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Woodchuck Hepatocellular Carcinoma

MedGen UID:
899094
•Concept ID:
C4086965
•
Neoplastic Process

Definition

Hepatocellular carcinoma (HCC) occurring in a woodchuck, usually as a result of chronic infection by the woodchuck hepatitis virus. The woodchuck model of viral-induced HCC provides an animal model that resembles the complex human liver environment of HCC in the context of chronic hepatitis B viral infection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVWoodchuck Hepatocellular Carcinoma

Professional guidelines

PubMed

Present and future DNA vaccines for chronic hepatitis B treatment.
Cova L
Expert Opin Biol Ther 2017 Feb;17(2):185-195. Epub 2016 Dec 14 doi: 10.1080/14712598.2017.1265940. PMID: 27892722
The role of the woodchuck model in the treatment of hepatitis B virus infection.
Kulkarni K, Jacobson IM, Tennant BC
Clin Liver Dis 2007 Nov;11(4):707-25, vii. doi: 10.1016/j.cld.2007.08.012. PMID: 17981226
Treatment of chronic viral hepatitis.
Main J, McCarron B, Thomas HC
Antivir Chem Chemother 1998 Nov;9(6):449-60. doi: 10.1177/095632029800900601. PMID: 9865383

Recent clinical studies

Diagnosis

Characterization of metastatic tumor antigen 1 and its interaction with hepatitis B virus X protein in NF-κB signaling and tumor progression in a woodchuck hepatocellular carcinoma model.
Li YT, Liu CJ, Su TH, Cheng HR, Jeng YM, Lin HL, Wang CC, Kao JH, Chen PJ, Chen DS, Wu HL
Oncotarget 2016 Jul 26;7(30):47173-47185. doi: 10.18632/oncotarget.9986. PMID: 27323415Free PMC Article
Gene expression studies of hepatitis virus-induced woodchuck hepatocellular carcinoma in correlation with human results.
Wang F, Anderson PW, Salem N, Kuang Y, Tennant BC, Lee Z
Int J Oncol 2007 Jan;30(1):33-44. PMID: 17143510

Prognosis

Characterization of metastatic tumor antigen 1 and its interaction with hepatitis B virus X protein in NF-κB signaling and tumor progression in a woodchuck hepatocellular carcinoma model.
Li YT, Liu CJ, Su TH, Cheng HR, Jeng YM, Lin HL, Wang CC, Kao JH, Chen PJ, Chen DS, Wu HL
Oncotarget 2016 Jul 26;7(30):47173-47185. doi: 10.18632/oncotarget.9986. PMID: 27323415Free PMC Article
Gene expression studies of hepatitis virus-induced woodchuck hepatocellular carcinoma in correlation with human results.
Wang F, Anderson PW, Salem N, Kuang Y, Tennant BC, Lee Z
Int J Oncol 2007 Jan;30(1):33-44. PMID: 17143510

Clinical prediction guides

Gene expression studies of hepatitis virus-induced woodchuck hepatocellular carcinoma in correlation with human results.
Wang F, Anderson PW, Salem N, Kuang Y, Tennant BC, Lee Z
Int J Oncol 2007 Jan;30(1):33-44. PMID: 17143510
Frequent activation of N-myc genes by hepadnavirus insertion in woodchuck liver tumours.
Fourel G, Trepo C, Bougueleret L, Henglein B, Ponzetto A, Tiollais P, Buendia MA
Nature 1990 Sep 20;347(6290):294-8. doi: 10.1038/347294a0. PMID: 2205804

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