro M, Paola G, Fontana A, Calapai F, Cannavò S, Wasniewska M
Front Endocrinol (Lausanne) 2023;14:1270518. Epub 2023 Sep 19 doi: 10.3389/fendo.2023.1270518. PMID: 37795368Free PMC Article
Wei X, Wang X, Xiong J, Li C, Liao Y, Zhu Y, Mao J
Biomed Res Int 2022;2022:9959649. Epub 2022 May 18 doi: 10.1155/2022/9959649. PMID: 35647194Free PMC Article
van Dijk SPJ, Coerts HI, Gunput STG, van Velsen EFS, Medici M, Moelker A, Peeters RP, Verhoef C, van Ginhoven TM
JAMA Otolaryngol Head Neck Surg 2022 Apr 1;148(4):317-325. doi: 10.1001/jamaoto.2021.4381. PMID: 35142816Free PMC Article
Mao J, Zhang Q, Zhang H, Zheng K, Wang R, Wang G
Front Endocrinol (Lausanne) 2020;11:265. Epub 2020 May 15 doi: 10.3389/fendo.2020.00265. PMID: 32477264Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2022
      UK NICE Guideline NG230, Thyroid cancer: assessment and management

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