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Metastatic seminoma

MedGen UID:
872999
•Concept ID:
C4040134
•
Neoplastic Process
Synonym: Seminoma, metastatic
SNOMED CT: Metastatic seminoma (708937004); Seminoma, metastatic (708937004)

Professional guidelines

PubMed

Primary Retroperitoneal Lymph Node Dissection for Seminoma Metastatic to the Retroperitoneum.
Matulewicz RS, Benfante N, Funt SA, Feldman DR, Carver B, Doudt A, Knezevic A, Sheinfeld J
J Urol 2024 Jan;211(1):80-89. Epub 2023 Sep 6 doi: 10.1097/JU.0000000000003697. PMID: 37672753
Treatment de-escalation for stage II seminoma.
Wood GE, Chamberlain F, Tran B, Conduit C, Liow E, Nicol DL, Shamash J, Alifrangis C, Rajan P
Nat Rev Urol 2023 Aug;20(8):502-512. Epub 2023 Mar 7 doi: 10.1038/s41585-023-00727-0. PMID: 36882564
Clinical stage II seminoma: management options.
Alsyouf M, Daneshmand S
World J Urol 2022 Feb;40(2):343-348. Epub 2021 Oct 16 doi: 10.1007/s00345-021-03854-8. PMID: 34655305

Recent clinical studies

Etiology

Surgery in Early Metastatic Seminoma: A Phase II Trial of Retroperitoneal Lymph Node Dissection for Testicular Seminoma With Limited Retroperitoneal Lymphadenopathy.
Daneshmand S, Cary C, Masterson T, Einhorn L, Adra N, Boorjian SA, Kollmannsberger C, Schuckman A, So A, Black P, Bagrodia A, Skinner E, Alemozaffar M, Brand T, Eggener S, Pierorazio P, Stratton K, Nappi L, Nichols C, Luo C, Li M, Hu B
J Clin Oncol 2023 Jun 1;41(16):3009-3018. Epub 2023 Mar 13 doi: 10.1200/JCO.22.00624. PMID: 36913642
Treatment de-escalation for stage II seminoma.
Wood GE, Chamberlain F, Tran B, Conduit C, Liow E, Nicol DL, Shamash J, Alifrangis C, Rajan P
Nat Rev Urol 2023 Aug;20(8):502-512. Epub 2023 Mar 7 doi: 10.1038/s41585-023-00727-0. PMID: 36882564
Single-agent carboplatin AUC10 in metastatic seminoma: A multi-centre UK study of 216 patients.
Alifrangis C, Sharma A, Chowdhury S, Duncan S, Milic M, Gogbashian A, Agarwal S, Sahdev A, Wilson P, Harland S, Stoneham S, Lockley M, Rustin G, Oliver T, Berney D, Shamash J
Eur J Cancer 2022 Mar;164:105-113. Epub 2020 Oct 8 doi: 10.1016/j.ejca.2020.08.031. PMID: 33041185
Survival and New Prognosticators in Metastatic Seminoma: Results From the IGCCCG-Update Consortium.
Beyer J, Collette L, Sauvé N, Daugaard G, Feldman DR, Tandstad T, Tryakin A, Stahl O, Gonzalez-Billalabeitia E, De Giorgi U, Culine S, de Wit R, Hansen AR, Bebek M, Terbuch A, Albany C, Hentrich M, Gietema JA, Negaard H, Huddart RA, Lorch A, Cafferty FH, Heng DYC, Sweeney CJ, Winquist E, Chovanec M, Fankhauser C, Stark D, Grimison P, Necchi A, Tran B, Heidenreich A, Shamash J, Sternberg CN, Vaughn DJ, Duran I, Bokemeyer C, Patrikidou A, Cathomas R, Assele S, Gillessen S; International Germ Cell Cancer Classification Update Consortium
J Clin Oncol 2021 May 10;39(14):1553-1562. Epub 2021 Mar 17 doi: 10.1200/JCO.20.03292. PMID: 33729863Free PMC Article
The search for biomarkers of metastatic seminoma.
Ruf CG, Khalili-Harbi N, Sachs S, Isbarn H, Wagner W, Matthies C, Meineke V, Fisch M, Chun FK, Abend M
J Urol 2013 Sep;190(3):1046-51. Epub 2013 Apr 10 doi: 10.1016/j.juro.2013.04.022. PMID: 23583226

