U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Childhood Astrocytoma

MedGen UID:
898003
•Concept ID:
C4086152
•
Neoplastic Process

Definition

An astrocytoma that occurs during childhood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood Astrocytoma

Professional guidelines

PubMed

The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen.
Malta TM, Sabedot TS, Morosini NS, Datta I, Garofano L, Vallentgoed W, Varn FS, Aldape K, D'Angelo F, Bakas S, Barnholtz-Sloan JS, Gan HK, Hasanain M, Hau AC, Johnson KC, Cazacu S, deCarvalho AC, Khasraw M, Kocakavuk E, Kouwenhoven MCM, Migliozzi S, Niclou SP, Niers JM, Ormond DR, Paek SH, Reifenberger G, Sillevis Smitt PA, Smits M, Stead LF, van den Bent MJ, Van Meir EG, Walenkamp A, Weiss T, Weller M, Westerman BA, Ylstra B, Wesseling P, Lasorella A, French PJ, Poisson LM; Consortium The GLASS, Verhaak RGW, Iavarone A, Noushmehr H
Cancer Res 2024 Mar 4;84(5):741-756. doi: 10.1158/0008-5472.CAN-23-2093. PMID: 38117484Free PMC Article
Clinical Features, Treatment and Outcome of Childhood Glial Tumors.
Kara B, Ertan K, Karabagli P, Karabagli H, Yavas G, Caglayan AO, Koksal Y
Turk Neurosurg 2022;32(1):135-142. doi: 10.5137/1019-5149.JTN.34801-21.2. PMID: 34751424
Childhood brain tumors: current management, biological insights, and future directions.
Pollack IF, Agnihotri S, Broniscer A
J Neurosurg Pediatr 2019 Mar 1;23(3):261-273. doi: 10.3171/2018.10.PEDS18377. PMID: 30835699Free PMC Article

Recent clinical studies

Etiology

Multi-ancestry genome-wide association study of 4069 children with glioma identifies 9p21.3 risk locus.
Foss-Skiftesvik J, Li S, Rosenbaum A, Hagen CM, Stoltze UK, Ljungqvist S, Hjalmars U, Schmiegelow K, Morimoto L, de Smith AJ, Mathiasen R, Metayer C, Hougaard D, Melin B, Walsh KM, Bybjerg-Grauholm J, Dahlin AM, Wiemels JL
Neuro Oncol 2023 Sep 5;25(9):1709-1720. doi: 10.1093/neuonc/noad042. PMID: 36810956Free PMC Article
Neuropsychological and socioeconomic outcomes in adult survivors of pediatric low-grade glioma.
Ris MD, Leisenring WM, Goodman P, Di C, Noll J, Levy W, Robison LL, Armstrong GT
Cancer 2019 Sep 1;125(17):3050-3058. Epub 2019 Jun 24 doi: 10.1002/cncr.32186. PMID: 31231797Free PMC Article
Adverse medical events associated with childhood cerebellar astrocytomas and medulloblastomas: natural history and relation to very long-term neurobehavioral outcome.
Roncadin C, Dennis M, Greenberg ML, Spiegler BJ
Childs Nerv Syst 2008 Sep;24(9):995-1002; discussion 1003. Epub 2008 Jun 25 doi: 10.1007/s00381-008-0658-9. PMID: 18581121
Parental occupation and childhood astrocytoma: results of a case-control study.
Kuijten RR, Bunin GR, Nass CC, Meadows AT
Cancer Res 1992 Feb 15;52(4):782-6. PMID: 1737337
Gestational and familial risk factors for childhood astrocytoma: results of a case-control study.
Kuijten RR, Bunin GR, Nass CC, Meadows AT
Cancer Res 1990 May 1;50(9):2608-12. PMID: 2328486

