U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Perinatal necrotizing enterocolitis

MedGen UID:
906305
Concept ID:
C4082937
Disease or Syndrome
Synonyms: enterocolitis, necrotizing; NEC - Necrotizing enterocolitis; Necrotizing Enterocolitis; Necrotizing enterocolitis; Necrotizing Enterocolitis in Fetus or Newborn; Necrotizing enterocolitis in fetus OR newborn; necrotizing enterocolitis in fetus or newborn; necrotizing enterocolitis in foetus or newborn; perinatal necrotising enterocolitis; perinatal necrotizing enterocolitis; Pseudomembranous enterocolitis in newborn; pseudomembranous enterocolitis in newborn
SNOMED CT: Perinatal necrotizing enterocolitis (397729009); Necrotizing enterocolitis (2707005); NEC - Necrotizing enterocolitis (2707005); Necrotizing enterocolitis in fetus OR newborn (2707005); Pseudomembranous enterocolitis in newborn (2707005)
 
Monarch Initiative: MONDO:0004639

Definition

A fulminating disease of neonates in which there is extensive mucosal ulceration, pseudomembrane formation, submucosal hemorrhage, and necrosis usually of the right colon, cecum, terminal ileum, and appendix, possibly due to perinatal intestinal ischemia and bacterial invasion. Progression can lead to necrosis, perforation and/or scarring of the intestinal tract. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPerinatal necrotizing enterocolitis

Professional guidelines

PubMed

Barrett JM, Boehm FH
Am J Obstet Gynecol 1982 Sep 1;144(1):12-6. doi: 10.1016/0002-9378(82)90386-6. PMID: 7114106

Recent clinical studies

Etiology

Duchon J, Barbian ME, Denning PW
Clin Perinatol 2021 Jun;48(2):229-250. doi: 10.1016/j.clp.2021.03.002. PMID: 34030811
Cuna A, Morowitz MJ, Ahmed I, Umar S, Sampath V
Am J Physiol Gastrointest Liver Physiol 2021 Apr 1;320(4):G411-G419. Epub 2021 Jan 13 doi: 10.1152/ajpgi.00399.2020. PMID: 33439103Free PMC Article
Meister AL, Doheny KK, Travagli RA
Exp Biol Med (Maywood) 2020 Jan;245(2):85-95. Epub 2019 Dec 6 doi: 10.1177/1535370219891971. PMID: 31810384Free PMC Article
Ficara M, Pietrella E, Spada C, Della Casa Muttini E, Lucaccioni L, Iughetti L, Berardi A
J Matern Fetal Neonatal Med 2020 Mar;33(6):1036-1043. Epub 2018 Sep 10 doi: 10.1080/14767058.2018.1506760. PMID: 30058404
Mitra S, Florez ID, Tamayo ME, Mbuagbaw L, Vanniyasingam T, Veroniki AA, Zea AM, Zhang Y, Sadeghirad B, Thabane L
JAMA 2018 Mar 27;319(12):1221-1238. doi: 10.1001/jama.2018.1896. PMID: 29584842Free PMC Article

