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Decreased circulating androgen concentration

MedGen UID:
892773
Concept ID:
C4072894
Finding
Synonym: Decreased circulating androgen level
 
HPO: HP:0030349

Definition

A reduction in the blood concentration of an androgen, that is, of a steroid hormone that controls development and maintenance of masculine characteristics. The androgens include testosterone and Dehydroepiandrosterone. [from HPO]

Professional guidelines

PubMed

Johansen N, Lindén Hirschberg A, Moen MH
Acta Obstet Gynecol Scand 2020 Aug;99(8):966-969. Epub 2020 Mar 2 doi: 10.1111/aogs.13819. PMID: 32027015
Yeap BB, Page ST, Grossmann M
Lancet Diabetes Endocrinol 2018 Aug;6(8):659-672. Epub 2018 Jul 17 doi: 10.1016/S2213-8587(17)30416-3. PMID: 30017800
Pugeat M, Plotton I, de la Perrière AB, Raverot G, Déchaud H, Raverot V
Eur J Endocrinol 2018 Apr;178(4):R141-R154. Epub 2018 Feb 16 doi: 10.1530/EJE-17-0776. PMID: 29453202

Recent clinical studies

Etiology

Marriott RJ, Murray K, Adams RJ, Antonio L, Ballantyne CM, Bauer DC, Bhasin S, Biggs ML, Cawthon PM, Couper DJ, Dobs AS, Flicker L, Handelsman DJ, Hankey GJ, Hannemann A, Haring R, Hsu B, Karlsson M, Martin SA, Matsumoto AM, Mellström D, Ohlsson C, O'Neill TW, Orwoll ES, Quartagno M, Shores MM, Steveling A, Tivesten Å, Travison TG, Vanderschueren D, Wittert GA, Wu FCW, Yeap BB
Ann Intern Med 2023 Sep;176(9):1221-1234. Epub 2023 Aug 29 doi: 10.7326/M23-0342. PMID: 37639720Free PMC Article
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
David K, Narinx N, Antonio L, Evenepoel P, Claessens F, Decallonne B, Vanderschueren D
Rev Endocr Metab Disord 2022 Dec;23(6):1173-1208. Epub 2022 Jul 16 doi: 10.1007/s11154-022-09738-5. PMID: 35841491
Labrie F, Bélanger A, Pelletier G, Martel C, Archer DF, Utian WH
Menopause 2017 Jun;24(6):702-712. doi: 10.1097/GME.0000000000000808. PMID: 28098598
Eckardstein Av, Wu FC
Growth Horm IGF Res 2003 Aug;13 Suppl A:S72-84. doi: 10.1016/s1096-6374(03)00059-5. PMID: 12914731

Diagnosis

Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
Albrethsen J, Østergren PB, Norup PB, Sønksen J, Fode M, Kistorp C, Nordsborg NB, Solheim SA, Mørkeberg J, Main KM, Juul A
J Clin Endocrinol Metab 2023 Oct 18;108(11):2834-2839. doi: 10.1210/clinem/dgad291. PMID: 37235781
Franik G, Plinta R, Madej P, Owczarek A, Bozentowicz-Wikarek M, Chudek J, Skrzypulec-Plinta V, Olszanecka-Glinianowicz M
Ginekol Pol 2020;91(5):251-255. doi: 10.5603/GP.2020.0056. PMID: 32495930
Kostakis EK, Gkioni LN, Macut D, Mastorakos G
Front Horm Res 2019;53:135-161. Epub 2019 Sep 9 doi: 10.1159/000494909. PMID: 31499509
Breckwoldt M, Zahradnik HP, Wieacker P
Hum Reprod 1989 Aug;4(6):601-4. doi: 10.1093/oxfordjournals.humrep.a136950. PMID: 2674189

Therapy

Marriott RJ, Murray K, Adams RJ, Antonio L, Ballantyne CM, Bauer DC, Bhasin S, Biggs ML, Cawthon PM, Couper DJ, Dobs AS, Flicker L, Handelsman DJ, Hankey GJ, Hannemann A, Haring R, Hsu B, Karlsson M, Martin SA, Matsumoto AM, Mellström D, Ohlsson C, O'Neill TW, Orwoll ES, Quartagno M, Shores MM, Steveling A, Tivesten Å, Travison TG, Vanderschueren D, Wittert GA, Wu FCW, Yeap BB
Ann Intern Med 2023 Sep;176(9):1221-1234. Epub 2023 Aug 29 doi: 10.7326/M23-0342. PMID: 37639720Free PMC Article
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
David K, Narinx N, Antonio L, Evenepoel P, Claessens F, Decallonne B, Vanderschueren D
Rev Endocr Metab Disord 2022 Dec;23(6):1173-1208. Epub 2022 Jul 16 doi: 10.1007/s11154-022-09738-5. PMID: 35841491
Labrie F, Bélanger A, Pelletier G, Martel C, Archer DF, Utian WH
Menopause 2017 Jun;24(6):702-712. doi: 10.1097/GME.0000000000000808. PMID: 28098598
Corrigan B
Clin J Sport Med 2002 Jul;12(4):236-41. doi: 10.1097/00042752-200207000-00006. PMID: 12131057