Diagnosis

Neuropsychological and socioeconomic outcomes in adult survivors of pediatric low-grade glioma.
Ris MD, Leisenring WM, Goodman P, Di C, Noll J, Levy W, Robison LL, Armstrong GT
Cancer 2019 Sep 1;125(17):3050-3058. Epub 2019 Jun 24 doi: 10.1002/cncr.32186. PMID: 31231797Free PMC Article
Development, characterization, and reversal of acquired resistance to the MEK1 inhibitor selumetinib (AZD6244) in an in vivo model of childhood astrocytoma.
Bid HK, Kibler A, Phelps DA, Manap S, Xiao L, Lin J, Capper D, Oswald D, Geier B, DeWire M, Smith PD, Kurmasheva RT, Mo X, Fernandez S, Houghton PJ
Clin Cancer Res 2013 Dec 15;19(24):6716-29. Epub 2013 Oct 16 doi: 10.1158/1078-0432.CCR-13-0842. PMID: 24132923Free PMC Article
Adverse medical events associated with childhood cerebellar astrocytomas and medulloblastomas: natural history and relation to very long-term neurobehavioral outcome.
Roncadin C, Dennis M, Greenberg ML, Spiegler BJ
Childs Nerv Syst 2008 Sep;24(9):995-1002; discussion 1003. Epub 2008 Jun 25 doi: 10.1007/s00381-008-0658-9. PMID: 18581121
Parental occupation and childhood astrocytoma: results of a case-control study.
Kuijten RR, Bunin GR, Nass CC, Meadows AT
Cancer Res 1992 Feb 15;52(4):782-6. PMID: 1737337
Gestational and familial risk factors for childhood astrocytoma: results of a case-control study.
Kuijten RR, Bunin GR, Nass CC, Meadows AT
Cancer Res 1990 May 1;50(9):2608-12. PMID: 2328486

Therapy

Inhibition of MEK confers hypersensitivity to X-radiation in the context of BRAF mutation in a model of childhood astrocytoma.
Studebaker A, Bondra K, Seum S, Shen C, Phelps DA, Chronowski C, Leasure J, Smith PD, Kurmasheva RT, Mo X, Fouladi M, Houghton PJ
Pediatr Blood Cancer 2015 Oct;62(10):1768-74. Epub 2015 May 15 doi: 10.1002/pbc.25579. PMID: 25981859Free PMC Article
Development, characterization, and reversal of acquired resistance to the MEK1 inhibitor selumetinib (AZD6244) in an in vivo model of childhood astrocytoma.
Bid HK, Kibler A, Phelps DA, Manap S, Xiao L, Lin J, Capper D, Oswald D, Geier B, DeWire M, Smith PD, Kurmasheva RT, Mo X, Fernandez S, Houghton PJ
Clin Cancer Res 2013 Dec 15;19(24):6716-29. Epub 2013 Oct 16 doi: 10.1158/1078-0432.CCR-13-0842. PMID: 24132923Free PMC Article
Family history of cancer and seizures in young children with brain tumors: a report from the Childrens Cancer Group (United States and Canada).
Kuijten RR, Strom SS, Rorke LB, Boesel CP, Buckley JD, Meadows AT, Bunin GR
Cancer Causes Control 1993 Sep;4(5):455-64. doi: 10.1007/BF00050865. PMID: 8218878
Parental occupation and childhood astrocytoma: results of a case-control study.
Kuijten RR, Bunin GR, Nass CC, Meadows AT
Cancer Res 1992 Feb 15;52(4):782-6. PMID: 1737337
Gestational and familial risk factors for childhood astrocytoma: results of a case-control study.
Kuijten RR, Bunin GR, Nass CC, Meadows AT
Cancer Res 1990 May 1;50(9):2608-12. PMID: 2328486