Diagnosis

Hansen ML, Pellicer A, Hyttel-Sørensen S, Ergenekon E, Szczapa T, Hagmann C, Naulaers G, Mintzer J, Fumagalli M, Dimitriou G, Dempsey E, Tkaczyk J, Cheng G, Fredly S, Heuchan AM, Pichler G, Fuchs H, Nesargi S, Hahn GH, Piris-Borregas S, Širc J, Alsina-Casanova M, Stocker M, Ozkan H, Sarafidis K, Hopper AO, Karen T, Rzepecka-Weglarz B, Oguz SS, Arruza L, Memisoglu AC, Del Rio Florentino R, Baserga M, Maton P, Truttmann AC, de Las Cuevas I, Agergaard P, Zafra P, Bender L, Lauterbach R, Lecart C, de Buyst J, El-Khuffash A, Curley A, Vaccarello OO, Miletin J, Papathoma E, Vesoulis Z, Vento G, Cornette L, Lopez LS, Yasa B, Klamer A, Agosti M, Baud O, Mastretta E, Cetinkaya M, McCall K, Zeng S, Hatzidaki E, Bargiel A, Marciniak S, Gao X, Huijia L, Chalak L, Yang L, Rao SA, Xu X, Gonzalez BL, Wilinska M, Yin Z, Sadowska-Krawczenko I, Serrano-Viñuales I, Krolak-Olejnik B, Ybarra MM, Morales-Betancourt C, Korček P, Teresa-Palacio M, Mosca F, Hergenhan A, Koksal N, Tsoni K, Kadri MM, Knöpfli C, Rafinska-Wazny E, Akin MS, Nordvik T, Peng Z, Kersin SG, Thewissen L, Alarcon A, Healy D, Urlesberger B, Baş M, Baumgartner J, Skylogianni E, Karadyova V, Valverde E, Bergon-Sendin E, Kucera J, Pisoni S, Wang L, Smits A, Sanchez-Salmador R, Rasmussen MI, Olsen MH, Jensen AK, Gluud C, Jakobsen JC, Greisen G
N Engl J Med 2023 Apr 20;388(16):1501-1511. doi: 10.1056/NEJMoa2207554. PMID: 37075142
Blakely ML, Tyson JE, Lally KP, Hintz SR, Eggleston B, Stevenson DK, Besner GE, Das A, Ohls RK, Truog WE, Nelin LD, Poindexter BB, Pedroza C, Walsh MC, Stoll BJ, Geller R, Kennedy KA, Dimmitt RA, Carlo WA, Cotten CM, Laptook AR, Van Meurs KP, Calkins KL, Sokol GM, Sanchez PJ, Wyckoff MH, Patel RM, Frantz ID 3rd, Shankaran S, D'Angio CT, Yoder BA, Bell EF, Watterberg KL, Martin CA, Harmon CM, Rice H, Kurkchubasche AG, Sylvester K, Dunn JCY, Markel TA, Diesen DL, Bhatia AM, Flake A, Chwals WJ, Brown R, Bass KD, St Peter SD, Shanti CM, Pegoli W Jr, Skarda D, Shilyansky J, Lemon DG, Mosquera RA, Peralta-Carcelen M, Goldstein RF, Vohr BR, Purdy IB, Hines AC, Maitre NL, Heyne RJ, DeMauro SB, McGowan EC, Yolton K, Kilbride HW, Natarajan G, Yost K, Winter S, Colaizy TT, Laughon MM, Lakshminrusimha S, Higgins RD; Eunice Kennedy Shriver National Institute of Child Health, Human Development Neonatal Research Network
Ann Surg 2021 Oct 1;274(4):e370-e380. doi: 10.1097/SLA.0000000000005099. PMID: 34506326Free PMC Article
Meister AL, Doheny KK, Travagli RA
Exp Biol Med (Maywood) 2020 Jan;245(2):85-95. Epub 2019 Dec 6 doi: 10.1177/1535370219891971. PMID: 31810384Free PMC Article
Bellodas Sanchez J, Kadrofske M
Neurogastroenterol Motil 2019 Mar;31(3):e13569. doi: 10.1111/nmo.13569. PMID: 30793842
Mitra S, Florez ID, Tamayo ME, Mbuagbaw L, Vanniyasingam T, Veroniki AA, Zea AM, Zhang Y, Sadeghirad B, Thabane L
JAMA 2018 Mar 27;319(12):1221-1238. doi: 10.1001/jama.2018.1896. PMID: 29584842Free PMC Article

Therapy

Duchon J, Barbian ME, Denning PW
Clin Perinatol 2021 Jun;48(2):229-250. doi: 10.1016/j.clp.2021.03.002. PMID: 34030811
Cuna A, Morowitz MJ, Ahmed I, Umar S, Sampath V
Am J Physiol Gastrointest Liver Physiol 2021 Apr 1;320(4):G411-G419. Epub 2021 Jan 13 doi: 10.1152/ajpgi.00399.2020. PMID: 33439103Free PMC Article
Bachnas MA, Akbar MIA, Dachlan EG, Dekker G
J Matern Fetal Neonatal Med 2021 Mar;34(6):966-978. Epub 2019 May 27 doi: 10.1080/14767058.2019.1619688. PMID: 31092073
Ficara M, Pietrella E, Spada C, Della Casa Muttini E, Lucaccioni L, Iughetti L, Berardi A
J Matern Fetal Neonatal Med 2020 Mar;33(6):1036-1043. Epub 2018 Sep 10 doi: 10.1080/14767058.2018.1506760. PMID: 30058404
Mitra S, Florez ID, Tamayo ME, Mbuagbaw L, Vanniyasingam T, Veroniki AA, Zea AM, Zhang Y, Sadeghirad B, Thabane L
JAMA 2018 Mar 27;319(12):1221-1238. doi: 10.1001/jama.2018.1896. PMID: 29584842Free PMC Article