Diagnosis

Comparative cost-effectiveness of contemporary treatment strategies for stage IIA seminoma.
Joyce DD, Sharma V, Wymer KM, Moriarty JP, Borah BJ, Walia A, Costello BA, Pagliaro LC, Daneshmand S, Leibovich BC, Boorjian SA
J Natl Cancer Inst 2024 Mar 7;116(3):468-475. doi: 10.1093/jnci/djad211. PMID: 37819776
Metastatic seminoma masquerading as sarcoidosis.
Shopsowitz KE, Wang XQ, Soleimani M, Hudoba M, Chen LYC, McGinnis E
Lancet Oncol 2023 Aug;24(8):e355. doi: 10.1016/S1470-2045(23)00287-5. PMID: 37541281
Paraneoplastic Demyelinating Inflammatory Neuropathy Revealing Metastatic Seminoma: A Case Report.
Cherifi F, Dereeper O, Forestier A, Joly F, Penel N
Chemotherapy 2022;67(4):256-260. Epub 2022 Jun 28 doi: 10.1159/000525154. PMID: 35700701
Management of Germ Cell Tumours of the Testes in Adult Patients: German Clinical Practice Guideline, PART II - Recommendations for the Treatment of Advanced, Recurrent, and Refractory Disease and Extragonadal and Sex Cord/Stromal Tumours and for the Management of Follow-Up, Toxicity, Quality of Life, Palliative Care, and Supportive Therapy.
Kliesch S, Schmidt S, Wilborn D, Aigner C, Albrecht W, Bedke J, Beintker M, Beyersdorff D, Bokemeyer C, Busch J, Classen J, de Wit M, Dieckmann KP, Diemer T, Dieing A, Gockel M, Göckel-Beining B, Hakenberg OW, Heidenreich A, Heinzelbecker J, Herkommer K, Hermanns T, Kaufmann S, Kornmann M, Kotzerke J, Krege S, Kristiansen G, Lorch A, Müller AC, Oechsle K, Ohloff T, Oing C, Otto U, Pfister D, Pichler R, Recken H, Rick O, Rudolph Y, Ruf C, Schirren J, Schmelz H, Schmidberger H, Schrader M, Schweyer S, Seeling S, Souchon R, Winter C, Wittekind C, Zengerling F, Zermann DH, Zillmann R, Albers P
Urol Int 2021;105(3-4):181-191. Epub 2021 Jan 22 doi: 10.1159/000511245. PMID: 33486494Free PMC Article
The search for biomarkers of metastatic seminoma.
Ruf CG, Khalili-Harbi N, Sachs S, Isbarn H, Wagner W, Matthies C, Meineke V, Fisch M, Chun FK, Abend M
J Urol 2013 Sep;190(3):1046-51. Epub 2013 Apr 10 doi: 10.1016/j.juro.2013.04.022. PMID: 23583226

Therapy

Surgery in Early Metastatic Seminoma: A Phase II Trial of Retroperitoneal Lymph Node Dissection for Testicular Seminoma With Limited Retroperitoneal Lymphadenopathy.
Daneshmand S, Cary C, Masterson T, Einhorn L, Adra N, Boorjian SA, Kollmannsberger C, Schuckman A, So A, Black P, Bagrodia A, Skinner E, Alemozaffar M, Brand T, Eggener S, Pierorazio P, Stratton K, Nappi L, Nichols C, Luo C, Li M, Hu B
J Clin Oncol 2023 Jun 1;41(16):3009-3018. Epub 2023 Mar 13 doi: 10.1200/JCO.22.00624. PMID: 36913642
Treatment de-escalation for stage II seminoma.
Wood GE, Chamberlain F, Tran B, Conduit C, Liow E, Nicol DL, Shamash J, Alifrangis C, Rajan P
Nat Rev Urol 2023 Aug;20(8):502-512. Epub 2023 Mar 7 doi: 10.1038/s41585-023-00727-0. PMID: 36882564
Clinical stage II seminoma: management options.
Alsyouf M, Daneshmand S
World J Urol 2022 Feb;40(2):343-348. Epub 2021 Oct 16 doi: 10.1007/s00345-021-03854-8. PMID: 34655305
Single-agent carboplatin AUC10 in metastatic seminoma: A multi-centre UK study of 216 patients.
Alifrangis C, Sharma A, Chowdhury S, Duncan S, Milic M, Gogbashian A, Agarwal S, Sahdev A, Wilson P, Harland S, Stoneham S, Lockley M, Rustin G, Oliver T, Berney D, Shamash J
Eur J Cancer 2022 Mar;164:105-113. Epub 2020 Oct 8 doi: 10.1016/j.ejca.2020.08.031. PMID: 33041185
Survival and New Prognosticators in Metastatic Seminoma: Results From the IGCCCG-Update Consortium.
Beyer J, Collette L, Sauvé N, Daugaard G, Feldman DR, Tandstad T, Tryakin A, Stahl O, Gonzalez-Billalabeitia E, De Giorgi U, Culine S, de Wit R, Hansen AR, Bebek M, Terbuch A, Albany C, Hentrich M, Gietema JA, Negaard H, Huddart RA, Lorch A, Cafferty FH, Heng DYC, Sweeney CJ, Winquist E, Chovanec M, Fankhauser C, Stark D, Grimison P, Necchi A, Tran B, Heidenreich A, Shamash J, Sternberg CN, Vaughn DJ, Duran I, Bokemeyer C, Patrikidou A, Cathomas R, Assele S, Gillessen S; International Germ Cell Cancer Classification Update Consortium
J Clin Oncol 2021 May 10;39(14):1553-1562. Epub 2021 Mar 17 doi: 10.1200/JCO.20.03292. PMID: 33729863Free PMC Article