Prognosis

Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
Franik G, Plinta R, Madej P, Owczarek A, Bozentowicz-Wikarek M, Chudek J, Skrzypulec-Plinta V, Olszanecka-Glinianowicz M
Ginekol Pol 2020;91(5):251-255. doi: 10.5603/GP.2020.0056. PMID: 32495930
Bonier F, Cox RM
Mol Cell Endocrinol 2020 Jan 15;500:110640. Epub 2019 Nov 9 doi: 10.1016/j.mce.2019.110640. PMID: 31715223
Yeap BB, Page ST, Grossmann M
Lancet Diabetes Endocrinol 2018 Aug;6(8):659-672. Epub 2018 Jul 17 doi: 10.1016/S2213-8587(17)30416-3. PMID: 30017800
Haring R
J Endocrinol 2012 Oct;215(1):3-16. Epub 2012 Apr 30 doi: 10.1530/JOE-12-0119. PMID: 22547567

Clinical prediction guides

Bergamini M, Dalla Volta A, Palumbo C, Zamboni S, Triggiani L, Zamparini M, Laganà M, Rinaudo L, Di Meo N, Caramella I, Bresciani R, Valcamonico F, Borghetti P, Guerini A, Farina D, Antonelli A, Simeone C, Mazziotti G, Berruti A
Elife 2024 Apr 24;13 doi: 10.7554/eLife.92655. PMID: 38656229Free PMC Article
Rinaldi S, Dossus L, Keski-Rahkonen P, Kiss A, Navionis AS, Biessy C, Travis R, Weiderpass E, Romieu I, Eriksen AK, Tjonneland A, Kvaskoff M, Canonico M, Truong T, Katzke V, Kaaks R, Catalano A, Panico S, Masala G, Tumino R, Lukic M, Olsen KS, Zamora-Ros R, Santiuste C, Aizpurua Atxega A, Guevara M, Rodriguez-Barranco M, Sandstrom M, Hennings J, Almquist M, Aglago Kouassivi E, Christakoudi S, Gunter M, Franceschi S
Int J Cancer 2024 Jun 15;154(12):2064-2074. Epub 2024 Feb 15 doi: 10.1002/ijc.34872. PMID: 38357914
Sun K, Ming Y, Xu J, Wu Y, Zeng Y, Wu L, Li M, Shen B
Orthop Surg 2023 Dec;15(12):3065-3074. Epub 2023 Sep 28 doi: 10.1111/os.13881. PMID: 37771125Free PMC Article
Eckardstein Av, Wu FC
Growth Horm IGF Res 2003 Aug;13 Suppl A:S72-84. doi: 10.1016/s1096-6374(03)00059-5. PMID: 12914731
Parker LN
Endocrinol Metab Clin North Am 1991 Mar;20(1):71-83. PMID: 2029889

Recent systematic reviews

Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
Escobar-Morreale HF, Santacruz E, Luque-Ramírez M, Botella Carretero JI
Hum Reprod Update 2017 Jul 1;23(4):390-408. doi: 10.1093/humupd/dmx012. PMID: 28486593
Ennour-Idrissi K, Maunsell E, Diorio C
Breast Cancer Res 2015 Nov 5;17(1):139. doi: 10.1186/s13058-015-0647-3. PMID: 26541144Free PMC Article
Zimmerman Y, Eijkemans MJ, Coelingh Bennink HJ, Blankenstein MA, Fauser BC
Hum Reprod Update 2014 Jan-Feb;20(1):76-105. Epub 2013 Sep 29 doi: 10.1093/humupd/dmt038. PMID: 24082040Free PMC Article
Kelly CJ, Stenton SR, Lashen H
Hum Reprod Update 2011 Jan-Feb;17(1):4-16. Epub 2010 Jul 15 doi: 10.1093/humupd/dmq027. PMID: 20634211

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