Prognosis

Blakely ML, Tyson JE, Lally KP, Hintz SR, Eggleston B, Stevenson DK, Besner GE, Das A, Ohls RK, Truog WE, Nelin LD, Poindexter BB, Pedroza C, Walsh MC, Stoll BJ, Geller R, Kennedy KA, Dimmitt RA, Carlo WA, Cotten CM, Laptook AR, Van Meurs KP, Calkins KL, Sokol GM, Sanchez PJ, Wyckoff MH, Patel RM, Frantz ID 3rd, Shankaran S, D'Angio CT, Yoder BA, Bell EF, Watterberg KL, Martin CA, Harmon CM, Rice H, Kurkchubasche AG, Sylvester K, Dunn JCY, Markel TA, Diesen DL, Bhatia AM, Flake A, Chwals WJ, Brown R, Bass KD, St Peter SD, Shanti CM, Pegoli W Jr, Skarda D, Shilyansky J, Lemon DG, Mosquera RA, Peralta-Carcelen M, Goldstein RF, Vohr BR, Purdy IB, Hines AC, Maitre NL, Heyne RJ, DeMauro SB, McGowan EC, Yolton K, Kilbride HW, Natarajan G, Yost K, Winter S, Colaizy TT, Laughon MM, Lakshminrusimha S, Higgins RD; Eunice Kennedy Shriver National Institute of Child Health, Human Development Neonatal Research Network
Ann Surg 2021 Oct 1;274(4):e370-e380. doi: 10.1097/SLA.0000000000005099. PMID: 34506326Free PMC Article
Cuna A, Morowitz MJ, Ahmed I, Umar S, Sampath V
Am J Physiol Gastrointest Liver Physiol 2021 Apr 1;320(4):G411-G419. Epub 2021 Jan 13 doi: 10.1152/ajpgi.00399.2020. PMID: 33439103Free PMC Article
Meister AL, Doheny KK, Travagli RA
Exp Biol Med (Maywood) 2020 Jan;245(2):85-95. Epub 2019 Dec 6 doi: 10.1177/1535370219891971. PMID: 31810384Free PMC Article
Bellodas Sanchez J, Kadrofske M
Neurogastroenterol Motil 2019 Mar;31(3):e13569. doi: 10.1111/nmo.13569. PMID: 30793842
Downes KL, Grantz KL, Shenassa ED
Am J Perinatol 2017 Aug;34(10):935-957. Epub 2017 Mar 22 doi: 10.1055/s-0037-1599149. PMID: 28329897Free PMC Article

Clinical prediction guides

Morowitz MJ, Katheria AC, Polin RA, Pace E, Huang DT, Chang CH, Yabes JG
Trials 2022 May 23;23(1):428. doi: 10.1186/s13063-022-06352-3. PMID: 35606829Free PMC Article
Meister AL, Doheny KK, Travagli RA
Exp Biol Med (Maywood) 2020 Jan;245(2):85-95. Epub 2019 Dec 6 doi: 10.1177/1535370219891971. PMID: 31810384Free PMC Article
McCall EM, Alderdice F, Halliday HL, Vohra S, Johnston L
Cochrane Database Syst Rev 2018 Feb 12;2(2):CD004210. doi: 10.1002/14651858.CD004210.pub5. PMID: 29431872Free PMC Article
Roberts D, Brown J, Medley N, Dalziel SR
Cochrane Database Syst Rev 2017 Mar 21;3(3):CD004454. doi: 10.1002/14651858.CD004454.pub3. PMID: 28321847Free PMC Article
Stoll BJ, Hansen NI, Bell EF, Walsh MC, Carlo WA, Shankaran S, Laptook AR, Sánchez PJ, Van Meurs KP, Wyckoff M, Das A, Hale EC, Ball MB, Newman NS, Schibler K, Poindexter BB, Kennedy KA, Cotten CM, Watterberg KL, D'Angio CT, DeMauro SB, Truog WE, Devaskar U, Higgins RD; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
JAMA 2015 Sep 8;314(10):1039-51. doi: 10.1001/jama.2015.10244. PMID: 26348753Free PMC Article

Recent systematic reviews

Quigley M, Embleton ND, McGuire W
Cochrane Database Syst Rev 2018 Jun 20;6(6):CD002971. doi: 10.1002/14651858.CD002971.pub4. PMID: 29926476Free PMC Article
Mitra S, Florez ID, Tamayo ME, Mbuagbaw L, Vanniyasingam T, Veroniki AA, Zea AM, Zhang Y, Sadeghirad B, Thabane L
JAMA 2018 Mar 27;319(12):1221-1238. doi: 10.1001/jama.2018.1896. PMID: 29584842Free PMC Article
Downes KL, Grantz KL, Shenassa ED
Am J Perinatol 2017 Aug;34(10):935-957. Epub 2017 Mar 22 doi: 10.1055/s-0037-1599149. PMID: 28329897Free PMC Article
Roberts D, Brown J, Medley N, Dalziel SR
Cochrane Database Syst Rev 2017 Mar 21;3(3):CD004454. doi: 10.1002/14651858.CD004454.pub3. PMID: 28321847Free PMC Article
Pammi M, Cope J, Tarr PI, Warner BB, Morrow AL, Mai V, Gregory KE, Kroll JS, McMurtry V, Ferris MJ, Engstrand L, Lilja HE, Hollister EB, Versalovic J, Neu J
Microbiome 2017 Mar 9;5(1):31. doi: 10.1186/s40168-017-0248-8. PMID: 28274256Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...