U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Undifferentiated round cell sarcoma

MedGen UID:
885673
Concept ID:
C4048304
Neoplastic Process
Synonyms: Undifferentiated Round Cell Sarcoma; undifferentiated round cell sarcoma
SNOMED CT: Undifferentiated round cell sarcoma (73506006); Undifferentiated round cell sarcoma (1290803006)
 
Monarch Initiative: MONDO:0020661

Definition

An undifferentiated soft tissue sarcoma characterized by the presence of uniform round or ovoid malignant cells with a high nuclear to cytoplasmic ratio. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUndifferentiated round cell sarcoma

Professional guidelines

PubMed

Merjaneh N, Kim H, Escoto H, Metts J, Ray A, Bukowinski A, LeBlanc Z, Fair D, Watanbe M, Alva E, Todd K, Daley J, Hartt D, Cramer SL, Szabo S, Pressey JG
J Pediatr Hematol Oncol 2023 Aug 1;45(6):315-321. Epub 2023 Jan 10 doi: 10.1097/MPH.0000000000002620. PMID: 36706311Free PMC Article
Rekhi B, Mridha A, Kattoor J
Indian J Pathol Microbiol 2019 Apr-Jun;62(2):199-205. doi: 10.4103/IJPM.IJPM_675_18. PMID: 30971540

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Soft Tissue Sarcoma, 2024

Recent clinical studies

Etiology

Palmerini E, Gambarotti M, Italiano A, Nathenson MJ, Ratan R, Dileo P, Provenzano S, Jones RL, DuBois SG, Martin-Broto J, de Alava E, Baldi GG, Grignani G, Ferraresi V, Brunello A, Paoluzzi L, Bertulli R, Hindi N, Montemurro M, Rothermundt C, Cocchi S, Salguero-Aranda C, Donati D, Martin JD, Abdelhamid Ahmed AH, Mazzocca A, Carretta E, Cesari M, Pierini M, Righi A, Sbaraglia M, Laginestra MA, Scotlandi K, Dei Tos AP, Ibrahim T, Stacchiotti S, Vincenzi B
Eur J Cancer 2023 Apr;183:11-23. Epub 2023 Jan 18 doi: 10.1016/j.ejca.2023.01.003. PMID: 36791667
Dickson BC
Surg Pathol Clin 2021 Dec;14(4):679-694. Epub 2021 Oct 7 doi: 10.1016/j.path.2021.06.009. PMID: 34742487
Aldera AP, Govender D
J Clin Pathol 2020 Jun;73(6):314-317. Epub 2020 Mar 11 doi: 10.1136/jclinpath-2020-206513. PMID: 32161069
Rekhi B, Mridha A, Kattoor J
Indian J Pathol Microbiol 2019 Apr-Jun;62(2):199-205. doi: 10.4103/IJPM.IJPM_675_18. PMID: 30971540
Mariño-Enríquez A, Fletcher CD
Int J Biochem Cell Biol 2014 Aug;53:493-504. Epub 2014 May 5 doi: 10.1016/j.biocel.2014.04.022. PMID: 24801613

Diagnosis

Machado I, Llombart-Bosch A, Charville GW, Navarro S, Domínguez Franjo MP, Bridge JA, Linos K
Surg Pathol Clin 2024 Mar;17(1):31-55. Epub 2023 Aug 7 doi: 10.1016/j.path.2023.07.001. PMID: 38278606
Palmerini E, Gambarotti M, Italiano A, Nathenson MJ, Ratan R, Dileo P, Provenzano S, Jones RL, DuBois SG, Martin-Broto J, de Alava E, Baldi GG, Grignani G, Ferraresi V, Brunello A, Paoluzzi L, Bertulli R, Hindi N, Montemurro M, Rothermundt C, Cocchi S, Salguero-Aranda C, Donati D, Martin JD, Abdelhamid Ahmed AH, Mazzocca A, Carretta E, Cesari M, Pierini M, Righi A, Sbaraglia M, Laginestra MA, Scotlandi K, Dei Tos AP, Ibrahim T, Stacchiotti S, Vincenzi B
Eur J Cancer 2023 Apr;183:11-23. Epub 2023 Jan 18 doi: 10.1016/j.ejca.2023.01.003. PMID: 36791667
Dickson BC
Surg Pathol Clin 2021 Dec;14(4):679-694. Epub 2021 Oct 7 doi: 10.1016/j.path.2021.06.009. PMID: 34742487
Aldera AP, Govender D
J Clin Pathol 2020 Jun;73(6):314-317. Epub 2020 Mar 11 doi: 10.1136/jclinpath-2020-206513. PMID: 32161069
Sbaraglia M, Righi A, Gambarotti M, Dei Tos AP
Virchows Arch 2020 Jan;476(1):109-119. Epub 2019 Dec 4 doi: 10.1007/s00428-019-02720-8. PMID: 31802230