Prognosis

Single-agent carboplatin AUC10 in metastatic seminoma: A multi-centre UK study of 216 patients.
Alifrangis C, Sharma A, Chowdhury S, Duncan S, Milic M, Gogbashian A, Agarwal S, Sahdev A, Wilson P, Harland S, Stoneham S, Lockley M, Rustin G, Oliver T, Berney D, Shamash J
Eur J Cancer 2022 Mar;164:105-113. Epub 2020 Oct 8 doi: 10.1016/j.ejca.2020.08.031. PMID: 33041185
Survival and New Prognosticators in Metastatic Seminoma: Results From the IGCCCG-Update Consortium.
Beyer J, Collette L, Sauvé N, Daugaard G, Feldman DR, Tandstad T, Tryakin A, Stahl O, Gonzalez-Billalabeitia E, De Giorgi U, Culine S, de Wit R, Hansen AR, Bebek M, Terbuch A, Albany C, Hentrich M, Gietema JA, Negaard H, Huddart RA, Lorch A, Cafferty FH, Heng DYC, Sweeney CJ, Winquist E, Chovanec M, Fankhauser C, Stark D, Grimison P, Necchi A, Tran B, Heidenreich A, Shamash J, Sternberg CN, Vaughn DJ, Duran I, Bokemeyer C, Patrikidou A, Cathomas R, Assele S, Gillessen S; International Germ Cell Cancer Classification Update Consortium
J Clin Oncol 2021 May 10;39(14):1553-1562. Epub 2021 Mar 17 doi: 10.1200/JCO.20.03292. PMID: 33729863Free PMC Article
The search for biomarkers of metastatic seminoma.
Ruf CG, Khalili-Harbi N, Sachs S, Isbarn H, Wagner W, Matthies C, Meineke V, Fisch M, Chun FK, Abend M
J Urol 2013 Sep;190(3):1046-51. Epub 2013 Apr 10 doi: 10.1016/j.juro.2013.04.022. PMID: 23583226
Carboplatin AUC 10 for IGCCCG good prognosis metastatic seminoma.
Tookman L, Rashid S, Matakidou A, Phillips M, Wilson P, Ansell W, Jamal-Hanjani M, Chowdhury S, Harland S, Sarwar N, Oliver T, Powles T, Shamash J
Acta Oncol 2013 Jun;52(5):987-93. Epub 2012 Sep 3 doi: 10.3109/0284186X.2012.714078. PMID: 22943385
Chemotherapy of metastatic seminoma.
Schuette J, Niederle N, Scheulen ME, Seeber S, Schmidt CG
Br J Cancer 1985 Apr;51(4):467-72. doi: 10.1038/bjc.1985.67. PMID: 2579665Free PMC Article

Clinical prediction guides

Paraneoplastic Demyelinating Inflammatory Neuropathy Revealing Metastatic Seminoma: A Case Report.
Cherifi F, Dereeper O, Forestier A, Joly F, Penel N
Chemotherapy 2022;67(4):256-260. Epub 2022 Jun 28 doi: 10.1159/000525154. PMID: 35700701
Transcriptome analysis reveals upregulation of immune response pathways at the invasive tumour front of metastatic seminoma germ cell tumours.
Nestler T, Dalvi P, Haidl F, Wittersheim M, von Brandenstein M, Paffenholz P, Wagener-Ryczek S, Pfister D, Koitzsch U, Hellmich M, Buettner R, Odenthal M, Heidenreich A
Br J Cancer 2022 Apr;126(6):937-947. Epub 2022 Jan 12 doi: 10.1038/s41416-021-01621-5. PMID: 35022523Free PMC Article
Single-agent carboplatin AUC10 in metastatic seminoma: A multi-centre UK study of 216 patients.
Alifrangis C, Sharma A, Chowdhury S, Duncan S, Milic M, Gogbashian A, Agarwal S, Sahdev A, Wilson P, Harland S, Stoneham S, Lockley M, Rustin G, Oliver T, Berney D, Shamash J
Eur J Cancer 2022 Mar;164:105-113. Epub 2020 Oct 8 doi: 10.1016/j.ejca.2020.08.031. PMID: 33041185
The search for biomarkers of metastatic seminoma.
Ruf CG, Khalili-Harbi N, Sachs S, Isbarn H, Wagner W, Matthies C, Meineke V, Fisch M, Chun FK, Abend M
J Urol 2013 Sep;190(3):1046-51. Epub 2013 Apr 10 doi: 10.1016/j.juro.2013.04.022. PMID: 23583226
Chemotherapy of metastatic seminoma.
Schuette J, Niederle N, Scheulen ME, Seeber S, Schmidt CG
Br J Cancer 1985 Apr;51(4):467-72. doi: 10.1038/bjc.1985.67. PMID: 2579665Free PMC Article

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