Prognosis

Multi-ancestry genome-wide association study of 4069 children with glioma identifies 9p21.3 risk locus.
Foss-Skiftesvik J, Li S, Rosenbaum A, Hagen CM, Stoltze UK, Ljungqvist S, Hjalmars U, Schmiegelow K, Morimoto L, de Smith AJ, Mathiasen R, Metayer C, Hougaard D, Melin B, Walsh KM, Bybjerg-Grauholm J, Dahlin AM, Wiemels JL
Neuro Oncol 2023 Sep 5;25(9):1709-1720. doi: 10.1093/neuonc/noad042. PMID: 36810956Free PMC Article
Adverse medical events associated with childhood cerebellar astrocytomas and medulloblastomas: natural history and relation to very long-term neurobehavioral outcome.
Roncadin C, Dennis M, Greenberg ML, Spiegler BJ
Childs Nerv Syst 2008 Sep;24(9):995-1002; discussion 1003. Epub 2008 Jun 25 doi: 10.1007/s00381-008-0658-9. PMID: 18581121
Increased incidence rates but no space-time clustering of childhood astrocytoma in Sweden, 1973-1992: a population-based study of pediatric brain tumors.
Hjalmars U, Kulldorff M, Wahlqvist Y, Lannering B
Cancer 1999 May 1;85(9):2077-90. PMID: 10223251
Immunohistochemical detection of p53 protein expression in various childhood astrocytoma subtypes: significance in tumor progression.
Bodey B, Gröger AM, Bodey B Jr, Siegel SE, Kaiser HE
Anticancer Res 1997 Mar-Apr;17(2A):1187-94. PMID: 9137469
Family history of cancer and seizures in young children with brain tumors: a report from the Childrens Cancer Group (United States and Canada).
Kuijten RR, Strom SS, Rorke LB, Boesel CP, Buckley JD, Meadows AT, Bunin GR
Cancer Causes Control 1993 Sep;4(5):455-64. doi: 10.1007/BF00050865. PMID: 8218878

Clinical prediction guides

Multi-ancestry genome-wide association study of 4069 children with glioma identifies 9p21.3 risk locus.
Foss-Skiftesvik J, Li S, Rosenbaum A, Hagen CM, Stoltze UK, Ljungqvist S, Hjalmars U, Schmiegelow K, Morimoto L, de Smith AJ, Mathiasen R, Metayer C, Hougaard D, Melin B, Walsh KM, Bybjerg-Grauholm J, Dahlin AM, Wiemels JL
Neuro Oncol 2023 Sep 5;25(9):1709-1720. doi: 10.1093/neuonc/noad042. PMID: 36810956Free PMC Article
Neuropsychological and socioeconomic outcomes in adult survivors of pediatric low-grade glioma.
Ris MD, Leisenring WM, Goodman P, Di C, Noll J, Levy W, Robison LL, Armstrong GT
Cancer 2019 Sep 1;125(17):3050-3058. Epub 2019 Jun 24 doi: 10.1002/cncr.32186. PMID: 31231797Free PMC Article
Development, characterization, and reversal of acquired resistance to the MEK1 inhibitor selumetinib (AZD6244) in an in vivo model of childhood astrocytoma.
Bid HK, Kibler A, Phelps DA, Manap S, Xiao L, Lin J, Capper D, Oswald D, Geier B, DeWire M, Smith PD, Kurmasheva RT, Mo X, Fernandez S, Houghton PJ
Clin Cancer Res 2013 Dec 15;19(24):6716-29. Epub 2013 Oct 16 doi: 10.1158/1078-0432.CCR-13-0842. PMID: 24132923Free PMC Article
Parental occupation and childhood astrocytoma: results of a case-control study.
Kuijten RR, Bunin GR, Nass CC, Meadows AT
Cancer Res 1992 Feb 15;52(4):782-6. PMID: 1737337
Gestational and familial risk factors for childhood astrocytoma: results of a case-control study.
Kuijten RR, Bunin GR, Nass CC, Meadows AT
Cancer Res 1990 May 1;50(9):2608-12. PMID: 2328486

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...