Therapy

Piques F, Penicaud M, Essamet W, Cabello-Aguilar S, Trinquet A, Vendrell JA, Costes V, Solassol J
Pathobiology 2024;91(5):370-374. Epub 2024 May 8 doi: 10.1159/000539239. PMID: 38718771
Ota T, Ishikawa T, Yasuda R, Yasuda T, Okayama T, Inoue K, Dohi O, Yoshida N, Kamada K, Uchiyama K, Takagi T, Konishi H, Naito Y, Matsuyama K, Yamaguchi T, Ootsuka K, Yoshida A, Kishimoto M, Itoh Y
Clin J Gastroenterol 2022 Jun;15(3):531-536. Epub 2022 Feb 17 doi: 10.1007/s12328-022-01606-8. PMID: 35175571
Bissonnette C, Shilo K, Liebner D, Rogers A, Pollock RE, Iwenofu OH
Int J Surg Pathol 2021 Feb;29(1):109-116. Epub 2020 Jun 7 doi: 10.1177/1066896920929081. PMID: 32506986
Helal A, Graffeo CS, Perry A, Cheville JC, Link MJ, Pollock BE
World Neurosurg 2020 Jul;139:12-19. Epub 2020 Apr 3 doi: 10.1016/j.wneu.2020.03.158. PMID: 32251827
Xiong J, Zhu K, Mao J, Cai J, He M, Li L, Wang J, Wang L
Medicine (Baltimore) 2019 Nov;98(45):e17872. doi: 10.1097/MD.0000000000017872. PMID: 31702654Free PMC Article

Prognosis

Machado I, Llombart-Bosch A, Charville GW, Navarro S, Domínguez Franjo MP, Bridge JA, Linos K
Surg Pathol Clin 2024 Mar;17(1):31-55. Epub 2023 Aug 7 doi: 10.1016/j.path.2023.07.001. PMID: 38278606
Palmerini E, Gambarotti M, Italiano A, Nathenson MJ, Ratan R, Dileo P, Provenzano S, Jones RL, DuBois SG, Martin-Broto J, de Alava E, Baldi GG, Grignani G, Ferraresi V, Brunello A, Paoluzzi L, Bertulli R, Hindi N, Montemurro M, Rothermundt C, Cocchi S, Salguero-Aranda C, Donati D, Martin JD, Abdelhamid Ahmed AH, Mazzocca A, Carretta E, Cesari M, Pierini M, Righi A, Sbaraglia M, Laginestra MA, Scotlandi K, Dei Tos AP, Ibrahim T, Stacchiotti S, Vincenzi B
Eur J Cancer 2023 Apr;183:11-23. Epub 2023 Jan 18 doi: 10.1016/j.ejca.2023.01.003. PMID: 36791667
Aldera AP, Govender D
J Clin Pathol 2020 Jun;73(6):314-317. Epub 2020 Mar 11 doi: 10.1136/jclinpath-2020-206513. PMID: 32161069
Sbaraglia M, Righi A, Gambarotti M, Dei Tos AP
Virchows Arch 2020 Jan;476(1):109-119. Epub 2019 Dec 4 doi: 10.1007/s00428-019-02720-8. PMID: 31802230
Mariño-Enríquez A, Fletcher CD
Int J Biochem Cell Biol 2014 Aug;53:493-504. Epub 2014 May 5 doi: 10.1016/j.biocel.2014.04.022. PMID: 24801613

Clinical prediction guides

Palmerini E, Gambarotti M, Italiano A, Nathenson MJ, Ratan R, Dileo P, Provenzano S, Jones RL, DuBois SG, Martin-Broto J, de Alava E, Baldi GG, Grignani G, Ferraresi V, Brunello A, Paoluzzi L, Bertulli R, Hindi N, Montemurro M, Rothermundt C, Cocchi S, Salguero-Aranda C, Donati D, Martin JD, Abdelhamid Ahmed AH, Mazzocca A, Carretta E, Cesari M, Pierini M, Righi A, Sbaraglia M, Laginestra MA, Scotlandi K, Dei Tos AP, Ibrahim T, Stacchiotti S, Vincenzi B
Eur J Cancer 2023 Apr;183:11-23. Epub 2023 Jan 18 doi: 10.1016/j.ejca.2023.01.003. PMID: 36791667
Merjaneh N, Kim H, Escoto H, Metts J, Ray A, Bukowinski A, LeBlanc Z, Fair D, Watanbe M, Alva E, Todd K, Daley J, Hartt D, Cramer SL, Szabo S, Pressey JG
J Pediatr Hematol Oncol 2023 Aug 1;45(6):315-321. Epub 2023 Jan 10 doi: 10.1097/MPH.0000000000002620. PMID: 36706311Free PMC Article
Chaib B, Malhotra K, Khoo M, Saifuddin A
Br J Radiol 2021 Sep 1;94(1125):20201341. Epub 2021 Jul 28 doi: 10.1259/bjr.20201341. PMID: 34319796Free PMC Article
Antonescu CR, Kao YC, Xu B, Fujisawa Y, Chung C, Fletcher CDM, Graf N, Suurmeijer AJ, Zin A, Wexler LH, Ferrari A, Bisogno G, Alaggio R
Mod Pathol 2020 Sep;33(9):1669-1677. Epub 2020 May 5 doi: 10.1038/s41379-020-0557-5. PMID: 32372022Free PMC Article
Sbaraglia M, Righi A, Gambarotti M, Dei Tos AP
Virchows Arch 2020 Jan;476(1):109-119. Epub 2019 Dec 4 doi: 10.1007/s00428-019-02720-8. PMID: 31802230

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Soft Tissue Sarcoma, 2024

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...